ARTHUR PALMER

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Thermal adaptation of conformational dynamics in ribonuclease H
    Kate A Stafford
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America
    PLoS Comput Biol 9:e1003218. 2013
  2. ncbi request reprint Chemical exchange in biomacromolecules: past, present, and future
    Arthur G Palmer
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, United States Electronic address
    J Magn Reson 241:3-17. 2014
  3. ncbi request reprint NMR characterization of the dynamics of biomacromolecules
    Arthur G Palmer
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Chem Rev 104:3623-40. 2004
  4. ncbi request reprint Characterization of the dynamics of biomacromolecules using rotating-frame spin relaxation NMR spectroscopy
    Arthur G Palmer
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Chem Rev 106:1700-19. 2006
  5. ncbi request reprint Probing molecular motion by NMR
    A G Palmer
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Curr Opin Struct Biol 7:732-7. 1997
  6. ncbi request reprint Nmr probes of molecular dynamics: overview and comparison with other techniques
    A G Palmer
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA
    Annu Rev Biophys Biomol Struct 30:129-55. 2001
  7. pmc Partially folded equilibrium intermediate of the villin headpiece HP67 defined by 13C relaxation dispersion
    Nichole E O'Connell
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    J Biomol NMR 45:85-98. 2009
  8. ncbi request reprint Microsecond-to-millisecond conformational dynamics demarcate the GluR2 glutamate receptor bound to agonists glutamate, quisqualate, and AMPA
    Elizabeth R Valentine
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Biochemistry 44:3410-7. 2005
  9. ncbi request reprint Solution NMR and computer simulation studies of active site loop motion in triosephosphate isomerase
    Francesca Massi
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Biochemistry 45:10787-94. 2006
  10. pmc TROSY-selected ZZ-exchange experiment for characterizing slow chemical exchange in large proteins
    Ying Li
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    J Biomol NMR 45:357-60. 2009

Collaborators

Detail Information

Publications50

  1. pmc Thermal adaptation of conformational dynamics in ribonuclease H
    Kate A Stafford
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America
    PLoS Comput Biol 9:e1003218. 2013
    ..Additional key residues within these two categories are identified through the temperature-dependence of these conformational processes. ..
  2. ncbi request reprint Chemical exchange in biomacromolecules: past, present, and future
    Arthur G Palmer
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, United States Electronic address
    J Magn Reson 241:3-17. 2014
    ..Applications to folding, molecular recognition, catalysis, and allostery by proteins and nucleic acids are highlighted. ..
  3. ncbi request reprint NMR characterization of the dynamics of biomacromolecules
    Arthur G Palmer
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Chem Rev 104:3623-40. 2004
  4. ncbi request reprint Characterization of the dynamics of biomacromolecules using rotating-frame spin relaxation NMR spectroscopy
    Arthur G Palmer
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Chem Rev 106:1700-19. 2006
  5. ncbi request reprint Probing molecular motion by NMR
    A G Palmer
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Curr Opin Struct Biol 7:732-7. 1997
    ..Theoretical interpretations of the relaxation data provide insights into the biophysical and functional properties of proteins...
  6. ncbi request reprint Nmr probes of molecular dynamics: overview and comparison with other techniques
    A G Palmer
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA
    Annu Rev Biophys Biomol Struct 30:129-55. 2001
    ..Insights into the dynamical properties of proteins obtained from NMR spin relaxation spectroscopy are compared with results derived from other experimental and theoretical techniques...
  7. pmc Partially folded equilibrium intermediate of the villin headpiece HP67 defined by 13C relaxation dispersion
    Nichole E O'Connell
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    J Biomol NMR 45:85-98. 2009
    ..In addition, a second faster process was detected that appears to represent local dynamics within the folded state of the molecule and is largely confined to the hydrophobic interface between the N- and C-terminal subdomains...
  8. ncbi request reprint Microsecond-to-millisecond conformational dynamics demarcate the GluR2 glutamate receptor bound to agonists glutamate, quisqualate, and AMPA
    Elizabeth R Valentine
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Biochemistry 44:3410-7. 2005
    ..The sites of conformational mobility in GluR2 S1S2 imply that subtle differences exist between the agonists glutamate, quisqualate, and AMPA in modulating glutamate receptor function...
  9. ncbi request reprint Solution NMR and computer simulation studies of active site loop motion in triosephosphate isomerase
    Francesca Massi
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Biochemistry 45:10787-94. 2006
    ..The results of the joint NMR and MD study provide global insight into the role of conformational dynamic processes in the function of TIM...
