Panos N Papapanou

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Using ANOVA for gene selection from microarray studies of the nervous system
    Paul Pavlidis
    Department of Biomedical Informatics and Columbia Genome Center, Columbia University, Rm 121J, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Methods 31:282-9. 2003
  2. pmc Coexpression analysis of human genes across many microarray data sets
    Homin K Lee
    Columbia Genome Center, Columbia University, New York, New York 10032, USA
    Genome Res 14:1085-94. 2004
  3. pmc A Mendelian locus on chromosome 16 determines susceptibility to doxorubicin nephropathy in the mouse
    Zongyu Zheng
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:2502-7. 2005
  4. pmc An examination of periodontal treatment and per member per month (PMPM) medical costs in an insured population
    David A Albert
    Columbia University College of Dental Medicine, New York, New York, USA
    BMC Health Serv Res 6:103. 2006
  5. pmc Periodontal therapy alters gene expression of peripheral blood monocytes
    Panos N Papapanou
    Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, NY 10032, USA
    J Clin Periodontol 34:736-47. 2007
  6. ncbi request reprint Population studies of microbial ecology in periodontal health and disease
    Panos N Papapanou
    Division of Periodontics, Columbia University School of Dental and Oral Surgery, New York, New York, USA
    Ann Periodontol 7:54-61. 2002
  7. pmc Subgingival bacterial colonization profiles correlate with gingival tissue gene expression
    Panos N Papapanou
    Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, NY, USA
    BMC Microbiol 9:221. 2009
  8. ncbi request reprint Longitudinal stability of serum immunoglobulin G responses to periodontal bacteria
    P N Papapanou
    Division of Periodontics, Section of Oral and Diagnostic Sciences, Columbia University School of Dental and Oral Surgery, New York, NY 10033, USA
    J Clin Periodontol 31:985-90. 2004
  9. ncbi request reprint Gene expression signatures in chronic and aggressive periodontitis: a pilot study
    Panos N Papapanou
    Division of Periodontics, Section of Oral and Diagnostic Sciences, School of Dental and Oral Surgery, Columbia University, New York, NY 10032, USA
    Eur J Oral Sci 112:216-23. 2004
  10. ncbi request reprint Epidemiology of periodontal diseases: an update
    P N Papapanou
    Division of Periodontics, Columbia University School of Dental and Oral Surgery, New York, NY, USA
    J Int Acad Periodontol 1:110-6. 1999

Research Grants

Detail Information

Publications79

  1. ncbi request reprint Using ANOVA for gene selection from microarray studies of the nervous system
    Paul Pavlidis
    Department of Biomedical Informatics and Columbia Genome Center, Columbia University, Rm 121J, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Methods 31:282-9. 2003
    ..Instructions for running typical analyses are given in the R programming environment. R code and the sample data set used to generate the examples are available at http://microarray.cpmc.columbia.edu/pavlidis/pub/aovmethods/...
  2. pmc Coexpression analysis of human genes across many microarray data sets
    Homin K Lee
    Columbia Genome Center, Columbia University, New York, New York 10032, USA
    Genome Res 14:1085-94. 2004
    ..Our findings demonstrate how the large body of accumulated microarray data can be exploited to increase the reliability of inferences about gene function...
  3. pmc A Mendelian locus on chromosome 16 determines susceptibility to doxorubicin nephropathy in the mouse
    Zongyu Zheng
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:2502-7. 2005
    ..Elucidation of DOX nephropathy may simultaneously provide insight into the pathogenesis of renal failure and mechanisms of cytotoxicity induced by chemotherapeutic agents...
  4. pmc An examination of periodontal treatment and per member per month (PMPM) medical costs in an insured population
    David A Albert
    Columbia University College of Dental Medicine, New York, New York, USA
    BMC Health Serv Res 6:103. 2006
    ..This study examined if periodontal treatment can contribute to changes in overall risk and medical expenditures for three chronic conditions [Diabetes Mellitus (DM), Coronary Artery Disease (CAD), and Cerebrovascular Disease (CVD)]...
