Maria Oquendo

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi Machine learning and data mining: strategies for hypothesis generation
    M A Oquendo
    Department of Psychiatry, New York State Psychiatric Institute and Columbia University, New York, NY 10032, USA
    Mol Psychiatry 17:956-9. 2012
  2. ncbi Increased risk for suicidal behavior in comorbid bipolar disorder and alcohol use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)
    Maria A Oquendo
    Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    J Clin Psychiatry 71:902-9. 2010
  3. ncbi Suicidal behavior: a developmental perspective
    Maria A Oquendo
    Columbia University, NYSPI Unit #42, 1051 Riverside Drive, New York, NY 10032, USA
    Psychiatr Clin North Am 31:xiii-xvi. 2008
  4. ncbi Are high-lethality suicide attempters with bipolar disorder a distinct phenotype?
    Maria A Oquendo
    Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
    Arch Suicide Res 13:247-56. 2009
  5. ncbi Genetic repositories for the study of major psychiatric conditions: what do we know about ethnic minorities' genetic vulnerability?
    M A Oquendo
    New York State Psychiatric Institute and Columbia University, New York, NY 10032, USA
    Mol Psychiatry 15:970-5. 2010
  6. ncbi Nurture versus nature: evidence of intrauterine effects on suicidal behaviour
    Maria A Oquendo
    Department of Psychiatry at Columbia University, New York, NY 10032, USA
    Lancet 364:1102-4. 2004
  7. ncbi Variability in the definition and reporting of adverse events in suicide prevention trials: an examination of the issues and a proposed solution
    Maria A Oquendo
    New York State Psychiatric Institute, Columbia University, New York, 10032, USA
    Arch Suicide Res 15:29-42. 2011
  8. ncbi Intervention research for suicidal behaviour
    Maria A Oquendo
    Department of Neuroscience, New York State Psychiatric Institute and Columbia University, New York, NY 10032, USA
    Lancet 362:844-5. 2003
  9. ncbi Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression
    Maria A Oquendo
    Department of Psychiatry, Columbia University, New York, USA
    Arch Gen Psychiatry 60:14-22. 2003
  10. ncbi Treatment of suicide attempters with bipolar disorder: a randomized clinical trial comparing lithium and valproate in the prevention of suicidal behavior
    Maria A Oquendo
    Columbia University, New York State Psychiatric Institute, New York, USA
    Am J Psychiatry 168:1050-6. 2011

Research Grants

  1. PHARMACOTHERAPY OF HIGH-RISK BIPOLAR DISORDER
    Maria Oquendo; Fiscal Year: 2004
  2. Future Suicide Attempt: Psychobiological Features
    Maria Oquendo; Fiscal Year: 2009
  3. Future Suicide Attempt: Psychobiological Features
    Maria A Oquendo; Fiscal Year: 2010
  4. Future Suicide Attempt: Psychobiological Features
    Maria A Oquendo; Fiscal Year: 2011

Detail Information

Publications94

  1. ncbi Machine learning and data mining: strategies for hypothesis generation
    M A Oquendo
    Department of Psychiatry, New York State Psychiatric Institute and Columbia University, New York, NY 10032, USA
    Mol Psychiatry 17:956-9. 2012
    ....
  2. ncbi Increased risk for suicidal behavior in comorbid bipolar disorder and alcohol use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)
    Maria A Oquendo
    Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    J Clin Psychiatry 71:902-9. 2010
    ..Whether risk for suicidal behavior is elevated when these conditions are comorbid has not been addressed in epidemiologic studies...
  3. ncbi Suicidal behavior: a developmental perspective
    Maria A Oquendo
    Columbia University, NYSPI Unit #42, 1051 Riverside Drive, New York, NY 10032, USA
    Psychiatr Clin North Am 31:xiii-xvi. 2008
  4. ncbi Are high-lethality suicide attempters with bipolar disorder a distinct phenotype?
    Maria A Oquendo
    Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
    Arch Suicide Res 13:247-56. 2009
    ..A subset of high-lethality attempters make only high-lethality attempts. However, presence of previous low-lethality attempts does not indicate that risk for more lethal, possibly successful, attempts is reduced...
  5. ncbi Genetic repositories for the study of major psychiatric conditions: what do we know about ethnic minorities' genetic vulnerability?
    M A Oquendo
    New York State Psychiatric Institute and Columbia University, New York, NY 10032, USA
    Mol Psychiatry 15:970-5. 2010
    ....
