Research Topics
Genomes and Genes | VIRGINIA PAPAIOANNOUSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Can mammalian cloning combined with embryonic stem cell technologies be used to treat human diseases?Anna Katerina Hadjantonakis
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Genome Biol 3:REVIEWS1023. 2002..A recent report offers the first 'proof of principle' of such cloning for therapeutic purposes, referred to as nuclear transplantation to produce stem cells for autologous transplantation...- Unusual misregulation of RNA splicing caused by insertion of a transposable element into the T (Brachyury) locusSarah N Goldin
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
BMC Genomics 4:14. 2003..This study sought to further characterize the mutant TWis allele by investigating the nature of the transcripts produced by insertion of this transposable element... - Dynamic in vivo imaging and cell tracking using a histone fluorescent protein fusion in miceAnna Katerina Hadjantonakis
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th St, New York, NY 10032, USA
BMC Biotechnol 4:33. 2004..As a result, imaging using autofluorescent protein reporters is gaining popularity in mouse transgenic and targeted mutagenesis applications... 
T-box family reunionV E Papaioannou
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032 USA
Trends Genet 13:212-3. 1997- Early embryonic lethality in genetically engineered mice: diagnosis and phenotypic analysisV E Papaioannou
Department of Genetics and Development, Columbia University Medical Center, 701 W 168th St, New York, NY 10032, USA
Vet Pathol 49:64-70. 2012..Here we summarize general strategies for analyzing early embryonic lethal phenotypes in genetically engineered mouse mutants... - Mice get their annual check-upVirginia E Papaioannou
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701W, 168th St, New York, NY 10032, USA
Genome Biol 5:358. 2004..A report on the 2004 meeting on Mouse Molecular Genetics, Cold Spring Harbor, USA, 1-5 September 2004... - Embryonic stem cells and mouse models of human syndromes: examples from the T-box gene familyVirginia E Papaioannou
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 W 168th Street, New York, NY 10032, USA
Reprod Biomed Online 4:68-71. 2002..The ulnar-mammary syndrome and the DiGeorge syndrome are two developmental syndromes that are currently being explored in this way... - The T-box gene familyV E Papaioannou
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Bioessays 20:9-19. 1998..This review presents a current overview of progress made in the analysis of T-box genes and their products in a variety of model systems... - Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart developmentZachary Harrelson
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Development 131:5041-52. 2004.... - Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndromeTodd G Davenport
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 W 168th Street, New York, NY 10032, USA
Development 130:2263-73. 2003.... - Visualization of outflow tract development in the absence of Tbx1 using an FgF10 enhancer trap transgeneRobert G Kelly
Department of Genetics and Development, Columbia University, New York, NY, USA
Dev Dyn 236:821-8. 2007..Furthermore, although normal Fgf10 levels are dependent on Tbx1, loss of Fgf10 alleles does not significantly modify the cardiac phenotype of Tbx1 heterozygous or homozygous mutant embryos... - T-box genes in vertebrate developmentL A Naiche
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Annu Rev Genet 39:219-39. 2005..The few downstream target genes that have been identified indicate a wide range of downstream effectors... - Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantoisL A Naiche
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 W 168th Street, New York, NY 10032, USA
Development 130:2681-93. 2003.... - The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesisRobert G Kelly
Department of Genetics and Development, Columbia University, New York, NY 10032, USA
Hum Mol Genet 13:2829-40. 2004..While no abnormalities in branchiomeric myogenesis were detected in Tbx1(+/-) mice, reduced TBX1 levels may contribute to pharyngeal hypotonia in del22q11.2 patients... - Segmental expression of the T-box transcription factor, Tbx2, during early somitogenesisZachary Harrelson
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York, USA
Dev Dyn 235:3080-4. 2006..In addition, Tbx2 expression is observed during somitogenesis beginning at E9.5, both in the posterior half of prospective somites and in a progressively restricted pattern in recently formed somites... - Tbx4 is not required for hindlimb identity or post-bud hindlimb outgrowthL A Naiche
Columbia University, College of Physicians and Surgeons, Department of Genetics and Development, 701 W 168th St, New York, NY 10032, USA
Development 134:93-103. 2007..Despite evidence from ectopic expression studies, our work establishes that loss of Tbx4 has no effect on hindlimb identity as assessed by morphology or molecular markers... - Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathwayLoydie A Jerome-Majewska
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Dev Dyn 234:922-33. 2005.... - Critical role for Tbx6 in mesoderm specification in the mouse embryoDeborah L Chapman
College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, NY 10032, USA
Mech Dev 120:837-47. 2003..However, homozygosity for Tbx6(tm1Pa) and heterozygosity for T(Wis) mutation shows a combinatorial interaction at the phenotypic level... - TM1 and TM2: two mutant alleles that constitute a genetic trait controlling thymocyte developmentFang Huang
Department of Microbiology, Columbia University College of Physicians and Surgeons, HHSC Rm6 611, 701 West 168th Street, New York, NY 10032, USA
