Dane Parker

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Epithelial uptake of flagella initiates proinflammatory signaling
    Dane Parker
    Department of Pediatrics, Columbia University, New York, New York, United States of America
    PLoS ONE 8:e59932. 2013
  2. pmc Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract
    Dane Parker
    Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    MBio 2:e00016-11. 2011
  3. pmc Induction of type I interferon signaling by Pseudomonas aeruginosa is diminished in cystic fibrosis epithelial cells
    Dane Parker
    Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Am J Respir Cell Mol Biol 46:6-13. 2012
  4. pmc Crystal structures of respiratory pathogen neuraminidases
    Yu Shan Hsiao
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Biochem Biophys Res Commun 380:467-71. 2009
  5. pmc Participation of CD11c(+) leukocytes in methicillin-resistant Staphylococcus aureus clearance from the lung
    Francis J Martin
    Department of Pharmacology, Columbia University, New York, NY 10032, USA
    Infect Immun 79:1898-904. 2011
  6. pmc The NanA neuraminidase of Streptococcus pneumoniae is involved in biofilm formation
    Dane Parker
    Department of Pediatrics and Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Infect Immun 77:3722-30. 2009
  7. pmc Staphylococcus aureus induces type I IFN signaling in dendritic cells via TLR9
    Dane Parker
    Department of Pediatrics, Columbia University, New York, NY 10032, USA
    J Immunol 189:4040-6. 2012
  8. pmc Staphylococcus aureus activation of caspase 1/calpain signaling mediates invasion through human keratinocytes
    Grace Soong
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    J Infect Dis 205:1571-9. 2012
  9. pmc Type I interferon response to extracellular bacteria in the airway epithelium
    Dane Parker
    Department of Pediatrics, Columbia University, New York, NY, USA
    Trends Immunol 32:582-8. 2011
  10. pmc CD4+ T cells promote the pathogenesis of Staphylococcus aureus pneumonia
    Dane Parker
    Department of Pediatrics, Columbia University
    J Infect Dis 211:835-45. 2015

Collaborators

  • Adam J Ratner
  • Liang Tong
  • Katherine A Fitzgerald
  • Alice Prince
  • Grace Soong
  • Kipyegon Kitur
  • Fábio E Amaral
  • Francis J Martin
  • Yu Shan Hsiao
  • Pamela Nieto
  • Tara M Randis
  • Samuel Chung
  • Ritwij Kulkarni
  • Mimi M Shirasu-Hiza
  • Susan Bueno
  • Sarah Wachtel
  • Taylor S Cohen
  • Danielle S Ahn
  • Jarin Chun
  • Bryan S Harfenist
  • Mariah Magargee