  5. pmc Periodontal therapy alters gene expression of peripheral blood monocytes
    Panos N Papapanou
    Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, NY 10032, USA
    J Clin Periodontol 34:736-47. 2007
    ..We investigated the effects of periodontal therapy on gene expression of peripheral blood monocytes...
  6. ncbi request reprint Population studies of microbial ecology in periodontal health and disease
    Panos N Papapanou
    Division of Periodontics, Columbia University School of Dental and Oral Surgery, New York, New York, USA
    Ann Periodontol 7:54-61. 2002
    ....
  7. pmc Subgingival bacterial colonization profiles correlate with gingival tissue gene expression
    Panos N Papapanou
    Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, NY, USA
    BMC Microbiol 9:221. 2009
    ..Random effects linear regression models considered bacterial levels as exposure and expression profiles as outcome variables. Gene Ontology analyses summarized the expression patterns into biologically relevant categories...
  8. ncbi request reprint Longitudinal stability of serum immunoglobulin G responses to periodontal bacteria
    P N Papapanou
    Division of Periodontics, Section of Oral and Diagnostic Sciences, Columbia University School of Dental and Oral Surgery, New York, NY 10033, USA
    J Clin Periodontol 31:985-90. 2004
    ..This study examined serum immunoglobulin (IgG) responses to periodontal bacteria in patients with periodontitis and periodontitis-free individuals over a 30-month period...
  9. ncbi request reprint Gene expression signatures in chronic and aggressive periodontitis: a pilot study
    Panos N Papapanou
    Division of Periodontics, Section of Oral and Diagnostic Sciences, School of Dental and Oral Surgery, Columbia University, New York, NY 10032, USA
    Eur J Oral Sci 112:216-23. 2004
    ..These early data point to the usefulness of gene expression profiling techniques in the identification of subclasses of periodontitis with common pathobiology...
  10. ncbi request reprint Epidemiology of periodontal diseases: an update
    P N Papapanou
    Division of Periodontics, Columbia University School of Dental and Oral Surgery, New York, NY, USA
    J Int Acad Periodontol 1:110-6. 1999
    ..Importantly, the role of periodontal infections as a modifier of systemic health is being increasingly explored...
  11. ncbi request reprint Interleukin-1 gene polymorphism and periodontal status. A case-control study
    P N Papapanou
    Department of Oral Microbiology, Faculty of Odontology, Goteborg University, Sweden
    J Clin Periodontol 28:389-96. 2001
    ..This case-control study examined polymorphisms at the interleukin-1 gene in relation to periodontal status, subgingival bacteria and systemic antibodies to periodontal microbiota...
  12. ncbi request reprint "Checkerboard" assessments of periodontal microbiota and serum antibody responses: a case-control study
    P N Papapanou
    Department of Oral Microbiology, Faculty of Odontology, Goteborg University, Sweden
    J Periodontol 71:885-97. 2000
    ..We explored the association between subgingival microbial profiles and serum IgG responses to periodontal microbiota in relation to clinical periodontal status...
  13. ncbi request reprint Checkerboard assessments of serum antibodies to oral microbiota as surrogate markers of clinical periodontal status
    P N Papapanou
    Division of Periodontics, Columbia University School of Dental and Oral Surgery, New York, NY 10032, USA
    J Clin Periodontol 28:103-6. 2001
    ..This study addresses whether checkerboard assessments of serum IgG antibodies to oral bacteria may serve as surrogate markers of clinical periodontal status in epidemiologic studies...
  14. pmc Heterogeneity of systemic inflammatory responses to periodontal therapy
    Jan H Behle
    Division of Periodontics, Section of Oral and Diagnostic Sciences, Columbia University College of Dental Medicine, New York, NY 10032, USA
    J Clin Periodontol 36:287-94. 2009
    ..We investigated the effect of comprehensive periodontal therapy on the levels of multiple systemic inflammatory biomarkers...