  6. ncbi Nurture versus nature: evidence of intrauterine effects on suicidal behaviour
    Maria A Oquendo
    Department of Psychiatry at Columbia University, New York, NY 10032, USA
    Lancet 364:1102-4. 2004
  7. ncbi Variability in the definition and reporting of adverse events in suicide prevention trials: an examination of the issues and a proposed solution
    Maria A Oquendo
    New York State Psychiatric Institute, Columbia University, New York, 10032, USA
    Arch Suicide Res 15:29-42. 2011
    ..Clear and consistently applied definitions of adverse and serious adverse events and reporting requirements would enhance the comparability of intervention studies in suicidal populations...
  8. ncbi Intervention research for suicidal behaviour
    Maria A Oquendo
    Department of Neuroscience, New York State Psychiatric Institute and Columbia University, New York, NY 10032, USA
    Lancet 362:844-5. 2003
  9. ncbi Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression
    Maria A Oquendo
    Department of Psychiatry, Columbia University, New York, USA
    Arch Gen Psychiatry 60:14-22. 2003
    ..Postmortem studies of serotonin receptors in suicides localize changes to the ventral prefrontal cortex (PFC). We studied serotonergic response in ventral PFC in depressed patients surviving a high-lethality suicide attempt...
  10. ncbi Treatment of suicide attempters with bipolar disorder: a randomized clinical trial comparing lithium and valproate in the prevention of suicidal behavior
    Maria A Oquendo
    Columbia University, New York State Psychiatric Institute, New York, USA
    Am J Psychiatry 168:1050-6. 2011
    ..The authors tested the hypothesis that lithium offers bipolar patients with a history of suicide attempt greater protection against suicidal behavior compared to valproate...
  11. ncbi Familial transmission of suicidal behavior: factors mediating the relationship between childhood abuse and offspring suicide attempts
    Beth S Brodsky
    Department of Psychiatry, Columbia University New York State Psychiatric Institute, New York 10032, USA
    J Clin Psychiatry 69:584-96. 2008
    ..The current study investigates the relationship between reported childhood abuse and the familial transmission of suicidal behavior and other related risk factors...
  12. ncbi Familial pathways to early-onset suicidal behavior: familial and individual antecedents of suicidal behavior
    Nadine M Melhem
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Psychiatry 164:1364-70. 2007
    ..The authors sought to identify clinical predictors of new-onset suicidal behavior in children of parents with a history of mood disorder and suicidal behavior...
  13. ncbi Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression
    Gil Zalsman
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Dr, Box 42, New York, NY 10032, USA
    Am J Psychiatry 163:1588-93. 2006
    ..The authors examined the relationship of a triallelic 5-HTTLPR polymorphism to stressful life events, severity of major depression, and suicidality...
  14. ncbi Protective factors against suicidal behavior in depressed adults reporting childhood abuse
    Kanita Dervic
    Department of Neuroscience, New York State Psychiatric Institute, and Columbia University, New York, New York 10032, USA
    J Nerv Ment Dis 194:971-4. 2006
    ..The results of this clinical study add support to previous reports that religious/spiritual coping could serve as an additional resource in prevention of suicidal behavior for subjects with reported childhood abuse...
  15. ncbi No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover
    J John Mann
    Department of Neuroscience, New York State Psychiatric Institute, NY 10032, USA
    J Affect Disord 106:117-21. 2008
    ..Associations are reported of TPH2 polymorphisms with MDD, bipolar disorder and suicidal behavior. This study examines a single nucleotide polymorphism in the putative promoter region of the TPH2 gene...
  16. ncbi Response of cortical metabolic deficits to serotonergic challenge in familial mood disorders
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University, New York, NY, USA
    Am J Psychiatry 160:76-82. 2003
    ..The authors applied a dl-fenfluramine challenge method to study metabolic response in this region to serotonergic challenge in familial major depression...
  17. ncbi Protective factors against suicidal behavior in Latinos
    Maria A Oquendo
    Department of Neuroscience, New York State Psychiatric Institute and Columbia University, New York, NY, USA
    J Nerv Ment Dis 193:438-43. 2005
    ..Further studies to elucidate the impact of these factors on suicidal behavior and their relationship to specific cultural constructs would be of interest...
  18. ncbi An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences
    Yung Yu Huang
    Department of Neuroscience, New York State Psychiatric Institute, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 29:1498-505. 2004
    ..The polymorphism may be a marker for impulsivity that in turn may contribute to the risk for abuse. This trait could then be further aggravated by abuse...
