M Packer

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study
    Milton Packer
    College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Circulation 106:2194-9. 2002
  2. ncbi request reprint Terms of reference for Data and Safety Monitoring Committees
    M Packer
    Division of Circulatory Physiology, Columbia Presbyterian Medical Center, 5 435, 177 Fort Washington Ave, New York, NY 10032, USA
    Am Heart J 141:542-7. 2001
  3. ncbi request reprint Effect of carvedilol on survival in severe chronic heart failure
    M Packer
    Division of Circulatory Physiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    N Engl J Med 344:1651-8. 2001
  4. ncbi request reprint Comparison of omapatrilat and enalapril in patients with chronic heart failure: the Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE)
    Milton Packer
    Division of Circulatory Physiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Circulation 106:920-6. 2002
  5. ncbi request reprint Should B-type natriuretic peptide be measured routinely to guide the diagnosis and management of chronic heart failure?
    Milton Packer
    Division of Circulatory Physiology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Circulation 108:2950-3. 2003
  6. ncbi request reprint Current role of beta-adrenergic blockers in the management of chronic heart failure
    M Packer
    Division of Circulatory Physiology and The Heart Failure Center, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Med 110:81S-94S. 2001
  7. ncbi request reprint Comparative effects of carvedilol and metoprolol on left ventricular ejection fraction in heart failure: results of a meta-analysis
    M Packer
    Division of Circulatory Physiology, Columbia University College of Physicians and Surgeons, New York, USA
    Am Heart J 141:899-907. 2001
  8. ncbi request reprint Selecting patients for heart transplantation: which patients are too well for transplant?
    M C Deng
    Heart Failure Center, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, Milstein Hospital Building Room 5 407, 177 Fort Washington Avenue, New York, NY 10032, USA
    Curr Opin Cardiol 17:137-44. 2002
  9. ncbi request reprint Proposal for a new clinical end point to evaluate the efficacy of drugs and devices in the treatment of chronic heart failure
    M Packer
    Division of Circulatory Physiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Card Fail 7:176-82. 2001
  10. ncbi request reprint Beta-blockade in heart failure. Basic concepts and clinical results
    M Packer
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Am J Hypertens 11:23S-37S. 1998

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study
    Milton Packer
    College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Circulation 106:2194-9. 2002
    ..Beta-blocking agents improve functional status and reduce morbidity in mild-to-moderate heart failure, but it is not known whether they produce such benefits in severe heart failure...
  2. ncbi request reprint Terms of reference for Data and Safety Monitoring Committees
    M Packer
    Division of Circulatory Physiology, Columbia Presbyterian Medical Center, 5 435, 177 Fort Washington Ave, New York, NY 10032, USA
    Am Heart J 141:542-7. 2001
    ....
  3. ncbi request reprint Effect of carvedilol on survival in severe chronic heart failure
    M Packer
    Division of Circulatory Physiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    N Engl J Med 344:1651-8. 2001
    ..Beta-blocking agents reduce the risk of hospitalization and death in patients with mild-to-moderate heart failure, but little is known about their effects in severe heart failure...
  4. ncbi request reprint Comparison of omapatrilat and enalapril in patients with chronic heart failure: the Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE)
    Milton Packer
    Division of Circulatory Physiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Circulation 106:920-6. 2002
    ..Combined inhibition of the angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) may produce greater benefits in heart failure than ACE inhibition alone...
  5. ncbi request reprint Should B-type natriuretic peptide be measured routinely to guide the diagnosis and management of chronic heart failure?
    Milton Packer
    Division of Circulatory Physiology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Circulation 108:2950-3. 2003
  6. ncbi request reprint Current role of beta-adrenergic blockers in the management of chronic heart failure
    M Packer
    Division of Circulatory Physiology and The Heart Failure Center, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Med 110:81S-94S. 2001
    ....
  7. ncbi request reprint Comparative effects of carvedilol and metoprolol on left ventricular ejection fraction in heart failure: results of a meta-analysis
    M Packer
    Division of Circulatory Physiology, Columbia University College of Physicians and Surgeons, New York, USA
    Am Heart J 141:899-907. 2001
    ..CONCLUSION: Long-term treatment with carvedilol produces greater effects on left ventricular ejection fraction than metoprolol when both drugs are prescribed in doses similar to those that have been shown to prolong life...