  10. pmc TROSY-selected ZZ-exchange experiment for characterizing slow chemical exchange in large proteins
    Ying Li
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    J Biomol NMR 45:357-60. 2009
    ..J Am Chem Soc 129: 13232-13237, 2007), by preserving the TROSY effect during the mixing period as well as the frequency encoding periods...
  11. pmc Structural analysis of protein dynamics by MD simulations and NMR spin-relaxation
    Nikola Trbovic
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Proteins 71:684-94. 2008
    ..Structural analysis reveals that relative imbalance between the description of hydrogen bonding and other terms of modern force fields may be responsible for disagreement...
  12. pmc Protein side-chain dynamics and residual conformational entropy
    Nikola Trbovic
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    J Am Chem Soc 131:615-22. 2009
    ..Dynamic decoupling thus may represent a general biophysical strategy for minimizing the entropic penalties of folding and binding...
  13. ncbi request reprint R(1rho) relaxation for two-site chemical exchange: general approximations and some exact solutions
    Vesselin Z Miloushev
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    J Magn Reson 177:221-7. 2005
    ..The solutions are exact when the R1 and R2 relaxation rate constants are identical, and nearly exact under realistic experimental conditions...
  14. ncbi request reprint Temperature dependence of NMR order parameters and protein dynamics
    Francesca Massi
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    J Am Chem Soc 125:11158-9. 2003
    ..The results provide a linkage between experimental and theoretical measures of the temperature dependence of protein motions...
  15. pmc Dynamic properties of a type II cadherin adhesive domain: implications for the mechanism of strand-swapping of classical cadherins
    Vesselin Z Miloushev
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Structure 16:1195-205. 2008
    ..The results suggest possible kinetic mechanisms for EC1 dimerization...
  16. pmc Characterization of chemical exchange using residual dipolar coupling
    Tatyana I Igumenova
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    J Am Chem Soc 129:13396-7. 2007
  17. pmc Phi-value analysis for ultrafast folding proteins by NMR relaxation dispersion
    Jae Hyun Cho
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    J Am Chem Soc 132:450-1. 2010
    ..The transition and intermediate states of the villin headpiece domain, HP67, are characterized in varying solvent conditions to validate the method...
  18. pmc Protein conformational flexibility prediction using machine learning
    Oleg Trott
    Department of Biochemistry and Molecular Biophysics, The Columbia University College of Physicians and Surgeons, Columbia University, Box 36, 630 West 168th Street, New York, NY 10032, USA
    J Magn Reson 192:37-47. 2008
    ..70. Predicted order parameters for non-terminal amino acid residues depends most strongly on the local packing density and the probability that the residue is located in regular secondary structure...
  19. pmc Conformational dynamics in loop swap mutants of homologous fibronectin type III domains
    Keri Siggers
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Biophys J 93:2447-56. 2007
    ..The results suggest that changes in conformational dynamics of mutant proteins must be considered in both theoretical studies and protein design efforts...
  20. ncbi request reprint Off-resonance TROSY-selected R 1rho experiment with improved sensitivity for medium- and high-molecular-weight proteins
    Tatyana I Igumenova
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    J Am Chem Soc 128:8110-1. 2006
    ..The method is validated using [90%-15N, 70%-2H] ubiquitin at 280 K. The TROSY-selected R1rho experiment enables characterization of backbone dynamics on the microsecond time scale in large proteins...
  21. ncbi request reprint Disulfide bond isomerization in basic pancreatic trypsin inhibitor: multisite chemical exchange quantified by CPMG relaxation dispersion and chemical shift modeling
    Michael J Grey
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    J Am Chem Soc 125:14324-35. 2003
    ..A comparison of the kinetics and thermodynamics for the transitions between the two alternative Cys 14-Cys 38 conformations highlights the factors that affect the contribution of disulfide bonds to protein stability...
  22. ncbi request reprint Theoretical study of R(1rho) rotating-frame and R2 free-precession relaxation in the presence of n-site chemical exchange
    Oleg Trott
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    J Magn Reson 170:104-12. 2004
    ..The perturbation treatment is valid whenever the population of one site is dominant. The new results are generally applicable to investigations of kinetic processes by NMR spectroscopy...
  23. ncbi request reprint Kurt Wüthrich and NMR of biological macromolecules
    Arthur G Palmer
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10025, USA
    Structure 10:1603-4. 2002
    ..Wüthrich shared the prize with John B. Fenn and Koichi Tanaka, who were recognized for the development of ionization methods for the analysis of proteins using mass spectrometry...