  19. ncbi Human 5-HT1A receptor C(-1019)G polymorphism and psychopathology
    Yung Yu Huang
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Neuropsychopharmacol 7:441-51. 2004
    ..The relationship does not appear to be explained by binding differences, although we cannot rule out altered receptor affinity and transduction...
  20. ncbi Clinical correlates of planned, more lethal suicide attempts in major depressive disorder
    Atsuo Nakagawa
    Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY 10032, USA
    J Affect Disord 112:237-42. 2009
    ..The purpose of this study was to investigate clinical correlates of suicide planning in depressed patients...
  21. ncbi Suicidal behavior and mild traumatic brain injury in major depression
    Maria A Oquendo
    Department of Neuroscience, New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
    J Nerv Ment Dis 192:430-4. 2004
    ..Our data suggest that suicidal behavior and TBI share antecedent risk factors: hostility and aggression. Future studies may yield confirmation using a prospective design...
  22. ncbi Moral objections to suicide: Can they counteract suicidality in patients with cluster B psychopathology?
    Kanita Dervic
    Department of Neuroscience, Columbia University, New York, NY, USA
    J Clin Psychiatry 67:620-5. 2006
    ..The effect of MOS was then examined in relation to other mechanisms affecting suicide risk including trait aggressivity and the presence of effective coping strategies...
  23. ncbi Are BPI and BPII suicide attempters distinct neuropsychologically?
    Jill M Harkavy-Friedman
    New York State Psychiatric Institute and Columbia University, USA
    J Affect Disord 94:255-9. 2006
    ..Neuropsychological functioning is a means of understanding similarities and differences between diagnostic groups...
  24. ncbi Posttraumatic stress disorder comorbid with major depression: factors mediating the association with suicidal behavior
    Maria Oquendo
    Department of Neuroscience, New York State Psychiatric Institute Columbia University, 1051 Riverside Dr, Unit 42, New York, NY 10032, USA
    Am J Psychiatry 162:560-6. 2005
    ....
  25. ncbi Objections to suicide among depressed patients with alcohol use disorders
    Randall Richardson-Vejlgaard
    Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, NY 10032, United States
    J Affect Disord 117:197-201. 2009
    ..One measure of suicide non-acceptability is the Moral Objections to Suicide (MOS) subscale of the Reasons for Living Inventory (RFLI)...
  26. ncbi Regional brain responses to serotonin in major depressive disorder
    Amy D Anderson
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    J Affect Disord 82:411-7. 2004
    ..Differences in specific brain regions affected between this study and previous studies may be attributable to gender differences...
  27. ncbi Sex differences in the familial transmission of mood disorders
    Dianne Currier
    Department of Neuroscience, New York State Psychiatric Institute/Columbia University College of Physicians and Surgeons New York, NY 10032, USA
    J Affect Disord 95:51-60. 2006
    ..Future studies need to determine the relative contribution of genetic and non-genetic factors and identify the factors responsible for higher rates of transmission of mood disorders by females with a mood disorder...
  28. ncbi Neurobiology of suicidal behavior. An integration of biological and clinical findings
    Juan J Carballo
    New York State Psychiatric Institute and the College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Arch Suicide Res 12:93-110. 2008
    ....
  29. ncbi Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism
    Yung Yu Huang
    Department of Neuroscience, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Neuropsychopharmacology 28:163-9. 2003
    ..This preliminary result will need replication, given the limitations of association studies...
  30. ncbi No association of COMT Val158Met polymorphism with suicidal behavior or CSF monoamine metabolites in mood disorders
    Gil Zalsman
    Department of Psychiatry, Division of Neuroscience, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Arch Suicide Res 12:327-35. 2008
    ..The COMT-V158M polymorphism was not associated with suicidal behavior in a Caucasian sample of mood disorder subjects, or with possible clinical or biological endophenotypes...
  31. ncbi A comparison of the medical lethality of suicide attempts in bipolar and major depressive disorders
    Gil Zalsman
    Division of Neuroscience, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    Bipolar Disord 8:558-65. 2006
    ....
  32. ncbi The impact of borderline personality disorder and anxiety on neuropsychological performance in major depression
    Eric A Fertuck
    Department of Neuroscience, Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
    J Pers Disord 20:55-70. 2006
    ....
  33. ncbi Does first episode polarity predict risk for suicide attempt in bipolar disorder?
    Sadia R Chaudhury
    Department of Neuroscience, New York State Psychiatric Institute and Columbia University, 1051 Riverside Drive, Box 42, New York, NY 10032, United States
    J Affect Disord 104:245-50. 2007
    ..We tested the hypothesis that the polarity of a patient's first mood episode would be a marker for BD subtypes with differential risk for suicidality...
