Research Topics
| Dane ParkerSummaryAffiliation: Columbia University Country: USA Publications
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Detail Information
Publications
Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tractDane Parker
Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, USA
MBio 2:e00016-11. 2011..Mice lacking the receptor to type I IFNs have a reduced ability to clear S. pneumoniae, suggesting that the type I IFN cascade is central to the mucosal clearance of this important pathogen...- Induction of type I interferon signaling by Pseudomonas aeruginosa is diminished in cystic fibrosis epithelial cellsDane Parker
Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Am J Respir Cell Mol Biol 46:6-13. 2012..These observations suggest that dysfunction of the CFTR in airway epithelial cells may contribute to impaired immune surveillance in the CF airway and resultant colonization by P. aeruginosa... 
Crystal structures of respiratory pathogen neuraminidasesYu Shan Hsiao
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Biochem Biophys Res Commun 380:467-71. 2009..This work represents an important step in the development of drugs to prevent respiratory tract colonization by these two pathogens...- The NanA neuraminidase of Streptococcus pneumoniae is involved in biofilm formationDane Parker
Department of Pediatrics and Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Infect Immun 77:3722-30. 2009..This work highlights the role played by the neuraminidase in pathogenesis and represents an important step in drug development for prevention of colonization of the respiratory tract by this important pathogen... - Staphylococcus aureus activation of caspase 1/calpain signaling mediates invasion through human keratinocytesGrace Soong
Department of Pediatrics, Columbia University, New York, New York 10032, USA
J Infect Dis 205:1571-9. 2012..These studies suggest that pharmacological interruption of specific keratinocyte signaling cascades as well as targeting the Hla might prevent invasive skin infection by staphylococci... - Staphylococcus aureus induces type I IFN signaling in dendritic cells via TLR9Dane Parker
Department of Pediatrics, Columbia University, New York, NY 10032, USA
J Immunol 189:4040-6. 2012..aureus, illustrating an additional mechanism through which S. aureus exploits innate immune signaling to facilitate infection... - Participation of CD11c(+) leukocytes in methicillin-resistant Staphylococcus aureus clearance from the lungFrancis J Martin
Department of Pharmacology, Columbia University, New York, NY 10032, USA
Infect Immun 79:1898-904. 2011..The results of these experiments suggest that CD11c(+) cells, the induction of CXCR3 ligand expression, and subsequent CD4(+) cell recruitment have an important role in the pathogenesis of severe MRSA pulmonary infection... - Type I interferon response to extracellular bacteria in the airway epitheliumDane Parker
Department of Pediatrics, Columbia University, New York, NY, USA
Trends Immunol 32:582-8. 2011.... - Immunopathogenesis of Staphylococcus aureus pulmonary infectionDane Parker
Department of Pediatrics, Columbia University, New York, NY, USA
Semin Immunopathol 34:281-97. 2012..aureus virulence factors, particularly the α-hemolysin and protein A, with diverse immune effectors in the lung such as ADAM10, TNFR1, EGFR, immunoglobulin, and complement all contribute to the pathogenesis of staphylococcal pneumonia... - Innate immunity in the respiratory epitheliumDane Parker
Department of Pediatrics, Columbia University, New York, NY 10027, USA
Am J Respir Cell Mol Biol 45:189-201. 2011..This review focuses on the innate immune capabilities of the airway epithelium and its role in protecting the lung from infection as well as the outcomes when its function is compromised... - The type III toxins of Pseudomonas aeruginosa disrupt epithelial barrier functionGrace Soong
Department of Pediatrics and Pharmacology, College of Physicians and Surgeons, Columbia University, 650 West 168th Street, New York, NY 10032, USA
J Bacteriol 190:2814-21. 2008..These studies support the hypothesis that type III toxins enhance P. aeruginosa's invasive capabilities by interacting with multiple eukaryotic cytoskeletal components...