RAMIN PARSEY

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Higher 5-HT1A receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic study
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 31:1745-9. 2006
  2. ncbi request reprint Quantitative analysis of T2 signal intensities in Alzheimer's disease
    R V Parsey
    Columbia University, New York State Psychiatric Institute, New York 10032, USA
    Psychiatry Res 82:181-5. 1998
  3. ncbi request reprint Amyloid plaque imaging agent [C-11]-6-OH-BTA-1: biodistribution and radiation dosimetry in baboon
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and Division of Brain Imaging cDepartment of Neuroscience, New York State Psychiatric Institute, New York 10032, USA
    Nucl Med Commun 26:875-80. 2005
  4. ncbi request reprint Biodistribution and radiation dosimetry of 11C-WAY100,635 in humans
    Ramin V Parsey
    Division of Brain Imaging, Department of Neuroscience, New York State Psychiatric Institute, New York, New York, USA
    J Nucl Med 46:614-9. 2005
  5. ncbi request reprint Acute occupancy of brain serotonin transporter by sertraline as measured by [11C]DASB and positron emission tomography
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 59:821-8. 2006
  6. ncbi request reprint Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography
    Ramin V Parsey
    Department of Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    J Cereb Blood Flow Metab 25:785-93. 2005
  7. ncbi request reprint Lower serotonin transporter binding potential in the human brain during major depressive episodes
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 163:52-8. 2006
  8. ncbi request reprint Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 59:106-13. 2006
  9. ncbi request reprint Metabolite considerations in the in vivo quantification of serotonin transporters using 11C-DASB and PET in humans
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Nucl Med 47:1796-802. 2006
  10. ncbi request reprint Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 163:48-51. 2006

Research Grants

Detail Information

Publications67

  1. ncbi request reprint Higher 5-HT1A receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic study
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 31:1745-9. 2006
    ..Higher 5-HT1A BP, perhaps due to greater gene expression, may predict antidepressant medication nonremission. The findings should be tested in a controlled prospective treatment study...
  2. ncbi request reprint Quantitative analysis of T2 signal intensities in Alzheimer's disease
    R V Parsey
    Columbia University, New York State Psychiatric Institute, New York 10032, USA
    Psychiatry Res 82:181-5. 1998
    ..We were unable to detect differences in intensities in a whole slice or the frontal lobe. To our knowledge this is the first quantitative comparison of MRI signal intensities in Alzheimer's Disease...
  3. ncbi request reprint Amyloid plaque imaging agent [C-11]-6-OH-BTA-1: biodistribution and radiation dosimetry in baboon
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and Division of Brain Imaging cDepartment of Neuroscience, New York State Psychiatric Institute, New York 10032, USA
    Nucl Med Commun 26:875-80. 2005
    ..It crosses the blood brain barrier, and is a promising tracer for imaging plaques in vivo using positron emission tomography. We now report the biodistribution and dosimetry of [C-11]-6-OH-BTA-1 in baboons...
  4. ncbi request reprint Biodistribution and radiation dosimetry of 11C-WAY100,635 in humans
    Ramin V Parsey
    Division of Brain Imaging, Department of Neuroscience, New York State Psychiatric Institute, New York, New York, USA
    J Nucl Med 46:614-9. 2005
    ..Dose estimates for current human studies are based on data from rat dosimetry studies. We report the biodistribution and dosimetry of the PET serotonin 1A antagonist 11C-WAY100,635 in humans...
  5. ncbi request reprint Acute occupancy of brain serotonin transporter by sertraline as measured by [11C]DASB and positron emission tomography
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 59:821-8. 2006
    ..Previous studies used chronic SSRI administration that may down-regulate 5-HTT and used the cerebellum as reference region despite measurable 5-HTT. We examine the reference region and occupancy after acute sertraline dosing...
  6. ncbi request reprint Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography
    Ramin V Parsey
    Department of Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    J Cereb Blood Flow Metab 25:785-93. 2005
    ..With CW as a reference region, V(3)'' cannot be used to detect differences in 5-HT(1A) receptors between men and women, suggesting the need for arterial input functions to determine BP...
  7. ncbi request reprint Lower serotonin transporter binding potential in the human brain during major depressive episodes
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 163:52-8. 2006
    ..On the basis of postmortem and imaging studies, the authors hypothesized that subjects with major depressive disorder in a major depressive episode have fewer serotonin transporter sites, compared with healthy subjects...
