Thomas L Nickolas

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Pancreas-kidney transplantation is associated with reduced fracture risk compared with kidney-alone transplantation in men with type 1 diabetes
    Lucas E Nikkel
    Penn State Hershey College of Medicine, Hershey, Pennsylvania, USA
    Kidney Int 83:471-8. 2013
  2. pmc Rapid cortical bone loss in patients with chronic kidney disease
    Thomas L Nickolas
    Columbia University Medical Center, Department of Medicine, Division of Nephrology, New York, NY, USA
    J Bone Miner Res 28:1811-20. 2013
  3. pmc NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease
    Thomas L Nickolas
    Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Kidney Int 82:718-22. 2012
  4. pmc Discriminants of prevalent fractures in chronic kidney disease
    Thomas L Nickolas
    Department of Medicine, Divisions of Nephrology, Columbia University Medical Center, New York, New York, USA
    J Am Soc Nephrol 22:1560-72. 2011
  5. ncbi request reprint Awareness of kidney disease in the US population: findings from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2000
    Thomas L Nickolas
    Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Kidney Dis 44:185-97. 2004
  6. ncbi request reprint Chronic kidney disease and bone fracture: a growing concern
    Thomas L Nickolas
    Division of Nephrology, Department of Medicine, Columbia University Medical Center, New York, New York, USA
    Kidney Int 74:721-31. 2008
  7. pmc Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury
    Thomas L Nickolas
    Columbia University, New York, New York 10032, USA
    Ann Intern Med 148:810-9. 2008
  8. pmc Bone mass and microarchitecture in CKD patients with fracture
    Thomas L Nickolas
    Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    J Am Soc Nephrol 21:1371-80. 2010
  9. pmc Teriparatide for idiopathic osteoporosis in premenopausal women: a pilot study
    Adi Cohen
    Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Endocrinol Metab 98:1971-81. 2013
  10. pmc PTH(1-84) administration reverses abnormal bone-remodeling dynamics and structure in hypoparathyroidism
    Mishaela R Rubin
    Department of Medicine, Division of Endocrinology, Metabolic Bone Diseases Unit, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Bone Miner Res 26:2727-36. 2011