  34. ncbi Association of serotonin 5-HT2A receptor binding and the T102C polymorphism in depressed and healthy Caucasian subjects
    Vadim D Khait
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 30:166-72. 2005
    ..The TT genotype appears associated with higher platelet 5-HT2A Bmax in the healthy population, but this genotypic effect appears absent in mood disorders and unrelated to psychopathology...
  35. ncbi Volumetric analysis of the prefrontal cortex, amygdala, and hippocampus in major depression
    Ramin S Hastings
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 29:952-9. 2004
    ..The biology of mood disorders in females may differ in some aspects from males, and may contribute to the higher rate of depression in women...
  36. ncbi Family history of suicidal behavior and early traumatic experiences: additive effect on suicidality and course of bipolar illness?
    Juan J Carballo
    Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, United States
    J Affect Disord 109:57-63. 2008
    ..Bipolar disorder (BD) is associated with a high prevalence of suicide attempt and completion. Family history of suicidal behavior and personal history of childhood abuse are reported risk factors for suicide among BD subjects...
  37. ncbi Is there circannual variation of human platelet 5-HT(2A) binding in depression?
    Vadim D Khait
    Department of Neuroscience, New York State Psychiatric Institute, Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    J Affect Disord 71:249-58. 2002
    ..Seasonal variations in onset of mood disorders and in serotonergic function are reported, but their relationship is unclear...
  38. ncbi Is impulsivity a link between childhood abuse and suicide?
    M Dolores Braquehais
    Department of Psychiatry Columbia University, New York, NY 10032, USA
    Compr Psychiatry 51:121-9. 2010
    ..Prevention of childhood abuse could significantly reduce suicidal behavior in adolescents and adults, in part, through a decrease in the frequency of impulsive behaviors in the future...
  39. ncbi Religious affiliation and suicide attempt
    Kanita Dervic
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Dr, Unit Number 42, New York, NY 10032, USA
    Am J Psychiatry 161:2303-8. 2004
    ..Further study about the influence of religious affiliation on aggressive behavior and how moral objections can reduce the probability of acting on suicidal thoughts may offer new therapeutic strategies in suicide prevention...
  40. ncbi Perceived reasons for living at index hospitalization and future suicide attempt
    Dana Lizardi
    Columbia University School of Social Work, New York, New York 10027, USA
    J Nerv Ment Dis 195:451-5. 2007
    ..Perceived reasons for living serve as protective factors against suicide attempt in women and not in men...
  41. ncbi Classification trees distinguish suicide attempters in major psychiatric disorders: a model of clinical decision making
    J John Mann
    Department of Neuroscience, New York State Psychiatric Institute, New York 10032, USA
    J Clin Psychiatry 69:23-31. 2008
    ..Hypothetical decision trees to identify recent and remote suicide attempters, weighted to increase sensitivity, were generated for psychiatric patients using correlates of past suicidal behavior...
  42. ncbi Reported childhood abuse is associated with low serotonin transporter binding in vivo in major depressive disorder
    Jeffrey M Miller
    Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York, USA
    Synapse 63:565-73. 2009
    ..We examined healthy volunteers and subjects with major depressive disorder, a sample enriched for childhood abuse...
  43. ncbi Higher serotonin 1A binding in a second major depression cohort: modeling and reference region considerations
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Biol Psychiatry 68:170-8. 2010
    ..Discrepancies can be related to differences in study population or methodology. We sought to replicate our findings in a novel cohort and determine whether choice of reference region and outcome measure could explain discrepancies...
  44. ncbi Association of suicide and antidepressant prescription rates in Japan, 1999-2003
    Atsuo Nakagawa
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    J Clin Psychiatry 68:908-16. 2007
    ..We examined the relationship of increasing prescription volume of newer antidepressants, introduced in Japan in 1999, to national rates of suicide...
  45. ncbi Serotonin transporter binding as a possible predictor of one-year remission in major depressive disorder
    Jeffrey M Miller
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Unit 42, New York, NY, United States
    J Psychiatr Res 42:1137-44. 2008
    ..We assessed baseline 5-HTT binding as a predictor of one-year remission from a MDE, examining binding in brain regions implicated in the pathophysiology of major depressive disorder (MDD)...
  46. ncbi Regional brain metabolic correlates of self-reported depression severity contrasted with clinician ratings
    Matthew S Milak
    Department of Psychiatry, Columbia University, New York, NY 10032, USA
    J Affect Disord 126:113-24. 2010
    ....