  8. ncbi request reprint Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 59:106-13. 2006
    ..We measure 5-HT(1A) in MDD, assess the effects of antidepressant exposure (AE), and examine the role of the C(-1019)G polymorphism...
  9. ncbi request reprint Metabolite considerations in the in vivo quantification of serotonin transporters using 11C-DASB and PET in humans
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Nucl Med 47:1796-802. 2006
    ..To determine whether binding to an extracranial pool of 5-HT transporters contributes to the lower initial level of unmetabolized (11)C-DASB, we examined the effects of sertraline...
  10. ncbi request reprint Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 163:48-51. 2006
    ....
  11. ncbi request reprint Determination of volume of distribution using likelihood estimation in graphical analysis: elimination of estimation bias
    Ramin V Parsey
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    J Cereb Blood Flow Metab 23:1471-8. 2003
    ..As predicted by simulations, LEGA eliminates the noise-dependent bias associated with GA using OLS. This method is a valuable addition to the tools available for the quantification of radioligand binding data in PET and SPECT...
  12. ncbi request reprint Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635
    Ramin V Parsey
    Division of Neuroscience, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Brain Res 954:173-82. 2002
    ..Lower 5-HT(1A) binding in more aggressive individuals is consistent with pharmacological challenge studies. Future studies should determine whether the binding is a state or trait effect...
  13. ncbi request reprint Biodistribution and radiation dosimetry of [11C]DASB in baboons
    Marie Jose Belanger
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nucl Med Biol 31:1097-102. 2004
    ..We report on the biodistribution and dosimetry of [(11)C]DASB in the baboon as this species may be a more reliable surrogate for human dosimetry...
  14. ncbi request reprint Biodistribution and radiation dosimetry of 11C-harmine in baboons
    Rajan Murthy
    Department of Neuroscience, Division of Brain Imaging, New York State Psychiatric Institute, New York 10032, USA
    Nucl Med Commun 28:748-54. 2007
    ..This study describes the biodistribution and dosimetry of 11C-harmine, a tracer designed to specifically bind to monoamine oxidase A for positron emission tomography imaging...
  15. ncbi request reprint Whole body [11C]-dihydrotetrabenazine imaging of baboons: biodistribution and human radiation dosimetry estimates
    Rajan Murthy
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Eur J Nucl Med Mol Imaging 35:790-7. 2008
    ..To support the feasibility of long-term repeated administrations, we estimate the biodistribution and dosimetry of [(11)C]-DTBZ in humans...
  16. pmc 11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls
    Robin Goland
    Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, New York, USA
    J Nucl Med 50:382-9. 2009
    ..We evaluated the feasibility of (11)C-dihydrotetrabenazine PET quantification of pancreatic VMAT2 binding in healthy subjects and patients with long-standing type 1 diabetes...
  17. ncbi request reprint Regional brain responses to serotonin in major depressive disorder
    Amy D Anderson
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    J Affect Disord 82:411-7. 2004
    ..Positron Emission Tomography (PET) studies have reported altered resting regional brain glucose metabolism in mood disorders. This study examines the relationship of such changes to serotonin system abnormalities associated with depression...
  18. pmc Synthesis, in vitro and in vivo evaluation of [11C]MMTP: a potential PET ligand for mGluR1 receptors
    Jaya Prabhakaran
    Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University, USA
    Bioorg Med Chem Lett 20:3499-501. 2010
    ..These findings suggest [(11)C]1 is a promising PET radiotracer candidate for mGluR1...
  19. ncbi request reprint Volumetric analysis of the prefrontal cortex, amygdala, and hippocampus in major depression
    Ramin S Hastings
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 29:952-9. 2004
    ..The biology of mood disorders in females may differ in some aspects from males, and may contribute to the higher rate of depression in women...
  20. ncbi request reprint In vivo assessment of [11C]MRB as a prospective PET ligand for imaging the norepinephrine transporter
    Alin J Severance
    Division of Brain Imaging, Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, P O Box 42, New York, NY 10032, USA
    Eur J Nucl Med Mol Imaging 34:688-93. 2007
    ..S,S)-Methylreboxetine (MRB) is among the more promising ligands recently adapted for positron emission tomography (PET), and the present study aimed to evaluate its potential for use in higher primates...
  21. ncbi request reprint Optimal metabolite curve fitting for kinetic modeling of 11C-WAY-100635
    Songmei Wu
    New York City Department of Health and Mental Hygiene, New York, New York, USA
    J Nucl Med 48:926-31. 2007
    ..11)C-WAY 100635 is a rapidly metabolized radioligand used extensively in mapping the 5-hydroxytryptamine receptor 1A system...
