VIRGINIA PAPAIOANNOU

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling
    Anna Katerina Hadjantonakis
    Developmental Biology Program, Sloan Kettering Institute, New York, New York, United States of America
    PLoS ONE 3:e2511. 2008
  2. pmc Lack of genetic interaction between Tbx20 and Tbx3 in early mouse heart development
    Svetlana Gavrilov
    Department of Genetics and Development, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 8:e70149. 2013
  3. pmc Candidate gene approach identifies multiple genes and signaling pathways downstream of Tbx4 in the developing allantois
    Ripla Arora
    Department of Genetics and Development, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 7:e43581. 2012
  4. pmc Multiple roles and interactions of Tbx4 and Tbx5 in development of the respiratory system
    Ripla Arora
    Department of Genetics and Development, Columbia University Medical Center, New York, New York, United States of America
    PLoS Genet 8:e1002866. 2012
  5. pmc Derivation of two new human embryonic stem cell lines from nonviable human embryos
    Svetlana Gavrilov
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Stem Cells Int 2011:765378. 2011
  6. pmc Can mammalian cloning combined with embryonic stem cell technologies be used to treat human diseases?
    Anna Katerina Hadjantonakis
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Genome Biol 3:REVIEWS1023. 2002
  7. pmc Unusual misregulation of RNA splicing caused by insertion of a transposable element into the T (Brachyury) locus
    Sarah N Goldin
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    BMC Genomics 4:14. 2003
  8. pmc Dynamic in vivo imaging and cell tracking using a histone fluorescent protein fusion in mice
    Anna Katerina Hadjantonakis
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th St, New York, NY 10032, USA
    BMC Biotechnol 4:33. 2004
  9. ncbi request reprint T-box family reunion
    V E Papaioannou
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032 USA
    Trends Genet 13:212-3. 1997
  10. pmc Early embryonic lethality in genetically engineered mice: diagnosis and phenotypic analysis
    V E Papaioannou
    Department of Genetics and Development, Columbia University Medical Center, 701 W 168th St, New York, NY 10032, USA
    Vet Pathol 49:64-70. 2012

Research Grants

  1. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2004
  2. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2005
  3. Islet growth in NOD mice tolerant to autoimmune diabetes
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2004
  4. Islet growth in NOD mice tolerant to autoimmune diabetes
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2005
  5. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2006
  6. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2007
  7. PREDOCTORAL TRAINING GRANT IN GENETICS AND DEVELOPMENT
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2007
  8. T-box gene effects on left-right body axis determination
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2009
  9. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2003
  10. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2002

