Joseph Parker

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Wingless promotes cell survival but constrains growth during Drosophila wing development
    Laura A Johnston
    Department of Genetics and Development, College of Physicians and Surgeons Columbia University 701 West 168th Street, New York, NY 10032, USA
    Nat Cell Biol 5:827-33. 2003
  2. pmc The proximate determinants of insect size
    Joseph Parker
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY 10032, USA
    J Biol 5:15. 2006
  3. ncbi request reprint Control of growth and organ size in Drosophila
    Laura A Johnston
    Columbia University, Department of Genetics and Development, 701 West 168th Street, New York, NY, USA
    Bioessays 24:54-64. 2002
  4. pmc Competitive interactions between cells: death, growth, and geography
    Laura A Johnston
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Science 324:1679-82. 2009
  5. doi request reprint Morphogens, nutrients, and the basis of organ scaling
    Joseph Parker
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA
    Evol Dev 13:304-14. 2011
  6. ncbi request reprint Drosophila myc regulates organ size by inducing cell competition
    Claire de la Cova
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, Room 704, New York, NY 10032, USA
    Cell 117:107-16. 2004
  7. pmc Mechanisms of growth and homeostasis in the Drosophila wing
    Ricardo M Neto-Silva
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Annu Rev Cell Dev Biol 25:197-220. 2009
  8. pmc Temporal regulation of metamorphic processes in Drosophila by the let-7 and miR-125 heterochronic microRNAs
    Elizabeth E Caygill
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Curr Biol 18:943-50. 2008
  9. pmc Control of wing size and proportions by Drosophila myc
    D Christine Wu
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Genetics 184:199-211. 2010
  10. ncbi request reprint Regeneration and transdetermination: new tricks from old cells
    Laura A Johnston
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Cell 120:288-90. 2005

Collaborators

  • Peter Gallant
  • Laura A Johnston
  • Claire de la Cova
  • Brent S Wells
  • D Christine Wu
  • Ricardo M Neto-Silva
  • Elizabeth E Caygill
  • Nanami Senoo-Matsuda
  • Molly Duman-Scheel
  • Eri Yoshida
  • Wei Du
  • Mauricio Abril
  • Paola Bellosta

Detail Information

Publications14

  1. ncbi request reprint Wingless promotes cell survival but constrains growth during Drosophila wing development
    Laura A Johnston
    Department of Genetics and Development, College of Physicians and Surgeons Columbia University 701 West 168th Street, New York, NY 10032, USA
    Nat Cell Biol 5:827-33. 2003
    ..We propose that the cell-survival- and growth-constraining activities of Wg function to sculpt and delimit final wing size as part of its overall patterning programme...
  2. pmc The proximate determinants of insect size
    Joseph Parker
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY 10032, USA
    J Biol 5:15. 2006
    ..A new study employs a modeling approach to expose the factors that matter in the control of insect size...
  3. ncbi request reprint Control of growth and organ size in Drosophila
    Laura A Johnston
    Columbia University, Department of Genetics and Development, 701 West 168th Street, New York, NY, USA
    Bioessays 24:54-64. 2002
    ..In addition, we speculate about possible connections between the extrinsic and intrinsic pathways controlling growth and pattern...
  4. pmc Competitive interactions between cells: death, growth, and geography
    Laura A Johnston
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Science 324:1679-82. 2009
    ..Both types of competition are conserved physiological processes, with much to tell us about how cellular neighborhoods influence cell behavior, and have importance to stem cell biology, regeneration and transplantation, and cancer...
  5. doi request reprint Morphogens, nutrients, and the basis of organ scaling
    Joseph Parker
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA
    Evol Dev 13:304-14. 2011
    ..Here, the problem is illustrated using the Drosophila wing--a paradigm for organ growth and size control--and a potential solution suggested...
  6. ncbi request reprint Drosophila myc regulates organ size by inducing cell competition
    Claire de la Cova
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, Room 704, New York, NY 10032, USA
    Cell 117:107-16. 2004
    ..Modulating dmyc levels to create cell competition and hid-dependent cell death may be a mechanism used during normal development to control organ size...
  7. pmc Mechanisms of growth and homeostasis in the Drosophila wing
    Ricardo M Neto-Silva
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Annu Rev Cell Dev Biol 25:197-220. 2009
    ..We focus on two topics currently under intense study: the influence of pattern regulators on organ and tissue growth and the role of local competitive interactions between cells in tissue homeostasis and final size...
  8. pmc Temporal regulation of metamorphic processes in Drosophila by the let-7 and miR-125 heterochronic microRNAs
    Elizabeth E Caygill
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Curr Biol 18:943-50. 2008
    ..Little is known, however, about their requirement outside the nematode or whether they universally control the timing of developmental processes...
  9. pmc Control of wing size and proportions by Drosophila myc
    D Christine Wu
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Genetics 184:199-211. 2010
    ..Overall, however, an appropriate level of dMyc expression in the wing disc is necessary for each region to achieve a proportionately correct size...
  10. ncbi request reprint Regeneration and transdetermination: new tricks from old cells
    Laura A Johnston
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Cell 120:288-90. 2005
    ....
  11. pmc Soluble factors mediate competitive and cooperative interactions between cells expressing different levels of Drosophila Myc
    Nanami Senoo-Matsuda
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 701 West 168th Street, HHSC 704, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:18543-8. 2007
    ....
  12. pmc Myc in model organisms: a view from the flyroom
    Claire de la Cova
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Semin Cancer Biol 16:303-12. 2006
    ..In this review, we describe recent research on the biology of Myc and its family members in Drosophila, paying particular attention to its role in the control of growth during development...
  13. pmc Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity
    Brent S Wells
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Curr Biol 16:1606-15. 2006
    ..Here we provide evidence that Drosophila p53 (dp53) has a previously unidentified role in coordinating the compensatory growth response to tissue damage...
  14. pmc Repression of dMyc expression by Wingless promotes Rbf-induced G1 arrest in the presumptive Drosophila wing margin
    Molly Duman-Scheel
    Ben May Institute for Cancer Research and Center for Molecular Oncology, University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 101:3857-62. 2004
    ..Although Rbf/E2f pathway components mediate the ability of dMyc to promote G(1) progression, dMyc appears to regulate growth independently of the RBF/E2f pathway...

Research Grants10

  1. Mechanisms of cell competition that regulate growth during development
    Laura Johnston; Fiscal Year: 2009
    ..We postulate that cell competition in Drosophila may provide a unique model with which genes that are involved in the earliest steps of cancer progression can be identified. ..
  2. Coordination of growth and patterning during development
    Laura Johnston; Fiscal Year: 2007
    ..abstract_text> ..
  3. Mechanisms of cell competition that regulate growth during development
    Laura Johnston; Fiscal Year: 2009
    ..We postulate that cell competition in Drosophila may provide a unique model with which genes that are involved in the earliest steps of cancer progression can be identified. ..