Immunogenetics 59:473-7. 2007..Thus, TM1 and TM2 represent two novel alleles that define a genetic trait controlling thymocyte development... - Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signalingAnna Katerina Hadjantonakis
Developmental Biology Program, Sloan Kettering Institute, New York, New York, United States of America
PLoS ONE 3:e2511. 2008..Here we describe a novel role for the T-box transcription factor gene Tbx6 in left/right body axis determination in the mouse... - Live imaging of fluorescent proteins in chordate embryos: from ascidians to miceYale J Passamaneck
Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
Microsc Res Tech 69:160-7. 2006.... - Cre activity causes widespread apoptosis and lethal anemia during embryonic developmentL A Naiche
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Genesis 45:768-75. 2007..This information will be critical in both evaluating previously published work using cre alleles and in designing future experiments... - Non-viable human embryos as a source of viable cells for embryonic stem cell derivationSvetlana Gavrilov
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, NY 10032, USA
Reprod Biomed Online 18:301-8. 2009.... - Tbx3 is required for outflow tract developmentKarim Mesbah
Developmental Biology Institute of Marseilles Luminy, France
Circ Res 103:743-50. 2008.... - Molecular pathway for the localized formation of the sinoatrial nodeMathilda T M Mommersteeg
Center for Heart Failure Research, Academic Medical Centre, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
Circ Res 100:354-62. 2007.... - Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear developmentFilipa Moraes
Instituto Gulbenkian de Ciencia, UT, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
Mech Dev 122:199-212. 2005..The inability of the Tbx1(-/-) embryos to keep properly segregated functional domains in the otocyst is likely the cause of the strong inner ear phenotypes observed in these mutants... - Aortic arch and pharyngeal phenotype in the absence of BMP-dependent neural crest in the mouseSabine Ohnemus
Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
Mech Dev 119:127-35. 2002.... - Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndromeDeborah L Guris
The Ben May Institute for Cancer Research and Center for Molecular Oncology, The University of Chicago, Chicago, Illinois 60637, USA
Dev Cell 10:81-92. 2006..Thus, we suggest that del22q11 is a contiguous gene syndrome involving dose-sensitive interaction of CRKL and TBX1 and locally aberrant RA signaling... - The mouse rib-vertebrae mutation is a hypomorphic Tbx6 alleleMasami Watabe-Rudolph
Institut fur Molekularbiologie, Medizinische Hochschule, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
Mech Dev 119:251-6. 2002..Our results indicate that rv is a regulatory mutation of Tbx6 causing a hypomorphic phenotype... - Developmental potential and behavior of tetraploid cells in the mouse embryoGuy S Eakin
Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
Dev Biol 288:150-9. 2005..These findings suggest that the results of previously published tetraploid complementation assays may be influenced by the presence of tetraploid cells in the otherwise diploid embryonic regions... - Downregulation of Par3 and aPKC function directs cells towards the ICM in the preimplantation mouse embryoBerenika Plusa
Wellcome Trust and Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge CB2 1QR, UK
J Cell Sci 118:505-15. 2005..In addition, this experimental approach illustrates a powerful means of manipulating gene expression in a specific clonal population of cells in the preimplantation embryo... - The first cleavage of the mouse zygote predicts the blastocyst axisBerenika Plusa
Wellcome Trust and Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Nature 434:391-5. 2005..Thus, the first cleavage contributes to breaking the symmetry of the embryo, generating blastomeres with different developmental characteristics...
Research Grants
- Islet growth in NOD mice tolerant to autoimmune diabetesVIRGINIA PAPAIOANNOU; Fiscal Year: 2005..Kevan Herold, whose work has been in the immunology and immunotherapy of Type 1 diabetes and Dr. Virginia Papaioannou, who is an expert in the field of developmental biology but who has not previously worked in the field of ..
- Role of T-box Genes in Mouse DevelopmentVIRGINIA PAPAIOANNOU; Fiscal Year: 2006..Produce a conditional allele of Tbx4 to study gene function late in development. Specific Aim 3. Investigate regulatory and genetic interactions between the genes of the Tbx subfamily, Tbx2, Tbx3, Tbx4, and Tbx5. ..
- Role of T-box Genes in Mouse DevelopmentVIRGINIA PAPAIOANNOU; Fiscal Year: 2007....
- PREDOCTORAL TRAINING GRANT IN GENETICS AND DEVELOPMENTVIRGINIA PAPAIOANNOU; Fiscal Year: 2007..Many research projects available to trainees include components directly related to specific human diseases ranging from psychological disorders to congenital developmental abnormalities to mitochondria diseases. ..
- EXPRESSION AND ROLE OF T-BOX GENES IN MOUSE DEVELOPMENTVIRGINIA PAPAIOANNOU; Fiscal Year: 2000..The phenotype of resulting mutant animals will be analyzed and the mutants will be mated together to study possible interactions between different genes. ..
- ROLE OF TBX6 IN MESODERM PATTERING AND SOMITE FORMATIONVIRGINIA PAPAIOANNOU; Fiscal Year: 2003..Specific Aim 4. To isolate and characterize additional members of the Tbx6 subfamily in the mouse with special emphasis on isolating the orthologs of genes known in other species to play a role in mesoderm development. ..
- T-box gene effects on left-right body axis determinationVirginia E Papaioannou; Fiscal Year: 2010..Specific Aim 3. To determine the lineage of cells of the node with respect to their prior expression of Tbx6. ..