  47. ncbi Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls
    Leo Sher
    Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, NY 10032, USA
    Eur Neuropsychopharmacol 18:692-9. 2008
    ..The difference in prolactin responses between MDD/AUD and MDD only could be attributed to higher aggression scores in the MDD/AUD group compared to the MDD group...
  48. ncbi Lower CSF MHPG predicts short-term risk for suicide attempt
    Hanga Galfalvy
    Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Neuropsychopharmacol 12:1327-35. 2009
    ..Psychopathology that mediates the relationship between lower CSF MHPG and future suicidal behaviour needs to be identified...
  49. ncbi The number of previous depressive episodes is positively associated with cortisol response to fenfluramine administration
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
    Ann N Y Acad Sci 1032:283-6. 2004
    ..Our finding highlights the importance of possible cumulative effects of repeated episodes of major depression. Prevention and early recognition of depressive episodes may prevent these cumulative adverse effects...
  50. ncbi Pretreatment regional brain glucose uptake in the midbrain on PET may predict remission from a major depressive episode after three months of treatment
    Matthew S Milak
    Department of Psychiatry, Columbia University, New York, NY, United States
    Psychiatry Res 173:63-70. 2009
    ..Prospective studies are needed to replicate these findings and determine whether outcome prediction is limited to a specific class of antidepressants...
  51. ncbi Treatment of depressed bipolar patients with alcohol use disorders: plenty of room for improvement
    Enrique Baca-Garcia
    Molecular Imaging and Neuropathology Division, NYS Psychiatric Institute and Columbia University, New York 10032, USA
    J Affect Disord 115:262-8. 2009
    ..We hypothesize that the adequacy of antidepressant treatment and the compliance with treatment for those with AUD are lower than for those without AUD...
  52. ncbi Effect of BDNF val66met polymorphism on age-related amygdala volume changes in healthy subjects
    M E Sublette
    Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, Unit 42, New York, NY 10032, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:1652-5. 2008
    ..Using an ANCOVA model, we found that amygdala volumes were inversely correlated with age in BDNF val66met carriers but not in non-carriers. This is the first report of age-related BDNF val66met polymorphism effects on amygdala volume...
  53. ncbi Moral objections to suicide and suicidal ideation among mood disordered Whites, Blacks, and Hispanics
    Randall Richardson-Vejlgaard
    Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, NY 10032, USA
    J Psychiatr Res 43:360-5. 2009
    ..This study examined the MOS and suicidal ideation of White, Black, and Hispanic individuals with mood disorders. We expected minority individuals to have stronger objections to suicide...
  54. ncbi The tryptophan hydroxylase-1 A218C polymorphism is associated with diagnosis, but not suicidal behavior, in borderline personality disorder
    Scott T Wilson
    New York State Psychiatric Institute, New York, USA
    Am J Med Genet B Neuropsychiatr Genet 150:202-8. 2009
    ..An aspect of BPD pathology may be due to serotonergic dysfunction...
  55. ncbi Nucleotide variation in central nervous system genes among male suicide attempters
    Enrique Baca-Garcia
    Department of Psychiatry at Fundacion Jimenez Diaz Hospital, Autonoma University, Madrid, Spain
    Am J Med Genet B Neuropsychiatr Genet 153:208-13. 2010
    ..This strategy may uncover new pathophysiological pathways regarding the neurobiology of suicidal acts...
  56. ncbi Triggers for suicidal behavior in depressed older adolescents and young adults: do alcohol use disorders make a difference?
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Int J Adolesc Med Health 19:91-8. 2007
    ..We compared demographic and clinical characteristics, prevalence of interpersonal triggers and the number of triggers for suicidal behavior in depressed late adolescents and young adults with or without comorbid alcohol use disorders...
  57. ncbi Lower CSF homovanillic acid levels in depressed patients with a history of alcoholism
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 28:1712-9. 2003
    ..Low CSF HVA suggests that impaired dopaminergic activity is associated with a history of alcoholism in persons with current MDE...
  58. ncbi Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 163:48-51. 2006
    ....
  59. ncbi Selective serotonin reuptake inhibitors and the risk for suicidality in adolescents: an update
    Lucas Giner
    Puerta de Hierro Hospital, Universidad Autonoma de Madrid, Madrid, Spain
    Int J Adolesc Med Health 17:211-20. 2005
    ..We address the debate concerning this warning and its clinical implications and review the latest contributions to the literature...