  22. doi request reprint Synthesis and in vivo evaluation of [11C]MPTQ: a potential PET tracer for alpha2A-adrenergic receptors
    Jaya Prabhakaran
    Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University, New York, USA
    Bioorg Med Chem Lett 20:3654-7. 2010
    ..The total synthesis time was 30 min from EOB. PET studies in anesthetized baboon show that [(11)C]1 penetrates BBB and accumulates in alpha2A-AR enriched brain areas...
  23. pmc (99m)Tc hexamethyl-propylene-aminoxime single-photon emission computed tomography prediction of conversion from mild cognitive impairment to Alzheimer disease
    D P Devanand
    NYSPI, Columbia University, New York, NY 10032, USA
    Am J Geriatr Psychiatry 18:959-72. 2010
    ..To examine the utility of single-photon emission computed tomography (SPECT) to predict conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD)...
  24. doi request reprint Serotonin receptor imaging: clinically useful?
    Ramin V Parsey
    Columbia University and the New York State Psychiatric Institute, New York 10032, USA
    J Nucl Med 51:1495-8. 2010
    ..Through concerted, directed, and cooperative efforts, the routine use of serotonin imaging in the clinic will most likely be achieved in the next decade...
  25. pmc Plasma polyunsaturated fatty acids and regional cerebral glucose metabolism in major depression
    M Elizabeth Sublette
    Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, Unit 42, New York, NY 10032, USA
    Prostaglandins Leukot Essent Fatty Acids 80:57-64. 2009
    ..This pilot study is the first to demonstrate fatty acid and regionally specific correlations in the brain between plasma PUFA and rCMRglu in humans...
  26. pmc Voxel-based analysis of 11C-PIB scans for diagnosing Alzheimer's disease
    Arthur Mikhno
    Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York, USA
    J Nucl Med 49:1262-9. 2008
    ..We assessed the use of data-determined standardized voxels of interest (VOIs) to improve the classification capability of 11C-PIB scans on patients with AD...
  27. pmc Effect of BDNF val66met polymorphism on age-related amygdala volume changes in healthy subjects
    M E Sublette
    Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, Unit 42, New York, NY 10032, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:1652-5. 2008
    ..Using an ANCOVA model, we found that amygdala volumes were inversely correlated with age in BDNF val66met carriers but not in non-carriers. This is the first report of age-related BDNF val66met polymorphism effects on amygdala volume...
  28. pmc Modeling considerations for 11C-CUMI-101, an agonist radiotracer for imaging serotonin 1A receptor in vivo with PET
    Matthew S Milak
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Nucl Med 49:587-96. 2008
    ..Here we determine the optimal modeling parameters for 11C-MMP under its new name, 11C-CUMI-101, in Papio anubis...
  29. pmc Serotonin transporter binding as a possible predictor of one-year remission in major depressive disorder
    Jeffrey M Miller
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Unit 42, New York, NY, United States
    J Psychiatr Res 42:1137-44. 2008
    ..We assessed baseline 5-HTT binding as a predictor of one-year remission from a MDE, examining binding in brain regions implicated in the pathophysiology of major depressive disorder (MDD)...
  30. doi request reprint In vivo quantification of human serotonin 1A receptor using 11C-CUMI-101, an agonist PET radiotracer
    Matthew S Milak
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Nucl Med 51:1892-900. 2010
    ..Here, we report the optimal modeling parameters of (11)C-CUMI-101 for human PET studies...
  31. pmc Simultaneous estimation of input functions: an empirical study
    R Todd Ogden
    Department of Biostatistics, Columbia University, Mailman School of Public Health, 722 W 168th St, 6th Floor, New York, NY 10032, USA
    J Cereb Blood Flow Metab 30:816-26. 2010
    ..Results indicate that SIME provides a promising alternative for all the radioligands considered...
  32. pmc Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression
    Gregory M Sullivan
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Unit 41, New York, NY 10032, USA
    Biol Psychiatry 66:223-30. 2009
    ....
  33. pmc Regional brain metabolic correlates of self-reported depression severity contrasted with clinician ratings
    Matthew S Milak
    Department of Psychiatry, Columbia University, New York, NY 10032, USA
    J Affect Disord 126:113-24. 2010
    ....