  15. pmc Transcriptomes in healthy and diseased gingival tissues
    Ryan T Demmer
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Periodontol 79:2112-24. 2008
    ..We hypothesized that a comparison of gene expression signatures between healthy and diseased gingival tissues would provide novel insights in the pathobiology of periodontitis and would inform the design of future studies...
  16. pmc Gingival tissue transcriptomes in experimental gingivitis
    Daniel Jönsson
    Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, NY 10032, USA
    J Clin Periodontol 38:599-611. 2011
    ..We investigated the sequential gene expression in the gingiva during the induction and resolution of experimental gingivitis...
  17. ncbi request reprint Determinants of serum IgG responses to periodontal bacteria in a nationally representative sample of US adults
    Christian Vlachojannis
    Division of Periodontics, Section of Oral and Diagnostic Sciences, Columbia University College of Dental Medicine, New York, NY, USA
    J Clin Periodontol 37:685-96. 2010
    ....
  18. ncbi request reprint Periodontal infection profiles in type 1 diabetes
    Evanthia Lalla
    Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, NY 10032, USA
    J Clin Periodontol 33:855-62. 2006
    ..We investigated the levels of subgingival plaque bacteria and serum IgG responses in patients with type 1 diabetes and non-diabetic controls of comparable periodontal status...
  19. doi request reprint Bleeding on probing differentially relates to bacterial profiles: the Oral Infections and Vascular Disease Epidemiology Study
    Ryan T Demmer
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Clin Periodontol 35:479-86. 2008
    ..Various bacterial species are differentially prevalent in periodontal health, gingivitis or periodontitis. We tested the independent associations between three bacterial groupings and gingival inflammation in an epidemiological study...
  20. pmc Evaluating clinical periodontal measures as surrogates for bacterial exposure: the Oral Infections and Vascular Disease Epidemiology Study (INVEST)
    Ryan T Demmer
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    BMC Med Res Methodol 10:2. 2010
    ..We investigated the characteristics of clinical periodontal definitions that were most representative of exposure to bacterial species that are believed to be either markers, or themselves etiologic, of periodontal disease...
  21. pmc Periodontal bacteria and hypertension: the oral infections and vascular disease epidemiology study (INVEST)
    Moise Desvarieux
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    J Hypertens 28:1413-21. 2010
    ..Chronic infections, including periodontal infections, may predispose to cardiovascular disease. We investigated the relationship between periodontal microbiota and hypertension...
  22. pmc Changes in clinical and microbiological periodontal profiles relate to progression of carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology study
    Moise Desvarieux
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY
    J Am Heart Assoc 2:e000254. 2013
    ..No prospective studies exist on the relationship between change in periodontal clinical and microbiological status and progression of carotid atherosclerosis...
  23. pmc Diabetes and oral disease: implications for health professionals
    David A Albert
    Columbia University College of Dental Medicine, New York, New York 10032, USA
    Ann N Y Acad Sci 1255:1-15. 2012
    ..This report summarizes the scientific presentations of the event...
  24. pmc Periodontal infection, systemic inflammation, and insulin resistance: results from the continuous National Health and Nutrition Examination Survey (NHANES) 1999-2004
    Ryan T Demmer
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Diabetes Care 35:2235-42. 2012
    ..The roles of inflammatory mediation and effect modification were also studied...
  25. ncbi request reprint Analytical epidemiology of periodontitis
    Luisa N Borrell
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Clin Periodontol 32:132-58. 2005
    ....
  26. ncbi request reprint Periodontal infections and atherosclerotic vascular disease: an update
    Jan H Behle
    Division of Periodontics, Section of Oral and Diagnostic Sciences, Columbia University College of Dental Medicine, New York, NY 10032, USA
    Int Dent J 56:256-62. 2006
    ..The extent to which the control of periodontal infections results in lower incidence of ASVD events is logistically difficult to assess and has not been addressed in any study so far...
