ALISON PACK

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy
    Alison M Pack
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Ann Neurol 57:252-7. 2005
  2. ncbi request reprint Therapy insight: clinical management of pregnant women with epilepsy
    Alison M Pack
    Neurological Institute, New York, NY 10032, USA
    Nat Clin Pract Neurol 2:190-200. 2006
  3. ncbi request reprint Adverse effects of antiepileptic drugs on bone structure: epidemiology, mechanisms and therapeutic implications
    A M Pack
    Neurological Institute, Columbia University, New York, New York 10032, USA
    CNS Drugs 15:633-42. 2001
  4. ncbi request reprint Treatment of epilepsy to optimize bone health
    Alison M Pack
    710 West 168th Street, New York, NY, 10032, USA
    Curr Treat Options Neurol 13:346-54. 2011
  5. doi request reprint Implications of hormonal and neuroendocrine changes associated with seizures and antiepileptic drugs: a clinical perspective
    Alison M Pack
    Department of Clinical Neurology, Columbia University, New York, New York 10032, USA
    Epilepsia 51:150-3. 2010
  6. pmc Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy
    A M Pack
    Department of Neurology, Columbia University, New York, NY, USA
    Neurology 70:1586-93. 2008
  7. doi request reprint Bone health in people with epilepsy: is it impaired and what are the risk factors?
    ALISON PACK
    Columbia University, 710 West 168th Street, New York, NY 10032, United States
    Seizure 17:181-6. 2008
  8. ncbi request reprint Bone disease associated with antiepileptic drugs
    Alison M Pack
    The Neurological Institute, Columbia Presbyterian Medical Center, 710 W 168th Street, New York, NY 10032, USA
    Cleve Clin J Med 71:S42-8. 2004
  9. ncbi request reprint Bone mineral density in an outpatient population receiving enzyme-inducing antiepileptic drugs
    Alison M Pack
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Epilepsy Behav 4:169-74. 2003
  10. pmc Normal vitamin D and low free estradiol levels in women on enzyme-inducing antiepileptic drugs
    Alison M Pack
    Department of Neurology, Columbia University, New York, NY, USA
    Epilepsy Behav 21:453-8. 2011