  34. pmc Pittsburgh compound B (11C-PIB) and fluorodeoxyglucose (18 F-FDG) PET in patients with Alzheimer disease, mild cognitive impairment, and healthy controls
    D P Devanand
    Division of Geriatric Psychiatry, Columbia University, New York, USA
    J Geriatr Psychiatry Neurol 23:185-98. 2010
    ..These PET techniques provide complementary information in strongly distinguishing diagnostic groups in cross-sectional comparisons that need testing in longitudinal studies...
  35. pmc Elevated serotonin 1A binding in remitted major depressive disorder: evidence for a trait biological abnormality
    Jeffrey M Miller
    Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, Columbia University, New York, NY 10033, USA
    Neuropsychopharmacology 34:2275-84. 2009
    ....
  36. pmc Higher serotonin 1A binding in a second major depression cohort: modeling and reference region considerations
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Biol Psychiatry 68:170-8. 2010
    ..Discrepancies can be related to differences in study population or methodology. We sought to replicate our findings in a novel cohort and determine whether choice of reference region and outcome measure could explain discrepancies...
  37. pmc Modeling considerations for in vivo quantification of the dopamine transporter using [(11)C]PE2I and positron emission tomography
    Christine DeLorenzo
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, Unit 42, 1051 Riverside Drive, New York, NY 10032, USA
    J Cereb Blood Flow Metab 29:1332-45. 2009
    ..Eleven modeling methods were tested and six metrics were used for method evaluation. A noniterative two-tissue compartment method with 100 mins of scanning time was found to be optimal for characterizing [(11)C]PE2I...
  38. doi request reprint Nucleotide variation in central nervous system genes among male suicide attempters
    Enrique Baca-Garcia
    Department of Psychiatry at Fundacion Jimenez Diaz Hospital, Autonoma University, Madrid, Spain
    Am J Med Genet B Neuropsychiatr Genet 153:208-13. 2010
    ..This strategy may uncover new pathophysiological pathways regarding the neurobiology of suicidal acts...
  39. pmc Pretreatment regional brain glucose uptake in the midbrain on PET may predict remission from a major depressive episode after three months of treatment
    Matthew S Milak
    Department of Psychiatry, Columbia University, New York, NY, United States
    Psychiatry Res 173:63-70. 2009
    ..Prospective studies are needed to replicate these findings and determine whether outcome prediction is limited to a specific class of antidepressants...
  40. pmc Reported childhood abuse is associated with low serotonin transporter binding in vivo in major depressive disorder
    Jeffrey M Miller
    Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York, USA
    Synapse 63:565-73. 2009
    ..We examined healthy volunteers and subjects with major depressive disorder, a sample enriched for childhood abuse...
  41. ncbi request reprint Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptors
    J S Dileep Kumar
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Bioorg Med Chem 14:4029-34. 2006
    ..PET studies in baboon show that [11C]6 penetrates the BBB and accumulates in brain. No detectable specific binding was observed, likely due to the rapid metabolism or low density of CRF1 receptors in primate brain...
  42. ncbi request reprint Quantitative wavelet domain image processing of dynamic PET data
    Kjell Erlandsson
    Dept of Psychiatry and Radiol, Columbia Univ, New York, NY 10032, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2787-90. 2006
    ..Our results showed that, although non-linear effects may appear in low-contrast areas, it is possible to achieve accurate quantification with wavelet-based image processing...
  43. ncbi request reprint Synthesis and in vivo evaluation of [O-methyl-11C](2R,4R)-4-hydroxy-2-[2-[2-[2-(3-methoxy)phenyl]ethyl]phenoxy]ethyl-1-methylpyrrolidine as a 5-HT2A receptor PET ligand
    J S Dileep Kumar
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Nucl Med Biol 33:565-74. 2006
    ....
  44. ncbi request reprint Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand
    Jaya Prabhakaran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, NY 10032, USA
    Bioorg Med Chem Lett 16:2101-4. 2006
    ..PET studies in baboon show that [11C]5 penetrates the blood-brain barrier but, because of low specific binding and fast clearance of radioactivity it is not a suitable PET tracer for the in vivo quantification of 5-HT1AR...
  45. ncbi request reprint Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand
    J S Dileep Kumar
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Med Chem 49:125-34. 2006
    ..The regional brain volumes of distribution (V(T)) of [(11)C]10 in baboon correlate with [(11)C]WAY100635 V(T) in baboons. These data provide evidence that [(11)C]10 is the first promising agonist PET tracer for the 5-HT(1A) receptors...