Collaborators

Detail Information

Publications36

  1. pmc Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling
    Anna Katerina Hadjantonakis
    Developmental Biology Program, Sloan Kettering Institute, New York, New York, United States of America
    PLoS ONE 3:e2511. 2008
    ..Here we describe a novel role for the T-box transcription factor gene Tbx6 in left/right body axis determination in the mouse...
  2. pmc Lack of genetic interaction between Tbx20 and Tbx3 in early mouse heart development
    Svetlana Gavrilov
    Department of Genetics and Development, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 8:e70149. 2013
    ..Thus the effects of Tbx20 are epistatic to Tbx3 in the heart but Tbx3 is epistatic to Tbx20 with respect to developmental delay. ..
  3. pmc Candidate gene approach identifies multiple genes and signaling pathways downstream of Tbx4 in the developing allantois
    Ripla Arora
    Department of Genetics and Development, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 7:e43581. 2012
    ..In vivo, Tbx4 and Wnt2 double heterozygous placentas show decreased vasculature suggesting interactions between Tbx4 and the canonical Wnt signaling pathway in the process of allantois-derived blood vessel formation...
  4. pmc Multiple roles and interactions of Tbx4 and Tbx5 in development of the respiratory system
    Ripla Arora
    Department of Genetics and Development, Columbia University Medical Center, New York, New York, United States of America
    PLoS Genet 8:e1002866. 2012
    ..Finally, we show that Tbx4 and Tbx5 interact with Fgf10 during the process of lung growth and branching but not during tracheal/bronchial cartilage development...
  5. pmc Derivation of two new human embryonic stem cell lines from nonviable human embryos
    Svetlana Gavrilov
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Stem Cells Int 2011:765378. 2011
    ....
  6. pmc Can mammalian cloning combined with embryonic stem cell technologies be used to treat human diseases?
    Anna Katerina Hadjantonakis
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Genome Biol 3:REVIEWS1023. 2002
    ..A recent report offers the first 'proof of principle' of such cloning for therapeutic purposes, referred to as nuclear transplantation to produce stem cells for autologous transplantation...
  7. pmc Unusual misregulation of RNA splicing caused by insertion of a transposable element into the T (Brachyury) locus
    Sarah N Goldin
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    BMC Genomics 4:14. 2003
    ..This study sought to further characterize the mutant TWis allele by investigating the nature of the transcripts produced by insertion of this transposable element...
  8. pmc Dynamic in vivo imaging and cell tracking using a histone fluorescent protein fusion in mice
    Anna Katerina Hadjantonakis
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th St, New York, NY 10032, USA
    BMC Biotechnol 4:33. 2004
    ..As a result, imaging using autofluorescent protein reporters is gaining popularity in mouse transgenic and targeted mutagenesis applications...
  9. ncbi request reprint T-box family reunion
    V E Papaioannou
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032 USA
    Trends Genet 13:212-3. 1997
  10. pmc Early embryonic lethality in genetically engineered mice: diagnosis and phenotypic analysis
    V E Papaioannou
    Department of Genetics and Development, Columbia University Medical Center, 701 W 168th St, New York, NY 10032, USA
    Vet Pathol 49:64-70. 2012
    ..Here we summarize general strategies for analyzing early embryonic lethal phenotypes in genetically engineered mouse mutants...
  11. pmc Mice get their annual check-up
    Virginia E Papaioannou
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701W, 168th St, New York, NY 10032, USA
    Genome Biol 5:358. 2004
    ..A report on the 2004 meeting on Mouse Molecular Genetics, Cold Spring Harbor, USA, 1-5 September 2004...
  12. ncbi request reprint The T-box gene family
    V E Papaioannou
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Bioessays 20:9-19. 1998
    ..This review presents a current overview of progress made in the analysis of T-box genes and their products in a variety of model systems...
  13. ncbi request reprint Embryonic stem cells and mouse models of human syndromes: examples from the T-box gene family
    Virginia E Papaioannou
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 W 168th Street, New York, NY 10032, USA
    Reprod Biomed Online 4:68-71. 2002
    ..The ulnar-mammary syndrome and the DiGeorge syndrome are two developmental syndromes that are currently being explored in this way...
  14. ncbi request reprint Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development
    Zachary Harrelson
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Development 131:5041-52. 2004
    ....
  15. ncbi request reprint T-box genes in vertebrate development
    L A Naiche
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Annu Rev Genet 39:219-39. 2005
    ..The few downstream target genes that have been identified indicate a wide range of downstream effectors...
  16. ncbi request reprint Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois
    L A Naiche
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 W 168th Street, New York, NY 10032, USA
    Development 130:2681-93. 2003
    ....
  17. ncbi request reprint Visualization of outflow tract development in the absence of Tbx1 using an FgF10 enhancer trap transgene
    Robert G Kelly
    Department of Genetics and Development, Columbia University, New York, NY, USA
    Dev Dyn 236:821-8. 2007
    ..Furthermore, although normal Fgf10 levels are dependent on Tbx1, loss of Fgf10 alleles does not significantly modify the cardiac phenotype of Tbx1 heterozygous or homozygous mutant embryos...
  18. ncbi request reprint Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome
    Todd G Davenport
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 W 168th Street, New York, NY 10032, USA
    Development 130:2263-73. 2003
    ....