Collaborators

Detail Information

Publications32

  1. pmc Pancreas-kidney transplantation is associated with reduced fracture risk compared with kidney-alone transplantation in men with type 1 diabetes
    Lucas E Nikkel
    Penn State Hershey College of Medicine, Hershey, Pennsylvania, USA
    Kidney Int 83:471-8. 2013
    ..Prospective studies are needed to determine the gender-specific mechanisms by which pancreas-kidney transplantation reduces fracture risk in men...
  2. pmc Rapid cortical bone loss in patients with chronic kidney disease
    Thomas L Nickolas
    Columbia University Medical Center, Department of Medicine, Division of Nephrology, New York, NY, USA
    J Bone Miner Res 28:1811-20. 2013
    ..Future investigations are required to determine whether these cortical losses can be attenuated by treatments that reduce PTH levels and remodeling rates. ..
  3. pmc NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease
    Thomas L Nickolas
    Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Kidney Int 82:718-22. 2012
    ..01), and tubular atrophy (mild vs. severe disease; mean 54 vs. 164 μg uNGAL/g Cr, P<0.01). Monospecific assays of the NGAL monomer demonstrated a correlation with histology that typifies progressive, severe CKD...
  4. pmc Discriminants of prevalent fractures in chronic kidney disease
    Thomas L Nickolas
    Department of Medicine, Divisions of Nephrology, Columbia University Medical Center, New York, New York, USA
    J Am Soc Nephrol 22:1560-72. 2011
    ..In summary, these cross-sectional data suggest that measurement of bone turnover markers may increase the diagnostic accuracy of densitometry to identify patients with CKD at high risk for fracture...
  5. ncbi request reprint Awareness of kidney disease in the US population: findings from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2000
    Thomas L Nickolas
    Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Kidney Dis 44:185-97. 2004
    ..CKD awareness among patients is crucial to early intervention programs, but its prevalence and characteristics in the noninstitutionalized US population are unknown...
  6. ncbi request reprint Chronic kidney disease and bone fracture: a growing concern
    Thomas L Nickolas
    Division of Nephrology, Department of Medicine, Columbia University Medical Center, New York, New York, USA
    Kidney Int 74:721-31. 2008
    ....
  7. pmc Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury
    Thomas L Nickolas
    Columbia University, New York, New York 10032, USA
    Ann Intern Med 148:810-9. 2008
    ..A single serum creatinine measurement cannot distinguish acute kidney injury from chronic kidney disease or prerenal azotemia...
  8. pmc Bone mass and microarchitecture in CKD patients with fracture
    Thomas L Nickolas
    Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    J Am Soc Nephrol 21:1371-80. 2010
    ..These density and structural differences may underlie the increased susceptibility to fracture among patients with CKD...
  9. pmc Teriparatide for idiopathic osteoporosis in premenopausal women: a pilot study
    Adi Cohen
    Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Endocrinol Metab 98:1971-81. 2013
    ..Premenopausal women with idiopathic osteoporosis (IOP) have abnormal cortical and trabecular bone microarchitecture...
  10. pmc PTH(1-84) administration reverses abnormal bone-remodeling dynamics and structure in hypoparathyroidism
    Mishaela R Rubin
    Department of Medicine, Division of Endocrinology, Metabolic Bone Diseases Unit, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Bone Miner Res 26:2727-36. 2011
    ..These changes suggest that PTH(1-84) improves abnormal skeletal properties in hypoparathyroidism and restores bone metabolism toward normal euparathyroid levels...
  11. pmc Abdominal fat is associated with lower bone formation and inferior bone quality in healthy premenopausal women: a transiliac bone biopsy study
    Adi Cohen
    Department of Medicine, Columbia University, College of Physicians and Surgeons, PH8 864 630 West 168th Street, New York, New York 10032, USA
    J Clin Endocrinol Metab 98:2562-72. 2013
    ..It is controversial whether effects of obesity on bone are mediated by increased bone resorption or decreased bone formation...
  12. pmc Microarchitectural abnormalities are more severe in postmenopausal women with vertebral compared to nonvertebral fractures
    Emily M Stein
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, PH8 West 864, New York, New York 10032, USA
    J Clin Endocrinol Metab 97:E1918-26. 2012
    ..Abnormal bone microarchitecture predisposes postmenopausal women to fragility fractures. Whether women with vertebral fractures have worse microarchitecture than those with nonvertebral fractures is unknown...
  13. pmc Increased marrow adiposity in premenopausal women with idiopathic osteoporosis
    Adi Cohen
    Columbia University, New York, New York 10032, USA
    J Clin Endocrinol Metab 97:2782-91. 2012
    ..Bone remodeling was heterogeneous. Those with low bone turnover had evidence of osteoblast dysfunction and the most marked deficits in microstructure and stiffness...
  14. pmc Individual trabecula segmentation (ITS)-based morphological analyses and microfinite element analysis of HR-pQCT images discriminate postmenopausal fragility fractures independent of DXA measurements
    X Sherry Liu
    Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Bone Miner Res 27:263-72. 2012
    ..We conclude that HR-pQCT-based ITS and µFEA measurements increase our understanding of the microstructural pathogenesis of fragility fracture in postmenopausal women...
  15. doi request reprint The modification of diet in renal disease (MDRD) and the prediction of kidney outcomes after lung transplantation
    Nadine Al-Naamani
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Heart Lung Transplant 27:1191-7. 2008
    ....
  16. pmc Abnormal microarchitecture and stiffness in postmenopausal women with ankle fractures
    Emily M Stein
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Endocrinol Metab 96:2041-8. 2011
    ..Ankle fractures are not typically considered osteoporotic fractures. However, bone quality in patients with low trauma ankle fractures has not been explored...
  17. pmc Abnormal bone microarchitecture and evidence of osteoblast dysfunction in premenopausal women with idiopathic osteoporosis
    Adi Cohen