  27. ncbi request reprint Infection with a periodontal pathogen increases mononuclear cell adhesion to human aortic endothelial cells
    Georg A Roth
    Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Atherosclerosis 190:271-81. 2007
    ....
  28. pmc Oral disease burden in Northern Manhattan patients with diabetes mellitus
    Evanthia Lalla
    Division of Periodontics, Section of Oral and Diagnostic Sciences, Columbia University School of Dental and Oral Surgery, 630 W 168th Street, PH7E 110, New York, NY 10032, USA
    Am J Public Health 94:755-8. 2004
    ..We explored the association between diabetes mellitus and oral disease in a low-socioeconomic-status urban population...
  29. pmc Receptor for advanced glycation endproducts mediates pro-atherogenic responses to periodontal infection in vascular endothelial cells
    Andreas Pollreisz
    Division of Periodontics, College of Dental Medicine, Columbia University, 630 W 168th Street, PH7E 110, New York, NY, United States
    Atherosclerosis 212:451-6. 2010
    ..The receptor for advanced glycation endproducts (RAGE) regulates vascular inflammation and atherogenesis. We hypothesized that RAGE is involved in P. gingivalis's contribution to pro-atherogenic responses in vascular endothelial cells...
  30. pmc Porphyromonas gingivalis infection and prothrombotic effects in human aortic smooth muscle cells
    Georg A Roth
    Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Thromb Res 123:780-4. 2009
    ..Tissue factor (TF) and its specific tissue factor pathway inhibitor (TFPI) are produced by vascular cells and are important regulators of the coagulation cascade...
  31. ncbi request reprint Molecular aging in human prefrontal cortex is selective and continuous throughout adult life
    Loubna Erraji-Benchekroun
    Department of Psychiatry, Columbia University, New York, New York, USA
    Biol Psychiatry 57:549-58. 2005
    ..Aging leads to morphologic and functional changes in the brain and is associated with increased risk for psychiatric and neurological disorders...
  32. doi request reprint Radiographic periodontal bone loss in chronic kidney disease
    Marie Danielle Messier
    College of Dental Medicine, Columbia University, New York, NY, USA
    J Periodontol 83:602-11. 2012
    ..We examined the extent and severity of radiographic periodontal bone loss in patients with different stages of chronic kidney disease (CKD) and explored a potential dose-response relationship between bone loss and CKD-related biomarkers...
  33. ncbi request reprint Infection patterns in chronic and aggressive periodontitis
    Doros K Picolos
    Division of Periodontics, Section of Oral and Diagnostic Sciences, Columbia University School of Dental and Oral Surgery, New York, NY, USA
    J Clin Periodontol 32:1055-61. 2005
    ..We also studied ab responses in localized chronic (LCP) and generalized chronic periodontitis (GCP)...
  34. pmc Radiographic measures of chronic periodontitis and carotid artery plaque
    Steven P Engebretson
    Division of Periodontics, College of Physicians and Surgeons, Columbia University Medical Center, 630 W 168th St, PH7 E 125A New York, NY 10032, USA
    Stroke 36:561-6. 2005
    ..The purpose of this study was to determine whether radiographically assessed CP is associated with nonstenotic carotid artery plaque as an ultrasound measure of subclinical atherosclerosis...
  35. doi request reprint Periodontal microbial complexes associated with specific cell and tissue responses
    Moritz Kebschull
    Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine Columbia University, New York, NY 10032, USA
    J Clin Periodontol 38:17-27. 2011
    ..In this review, we summarize data on the association between specific periodontal bacterial profiles and tissue gene/protein expression, generated from cell culture models and in vivo studies...
  36. doi request reprint Diabetes mellitus and periodontitis: a tale of two common interrelated diseases
    Evanthia Lalla
    Division of Periodontics, College of Dental Medicine, Columbia University, 630 West 168th Street, PH7E 110, New York, NY 10032, USA
    Nat Rev Endocrinol 7:738-48. 2011
    ....
