Rajesh Narendran

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Altered prefrontal dopaminergic function in chronic recreational ketamine users
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Psychiatry 162:2352-9. 2005
  2. ncbi request reprint Measurement of the proportion of D2 receptors configured in state of high affinity for agonists in vivo: a positron emission tomography study using [11C]N-propyl-norapomorphine and [11C]raclopride in baboons
    Rajesh Narendran
    New York State Psychiatric Institute, 1051 Riverside Dr, Box 31, New York, NY 10032, USA
    J Pharmacol Exp Ther 315:80-90. 2005
  3. ncbi request reprint In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Synapse 52:188-208. 2004
  4. pmc Dopamine D1 receptors in cocaine dependence measured with PET and the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neuropsychopharmacology 34:1774-82. 2009
  5. ncbi request reprint Amphetamine-induced dopamine release: duration of action as assessed with the D2/3 receptor agonist radiotracer (-)-N-[(11)C]propyl-norapomorphine ([11C]NPA) in an anesthetized nonhuman primate
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Synapse 61:106-9. 2007
  6. ncbi request reprint Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York 10032, USA
    Synapse 60:485-95. 2006
  7. pmc Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion
    Diana Martinez
    Department of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 166:1170-7. 2009
  8. pmc Dopamine type 2/3 receptor availability in the striatum and social status in human volunteers
    Diana Martinez
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 67:275-8. 2010
  9. ncbi request reprint Modulation of amphetamine-induced dopamine release by group II metabotropic glutamate receptor agonist LY354740 in non-human primates studied with positron emission tomography
    Bart N M van Berckel
    Department of Psychiatry, Columbia University, New York, NY, USA
    Neuropsychopharmacology 31:967-77. 2006
  10. ncbi request reprint Quantitative analysis of (-)-N-(11)C-propyl-norapomorphine in vivo binding in nonhuman primates
    Dah Ren Hwang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Nucl Med 45:338-46. 2004

Detail Information

Publications21

  1. ncbi request reprint Altered prefrontal dopaminergic function in chronic recreational ketamine users
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Psychiatry 162:2352-9. 2005
    ..In this study, dopamine D1 receptor availability was assessed by using positron emission tomography and the selective D1 receptor radioligand [11C]NNC 112 in a group of 14 recreational chronic ketamine users and matched healthy subjects...
  2. ncbi request reprint Measurement of the proportion of D2 receptors configured in state of high affinity for agonists in vivo: a positron emission tomography study using [11C]N-propyl-norapomorphine and [11C]raclopride in baboons
    Rajesh Narendran
    New York State Psychiatric Institute, 1051 Riverside Dr, Box 31, New York, NY 10032, USA
    J Pharmacol Exp Ther 315:80-90. 2005
    ....
  3. ncbi request reprint In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Synapse 52:188-208. 2004
    ..In conclusion, [11C]NPA might provide a superior radiotracer to probe presynaptic DA function with PET in health and disease...
  4. pmc Dopamine D1 receptors in cocaine dependence measured with PET and the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neuropsychopharmacology 34:1774-82. 2009
    ....
  5. ncbi request reprint Amphetamine-induced dopamine release: duration of action as assessed with the D2/3 receptor agonist radiotracer (-)-N-[(11)C]propyl-norapomorphine ([11C]NPA) in an anesthetized nonhuman primate
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Synapse 61:106-9. 2007
  6. ncbi request reprint Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York 10032, USA
    Synapse 60:485-95. 2006
    ..This property might contribute to its higher vulnerability to endogenous DA compared to [11C]raclopride and [11C]NPA...
  7. pmc Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion
    Diana Martinez
    Department of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 166:1170-7. 2009
    ..The purpose of this study was to measure D(2)/D(3) receptors following acute dopamine depletion in cocaine-dependent volunteers relative to healthy comparison subjects...
  8. pmc Dopamine type 2/3 receptor availability in the striatum and social status in human volunteers
    Diana Martinez
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 67:275-8. 2010
    ..The goal of the present study was to examine this phenomena in human subjects using PET and the radiotracer [(11)C]raclopride...
  9. ncbi request reprint Modulation of amphetamine-induced dopamine release by group II metabotropic glutamate receptor agonist LY354740 in non-human primates studied with positron emission tomography
    Bart N M van Berckel
    Department of Psychiatry, Columbia University, New York, NY, USA
    Neuropsychopharmacology 31:967-77. 2006
    ....
  10. ncbi request reprint Quantitative analysis of (-)-N-(11)C-propyl-norapomorphine in vivo binding in nonhuman primates
    Dah Ren Hwang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Nucl Med 45:338-46. 2004
    ..The goal of this study was to develop and evaluate analytic strategies to derive in vivo (11)C-NPA binding parameters...
  11. ncbi request reprint Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, NY 10032, USA
    J Nucl Med 47:815-26. 2006
    ..The aim of the present study was to define the optimal analytic method to derive accurate and reliable serotonin transporter (SERT) receptor parameters with (11)C-3-amino-4-(2-[(dimethylamino)methyl]phenylthio)benzonitrile ((11)C-DASB)...
  12. ncbi request reprint Serotonin transporter availability in patients with schizophrenia: a positron emission tomography imaging study with [11C]DASB
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 57:1510-6. 2005
    ..The aim of this study was to compare SERT availability in vivo in patients with schizophrenia and matched control subjects...
  13. ncbi request reprint Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Psychiatry 164:622-9. 2007
    ..Furthermore, the relationship between this dopamine response and the choice to self-administer cocaine in a laboratory model of relapse was investigated...
  14. ncbi request reprint Mechanism of action of antipsychotic drugs: from dopamine D(2) receptor antagonism to glutamate NMDA facilitation
    Marc Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Clin Ther 27:S16-24. 2005
    ..The fundamental pathologic processes associated with schizophrenia remain uncertain...
  15. doi request reprint Synthesis and characterization of two PET radioligands for the metabotropic glutamate 1 (mGlu1) receptor
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Synapse 66:1002-14. 2012
    ..Radioligands with higher affinity and/or lower lipophilicity are needed to successfully image the mGlu1 receptor in humans...
  16. doi request reprint No effect of dopamine depletion on the binding of the high-affinity D 2/3 radiotracer [11C]FLB 457 in the human cortex
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 64:879-85. 2010
    ..In contrast to the measurement of DA release, the combination of low D(2) receptor density and low basal DA levels in the cortex greatly reduce the power to detect alterations in [(11)C]FLB 457 binding secondary to DA depletion...
  17. pmc Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjects
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 34:624-33. 2009
    ....
  18. doi request reprint Imaging neurotransmitter release by drugs of abuse
    Diana Martinez
    NYS Psychiatric Institute, New York, NY 10032, USA
    Curr Top Behav Neurosci 3:219-45. 2010
    ..The results of these studies suggest that cocaine and alcohol addiction are associated with a loss of dopamine transmission, and a number of studies show that this loss correlates with severity of disease...
  19. ncbi request reprint Who are patients on conventional antipsychotics?
    Antoinette M Valenti
    University at Buffalo School of Medicine and Biomedical Sciences, Department of Psychiatry, State University of New York at Buffalo, USA
    Schizophr Bull 29:195-9. 2003
    ....
  20. ncbi request reprint Efficacy of clozapine in the treatment of atypical antipsychotic refractory schizophrenia: a pilot study
    Rajesh Narendran
    J Clin Psychopharmacol 23:103-4. 2003
  21. ncbi request reprint Is psychosis exacerbated by modafinil?
    Rajesh Narendran
    Arch Gen Psychiatry 59:292-3. 2002