  24. pmc Narrowing of protein NMR spectral lines broadened by chemical exchange
    Ying Li
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    J Am Chem Soc 132:8856-7. 2010
    ....
  25. ncbi request reprint Continuum secondary structure captures protein flexibility
    Claus A F Andersen
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Structure 10:175-84. 2002
    ..Thus, continuous assignments of secondary structure may affect future protein structure analysis, comparison, and prediction...
  26. pmc Microsecond timescale backbone conformational dynamics in ubiquitin studied with NMR R1rho relaxation experiments
    Francesca Massi
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Protein Sci 14:735-42. 2005
    ..These residues are located near or at the regions known to interact with various enzymes of the ubiquitin-dependent protein degradation pathway...
  27. ncbi request reprint The N-terminus is unstructured, but not dynamically disordered, in the complex between HK022 Nun protein and lambda-phage BoxB RNA hairpin
    Ashley C Stuart
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    FEBS Lett 553:95-8. 2003
    ..Restriction of conformation flexibility in the N-terminal extension of Nun may be important for binding to other target molecules involved in transcription termination...
  28. ncbi request reprint Mapping chemical exchange in proteins with MW > 50 kD
    Chunyu Wang
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    J Am Chem Soc 125:8968-9. 2003
    ..The success of our method is demonstrated in triosephosphate isomerase (TIM, MW = 54 kD)...
  29. pmc Joint composite-rotation adiabatic-sweep isotope filtration
    Elizabeth R Valentine
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    J Biomol NMR 38:11-22. 2007
    ....
  30. pmc Solution structure of the NaV1.2 C-terminal EF-hand domain
    Vesselin Z Miloushev
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032 3702, USA
    J Biol Chem 284:6446-54. 2009
    ..Clinically significant mutations identified in the C-terminal region of NaV1 sodium channels cluster in the helix I-IV interface and the helix II-III interhelical segment or in helices III and IV of the NaV1.2 (1777-1882) structure...
  31. ncbi request reprint Solution NMR spin relaxation methods for characterizing chemical exchange in high-molecular-weight systems
    Arthur G Palmer
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Methods Enzymol 394:430-65. 2005
    ....
  32. ncbi request reprint Dynamics of ATP-binding cassette contribute to allosteric control, nucleotide binding and energy transduction in ABC transporters
    Chunyu Wang
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 W 168th St, New York, NY 10032, USA
    J Mol Biol 342:525-37. 2004
    ..The restriction of correlated protein motions is likely a central mechanism for allosteric communications. Comparison between dynamics data from NMR and X-ray crystallography reveals their overall consistency and complementarity...
  33. ncbi request reprint Characterizing a partially folded intermediate of the villin headpiece domain under non-denaturing conditions: contribution of His41 to the pH-dependent stability of the N-terminal subdomain
    Michael J Grey
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    J Mol Biol 355:1078-94. 2006
    ....
  34. ncbi request reprint Multiple time scale backbone dynamics of homologous thermophilic and mesophilic ribonuclease HI enzymes
    Joel A Butterwick
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, Box 36, New York, NY 10032 3702, USA
    J Mol Biol 339:855-71. 2004
    ..Increased activation barriers, coupled with motion between alpha-helices B and C not present in ecRNH, may be associated with the reduced catalytic activity of the thermophilic enzyme at 310 K...
  35. ncbi request reprint Solution structure of the Vts1 SAM domain in the presence of RNA
    Thomas A Edwards
    Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, Box 1677, 1425 Madison Avenue, New York, NY 10029, USA
    J Mol Biol 356:1065-72. 2006
    ..These results provide a structural basis for the versatility of the SAM domain in protein and RNA-recognition...
  36. ncbi request reprint R1rho relaxation outside of the fast-exchange limit
    Oleg Trott
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    J Magn Reson 154:157-60. 2002
    ..The new expressions for R1rho will be particularly useful in analyzing experimental data when exchange is not fast and site populations are unequal...
  37. pmc Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4
    Jesko Koehnke
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Structure 16:410-21. 2008
    ..These results raise the possibility that beta-NRX insertion sequence 4 may function in roles independent of neuroligin binding...
  38. ncbi request reprint Differential multiple quantum relaxation caused by chemical exchange outside the fast exchange limit
    Chunyu Wang
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    J Biomol NMR 24:263-8. 2002
    ..The new theoretical expression is valuable for identification and characterization of exchange processes in proteins using differential relaxation of multiple quantum coherences...