  37. ncbi request reprint Markers of periodontal infection and preterm birth
    Karim Jarjoura
    Division of Periodontics, Section of Oral and Diagnostic Sciences, Columbia University School of Dental and Oral Surgery, New York, NY, USA
    Am J Obstet Gynecol 192:513-9. 2005
    ..This study was undertaken to explore the relationship between clinical, microbiologic, and serologic markers of periodontitis and preterm birth (PTB)...
  38. doi request reprint The use of gene arrays in deciphering the pathobiology of periodontal diseases
    Moritz Kebschull
    Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, NY, USA
    Methods Mol Biol 666:385-93. 2010
    ..In this chapter, we outline the laboratory steps required for the processing of gingival tissue and blood samples in view of hybridization with whole-genome microarrays...
  39. ncbi request reprint Porphyromonas gingivalis infection and cell death in human aortic endothelial cells
    Georg A Roth
    Division of Surgical Science, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    FEMS Microbiol Lett 272:106-13. 2007
    ..gingivalis at MOI 1:100. At higher MOI, at least in vitro, P. gingivalis mediates endothelial apoptosis, thereby potentially amplifying proatherogenic mechanisms in the perturbed vasculature...
  40. ncbi request reprint Learning gene functional classifications from multiple data types
    Paul Pavlidis
    Columbia Genome Center, Columbia University, New York, NY 10027, USA
    J Comput Biol 9:401-11. 2002
    ..In particular, we propose an SVM kernel function that is explicitly heterogeneous. In addition, we describe feature scaling methods for further exploiting prior knowledge of heterogeneity by giving each data type different weights...
  41. pmc Periodontal infection, impaired fasting glucose and impaired glucose tolerance: results from the Continuous National Health and Nutrition Examination Survey 2009-2010
    Nidhi Arora
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Clin Periodontol 41:643-52. 2014
    ..We investigated the relationship between periodontal disease, a clinical manifestation of periodontal infection, and pre-diabetes...
  42. ncbi request reprint Porphyromonas gingivalis induces its uptake by human macrophages and promotes foam cell formation in vitro
    Mary Beth Giacona
    Division of Periodontics, Section of Oral and Diagnostic Sciences, School of Dental and Oral Surgery, 630 W 168th Street, PH7E 110, New York, NY 10032, USA
    FEMS Microbiol Lett 241:95-101. 2004
    ..These results suggest that properties of P. gingivalis which render it capable of adhering to/invading other cell types may also be operative in macrophages and play an important role in its atherogenic potential...
  43. ncbi request reprint beta-catenin/TCF/Lef controls a differentiation-associated transcriptional program in renal epithelial progenitors
    Kai M Schmidt-Ott
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Development 134:3177-90. 2007
    ..Thus, beta-catenin/TCF/Lef-mediated transcriptional events control a subset of the differentiation-associated transcriptional program and thereby participate in maintenance, expansion and stage progression of the epithelial lineage...
  44. pmc ErmineJ: tool for functional analysis of gene expression data sets
    Homin K Lee
    Columbia Genome Center, Columbia University, New York, NY 10032, USA
    BMC Bioinformatics 6:269. 2005
    ..However, this method suffers from some limitations, and biologist-friendly tools that implement alternatives have not been reported...
  45. pmc Classification and subtype prediction of adult soft tissue sarcoma by functional genomics
    Neil H Segal
    Swim Across America Laboratory, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York and Columbia Genome Center, Columbia University, New York, New York 10021, USA
    Am J Pathol 163:691-700. 2003
    ..In conclusion, we showed gene expression profiling to be useful in classification and diagnosis, providing insights into pathogenesis and pointing to potential new therapeutic targets of soft tissue sarcoma...
  46. ncbi request reprint The effect of replication on gene expression microarray experiments
    Paul Pavlidis
    Columbia Genome Center, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Bioinformatics 19:1620-7. 2003
    ..We consider both the ability to find genes that meet particular statistical criteria as well as the stability of the results in the face of changing levels of replication...