  46. ncbi request reprint Neuroanatomic correlates of psychopathologic components of major depressive disorder
    Matthew S Milak
    Departments of Psychiatry and Radiology, Department of Neuroscience, NY State Psychiatric Institute, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Arch Gen Psychiatry 62:397-408. 2005
    ..The HDRS comprises distinct symptom clusters that may be associated with different patterns of regional brain glucose metabolism...
  47. ncbi request reprint Positron emission tomography of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without borderline personality disorder
    Maria A Oquendo
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 30:1163-72. 2005
    ..Controlling for the presence of BPD in future imaging studies of mood disorders may elucidate similarities and differences in regional serotonergic function in these two often comorbid disorders...
  48. ncbi request reprint Effects of tryptophan depletion on the binding of [11C]-DASB to the serotonin transporter in baboons: response to acute serotonin deficiency
    Matthew S Milak
    Department of Neuroscience, New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Psychiatry 57:102-6. 2005
    ..A ligand insensitive to EC can provide a measure of SERT unaffected by levels of 5-HT. Alternatively, serotonin depletion could accelerate internalization of SERT and reduce binding...
  49. ncbi request reprint Brain serotonin1A receptor binding in major depression is related to psychic and somatic anxiety
    Gregory M Sullivan
    Division of Neuroscience, Department of Psychiatry, New York 10032, USA
    Biol Psychiatry 58:947-54. 2005
    ..We investigated the relationship of anxiety expressed in major depressive disorder (MDD) to regional 5-HT1A binding...
  50. ncbi request reprint Synthesis of [O-methyl-11C]1-(2-chlorophenyl)-5-(4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide: a potential PET ligand for CB1 receptors
    J S Dileep Kumar
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Bioorg Med Chem Lett 14:2393-6. 2004
    ..The radiotracer was found to selectively label CB(1) receptors in slide-mounted sections of postmortem human brain containing prefrontal cortex as demonstrated by in vitro autoradiography using phosphor imaging...
  51. ncbi request reprint OS-EM and FBP reconstructions at low count rates: effect on 3D PET studies of [11C] WAY-100635
    Marie Jose Belanger
    Division of Neuroscience, New York State Psychiatric Institute, New York, NY, USA
    Neuroimage 21:244-50. 2004
    ..In neuroreceptor studies, if such a low count rate cannot be avoided, FBP reconstruction is preferable to OS-EM to estimate VT...
  52. pmc In vivo quantification of serotonin transporters using [(11)C]DASB and positron emission tomography in humans: modeling considerations
    R Todd Ogden
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Cereb Blood Flow Metab 27:205-17. 2007
    ..Average PD is 5.51 for V(T), 20.7 for BP, 17.2 for BP(1), and 16.5 for BP(2) across all regions. For voxel-level analysis we determined that the one-tissue compartment noniterative model is best...
  53. ncbi request reprint In vitro and in vivo evaluation of [11C]MPEPy as a potential PET ligand for mGlu5 receptors
    Alin J Severance
    Division of Brain Imaging, Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Nucl Med Biol 33:1021-7. 2006
    ..Despite the promising in vitro results, the low signal-to-noise ratio found in vivo does not justify the use of [(11)C]MPEPy as a PET radiotracer in humans...
  54. pmc PET Imaging of CRF1 with [11C]R121920 and [11C]DMP696: is the target of sufficient density?
    Gregory M Sullivan
    Division of Neuroscience, Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
    Nucl Med Biol 34:353-61. 2007
    ..The aim of this study was to investigate the in vivo binding characteristics of [11C]R121920 and [11C]DMP696 in the nonhuman primate for application in positron emission tomography (PET) studies of CRF1...
  55. pmc Positron emission tomography study of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without comorbid lifetime alcohol dependence
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Eur Neuropsychopharmacol 17:608-15. 2007
    ..The fact that the observed group difference disappeared after the fenfluramine challenge suggests that serotonergic mechanisms play a role in the observed differences between the groups...
  56. ncbi request reprint Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression
    Maria A Oquendo
    Department of Psychiatry, Columbia University, New York, USA
    Arch Gen Psychiatry 60:14-22. 2003
    ..Postmortem studies of serotonin receptors in suicides localize changes to the ventral prefrontal cortex (PFC). We studied serotonergic response in ventral PFC in depressed patients surviving a high-lethality suicide attempt...
  57. pmc Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography
    Maria A Oquendo
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Gen Psychiatry 64:201-8. 2007
    ..Associations of serotonin transporter promoter polymorphisms and bipolarity have been reported; however, research on alterations in serotonergic neurotransmission in bipolar depression remains scant...