  60. ncbi Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 59:106-13. 2006
    ..We measure 5-HT(1A) in MDD, assess the effects of antidepressant exposure (AE), and examine the role of the C(-1019)G polymorphism...
  61. ncbi Family history of suicidal behavior and mood disorders in probands with mood disorders
    J John Mann
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Dr, Box 42, New York, NY 10032, USA
    Am J Psychiatry 162:1672-9. 2005
    ..This study examined the shared and distinctive factors associated with familial mood disorders and familial suicidal behavior...
  62. ncbi Brain serotonin1A receptor binding in major depression is related to psychic and somatic anxiety
    Gregory M Sullivan
    Division of Neuroscience, Department of Psychiatry, New York 10032, USA
    Biol Psychiatry 58:947-54. 2005
    ..We investigated the relationship of anxiety expressed in major depressive disorder (MDD) to regional 5-HT1A binding...
  63. ncbi Can biological tests assist prediction of suicide in mood disorders?
    J John Mann
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Int J Neuropsychopharmacol 9:465-74. 2006
    ..Further work on refining biological predictors and integration with clinical predictors is needed to optimize a model to predict suicide in the clinic...
  64. ncbi Higher cortisol levels in spring and fall in patients with major depression
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:529-34. 2005
    ..This study sought to determine whether there is a seasonal effect on clinical parameters, baseline cortisol and prolactin levels, and cortisol and prolactin responses to fenfluramine administration in subjects with major depression...
  65. ncbi Neuroanatomic correlates of psychopathologic components of major depressive disorder
    Matthew S Milak
    Departments of Psychiatry and Radiology, Department of Neuroscience, NY State Psychiatric Institute, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Arch Gen Psychiatry 62:397-408. 2005
    ..The HDRS comprises distinct symptom clusters that may be associated with different patterns of regional brain glucose metabolism...
  66. ncbi Higher cerebrospinal fluid homovanillic acid levels in depressed patients with comorbid posttraumatic stress disorder
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
    Eur Neuropsychopharmacol 15:203-9. 2005
    ..Higher dopaminergic activity may contribute to alterations in memory and other cognitive functions, anhedonia, and hypervigilance observed in PTSD...
  67. ncbi Age effects on cortisol levels in depressed patients with and without comorbid post-traumatic stress disorder, and healthy volunteers
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
    J Affect Disord 82:53-9. 2004
    ..Therefore, we examined the effect of age on the hypothalamic-pituitary-adrenal (HPA) system in depressed patients with and without PTSD...
  68. ncbi Relationship of MAO-A promoter (u-VNTR) and COMT (V158M) gene polymorphisms to CSF monoamine metabolites levels in a psychiatric sample of caucasians: A preliminary report
    Gil Zalsman
    Department of Neuroscience, New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, Box 42, New York, NY 10032, USA
    Am J Med Genet B Neuropsychiatr Genet 132:100-3. 2005
    ..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299:1/suppmat/index.html...
  69. ncbi Modified dexamethasone suppression-corticotropin-releasing hormone stimulation test: A pilot study of young healthy volunteers and implications for alcoholism research in adolescents and young adults
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Int J Adolesc Med Health 18:133-7. 2006
    ..Therefore, studies of the HPA system in persons at risk for alcoholism may help understand the neurobiological mechanisms of predisposition to alcoholism...
  70. ncbi Prevalence of alcohol misuse among adolescents and young adults evaluated in a primary care setting
    Juan J Carballo
    Puerta de Hierro Hospital, Universidad Autonoma, Madrid, Spain
    Int J Adolesc Med Health 18:197-202. 2006
    ..To determine the prevalence of alcohol misuse among older adolescents and young adults evaluated in a primary care setting using the CAGE questionnaire...
  71. ncbi Factors in the assessment of suicidality in youth
    Kelly Posner
    Suicide Classification Center, Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
    CNS Spectr 12:156-62. 2007
    ..This paper provides the clinician with a summary of risk factors for youth suicide, as well as providing standardized terminology to enhance assessment of suicidal ideation and behavior...
  72. ncbi Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography
    Maria A Oquendo
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Gen Psychiatry 64:201-8. 2007
    ..Associations of serotonin transporter promoter polymorphisms and bipolarity have been reported; however, research on alterations in serotonergic neurotransmission in bipolar depression remains scant...