  47. ncbi request reprint Gene expression profiling of depression and suicide in human prefrontal cortex
    Etienne Sibille
    Department of Psychiatry, Columbia University, New York, NY, USA
    Neuropsychopharmacology 29:351-61. 2004
    ....
  48. ncbi request reprint Support vector machine classification on the web
    Paul Pavlidis
    Columbia Genome Center and Department of Biomedical Informatics, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Bioinformatics 20:586-7. 2004
    ..More advanced users can download the software and source code for local installation. The availability of these tools will permit more widespread application of this powerful learning algorithm in bioinformatics...
  49. ncbi request reprint Differential amplification of gene expression in lens cell lines conditioned to survive peroxide stress
    Abraham Spector
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Invest Ophthalmol Vis Sci 43:3251-64. 2002
    ..Therefore, mouse lens cell lines conditioned to survive different peroxide stresses have been analyzed to determine their global changes in gene expression...
  50. ncbi request reprint Using the gene ontology for microarray data mining: a comparison of methods and application to age effects in human prefrontal cortex
    Paul Pavlidis
    Department of Biomedical Informatics and Columbia Genome Center, Columbia University, New York, New York 10032, USA
    Neurochem Res 29:1213-22. 2004
    ....
  51. pmc Sex genes for genomic analysis in human brain: internal controls for comparison of probe level data extraction
    Hanga C Galfalvy
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    BMC Bioinformatics 4:37. 2003
    ..We introduce the idea of using sex-chromosome genes as an alternative to spiked-in control genes or simulations for assessment of microarray data and analysis methods...
  52. ncbi request reprint Microarray analysis of gene expression following the formalin test in the infant rat
    Gordon A Barr
    Department of Developmental Psychobiology, New York State Psychiatric Institute, New York, NY, USA
    Pain 117:6-18. 2005
    ..The increased expression of transcription factors and decreased expression of genes whose products are protective against cell death are hypothesized to underlie the long-term changes that are seen after injury in the neonate...
  53. ncbi request reprint Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice
    Marta Paterlini
    Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, New York 10032, USA
    Nat Neurosci 8:1586-94. 2005
    ..This interaction modulates a number of schizophrenia-related phenotypes, providing a framework for understanding the high disease risk associated with this locus, the expression of the phenotype, or both...
  54. ncbi request reprint Matrix2png: a utility for visualizing matrix data
    Paul Pavlidis
    Columbia Genome Center, Columbia University, New York, USA
    Bioinformatics 19:295-6. 2003
    ..In this note we describe some of matrix2png's features and describe some places it has been useful in the authors' work...
  55. pmc Periodontal infection and cardiorespiratory fitness in younger adults: results from continuous national health and nutrition examination survey 1999-2004
    Ashley Thai
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America
    PLoS ONE 9:e92441. 2014
    ..Our objective was to study the association between clinical measures of periodontal infection and cardiorespiratory fitness levels among a population-based sample of younger adults...
  56. pmc An examination of periodontal treatment, dental care, and pregnancy outcomes in an insured population in the United States
    David A Albert
    Division of Community Health, Columbia University College of Dental Medicine, New York, NY 10032, USA
    Am J Public Health 101:151-6. 2011
    ..We examined whether periodontal treatment or other dental care is associated with adverse birth outcomes within a medical and dental insurance database...
  57. ncbi request reprint Bioinformatics techniques in microarray research: applied microarray data analysis using R and SAS software
    Ryan T Demmer
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Methods Mol Biol 666:395-417. 2010
    ..All analyses described in this chapter can be performed using relatively limited computational resources such as a lap top PC with at least 2.0 GB of memory and 2.0 GHz of processing speed...
  58. ncbi request reprint The relationship of periodontal disease to diseases and disorders at distant sites: communication to health care professionals and patients
    Ira B Lamster
    College of Dental Medicine, Columbia University, New York, NY 10032, USA
    J Am Dent Assoc 139:1389-97. 2008
    ....