  58. ncbi request reprint Synthesis and in vivo evaluation of a novel 5-HT1A receptor agonist radioligand [O-methyl- 11C]2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)dione in nonhuman primates
    J S Dileep Kumar
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Eur J Nucl Med Mol Imaging 34:1050-60. 2007
    ..We now report the synthesis and evaluation of [11C]MMP as an agonist PET tracer for 5-HT1A receptors in baboons...
  59. ncbi request reprint Regional brain gray matter volume differences in patients with bipolar disorder as assessed by optimized voxel-based morphometry
    Richard A Lochhead
    Department of Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 55:1154-62. 2004
    ..We conducted both optimized VBM, comparing MRI gray matter volume, and traditional VBM, comparing MRI gray matter density, in 11 BD subjects and 31 healthy volunteers. To our knowledge, these are the first VBM analyses of BD...
  60. ncbi request reprint Applications of positron emission tomography in psychiatry
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Semin Nucl Med 33:129-35. 2003
    ..In that way PET scanning can contribute to both therapeutics and to drug development by more rapid identification of the likely therapeutic dose range compared with conventional parallel group dose comparisons or dose ranging studies...
  61. ncbi request reprint Synthesis and in vivo evaluation of [18F]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide as a PET imaging probe for COX-2 expression
    Jaya Prabhakaran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Bioorg Med Chem 15:1802-7. 2007
    ..A radiolabeling method that can generate consistent high specific activity is needed for routine human use...
  62. pmc Does first episode polarity predict risk for suicide attempt in bipolar disorder?
    Sadia R Chaudhury
    Department of Neuroscience, New York State Psychiatric Institute and Columbia University, 1051 Riverside Drive, Box 42, New York, NY 10032, United States
    J Affect Disord 104:245-50. 2007
    ..We tested the hypothesis that the polarity of a patient's first mood episode would be a marker for BD subtypes with differential risk for suicidality...
  63. pmc Evaluation of volume-based and surface-based brain image registration methods
    Arno Klein
    New York State Psychiatric Institute, Columbia University, NY, NY 10032, USA
    Neuroimage 51:214-20. 2010
    ..From the results of this study, we recommend constructing a custom template from a limited sample drawn from the same or a similar representative population, using the same algorithm used for registering brains to the template...
  64. pmc Empirical Bayesian estimation in graphical analysis: a voxel-based approach for the determination of the volume of distribution in PET studies
    Francesca Zanderigo
    Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA
    Nucl Med Biol 37:443-51. 2010
    ..We hypothesized that incorporating LEGA V(T) estimation in a Bayesian framework would shrink estimators towards prior means, reducing variability and producing meaningful and useful voxel images...
  65. pmc Evaluation of 14 nonlinear deformation algorithms applied to human brain MRI registration
    Arno Klein
    New York State Psychiatric Institute, Columbia University, NY, NY 10032, USA
    Neuroimage 46:786-802. 2009
    ..Updates will be published on the http://www.mindboggle.info/papers/ website...
  66. pmc Family history of suicidal behavior and early traumatic experiences: additive effect on suicidality and course of bipolar illness?
    Juan J Carballo
    Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, United States
    J Affect Disord 109:57-63. 2008
    ..Bipolar disorder (BD) is associated with a high prevalence of suicide attempt and completion. Family history of suicidal behavior and personal history of childhood abuse are reported risk factors for suicide among BD subjects...
  67. pmc What have we learned about the neurobiology of major depression?
    Maria A Oquendo
    Am J Psychiatry 164:540-2. 2007

Research Grants6

  1. Biological Predictors of Response to Antidepressants
    Ramin V Parsey; Fiscal Year: 2010
    ..Our overall goal is to reduce the trial and error associated with finding an effective antidepressant by using data from pre-treatment quantification of 5-HT1A receptors and 5-HTT to guide antidepressant treatment selection. ..
  2. Imaging of Serotonin Transporters in Depression
    RAMIN PARSEY; Fiscal Year: 2005
    ..These goals will be met by a combination of didactic I course work and supervision. ..
  3. Biological Predictors of Response to Antidepressants
    RAMIN PARSEY; Fiscal Year: 2007
    ..Our overall goal is to reduce the trial and error associated with finding an effective antidepressant by using data from pre-treatment quantification of 5-HT1A receptors and 5-HTT to guide antidepressant treatment selection. ..