Detail Information

Publications16

  1. pmc Epithelial uptake of flagella initiates proinflammatory signaling
    Dane Parker
    Department of Pediatrics, Columbia University, New York, New York, United States of America
    PLoS ONE 8:e59932. 2013
    ..Although flagella are important in invasion across the epithelial barrier their shedding in the airway lumen results in epithelial uptake and signaling that has a major role in the initial recruitment of immune cells in the lung...
  2. pmc Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract
    Dane Parker
    Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    MBio 2:e00016-11. 2011
    ....
  3. pmc Induction of type I interferon signaling by Pseudomonas aeruginosa is diminished in cystic fibrosis epithelial cells
    Dane Parker
    Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Am J Respir Cell Mol Biol 46:6-13. 2012
    ..These observations suggest that dysfunction of the CFTR in airway epithelial cells may contribute to impaired immune surveillance in the CF airway and resultant colonization by P. aeruginosa...
  4. pmc Crystal structures of respiratory pathogen neuraminidases
    Yu Shan Hsiao
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Biochem Biophys Res Commun 380:467-71. 2009
    ..This work represents an important step in the development of drugs to prevent respiratory tract colonization by these two pathogens...
  5. pmc Participation of CD11c(+) leukocytes in methicillin-resistant Staphylococcus aureus clearance from the lung
    Francis J Martin
    Department of Pharmacology, Columbia University, New York, NY 10032, USA
    Infect Immun 79:1898-904. 2011
    ..The results of these experiments suggest that CD11c(+) cells, the induction of CXCR3 ligand expression, and subsequent CD4(+) cell recruitment have an important role in the pathogenesis of severe MRSA pulmonary infection...
  6. pmc The NanA neuraminidase of Streptococcus pneumoniae is involved in biofilm formation
    Dane Parker
    Department of Pediatrics and Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Infect Immun 77:3722-30. 2009
    ..This work highlights the role played by the neuraminidase in pathogenesis and represents an important step in drug development for prevention of colonization of the respiratory tract by this important pathogen...
  7. pmc Staphylococcus aureus induces type I IFN signaling in dendritic cells via TLR9
    Dane Parker
    Department of Pediatrics, Columbia University, New York, NY 10032, USA
    J Immunol 189:4040-6. 2012
    ..aureus, illustrating an additional mechanism through which S. aureus exploits innate immune signaling to facilitate infection...
  8. pmc Staphylococcus aureus activation of caspase 1/calpain signaling mediates invasion through human keratinocytes
    Grace Soong
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    J Infect Dis 205:1571-9. 2012
    ..These studies suggest that pharmacological interruption of specific keratinocyte signaling cascades as well as targeting the Hla might prevent invasive skin infection by staphylococci...
  9. pmc Type I interferon response to extracellular bacteria in the airway epithelium
    Dane Parker
    Department of Pediatrics, Columbia University, New York, NY, USA
    Trends Immunol 32:582-8. 2011
    ....
  10. pmc CD4+ T cells promote the pathogenesis of Staphylococcus aureus pneumonia
    Dane Parker
    Department of Pediatrics, Columbia University
    J Infect Dis 211:835-45. 2015
    ..Our data suggest that T-cell-mediated hypercytokinemia induced by infection with MRSA strain USA300 contributes to pathogenesis and may be a therapeutic target for improving outcomes of this common infection in a clinical setting. ..
  11. pmc Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage
    Kipyegon Kitur
    Department of Pharmacology, Columbia University Graduate School of Arts and Sciences, Columbia University, New York, New York, United States of America
    PLoS Pathog 11:e1004820. 2015
    ..These findings indicate that toxin-induced necroptosis is a major cause of lung pathology in S. aureus pneumonia and suggest the possibility of targeting components of this signaling pathway as a therapeutic strategy. ..
  12. pmc Rational Manipulation of mRNA Folding Free Energy Allows Rheostat Control of Pneumolysin Production by Streptococcus pneumoniae
    Fábio E Amaral
    Department of Pediatrics, Columbia University, New York, NY United States of America Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal ICVS 3B s, PT Government Associate Laboratory, Braga Guimarães, Portugal
    PLoS ONE 10:e0119823. 2015
    ..pneumoniae on primary and immortalized human cells. These studies provide proof-of-principle for further investigation of mRNA ΔG manipulation as a tool in studies of bacterial pathogenesis. ..
  13. pmc Induction of type I interferon signaling determines the relative pathogenicity of Staphylococcus aureus strains
    Dane Parker
    Department of Pediatrics, Columbia University, New York, New York, United States of America
    PLoS Pathog 10:e1003951. 2014
    ..aureus pneumonia...
  14. pmc Immunopathogenesis of Staphylococcus aureus pulmonary infection
    Dane Parker
    Department of Pediatrics, Columbia University, New York, NY, USA
    Semin Immunopathol 34:281-97. 2012
    ..aureus virulence factors, particularly the α-hemolysin and protein A, with diverse immune effectors in the lung such as ADAM10, TNFR1, EGFR, immunoglobulin, and complement all contribute to the pathogenesis of staphylococcal pneumonia...
  15. pmc Innate immunity in the respiratory epithelium
    Dane Parker
    Department of Pediatrics, Columbia University, New York, NY 10027, USA
    Am J Respir Cell Mol Biol 45:189-201. 2011
    ..This review focuses on the innate immune capabilities of the airway epithelium and its role in protecting the lung from infection as well as the outcomes when its function is compromised...
  16. pmc The type III toxins of Pseudomonas aeruginosa disrupt epithelial barrier function
    Grace Soong
    Department of Pediatrics and Pharmacology, College of Physicians and Surgeons, Columbia University, 650 West 168th Street, New York, NY 10032, USA
    J Bacteriol 190:2814-21. 2008
    ..These studies support the hypothesis that type III toxins enhance P. aeruginosa's invasive capabilities by interacting with multiple eukaryotic cytoskeletal components...