  8. ncbi request reprint Selecting patients for heart transplantation: which patients are too well for transplant?
    M C Deng
    Heart Failure Center, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, Milstein Hospital Building Room 5 407, 177 Fort Washington Avenue, New York, NY 10032, USA
    Curr Opin Cardiol 17:137-44. 2002
    ....
  9. ncbi request reprint Proposal for a new clinical end point to evaluate the efficacy of drugs and devices in the treatment of chronic heart failure
    M Packer
    Division of Circulatory Physiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Card Fail 7:176-82. 2001
    ..In the trials that have been completed to date, the clinical composite score has been more sensitive than conventional approaches in discerning the presence or absence of a true treatment effect...
  10. ncbi request reprint Beta-blockade in heart failure. Basic concepts and clinical results
    M Packer
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Am J Hypertens 11:23S-37S. 1998
    ..These findings, taken together, suggest that pharmacologic interference with the sympathetic nervous system can produce important clinical benefits in patients with left ventricular systolic dysfunction...
  11. ncbi request reprint Clinical effects of endothelin receptor antagonism with bosentan in patients with severe chronic heart failure: results of a pilot study
    Milton Packer
    College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Card Fail 11:12-20. 2005
    ..Endothelin receptor antagonism produces favorable short-term hemodynamic effects in heart failure, but the clinical effects of longer term therapy have not been evaluated...
  12. ncbi request reprint Chronic kidney disease, cardiovascular risk, and response to angiotensin-converting enzyme inhibition after myocardial infarction: the Survival And Ventricular Enlargement (SAVE) study
    Mariya P Tokmakova
    Department of Cardiology, St George Hospital, Medical University Plovdiv, Plovdiv, Bulgaria
    Circulation 110:3667-73. 2004
    ..Future cardiovascular event rates and the relative response to therapy in persons with mild to moderate CKD are not well characterized...
  13. ncbi request reprint Prognostic impact of plasma N-terminal pro-brain natriuretic peptide in severe chronic congestive heart failure: a substudy of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) trial
    Franz Hartmann
    Medizinische Klinik II, Universitaetsklinikum Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Circulation 110:1780-6. 2004
    ....
  14. ncbi request reprint Do evidence-based treatments provide incremental benefits to patients with congestive heart failure already receiving angiotensin-converting enzyme inhibitors? A secondary analysis of one-year outcomes from the Assessment of Treatment with Lisinopril and
    Sumit R Majumdar
    Division of General Internal Medicine, Department of Medicine, University of Alberta, 251 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7
    Clin Ther 26:694-703. 2004
    ....
  15. ncbi request reprint Carvedilol reduces the costs of medical care in severe heart failure: an economic analysis of the COPERNICUS study applied to the United Kingdom
    Simon Stewart
    Division of Health Sciences, University of South Australia, City East Campus, Adelaide 5000, Australia
    Int J Cardiol 100:143-9. 2005
    ..The aim of this study was to determine the effects of carvedilol on the costs related to the treatment of severe chronic heart failure (CHF)...
  16. ncbi request reprint Prognostic benefit of beta-blockers in patients not receiving ACE-Inhibitors
    Henry Krum
    NHMRC Centre of Clinical Research Excellence in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University Central and Eastern Clinical School, Alfred Hospital, Melbourne 3004, Australia
    Eur Heart J 26:2154-8. 2005
    ..The magnitude of the prognostic benefit of BBs in the absence of ACE-I or ARB has not as yet been determined...
  17. ncbi request reprint Effect of angiotensin-converting enzyme or vasopeptidase inhibition on ventricular size and function in patients with heart failure: the Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE) echocardiographic study
    Scott D Solomon
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02445, USA
    Am Heart J 150:257-62. 2005
    ..Angiotensin-converting enzyme (ACE) inhibition attenuates ventricular remodeling and improves ventricular function in heart failure patients. Vasopeptidase inhibition has shown similar effects in experimental models...
  18. ncbi request reprint Are beta-blockers needed in patients receiving spironolactone for severe chronic heart failure? An analysis of the COPERNICUS study
    Henry Krum
    Monash University, Melbourne, Australia
    Am Heart J 151:55-61. 2006
    ..We therefore examined this question in the COPERNICUS study of 2289 patients with severe CHF receiving the beta1-beta2/alpha1 blocker carvedilol compared with placebo...