  19. ncbi request reprint The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis
    Robert G Kelly
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Hum Mol Genet 13:2829-40. 2004
    ..While no abnormalities in branchiomeric myogenesis were detected in Tbx1(+/-) mice, reduced TBX1 levels may contribute to pharyngeal hypotonia in del22q11.2 patients...
  20. ncbi request reprint Tbx4 is not required for hindlimb identity or post-bud hindlimb outgrowth
    L A Naiche
    Columbia University, College of Physicians and Surgeons, Department of Genetics and Development, 701 W 168th St, New York, NY 10032, USA
    Development 134:93-103. 2007
    ..Despite evidence from ectopic expression studies, our work establishes that loss of Tbx4 has no effect on hindlimb identity as assessed by morphology or molecular markers...
  21. ncbi request reprint Segmental expression of the T-box transcription factor, Tbx2, during early somitogenesis
    Zachary Harrelson
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Dev Dyn 235:3080-4. 2006
    ..In addition, Tbx2 expression is observed during somitogenesis beginning at E9.5, both in the posterior half of prospective somites and in a progressively restricted pattern in recently formed somites...
  22. ncbi request reprint Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway
    Loydie A Jerome-Majewska
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Dev Dyn 234:922-33. 2005
    ....
  23. ncbi request reprint Critical role for Tbx6 in mesoderm specification in the mouse embryo
    Deborah L Chapman
    College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Mech Dev 120:837-47. 2003
    ..However, homozygosity for Tbx6(tm1Pa) and heterozygosity for T(Wis) mutation shows a combinatorial interaction at the phenotypic level...
  24. ncbi request reprint Live imaging of fluorescent proteins in chordate embryos: from ascidians to mice
    Yale J Passamaneck
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Microsc Res Tech 69:160-7. 2006
    ....
  25. ncbi request reprint Non-viable human embryos as a source of viable cells for embryonic stem cell derivation
    Svetlana Gavrilov
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Reprod Biomed Online 18:301-8. 2009
    ....
  26. ncbi request reprint Cre activity causes widespread apoptosis and lethal anemia during embryonic development
    L A Naiche
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Genesis 45:768-75. 2007
    ..This information will be critical in both evaluating previously published work using cre alleles and in designing future experiments...
  27. ncbi request reprint TM1 and TM2: two mutant alleles that constitute a genetic trait controlling thymocyte development
    Fang Huang
    Department of Microbiology, Columbia University College of Physicians and Surgeons, HHSC Rm6 611, 701 West 168th Street, New York, NY 10032, USA
    Immunogenetics 59:473-7. 2007
    ..Thus, TM1 and TM2 represent two novel alleles that define a genetic trait controlling thymocyte development...
  28. ncbi request reprint Molecular pathway for the localized formation of the sinoatrial node
    Mathilda T M Mommersteeg
    Center for Heart Failure Research, Academic Medical Centre, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Circ Res 100:354-62. 2007
    ....
  29. ncbi request reprint Aortic arch and pharyngeal phenotype in the absence of BMP-dependent neural crest in the mouse
    Sabine Ohnemus
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Mech Dev 119:127-35. 2002
    ....
  30. pmc Tbx3 is required for outflow tract development
    Karim Mesbah
    Developmental Biology Institute of Marseilles Luminy, France
    Circ Res 103:743-50. 2008
    ....
  31. ncbi request reprint Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome
    Deborah L Guris
    The Ben May Institute for Cancer Research and Center for Molecular Oncology, The University of Chicago, Chicago, Illinois 60637, USA
    Dev Cell 10:81-92. 2006
    ..Thus, we suggest that del22q11 is a contiguous gene syndrome involving dose-sensitive interaction of CRKL and TBX1 and locally aberrant RA signaling...
  32. ncbi request reprint Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development
    Filipa Moraes
    Instituto Gulbenkian de Ciencia, UT, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
    Mech Dev 122:199-212. 2005
    ..The inability of the Tbx1(-/-) embryos to keep properly segregated functional domains in the otocyst is likely the cause of the strong inner ear phenotypes observed in these mutants...
  33. ncbi request reprint The mouse rib-vertebrae mutation is a hypomorphic Tbx6 allele
    Masami Watabe-Rudolph
    Institut fur Molekularbiologie, Medizinische Hochschule, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Mech Dev 119:251-6. 2002
    ..Our results indicate that rv is a regulatory mutation of Tbx6 causing a hypomorphic phenotype...
  34. ncbi request reprint Downregulation of Par3 and aPKC function directs cells towards the ICM in the preimplantation mouse embryo
    Berenika Plusa
    Wellcome Trust and Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge CB2 1QR, UK
    J Cell Sci 118:505-15. 2005
    ..In addition, this experimental approach illustrates a powerful means of manipulating gene expression in a specific clonal population of cells in the preimplantation embryo...
  35. ncbi request reprint The first cleavage of the mouse zygote predicts the blastocyst axis
    Berenika Plusa
    Wellcome Trust and Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Nature 434:391-5. 2005
    ..Thus, the first cleavage contributes to breaking the symmetry of the embryo, generating blastomeres with different developmental characteristics...
  36. ncbi request reprint Developmental potential and behavior of tetraploid cells in the mouse embryo
    Guy S Eakin
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Biol 288:150-9. 2005
    ..These findings suggest that the results of previously published tetraploid complementation assays may be influenced by the presence of tetraploid cells in the otherwise diploid embryonic regions...