  59. ncbi request reprint Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice
    Evanthia Lalla
    Division of Periodontics, School of Dental and Oral Surgery, Columbia University, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 23:1405-11. 2003
    ....
  60. ncbi request reprint Classification of clear-cell sarcoma as a subtype of melanoma by genomic profiling
    Neil H Segal
    Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 21:1775-81. 2003
    ..CCS/MSP also has typical melanoma features, including immunoreactivity for S100 and HMB45, pigmentation, MITF-M expression, and a propensity for regional lymph node metastases...
  61. pmc Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice
    Miguel Verbitsky
    Columbia Genome Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Learn Mem 11:253-60. 2004
    ..Those changes could be involved in the memory deficits we observed in the 15-month-old mice. In agreement with previous reports, we also found altered expression in genes related to inflammation, protein processing, and oxidative stress...
  62. ncbi request reprint Serum antibody responses to periodontal microbiota in chronic and aggressive periodontitis: a postulate revisited
    Andrew M Hwang
    Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, NY
    J Periodontol 85:592-600. 2014
    ..Antibody responses were further examined in localized and generalized chronic periodontitis (LCP and GCP)...
  63. pmc Discovering medical conditions associated with periodontitis using linked electronic health records
    Mary Regina Boland
    Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA
    J Clin Periodontol 40:474-82. 2013
    ..To use linked electronic medical and dental records to discover associations between periodontitis and medical conditions independent of a priori hypotheses...
  64. ncbi request reprint Longitudinal study of intrafamilial mutans streptococci ribotypes
    Birgitta Köhler
    Public Dental Service, Goteborg, Faculty of Odontology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Eur J Oral Sci 111:383-9. 2003
    ..The results support the notion of intrafamilial transfer of mutans streptococci, and suggest that colonization of early acquired strains persists into young adulthood...
  65. ncbi request reprint A multicenter study evaluating the sensitization potential of enamel matrix derivative after treatment of two infrabony defects
    Stuart Froum
    Department of Implant Dentistry, New York University, New York, NY, USA
    J Periodontol 75:1001-8. 2004
    ..This multi-center study evaluated the potential for sensitization to EMD in a subgroup of periodontal patients treated at least twice with at least 2 months between treatments...
  66. ncbi request reprint Cutting edge: STAT6 serves as a positive and negative regulator of gene expression in IL-4-stimulated B lymphocytes
    Andreas J Schroder
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    J Immunol 168:996-1000. 2002
    ..Furthermore, IL-4 induces expression of the transcription factor Krox20, which is required for maximal IL-4-induced transcription...
  67. ncbi request reprint Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model
    Kimberly L Stark
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, New York 10032, USA
    Nat Genet 40:751-60. 2008
    ..2 microdeletion...
  68. pmc Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning
    Wen Sung Lai
    Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:16906-11. 2006
    ....
  69. ncbi request reprint Activation of MAPK in hearts of EMD null mice: similarities between mouse models of X-linked and autosomal dominant Emery Dreifuss muscular dystrophy
    Antoine Muchir
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York 10032, USA
    Hum Mol Genet 16:1884-95. 2007
    ..Activation of MAPK signaling appears to be a cornerstone in the development of heart disease in both X-linked and autosomal dominant EDMD...
  70. ncbi request reprint Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins
    Amy Chen
    Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Neuron 39:655-69. 2003
    ..Relief of this inhibition lowers the threshold for hippocampal-dependent long-term synaptic potentiation and memory storage in mice...
  71. pmc Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy
    Antoine Muchir
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street New York, NY 10032, USA
    J Clin Invest 117:1282-93. 2007
    ..Activation of MAPK signaling by mutant A-type lamins could be a cornerstone in the development of heart disease in autosomal dominant Emery-Dreifuss muscular dystrophy...