  19. ncbi request reprint Utility of impedance cardiography for the identification of short-term risk of clinical decompensation in stable patients with chronic heart failure
    Milton Packer
    University of Texas Southwestern Medical Center, Dallas, Texas 75390 8822, USA
    J Am Coll Cardiol 47:2245-52. 2006
    ..This study sought to assess the potential utility of impedance cardiography (ICG) in predicting clinical deterioration in ambulatory patients with heart failure (HF)...
  20. ncbi request reprint Pharmacokinetic profile of controlled-release carvedilol in patients with left ventricular dysfunction associated with chronic heart failure or after myocardial infarction
    Milton Packer
    Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Am J Cardiol 98:39L-45L. 2006
    ..These data demonstrate that the new carvedilol CR formulation given once daily is equivalent to the currently available carvedilol IR formulation given twice daily in patients with heart failure and asymptomatic post-MI LVD...
  21. ncbi request reprint Controlled-release carvedilol: a concluding perspective
    Milton Packer
    Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Am J Cardiol 98:67L-69L. 2006
  22. ncbi request reprint Influence of pretreatment systolic blood pressure on the effect of carvedilol in patients with severe chronic heart failure: the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) study
    Jean L Rouleau
    Montreal Heart Institute, University of Montreal, Montreal, Canada
    J Am Coll Cardiol 43:1423-9. 2004
    ..We sought to evaluate the influence of pretreatment systolic blood pressure (SBP) on the efficacy and safety of carvedilol in patients with chronic heart failure (CHF)...
  23. ncbi request reprint Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)
    Douglas L Mann
    Winters Center for Heart Failure Research, Baylor College of Medicine and the Houston VA, Houston, Tex 77030, USA
    Circulation 109:1594-602. 2004
    ..Studies in experimental models and preliminary clinical experience suggested a possible therapeutic role for the soluble tumor necrosis factor antagonist etanercept in heart failure...
  24. ncbi request reprint Cardiac resynchronization in chronic heart failure
    William T Abraham
    Division of Cardiovascular Medicine, University of Kentucky College of Medicine, Lexington 40536 0284, USA
    N Engl J Med 346:1845-53. 2002
    ..We conducted a double-blind trial to evaluate this therapeutic approach...
  25. ncbi request reprint Diuretic resistance predicts mortality in patients with advanced heart failure
    Gerald W Neuberg
    Division of Circulatory Physiology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Am Heart J 144:31-8. 2002
    ..Because diuretic resistance can be overcome with escalating doses, the evaluation of CHF severity and prognosis may be incomplete without considering the intensity of therapy...
  26. ncbi request reprint Vasopressor response to angiotensin II infusion in patients with chronic heart failure receiving beta-blockers
    Timothy J Vittorio
    Division of Circulatory Physiology, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Circulation 107:290-3. 2003
    ..Accordingly, we compared the vasopressor response to infused Ang II in patients treated with carvedilol and metoprolol, a selective beta-antagonist...
  27. ncbi request reprint Effects of initiating carvedilol in patients with severe chronic heart failure: results from the COPERNICUS Study
    Henry Krum
    Dept of Medicine and Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, Victoria, 3181 Australia
    JAMA 289:712-8. 2003
    ..Beta-blockers remain underused despite their established utility for improving outcome in heart failure. Concerns that initiation of treatment produces few immediate benefits and may have important risks may be deterring widespread use...
  28. ncbi request reprint Omapatrilat and enalapril in patients with hypertension: the Omapatrilat Cardiovascular Treatment vs. Enalapril (OCTAVE) trial
    John B Kostis
    Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, One Robert Wood Johnson Place, PO Box 19, New Brunswick, NJ 08903 0019, USA
    Am J Hypertens 17:103-11. 2004
    ..We compared the efficacy and safety of omapatrilat to a representative angiotensin-converting enzyme (ACE) inhibitor, enalapril...
  29. ncbi request reprint Do beta-blockers prolong survival in heart failure only by inhibiting the beta1-receptor? A perspective on the results of the COMET trial
    Milton Packer
    Division of Circulatory Physiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Card Fail 9:429-43. 2003
    ....