  39. ncbi request reprint NMR R1 rho rotating-frame relaxation with weak radio frequency fields
    Francesca Massi
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    J Am Chem Soc 126:2247-56. 2004
    ..The new experiments also extend the capability of the R(1 rho) technique to study exchange processes outside the fast exchange limit...
  40. pmc An inserted Gly residue fine tunes dynamics between mesophilic and thermophilic ribonucleases H
    Joel A Butterwick
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Protein Sci 15:2697-707. 2006
    ....
  41. ncbi request reprint Biophysics: proteins hunt and gather
    David Eliezer
    Nature 447:920-1. 2007
  42. ncbi request reprint Approximate solutions of the Bloch-McConnell equations for two-site chemical exchange
    Daniel Abergel
    Laboratoire de Chimie, Ecole Normale Supérieure 24, rue Lhomond, 75005 Paris, France
    Chemphyschem 5:787-93. 2004
    ..These expressions are useful for interpretation of chemical exchange processes in NMR spectroscopy...
  43. ncbi request reprint Temperature dependence of the NMR generalized order parameter
    Eric Johnson
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267 0524, USA
    Proteins 66:796-803. 2007
    ..The analysis also provides evidence for variations in the potential of mean force for different secondary structural elements...
  44. ncbi request reprint Titration and exchange studies of liver fatty acid-binding protein with 13C-labeled long-chain fatty acids
    Hsin Wang
    Department of Chemistry, CUNY Graduate Center and College of Staten Island, Staten Island, New York 10314, USA
    Biochemistry 41:5453-61. 2002
    ..In light of these NMR measurements, possible molecular mechanisms for the ligand-exchange process are evaluated and implications for the anomalous fatty acid transport mechanism of LFABP are discussed...
  45. ncbi request reprint Beyond the decoupling approximation in the model free approach for the interpretation of NMR relaxation of macromolecules in solution
    Liliya Vugmeyster
    Department of Chemistry, SUNY Stony Brook, Stony Brook, NY 11794 3400, USA
    J Am Chem Soc 125:8400-4. 2003
    ..The parameters of the spectral density function provide insight into the effects on the MF parameters that result from violation of the decoupling approximation...
  46. ncbi request reprint A Markov model for relaxation and exchange in NMR spectroscopy
    Daniel Abergel
    Departement de Chimie, Ecole Normale Superieure, 24, rue Lhomond, 75231 Paris Cedex 05
    J Phys Chem B 109:4837-44. 2005
    ..Time-scale separation emerges as an essential feature from the lowest-order perturbation expansion of the average resolvent in the Laplace domain...
  47. ncbi request reprint Multistate folding of the villin headpiece domain
    Yuefeng Tang
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11790 3400, USA
    J Mol Biol 355:1066-77. 2006
    ..The mutation stabilizes both domains, but folding is still multistate, indicating that His41 is not solely responsible for the unusual equilibrium unfolding behavior of villin headpiece domain...
  48. ncbi request reprint Temperature-dependent dynamics of the villin headpiece helical subdomain, an unusually small thermostable protein
    Liliya Vugmeyster
    Department of Chemistry, SUNY Stony Brook, Stony Brook, NY 11794 3400, USA
    J Mol Biol 320:841-54. 2002
    ..The results suggest that backbone dynamics, as probed by relaxation measurements, make very little contribution to the heat capacity difference between folded and unfolded states for HP36...
  49. ncbi request reprint 1H, 15N and 13C backbone assignment of MJ1267, an ATP-binding cassette
    Chunyu Wang
    J Biomol NMR 24:167-8. 2002
  50. ncbi request reprint Disorder breathes life into a DEAD motor
    Lorraine F Cavanaugh
    Nat Struct Mol Biol 13:566-9. 2006

Research Grants31

  1. Nuclear Magnetic Resonance Studies of Proteins
    ARTHUR PALMER; Fiscal Year: 2005
    ..ABC MJ1267 represents an example of selected-fit molecular recognition and allosteric transmission of conformational changes between remote sites in proteins. ..
  2. Nuclear Magnetic Resonance Studies of Structures and Dynamics of Proteins
    ARTHUR PALMER; Fiscal Year: 2006
    ..ABC MJ1267 represents an example of selected-fit molecular recognition and allosteric transmission of conformational changes between remote sites in proteins. ..