    Department of Radiology, Columbia University, New York, New York 10032, USA
    J Clin Endocrinol Metab 96:3095-105. 2011
    ..It is unclear whether women with idiopathic low bone mineral density and no history of fragility fractures have osteoporosis...
  18. pmc Urinary neutrophil gelatinase-associated lipocalin predicts mortality and identifies acute kidney injury in cirrhosis
    Elizabeth C Verna
    Division of Digestive and Liver Diseases, Department of Medicine, Center for Liver Disease and Transplantation, Columbia University College of Physicians and Surgeons, 622 West 168th St, PH 20, New York, NY 10032, USA
    Dig Dis Sci 57:2362-70. 2012
    ..Kidney failure predicts mortality in patients with cirrhosis. Identification of kidney failure etiology and recognition of those at the highest mortality risk remains a challenge...
  19. doi request reprint Biomarkers in acute and chronic kidney disease
    Thomas L Nickolas
    Renal Division, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA
    Curr Opin Nephrol Hypertens 17:127-32. 2008
    ..The paucity of early, predictive, noninvasive biomarkers has impaired our ability to institute potentially effective therapies for acute kidney injury and chronic kidney disease in a timely manner...
  20. pmc Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage: a multicenter prospective cohort study
    Thomas L Nickolas
    Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Am Coll Cardiol 59:246-55. 2012
    ..This study aimed to determine the diagnostic and prognostic value of urinary biomarkers of intrinsic acute kidney injury (AKI) when patients were triaged in the emergency department...
  21. pmc Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures
    Emily M Stein
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Bone Miner Res 25:2572-81. 2010
    ..2010 American Society for Bone and Mineral Research...
  22. ncbi request reprint Relationship between moderate to severe kidney disease and hip fracture in the United States
    Thomas L Nickolas
    Division of Nephrology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    J Am Soc Nephrol 17:3223-32. 2006
    ..There is a significant association between hip fracture and moderate to severe degrees of CKD, particularly in younger individuals, that is independent of traditional risk factors for hip fracture...
  23. pmc Chronic kidney disease is associated with white matter hyperintensity volume: the Northern Manhattan Study (NOMAS)
    Minesh Khatri
    Division of Stroke and Critical Care, Department of Neurology, College of Physicians and Surgeons of Columbia University, NI Room 640, 710 W 168th Street, New York, NY 10032, USA
    Stroke 38:3121-6. 2007
    ..Few studies have explored the relationship between chronic kidney disease and white matter hyperintensities...
  24. pmc Urinary NGAL marks cystic disease in HIV-associated nephropathy
    Neal Paragas
    College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Am Soc Nephrol 20:1687-92. 2009
    ..These data show that marked upregulation of NGAL accompanies HIVAN and support further study of uNGAL levels in large cohorts to aid in the noninvasive diagnosis of HIVAN and screen for HIVAN-related tubular damage...
  25. pmc NGAL-Siderocalin in kidney disease
    Neal Paragas
    College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Biochim Biophys Acta 1823:1451-8. 2012
    ..This article is part of a Special Issue entitled: Cell Biology of Metals...
  26. doi request reprint Assessment of kidney function in lung transplant candidates
    Nadine Al-Naamani
    Lung Transplant Program, Columbia University, New York, New York 10032, USA
    J Heart Lung Transplant 27:635-41. 2008
    ..Although creatinine-based formulas that estimate GFR have been derived, none have been validated in patients with severe lung disease...
  27. pmc Urine neutrophil gelatinase-associated lipocalin identifies unilateral and bilateral urinary tract obstruction
    Meghan E Sise
    Department of Medicine, Columbia University, New York, NY, USA
    Nephrol Dial Transplant 26:4132-5. 2011
    ..Unilateral UTO may be difficult to diagnose. Urinary neutrophil gelatinase-associated Lipocalin (uNGAL) may identify unilateral and bilateral UTO...
  28. ncbi request reprint Mycophenolate mofetil for the treatment of interstitial nephritis
    Dean C Preddie
    Department of Medicine Division of Nephrology, Columbia University College of Physicians and Surgeons, 622 West 168th Street, PH4 124, New York, NY 10032, USA
    Clin J Am Soc Nephrol 1:718-22. 2006
    ..4 mo. MMF was well tolerated by all patients. It is concluded that MMF is a useful therapeutic option for steroid-resistant AIN and may be considered as potential first-line therapy in select populations...
  29. ncbi request reprint Hyperlipidemia and thrombotic complications in patients with membranous nephropathy
    Thomas L Nickolas
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Semin Nephrol 23:406-11. 2003
    ..Prospective trials in the future will provide definitive information on how to best treat these abnormalities...
  30. ncbi request reprint Nephrological and obstetric complications of the antiphospholipid syndrome
    Robert Isom
    Department of Nephrology, New York Presbyterian Hospital, PH 4 124, 622 W 168th St, New York, NY 10032, USA
    Expert Opin Investig Drugs 11:819-29. 2002
    ..Experimental treatments involving immunomodulatory therapy with intravenous immunoglobulin, apheresis and novel antibody therapy are being investigated with hopes of successful clinical applications...
  31. pmc The association between kidney disease and cardiovascular risk in a multiethnic cohort: findings from the Northern Manhattan Study (NOMAS)
    Thomas L Nickolas
    Stroke 39:2876-9. 2008
    ..The objective of this study was to determine the relationship between chronic kidney disease (CKD), race-ethnicity, and vascular outcomes...
  32. ncbi request reprint Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in children with chronic kidney disease
    Mark M Mitsnefes
    Divisions of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, MLC 7022, 3333 Burnet Avenue, Cincinnati, OH, 45229 3039, USA
    Pediatr Nephrol 22:101-8. 2007
    ..62), followed by cystatin C (r=0.41). We conclude that (a) both serum NGAL and cystatin C may prove useful in the quantitation of CKD, and (b) by correlation analysis, NGAL outperforms cystatin C and eGFR at lower levels of measured GFR...