Manuela Orjuela

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake
    Manuela A Orjuela
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
    Cancer 118:5912-9. 2012
  2. pmc Urinary naphthol metabolites and chromosomal aberrations in 5-year-old children
    Manuela A Orjuela
    Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 21:1191-202. 2012
  3. ncbi request reprint Fruit and vegetable intake during pregnancy and risk for development of sporadic retinoblastoma
    Manuela A Orjuela
    Department of Pediatrics, Mailman School of Public Health at Columbia University, Room B106, 60 Haven Avenue, New York, New York 10032, USA
    Cancer Epidemiol Biomarkers Prev 14:1433-40. 2005
  4. doi request reprint CD20 expression predicts survival in paediatric post-transplant lymphoproliferative disease (PTLD) following solid organ transplantation
    Manuela A Orjuela
    Departments of Pediatrics, Columbia University, New York Presbyterian Morgan Stanley Children s Hospital New York, NY, USA
    Br J Haematol 152:733-42. 2011
  5. doi request reprint Intensive multimodality therapy for patients with stage 4a metastatic retinoblastoma
    Ira J Dunkel
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Pediatr Blood Cancer 55:55-9. 2010
  6. doi request reprint Trilateral retinoblastoma: potentially curable with intensive chemotherapy
    Ira J Dunkel
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Pediatr Blood Cancer 54:384-7. 2010
  7. ncbi request reprint A pilot study of chemoimmunotherapy (cyclophosphamide, prednisone, and rituximab) in patients with post-transplant lymphoproliferative disorder following solid organ transplantation
    Manuela Orjuela
    Departments of Pediatrics, Columbia University, New York, New York 10032, USA
    Clin Cancer Res 9:3945S-52S. 2003
  8. pmc Traditional physical activity indexes derived from the Harvard alumni activity survey have low construct validity in a lower income, urban population
    Andrew Rundle
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Urban Health 84:722-32. 2007
  9. ncbi request reprint Androgen and c-Kit receptors in desmoplastic small round cell tumors resistant to chemotherapy: novel targets for therapy
    Robert L Fine
    College of Physicians and Surgeons of Columbia University, New York Presbyterian Medical Center and Morgan Stanley Children s Hospital, New York, NY, USA
    Cancer Chemother Pharmacol 59:429-37. 2007
  10. pmc Prenatal PAH exposure is associated with chromosome-specific aberrations in cord blood
    Manuela A Orjuela
    Departments of Pediatrics Oncology, Environmental Health Sciences, Biostatistics and Genetics, Columbia University, New York, NY, United States
    Mutat Res 703:108-14. 2010

Research Grants

  1. Folate Deficiency, Metabolism & Sporadic Retinoblastoma
    Manuela Orjuela; Fiscal Year: 2006
  2. Prenatal Exposures & Procarcinogenic Mutations
    Manuela Orjuela; Fiscal Year: 2007