Research Grants24

  1. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2004
    ..Produce a conditional allele of Tbx4 to study gene function late in development. Specific Aim 3. Investigate regulatory and genetic interactions between the genes of the Tbx subfamily, Tbx2, Tbx3, Tbx4, and Tbx5. ..
  2. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2005
    ..Produce a conditional allele of Tbx4 to study gene function late in development. Specific Aim 3. Investigate regulatory and genetic interactions between the genes of the Tbx subfamily, Tbx2, Tbx3, Tbx4, and Tbx5. ..
  3. Islet growth in NOD mice tolerant to autoimmune diabetes
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2004
    ..Kevan Herold, whose work has been in the immunology and immunotherapy of Type 1 diabetes and Dr. Virginia Papaioannou, who is an expert in the field of developmental biology but who has not previously worked in the field of ..
  4. Islet growth in NOD mice tolerant to autoimmune diabetes
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2005
    ..Kevan Herold, whose work has been in the immunology and immunotherapy of Type 1 diabetes and Dr. Virginia Papaioannou, who is an expert in the field of developmental biology but who has not previously worked in the field of ..
  5. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2006
    ..Produce a conditional allele of Tbx4 to study gene function late in development. Specific Aim 3. Investigate regulatory and genetic interactions between the genes of the Tbx subfamily, Tbx2, Tbx3, Tbx4, and Tbx5. ..
  6. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2007
    ....
  7. PREDOCTORAL TRAINING GRANT IN GENETICS AND DEVELOPMENT
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2007
    ..Many research projects available to trainees include components directly related to specific human diseases ranging from psychological disorders to congenital developmental abnormalities to mitochondria diseases. ..
  8. T-box gene effects on left-right body axis determination
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2009
    ..Specific Aim 3. To determine the lineage of cells of the node with respect to their prior expression of Tbx6. ..
  9. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2003
    ..Produce a conditional allele of Tbx4 to study gene function late in development. Specific Aim 3. Investigate regulatory and genetic interactions between the genes of the Tbx subfamily, Tbx2, Tbx3, Tbx4, and Tbx5. ..
  10. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2002
    ..Produce a conditional allele of Tbx4 to study gene function late in development. Specific Aim 3. Investigate regulatory and genetic interactions between the genes of the Tbx subfamily, Tbx2, Tbx3, Tbx4, and Tbx5. ..
  11. EXPRESSION AND ROLE OF T-BOX GENES IN MOUSE DEVELOPMENT
    VIRGINIA PAPAIOANNOU; Fiscal Year: 1999
    ..The phenotype of resulting mutant animals will be analyzed and the mutants will be mated together to study possible interactions between different genes. ..
  12. EXPRESSION AND ROLE OF T-BOX GENES IN MOUSE DEVELOPMENT
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2000
    ..The phenotype of resulting mutant animals will be analyzed and the mutants will be mated together to study possible interactions between different genes. ..
  13. ROLE OF TBX6 IN MESODERM PATTERING AND SOMITE FORMATION
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2000
    ..Specific Aim 4. To isolate and characterize additional members of the Tbx6 subfamily in the mouse with special emphasis on isolating the orthologs of genes known in other species to play a role in mesoderm development. ..
  14. ROLE OF TBX6 IN MESODERM PATTERING AND SOMITE FORMATION
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2001
    ..Specific Aim 4. To isolate and characterize additional members of the Tbx6 subfamily in the mouse with special emphasis on isolating the orthologs of genes known in other species to play a role in mesoderm development. ..
  15. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2002
    ..Produce a conditional allele of Tbx4 to study gene function late in development. Specific Aim 3. Investigate regulatory and genetic interactions between the genes of the Tbx subfamily, Tbx2, Tbx3, Tbx4, and Tbx5. ..
  16. ROLE OF TBX6 IN MESODERM PATTERING AND SOMITE FORMATION
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2001
    ..Specific Aim 4. To isolate and characterize additional members of the Tbx6 subfamily in the mouse with special emphasis on isolating the orthologs of genes known in other species to play a role in mesoderm development. ..
  17. ROLE OF TBX6 IN MESODERM PATTERING AND SOMITE FORMATION
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2002
    ..Specific Aim 4. To isolate and characterize additional members of the Tbx6 subfamily in the mouse with special emphasis on isolating the orthologs of genes known in other species to play a role in mesoderm development. ..
  18. ROLE OF TBX6 IN MESODERM PATTERING AND SOMITE FORMATION
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2003
    ..Specific Aim 4. To isolate and characterize additional members of the Tbx6 subfamily in the mouse with special emphasis on isolating the orthologs of genes known in other species to play a role in mesoderm development. ..
  19. T-box gene effects on left-right body axis determination
    Virginia E Papaioannou; Fiscal Year: 2010
    ..Specific Aim 3. To determine the lineage of cells of the node with respect to their prior expression of Tbx6. ..