  73. ncbi Low cerebrospinal fluid transthyretin levels in depression: correlations with suicidal ideation and low serotonin function
    Gregory M Sullivan
    Division of Neuroscience, Department of Psychiatry, Columbia University, NY 10032, USA
    Biol Psychiatry 60:500-6. 2006
    ..Transthyretin (TTR) is a thyroid hormone binding protein synthesized by choroid plexus and secreted into cerebrospinal fluid (CSF). We sought to replicate and extend our previous findings of lower CSF TTR in depression...
  74. ncbi Early visual information processing deficit in depression with and without Borderline Personality Disorder
    John G Keilp
    Department of Neuroscience, Columbia University Medical College and New York State Psychiatric Institute, Box 42, 1051 Riverside Drive, New York, NY 10032, USA
    Psychiatry Res 149:139-45. 2007
    ..Poor early information processing appears to be a feature of Borderline Personality Disorder, and may play a role in the impulsive behavior that is characteristic of the disorder...
  75. ncbi Cognitive-behavioral therapy for pathological gambling: cultural considerations
    Mayumi Okuda
    New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Psychiatry 166:1325-30. 2009
    ....
  76. ncbi Melancholia and the probability and lethality of suicide attempts
    Michael F Grunebaum
    Department of Neuroscience, New York State Psychiatric Institute and Columbia University, New York, New York 10032, USA
    Br J Psychiatry 184:534-5. 2004
    ..Controlling for depression severity and other covariates, melancholia at baseline assessment was associated with more serious past suicide attempts and with the probability of suicide attempt during follow-up...
  77. ncbi Suicide attempts and impulsivity
    Enrique Baca-Garcia
    Dept. of Psychiatry, , Madrid, Spain
    Eur Arch Psychiatry Clin Neurosci 255:152-6. 2005
    ..Opportunities for prevention of suicide attempts in major depression and some personality traits may exist but require attentive monitoring of suicidal ideation and intent...
  78. ncbi Low plasma cholesterol levels in suicidal males: a gender- and body mass index-matched case-control study of suicide attempters and nonattempters
    Carmen Diaz Sastre
    Centro de Salud Mental de Hortaleza, Avenida de Mar Caspio, Madrid 28050, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 31:901-5. 2007
    ..Serum cholesterol levels were significantly lower in suicide attempters than in controls. After gender stratification, the difference remained significant in men, but not in women...
  79. ncbi Premenstrual symptoms and luteal suicide attempts
    Enrique Baca-Garcia
    Department of Psychiatry, Fundacion Jimenez Diaz, Madrid, Spain
    Eur Arch Psychiatry Clin Neurosci 254:326-9. 2004
    ..001). CONCLUSION: This study was limited by the use of retrospective PMDD diagnosis but suggests that PMDD may not be associated with suicidal acts during the luteal phase,when PMS are present...
  80. ncbi Protection of human subjects in intervention research for suicidal behavior
    Maria A Oquendo
    Department of Neuroscience, New York State Psychiatric Institute Columbia University, 1051 Riverside Dr, Unit 42, New York, NY 10032, USA
    Am J Psychiatry 161:1558-63. 2004
    ..The authors examine these and other issues and discuss ways they can be addressed in research design...
  81. ncbi Instability of symptoms in recurrent major depression: a prospective study
    Maria A Oquendo
    Department of Neuroscience, New York State Psychiatric Institute, New York, USA
    Am J Psychiatry 161:255-61. 2004
    ..The authors prospectively studied major depressive episodes occurring within 2 years to determine whether symptoms in the second episode could be predicted on the basis of symptoms in the first...
  82. ncbi Clinical impact of a 2-week psychotropic medication washout in unipolar depressed inpatients
    Michael F Grunebaum
    The Mental Health Clinical Research Center for the Study of Suicidal Behavior, Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, Box 42, New York, NY 10032, USA
    J Affect Disord 75:291-6. 2003
    ..We studied the impact of a short-term medication washout in unipolar depressed patients consecutively admitted to hospital for neuroimaging and cerebrospinal fluid (CSF) studies...
  83. ncbi Comorbid anxiety in bipolar disorder: does it have an independent effect on suicidality?
    Atsuo Nakagawa
    Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan
    Bipolar Disord 10:530-8. 2008
    ..This study examined the impact of comorbid Cluster B personality disorder and anxiety disorder on suicidality in bipolar disorder...
  84. ncbi Columbia Classification Algorithm of Suicide Assessment (C-CASA): classification of suicidal events in the FDA's pediatric suicidal risk analysis of antidepressants
    Kelly Posner
    Division of Child and Adolescent Psychiatry, Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
    Am J Psychiatry 164:1035-43. 2007
    ....