Collaborators

Detail Information

Publications11

  1. pmc Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake
    Manuela A Orjuela
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
    Cancer 118:5912-9. 2012
    ..Maternal intake of naturally occurring folate from vegetables during pregnancy is associated inversely with the risk of retinoblastoma in offspring...
  2. pmc Urinary naphthol metabolites and chromosomal aberrations in 5-year-old children
    Manuela A Orjuela
    Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 21:1191-202. 2012
    ..Although prenatal (maternal) PAH exposure predicts chromosomal aberrations in cord blood, few studies have examined chromosomal aberrations in school-age children and none has examined their association with metabolites of specific PAHs...
  3. ncbi request reprint Fruit and vegetable intake during pregnancy and risk for development of sporadic retinoblastoma
    Manuela A Orjuela
    Department of Pediatrics, Mailman School of Public Health at Columbia University, Room B106, 60 Haven Avenue, New York, New York 10032, USA
    Cancer Epidemiol Biomarkers Prev 14:1433-40. 2005
    ..Fruits and vegetables are important sources of carotenoids and folate. We examined whether decreased gestational maternal intake of fruits and vegetables may contribute to development of sporadic retinoblastoma...
  4. doi request reprint CD20 expression predicts survival in paediatric post-transplant lymphoproliferative disease (PTLD) following solid organ transplantation
    Manuela A Orjuela
    Departments of Pediatrics, Columbia University, New York Presbyterian Morgan Stanley Children s Hospital New York, NY, USA
    Br J Haematol 152:733-42. 2011
    ..56·3%, P = 0·01). EBV expression was unrelated to PTLD-related EFS or OS. CD20 expression is associated with timing of development of PTLD and predicts survival in PTLD diagnosed following paediatric SOT...
  5. doi request reprint Intensive multimodality therapy for patients with stage 4a metastatic retinoblastoma
    Ira J Dunkel
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Pediatr Blood Cancer 55:55-9. 2010
    ....
  6. doi request reprint Trilateral retinoblastoma: potentially curable with intensive chemotherapy
    Ira J Dunkel
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Pediatr Blood Cancer 54:384-7. 2010
    ..We describe a series of 13 patients treated with intensive chemotherapy, defined as the intention to include high-dose chemotherapy with autologous hematopoietic stem cell rescue...
  7. ncbi request reprint A pilot study of chemoimmunotherapy (cyclophosphamide, prednisone, and rituximab) in patients with post-transplant lymphoproliferative disorder following solid organ transplantation
    Manuela Orjuela
    Departments of Pediatrics, Columbia University, New York, New York 10032, USA
    Clin Cancer Res 9:3945S-52S. 2003
    ..The response rate to immunotherapy (rituximab) is only about 46% with a 54% relapse/progression rate. In this study, we investigated the use of a combination of Cy/Pred with rituximab as treatment for this disease...
  8. pmc Traditional physical activity indexes derived from the Harvard alumni activity survey have low construct validity in a lower income, urban population
    Andrew Rundle
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Urban Health 84:722-32. 2007
    ..99 BMI units, 2.97 mmHg of diastolic blood pressure, and 3.96 mmHg of systolic blood pressure. This work suggests that the TWA scale has greater construct validity than the traditional PAI scale in this population...
  9. ncbi request reprint Androgen and c-Kit receptors in desmoplastic small round cell tumors resistant to chemotherapy: novel targets for therapy
    Robert L Fine
    College of Physicians and Surgeons of Columbia University, New York Presbyterian Medical Center and Morgan Stanley Children s Hospital, New York, NY, USA
    Cancer Chemother Pharmacol 59:429-37. 2007
    ..This predilection in young males led us to examine the role of androgen receptors (AR), testosterone, and growth factors in the biology of DSRCT...
  10. pmc Prenatal PAH exposure is associated with chromosome-specific aberrations in cord blood
    Manuela A Orjuela
    Departments of Pediatrics Oncology, Environmental Health Sciences, Biostatistics and Genetics, Columbia University, New York, NY, United States
    Mutat Res 703:108-14. 2010
    ..The observed chromosome-specific effects of prenatal airborne PAHs raise concern about potential cancer risk...
  11. doi request reprint Role of immunosuppression regimen in post-transplant lymphoproliferative disorder in pediatric heart transplant patients
    Jeffrey D Dayton
    Morgan Stanley Children s Hospital of New York Presbyterian, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Heart Lung Transplant 30:420-5. 2011
    ..Post-transplant lymphoproliferative disorder (PTLD) contributes to morbidity and mortality after transplantation. We examined the effect of immunosuppressive regimen on the risk of developing PTLD after pediatric heart transplantation...

Research Grants8

  1. Folate Deficiency, Metabolism & Sporadic Retinoblastoma
    Manuela Orjuela; Fiscal Year: 2006
    ..If our results are as anticipated, this project may lead to the development of new preventive strategies for those populations with an elevated incidence of sporadic retinoblastoma. ..
  2. Prenatal Exposures & Procarcinogenic Mutations
    Manuela Orjuela; Fiscal Year: 2007
    ..Thus, the ultimate goal of this research is to contribute to the prevention of future childhood ALL. ..