  3. Student Travel Stipends for Experimental NMR Conference
    ARTHUR PALMER; Fiscal Year: 2004
    ..This would permit an increased number of deserving students to attend the conference. ..
  4. NMR Studeis of Structures and Dynamics of Proteins
    ARTHUR PALMER; Fiscal Year: 2003
    ..abstract_text> ..
  5. PROTEIN MOTIONS IN RECOGNITION, REGULATION AND CATALYSIS
    ARTHUR PALMER; Fiscal Year: 2006
    ..The proposed research will measure these changes for three model protein systems involved in cellular structure, nerve transmission, and basic metabolism. ..
  6. PROTEIN MOTIONS IN RECOGNITION, REGULATION AND CATALYSIS
    ARTHUR PALMER; Fiscal Year: 2005
    ..Successful completion of these goals will enable the application of the techniques developed to a wide range of additional protein systems of biological interest. ..
  7. NMR Studies of Structures and Dynamics of Proteins
    Arthur G Palmer; Fiscal Year: 2010
    ....
  8. Nuclear Magnetic Resonance Studies of Structures and Dynamics of Proteins
    ARTHUR PALMER; Fiscal Year: 2009
    ..ABC MJ1267 represents an example of selected-fit molecular recognition and allosteric transmission of conformational changes between remote sites in proteins. ..
  9. STRUCTURE AND DYNAMICS OF RIBONUCLEASE H
    ARTHUR PALMER; Fiscal Year: 2000
    ....
  10. TRAINING PROGRAM IN MOLECULAR BIOPHYSICS
    ARTHUR PALMER; Fiscal Year: 2007
    ..abstract_text> ..
  11. PROTEIN MOTIONS IN RECOGNITION, REGULATION AND CATALYSIS
    ARTHUR PALMER; Fiscal Year: 2009
    ..The proposed research will measure these changes for three model protein systems involved in cellular structure, nerve transmission, and basic metabolism. ..
  12. NMR Studeis of Structures and Dynamics of Proteins
    ARTHUR PALMER; Fiscal Year: 2004
    ..abstract_text> ..
  13. Protein motions in recognition, regulation, and catalysis
    Arthur G Palmer; Fiscal Year: 2010
    ..Elaboration of the roles of conformational dynamics in actuating and regulating these processes is essential for understanding the fundamental functions of proteins in human health and disease. ..
  14. PROTEIN MOTIONS IN RECOGNITION, REGULATION AND CATALYSIS
    ARTHUR PALMER; Fiscal Year: 2003
    ..Successful completion of these goals will enable the application of the techniques developed to a wide range of additional protein systems of biological interest. ..
  15. STRUCTURE AND DYNAMICS OF RIBONUCLEASE H
    ARTHUR PALMER; Fiscal Year: 1999
    ....
  16. NMR Studeis of Structures and Dynamics of Proteins
    ARTHUR PALMER; Fiscal Year: 2001
    ..abstract_text> ..
  17. Cryoprobe Accesory for Bruker DRX 600 NMR Spectrometer
    ARTHUR PALMER; Fiscal Year: 2002
    ..In each of these cases, sufficient sensitivity cannot be obtained simply by increasing acquisition times, due to practical limitations on total experimental durations. ..
  18. PROTEIN MOTIONS IN RECOGNITION, REGULATION AND CATALYSIS
    ARTHUR PALMER; Fiscal Year: 2002
    ..Successful completion of these goals will enable the application of the techniques developed to a wide range of additional protein systems of biological interest. ..
  19. Nuclear Magnetic Resonance Studies of Structures and Dynamics of Proteins
    ARTHUR PALMER; Fiscal Year: 2007
    ..ABC MJ1267 represents an example of selected-fit molecular recognition and allosteric transmission of conformational changes between remote sites in proteins. ..
  20. NMR Studeis of Structures and Dynamics of Proteins
    ARTHUR PALMER; Fiscal Year: 2002
    ..abstract_text> ..
  21. PROTEIN MOTIONS IN RECOGNITION, REGULATION AND CATALYSIS
    ARTHUR PALMER; Fiscal Year: 2007
    ..The proposed research will measure these changes for three model protein systems involved in cellular structure, nerve transmission, and basic metabolism. ..
  22. PROTEIN MOTIONS IN RECOGNITION, REGULATION AND CATALYSIS
    ARTHUR PALMER; Fiscal Year: 2004
    ..Successful completion of these goals will enable the application of the techniques developed to a wide range of additional protein systems of biological interest. ..