  85. ncbi A pilot study on differences in aggression in New York City and Madrid, Spain, and their possible impact on suicidal behavior
    Enrique Baca-Garcia
    Department of Psychiatry, Fundacion Jimenez Diaz, Madrid, Spain
    J Clin Psychiatry 67:375-80. 2006
    ..The study goals were (1) to compare aggression scores in attempters and healthy volunteers between the 2 cities and (2) to determine whether higher aggression scores are associated with greater medical lethality of suicide attempts...
  86. ncbi Suicide in Austrian children and young adolescents aged 14 and younger
    Kanita Dervic
    Dept of Child and Adolescent Neuropsychiatry, University Hospital, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Eur Child Adolesc Psychiatry 15:427-34. 2006
    ..We investigated suicide cases of children and young adolescents in terms of prevalence, gender differences, suicide methods and monthly distribution during a period of 32 years...
  87. ncbi Aggressiveness, not impulsiveness or hostility, distinguishes suicide attempters with major depression
    John G Keilp
    Department of Neuroscience, New York State Psychiatric Institute, New York, USA
    Psychol Med 36:1779-88. 2006
    ....
  88. ncbi Periventricular white matter hyperintensities as predictors of suicide attempts in bipolar disorders and unipolar depression
    Maurizio Pompili
    Department of Psychiatry, Sant Andrea Hospital, Sapienza University of Rome, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 32:1501-7. 2008
    ..08). In conclusion, neuroimaging measures may be markers of risk for suicidal attempts in patients with major affective disorders...
  89. ncbi Higher postmortem prefrontal 5-HT2A receptor binding correlates with lifetime aggression in suicide
    Maria A Oquendo
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Biol Psychiatry 59:235-43. 2006
    ..We measured 5-hydroxytryptamine 2A (5-HT(2A)) receptor binding in prefrontal cortex of suicide and nonsuicide subjects and explored the relationship between 5-HT(2A) receptor binding, lifetime aggression, and suicide...
  90. ncbi Comparing impulsiveness, hostility, and depression in borderline personality disorder and bipolar II disorder
    Scott T Wilson
    Department of Neuroscience, New York State Psychiatric Institute, NY 10032, USA
    J Clin Psychiatry 68:1533-9. 2007
    ....
  91. ncbi Quantitative wavelet domain image processing of dynamic PET data
    Kjell Erlandsson
    Dept of Psychiatry and Radiol, Columbia Univ, New York, NY 10032, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2787-90. 2006
    ..Our results showed that, although non-linear effects may appear in low-contrast areas, it is possible to achieve accurate quantification with wavelet-based image processing...
  92. ncbi Symptom components of standard depression scales and past suicidal behavior
    Michael F Grunebaum
    Department of Neuroscience, New York State Psychiatric Institute and Columbia University, New York, NY 10032, United States
    J Affect Disord 87:73-82. 2005
    ..Global severity on depression scales may obscure associations between specific symptoms and suicidal behavior...
  93. ncbi Cluster C personality disorders in major depressive episodes: the relationship between hostility and suicidal behavior
    Kanita Dervic
    Department of Child and Adolescent Neuropsychiatry University Hospital, Medical University of Vienna, Austria
    Arch Suicide Res 11:83-90. 2007
    ..1990)...
  94. ncbi Psychological autopsy studies: the role of alcohol use in adolescent and young adult suicides
    Lucas Giner
    Department of Psychiatry, University of Seville, Spain
    Int J Adolesc Med Health 19:99-113. 2007
    ..Alcohol abusers seem to be prone to both suicide attempts and completions. The relationship between alcohol abuse and suicide in adolescence is complex...

Research Grants8

  1. PHARMACOTHERAPY OF HIGH-RISK BIPOLAR DISORDER
    Maria Oquendo; Fiscal Year: 2004
    ..3) Lithium treatment will be superior to valproate in decreasing aggression. ..
  2. Future Suicide Attempt: Psychobiological Features
    Maria Oquendo; Fiscal Year: 2009
    ..This data will permit construction of predictive and explanatory models for suicidal behavior. ..
  3. Future Suicide Attempt: Psychobiological Features
    Maria A Oquendo; Fiscal Year: 2010
    ..This data will permit construction of predictive and explanatory models for suicidal behavior. ..
  4. Future Suicide Attempt: Psychobiological Features
    Maria A Oquendo; Fiscal Year: 2011
    ..This data will permit construction of predictive and explanatory models for suicidal behavior. ..