  72. pmc Sharing and reusing gene expression profiling data in neuroscience
    Xiang Wan
    Department of Psychiatry, UBC Bioinformatics Centre, University of British Columbia, 177 Michael Smith Laboratories 2185 East Mall, Vancouver, BC V6T1Z4, Canada
    Neuroinformatics 5:161-75. 2007
    ..Techniques and tools for data reuse are also in need of improvement. Integration of expression profiling data with neuroscience-specific resources such as anatomical atlases will further increase the value of expression data...
  73. pmc Hierarchical model of gene regulation by transforming growth factor beta
    Yaw Ching Yang
    Departments of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461
    Proc Natl Acad Sci U S A 100:10269-74. 2003
    ....
  74. pmc Gene Ontology term overlap as a measure of gene functional similarity
    Meeta Mistry
    Department of Psychiatry and Centre for High Throughput Biology, University of British Columbia, British Columbia, Canada
    BMC Bioinformatics 9:327. 2008
    ..A number of groups have suggested that the semantic similarity of the GO annotations of genes can serve as a proxy for functional relatedness. Here we evaluate a simple measure of semantic similarity, term overlap (TO)...
  75. ncbi request reprint Cluster analysis of genes with significant change in expression in cells conditioned to survive TBOOH
    Dayu Li
    Exp Eye Res 78:301-8. 2004
    ..The analysis has revealed a small group of antioxidative defense genes that contribute to the survival of T and H cells when exposed to oxidative stress...
  76. pmc Experimental comparison and cross-validation of the Affymetrix and Illumina gene expression analysis platforms
    Michael Barnes
    Cincinnati Children s Hospital Medical Center, Division of Rheumatology, Cincinnati, OH, USA
    Nucleic Acids Res 33:5914-23. 2005
    ..The set of probes we found to be most highly reproducible can be used by others to help increase confidence in analyses of other data sets using these platforms...
  77. ncbi request reprint Informatics in neuroscience
    Leon French
    UBC Bioinformatics Centre UBiC, 177, Michael Smith Laboratories, 2185 East Mall, University of British Columbia, Vancouver BC V6T1Z4, Canada
    Brief Bioinform 8:446-56. 2007
    ..The continuing development of standards for data exchange and interoperability, together with increasing awareness and acceptance of the importance of data sharing, are among the key efforts required to advance the field...
  78. ncbi request reprint Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth
    Annie Varrault
    Institut de Genomique Fonctionnelle, CNRS UMR5203, INSERM U661, Universite Montpellier 1, Universite Montpellier 2, Montpellier, F 34094, France
    Dev Cell 11:711-22. 2006
    ..Accordingly, these data identify a network of imprinted genes, including Zac1, which controls embryonic growth and which may be the basis for the implementation of a common mechanism of gene regulation during mammalian evolution...
  79. ncbi request reprint An ancestral haplotype defines susceptibility to doxorubicin nephropathy in the laboratory mouse
    Zongyu Zheng
    Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Am Soc Nephrol 17:1796-800. 2006
    ..These data demonstrate that susceptibility to DOX nephropathy represents a founder mutation in the laboratory mouse. Haplotype analysis can be used for identification of the DOXNPH gene and prediction of strain susceptibility pattern...

Research Grants3

  1. Gene Expression in Chronic and Aggressive Periodontitis
    Panos Papapanou; Fiscal Year: 2004
    ..Ultimately, a pathobiology-based classification of periodontitis will facilitate correct diagnosis and targeted, efficient therapeutic prevention and intervention strategies. ..
  2. Gene Expression in Chronic and Aggressive Periodontitis
    Panos Papapanou; Fiscal Year: 2005
    ..Ultimately, a pathobiology-based classification of periodontitis will facilitate correct diagnosis and targeted, efficient therapeutic prevention and intervention strategies. ..
  3. Gene Expression in Chronic and Aggressive Periodontitis
    Panos Papapanou; Fiscal Year: 2006
    ..Ultimately, a pathobiology-based classification of periodontitis will facilitate correct diagnosis and targeted, efficient therapeutic prevention and intervention strategies. ..