  30. ncbi request reprint NT-proBNP in severe chronic heart failure: rationale, design and preliminary results of the COPERNICUS NT-proBNP substudy
    Franz Hartmann
    Medizinische Klinik II, Universitaetsklinikum Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Eur J Heart Fail 6:343-50. 2004
    ..Neither profiles nor prognostic value of cardiac N-terminal proBNP (NT-proBNP) have been prospectively evaluated in a sufficient number of patients with severe chronic heart failure (CHF) treated with carvedilol or placebo...
  31. ncbi request reprint Levosimendan vs dobutamine for patients with acute decompensated heart failure: the SURVIVE Randomized Trial
    Alexandre Mebazaa
    Department of Anesthesiology, Université Paris Diderot and Hospital Lariboisière AP HP, Paris, France
    JAMA 297:1883-91. 2007
    ..Because acute decompensated heart failure causes substantial morbidity and mortality, there is a need for agents that at least improve hemodynamics and relieve symptoms without adversely affecting survival...
  32. ncbi request reprint Cardiac troponin I, a possible predictor of survival in patients with stable congestive heart failure
    Eric B Stanton
    Division of Cardiology, McMaster University and St Joseph s Hospital, Hamilton, Ontario
    Can J Cardiol 21:39-43. 2005
    ..Cardiac troponin I (cTnI) has been validated as a sensitive and specific marker of myocyte damage, and is elevated in some patients with congestive heart failure...
  33. ncbi request reprint Associations of gender and etiology with outcomes in heart failure with systolic dysfunction: a pooled analysis of 5 randomized control trials
    Camille G Frazier
    Division of Cardiovascular Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 49:1450-8. 2007
    ..This study sought to explore the gender-related differences in etiology and outcomes in chronic heart failure (HF) patients from 5 randomized trials...
  34. ncbi request reprint The Warfarin and Antiplatelet Therapy in Heart Failure trial (WATCH): rationale, design, and baseline patient characteristics
    Barry M Massie
    Cardiology Division, San Francisco Veterans Affairs Medical Center, CA 94121, USA
    J Card Fail 10:101-12. 2004
    ..The WATCH trial will help define the optimal approach to antithrombotic therapy in the contemporary management of patients with chronic heart failure resulting from left ventricular systolic dysfunction...
  35. ncbi request reprint The impossible task of developing a new treatment for heart failure
    Milton Packer
    J Card Fail 8:193-6. 2002
  36. ncbi request reprint The Seattle Heart Failure Model: prediction of survival in heart failure
    Wayne C Levy
    University of Washington, Seattle, WA 98177, USA
    Circulation 113:1424-33. 2006
    ....
  37. ncbi request reprint Relation of circulating cardiac myosin light chain 1 isoform in stable severe congestive heart failure to survival and treatment with flosequinan
    Mark S Hansen
    Division of Cardiology of the University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada
    Am J Cardiol 90:969-73. 2002
    ..Flosequinan treatment eliminates this association, highlighting the complexity of the relation between cardiac myocyte damage, drug treatment, and mortality...
  38. ncbi request reprint Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-alpha, in patients with moderate-to-severe heart failure: results of the anti-TNF Therapy Against Congestive Heart Failure (AT
    Eugene S Chung
    The Lindner Center and Ohio Heart Health Center, Cincinnati 45219, USA
    Circulation 107:3133-40. 2003
    ..We evaluated the efficacy and safety of infliximab, a chimeric monoclonal antibody to TNFalpha, in patients with moderate-to-severe heart failure...
  39. ncbi request reprint Left heart failure with a normal ejection fraction: identification of different pathophysiologic mechanisms
    Mathew S Maurer
    Division of Circulatory Physiology, Columbia Universitry, 177 Fort Washington Avenue, MHB 5 435, New York, NY 10032, USA
    J Card Fail 11:177-87. 2005
    ..In view of the clinical heterogeneity of these patients, we hypothesized that subgroups of HFNEF patients may have different underlying pathophysiologic mechanisms...
  40. ncbi request reprint Analytical and clinical evaluation of the Bayer ADVIA Centaur automated B-type natriuretic peptide assay in patients with heart failure: a multisite study
    Alan H B Wu
    Department of Pathology and Laboratory Medicine, Hartford Hospital, 80 Seymour St, Hartford, CT 06102, USA
    Clin Chem 50:867-73. 2004
    ..B-Type natriuretic peptide (BNP) is released from the left ventricle of the heart into the circulation in response to ventricular stretching and volume overload. Increased BNP concentrations are associated with heart failure (HF)...