Research Grants

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy
    Alison M Pack
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Ann Neurol 57:252-7. 2005
    ..Subjects receiving lamotrigine had no significant reductions in calcium or increases in markers of bone turnover, suggesting this agent is less likely to have long-term adverse effects on bone...
  2. ncbi request reprint Therapy insight: clinical management of pregnant women with epilepsy
    Alison M Pack
    Neurological Institute, New York, NY 10032, USA
    Nat Clin Pract Neurol 2:190-200. 2006
    ..For all women of reproductive age, preconceptual counseling is important, and includes optimization of the AED regimen and advising the mother to take supplemental folic acid...
  3. ncbi request reprint Adverse effects of antiepileptic drugs on bone structure: epidemiology, mechanisms and therapeutic implications
    A M Pack
    Neurological Institute, Columbia University, New York, New York 10032, USA
    CNS Drugs 15:633-42. 2001
    ..The mechanisms of AED-associated bone disease are not clearly elucidated; however, several theories have been proposed to explain the link. No definitive guidelines for evaluation or treatment have yet been determined...
  4. ncbi request reprint Treatment of epilepsy to optimize bone health
    Alison M Pack
    710 West 168th Street, New York, NY, 10032, USA
    Curr Treat Options Neurol 13:346-54. 2011
    ..In addition, practitioners should work with other treating physicians to optimize bone health in these patients...
  5. doi request reprint Implications of hormonal and neuroendocrine changes associated with seizures and antiepileptic drugs: a clinical perspective
    Alison M Pack
    Department of Clinical Neurology, Columbia University, New York, New York 10032, USA
    Epilepsia 51:150-3. 2010
    ..Some AEDs are associated with abnormalities in BMD and bone and mineral metabolism...
  6. pmc Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy
    A M Pack
    Department of Neurology, Columbia University, New York, NY, USA
    Neurology 70:1586-93. 2008
    ..We therefore hypothesized that rates of bone loss would be higher in young women treated with phenytoin...
  7. doi request reprint Bone health in people with epilepsy: is it impaired and what are the risk factors?
    ALISON PACK
    Columbia University, 710 West 168th Street, New York, NY 10032, United States
    Seizure 17:181-6. 2008
    ..It is recommended that all persons obtain adequate amounts of calcium and vitamin D. In addition BMD screening is warranted for persons with long-term AED exposure particularly if they have other risk factors for bone disease...
  8. ncbi request reprint Bone disease associated with antiepileptic drugs
    Alison M Pack
    The Neurological Institute, Columbia Presbyterian Medical Center, 710 W 168th Street, New York, NY 10032, USA
    Cleve Clin J Med 71:S42-8. 2004
    ..Identifying AED-treated patients who are at risk for or have bone disease is important, as multiple therapies are available...
  9. ncbi request reprint Bone mineral density in an outpatient population receiving enzyme-inducing antiepileptic drugs
    Alison M Pack
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Epilepsy Behav 4:169-74. 2003
    ..There were no statistically significant differences found in the T or Z scores by gender; therefore all analyses combined both men and women. Significant reductions in both T and Z scores were present in men and women <50 and >or=50...
  10. pmc Normal vitamin D and low free estradiol levels in women on enzyme-inducing antiepileptic drugs
    Alison M Pack
    Department of Neurology, Columbia University, New York, NY, USA
    Epilepsy Behav 21:453-8. 2011
    ..04 and P=0.02) and a trend toward more bone loss at the lumbar spine (P=0.07 and P=0.08). These findings suggest that lower estrogen levels may contribute to bone loss in premenopausal women with epilepsy...
  11. ncbi request reprint Epilepsy and bone health in adults
    Alison M Pack
    Epilepsy Division, Department of Neurology, Columbia University, 710 West 168th Street, New York, NY 10032, USA
    Epilepsy Behav 5:S24-9. 2004
    ..Physicians should counsel patients taking AEDs about good bone health practices, and evaluation of bone health by measuring BMD is warranted after 5 years of AED treatment or before treatment in postmenopausal women...
  12. ncbi request reprint Bone disease in epilepsy
    Alison M Pack
    New York Neurological Institute, 710 West 168th Street, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 4:329-34. 2004
    ..Therapies are available for bone disease. However, few studies have evaluated the effects of treatment in bone disease associated with AEDs...
  13. pmc Foetal antiepileptic drug exposure and verbal versus non-verbal abilities at three years of age
    Kimford J Meador
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Brain 134:396-404. 2011
    ..Additional research is needed to confirm these findings, extend the study to other drugs, define the risks associated with drug treatment for seizures in the neonates, and understand the underlying mechanisms...
  14. pmc Effects of breastfeeding in children of women taking antiepileptic drugs
    K J Meador
    Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
    Neurology 75:1954-60. 2010
    ..Animal and human studies have demonstrated that some AEDs can adversely affect the immature brain. However, no investigation has examined effects of breastfeeding during AED therapy on subsequent cognitive abilities in children...
  15. doi request reprint Bone health in women with epilepsy: clinical features and potential mechanisms
    Alison M Pack
    Columbia University, New York, NY 10032, USA
    Int Rev Neurobiol 83:305-28. 2008
    ..For prolonged AED exposure, BMD screening is available, particularly if the patient has other risk factors...
  16. doi request reprint Reproductive history, sexual behavior and use of contraception in women with epilepsy
    Anne R Davis
    Department of Obstetrics and Gynecology, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Contraception 77:405-9. 2008
    ..Women with epilepsy experience more pregnancy-related risks than do their healthy peers. Guidelines recommend highly effective contraception. However, their contraceptive practices remain unknown...
  17. ncbi request reprint Epilepsy and common comorbidities: improving the outpatient epilepsy encounter
    Frank G Gilliam
    Department of Neurology, Neurological Institute, Columbia University, New York, NY 10032, USA
    Epileptic Disord 7:S27-33. 2005
    ..Management strategies employed in the outpatient clinic to maximize overall health outcomes should include screening and treatment for the commonly coexistent conditions in persons with epilepsy...
  18. ncbi request reprint Treatment of women with epilepsy
    Alison M Pack
    Department of Neurology, The Neurological Institute, Columbia University, New York, New York, USA
    Semin Neurol 22:289-98. 2002
    ..Seizure frequency may change during pregnancy, seizures may cause pregnancy complications, some AEDs are teratogenic, and many cross into breast milk. The treatment of a woman with epilepsy must consider all these issues...
  19. doi request reprint Antiepileptic drugs: are women aware of interactions with oral contraceptives and potential teratogenicity?
    Alison M Pack
    Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Epilepsy Behav 14:640-4. 2009
    ..WWE have limited knowledge of the potential interaction between AEDs and OCs and the teratogenic effects of AEDs. Educational efforts should highlight the reproductive health effects of AEDs in WWE...
  20. ncbi request reprint Pregnancy registries: what do they mean to clinical practice?
    Elizabeth Gerard
    Neurological Institute, Columbia University, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 8:325-32. 2008
    ..A second consistent finding is that valproate, particularly at higher doses, is associated with a higher risk of major congenital malformations than other AEDs...
  21. pmc Antiepileptic drug use in women of childbearing age
    Kimford J Meador
    Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Mail Stop 1930 001 1AN, Atlanta, GA 30322, USA
    Epilepsy Behav 15:339-43. 2009
    ..Except for the top two AED monotherapies, there were marked differences in other monotherapies and in polytherapies between U.S. and UK centers. Future investigations are needed to examine reasons for drug choice...
  22. pmc Laterality and location influence catamenial seizure expression in women with partial epilepsy
    M Quigg
    Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA
    Neurology 73:223-7. 2009
    ..The location and laterality of the epileptic lesion as well as patient age may affect periodicity...
  23. ncbi request reprint Sexual dysfunction, sex steroid hormone abnormalities, and depression in women with epilepsy treated with antiepileptic drugs
    Martha J Morrell
    The Neurological Institute, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Epilepsy Behav 6:360-5. 2005
    ..The mechanisms of sexual dysfunction in women with epilepsy are multifactorial, but AED choice appears to be one cause that is modifiable...
  24. ncbi request reprint Patient page. Antiseizure drugs and reduced bone density
    Robert A Gross
    Neurology 62:E24-5. 2004

Research Grants2

  1. Bone and Hormonal Health in Premenopausal Women with Epilepsy
    ALISON PACK; Fiscal Year: 2007
    ..By defining and understanding the risk that epilepsy and antiepileptic drugs have on bone health, we will significantly impact those persons with epilepsy treated with antiepileptic drugs. ..