Ben O Shaughnessy
Affiliation: Columbia University
Stachowiak M, Smith M, Blankman E, Chapin L, Balcioglu H, Wang S, et al
. A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton. Proc Natl Acad Sci U S A. 2014;111:17528-33 pubmed publisher
..Our results suggest that coordinated mechanical and biochemical signaling enables extended actomyosin assemblies to adapt dynamically to the mechanical stresses they convey and direct their own remodeling. ..
Pollard T, O Shaughnessy B. Molecular Mechanism of Cytokinesis. Annu Rev Biochem. 2019;: pubmed publisher
..Expected final online publication date for the Annual Review of Biochemistry Volume 88 is June 20, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates. ..
O Shaughnessy B, Thiyagarajan S. Mechanisms of contractile ring tension production and constriction. Biophys Rev. 2018;10:1667-1681 pubmed publisher
Thiyagarajan S, Munteanu E, Arasada R, Pollard T, O Shaughnessy B. The fission yeast cytokinetic contractile ring regulates septum shape and closure. J Cell Sci. 2015;128:3672-81 pubmed publisher
..Our results suggest that the fission yeast cytokinetic ring tension does not set the constriction rate but regulates septum closure by suppressing roughness produced by inherently stochastic molecular growth processes. ..
Stratton B, Warner J, Wu Z, Nikolaus J, Wei G, Wagnon E, et al
. Cholesterol Increases the Openness of SNARE-Mediated Flickering Fusion Pores. Biophys J. 2016;110:1538-1550 pubmed publisher
..Our results suggest that cholesterol opens pores directly by reducing the fusion-pore bending energy, and indirectly by concentrating several SNAREs into individual fusion events. ..
Stachowiak M, Laplante C, Chin H, Guirao B, Karatekin E, Pollard T, et al
. Mechanism of cytokinetic contractile ring constriction in fission yeast. Dev Cell. 2014;29:547-561 pubmed publisher
..Ring constriction depended on cell shape, revealing that the ring operates close to conditions of isometric tension. Thus, the fission yeast ring sets its own tension, but other processes set the constriction rate. ..
Thiyagarajan S, Wang S, O Shaughnessy B. A node organization in the actomyosin contractile ring generates tension and aids stability. Mol Biol Cell. 2017;28:3286-3297 pubmed publisher
..We show that the ring is vulnerable to intrinsic contractile instabilities, and protection from these instabilities and organizational homeostasis require both component turnover and anchoring of components to the plasma membrane. ..