Genomes and Genes
Affiliation: Columbia University
- The role of rodent models in the discovery of new treatments for schizophrenia: updating our strategyHolly Moore
Department of Integrative Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, Mail Unit 14, New York, NY 10032, USA
Schizophr Bull 36:1066-72. 2010....
- Harnessing cognitive neuroscience to develop new treatments for improving cognition in schizophrenia: CNTRICS selected cognitive paradigms for animal modelsHolly Moore
Department of Psychiatry, Columbia University, New York, NY, USA Department of Integrative Neuroscience, New York State Psychiatric Institute, New York, NY, USA Electronic address
Neurosci Biobehav Rev 37:2087-91. 2013..These paradigms are designed to measure cognitive constructs within the domains of perception, attention, executive function, working memory, object/relational long-term memory, and social/affective processes. ..
- A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophreniaHolly Moore
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Biol Psychiatry 60:253-64. 2006..Specifically, we tested whether this manipulation leads to disruptions of frontal and limbic corticostriatal circuit function, while producing schizophrenia-like, region-dependent reductions in gray matter in cortex and thalamus...
- Moderate recurrent hypoglycemia during early development leads to persistent changes in affective behavior in the ratHolly Moore
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Brain Behav Immun 24:839-49. 2010..Importantly, these phenotypes are not reversed with normalization of blood glucose and may persist into adulthood...
- Ventral striatum dopamine D2 receptor activity inhibits rat pups' vocalization response to loss of maternal contactJeff M Muller
New York State Psychiatric Institute, Department of Developmental Neuroscience, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Behav Neurosci 122:119-28. 2008..Because activity level was increased by both dorsal and ventral striatum infusions, activity level can not account for the results...
- Interneuron precursor transplants in adult hippocampus reverse psychosis-relevant features in a mouse model of hippocampal disinhibitionAhmed I Gilani
New York State Psychiatric Institute, New York, NY 10032 Department of Biological Sciences, Columbia University, New York, NY 10027 Departments of
Proc Natl Acad Sci U S A 111:7450-5. 2014....
- Dopamine's role in social modulation of infant isolation-induced vocalization: II. Maternally modulated infant separation responses are regulated by D1- and D2-family dopamine receptorsJeff M Muller
Division of Developmental Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 40, New York, NY 10032, USA
Dev Psychobiol 51:158-72. 2009..We conclude that D2 receptor family activation has a more selective effect of disrupting maternal potentiation than D1 receptor family activation...
- Effects of excessive glucocorticoid receptor stimulation during early gestation on psychomotor and social behavior in the ratKarine Kleinhaus
Department of Psychiatry New York University Medical Center, New York, NY, USA
Dev Psychobiol 52:121-32. 2010..Moreover, some of these deficits may be mediated by alterations in postnatal maternal behavior and physiology produced by early gestational exposure to excess glucocorticoids...
- Dopamine's role in social modulation of infant isolation-induced vocalization: I. Reunion responses to the dam, but not littermates, are dopamine dependentHarry N Shair
Division of Developmental Neuroscience New York State Psychiatric Institute New York, NY 10032, USA
Dev Psychobiol 51:131-46. 2009..This is also the first demonstration that the neurochemical substrates of an infant comfort response to dams differ from a behaviorally similar response to siblings...
- A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognitionMirna Kvajo
Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA
Proc Natl Acad Sci U S A 105:7076-81. 2008..Our results implicate malfunction of neural circuits within the hippocampus and medial prefrontal cortex and selective deficits in WM as contributing to the genetic risk conferred by this gene...
- Dopamine d2 receptors regulate the anatomical and functional balance of Basal Ganglia circuitryMaxime Cazorla
Department of Psychiatry, Columbia University, New York, NY 10032, USA Department of Pharmacology, Columbia University, New York, NY 10032, USA Department of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA
Neuron 81:153-64. 2014....
- Chronic 5-HT transporter blockade reduces DA signaling to elicit basal ganglia dysfunctionEmanuela Morelli
Division of Developmental Neuroscience, Department of Psychiatry, Columbia University, New York, New York 10032, USA
J Neurosci 31:15742-50. 2011..Our data suggest that augmentation of DA signaling would reduce side effects and increase efficacies of SSRI-based therapy...
- FoxG1 haploinsufficiency results in impaired neurogenesis in the postnatal hippocampus and contextual memory deficitsLijian Shen
Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York 10021, USA
Hippocampus 16:875-90. 2006....
- Type III neuregulin-1 is required for normal sensorimotor gating, memory-related behaviors, and corticostriatal circuit componentsYing Jiun J Chen
Department of Cell Biology and Pathology, School of Pubic Health, Columbia University, New York, New York, USA
J Neurosci 28:6872-83. 2008..Our findings demonstrate a role of type III Nrg1 signaling in the maintenance of corticostriatal components and in the neural circuits involved in sensorimotor gating and short-term memory...
- Prefrontal cortical inputs to the basal amygdala undergo pruning during late adolescence in the ratVictoria L Cressman
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Comp Neurol 518:2693-709. 2010..Moreover, the structural remodeling within these afferents may be accompanied by significant changes in neurite plasticity within the BA...
- Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioningChristoph Kellendonk
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, New York 10032, USA
Neuron 49:603-15. 2006..We found that D2R overexpression in the striatum impacts dopamine levels, rates of dopamine turnover, and activation of D1 receptors in the prefrontal cortex, measures that are critical for working memory...
- Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driverScott A Schobel
Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA
Neuron 78:81-93. 2013..These findings show that hippocampal hypermetabolism leads to atrophy in psychotic disorder and suggest glutamate as a pathogenic driver...
- The hippocampus and nucleus accumbens as potential therapeutic targets for neurosurgical intervention in schizophreniaCharles B Mikell
Department of Neurological Surgery, Columbia University, New York, NY 10032, USA
Stereotact Funct Neurosurg 87:256-65. 2009..Thus, we suggest a direction for further experimentation aimed at developing neurosurgical therapeutic approaches for this devastating disease...
- Dopamine neurons control striatal cholinergic neurons via regionally heterogeneous dopamine and glutamate signalingNao Chuhma
Department of Psychiatry, Columbia University, New York, NY 10032, USA Department of Molecular Therapeutics, NYS Psychiatric Institute, New York, NY 10032, USA Electronic address
Neuron 81:901-12. 2014..Overall, the present data indicate that dopamine neurons control striatal circuit function via discrete, plastic connections with cholinergic interneurons. ..
- Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia II: developing imaging biomarkers to enhance treatment development for schizophrenia and related disordersCameron S Carter
Department of Psychiatry, University of California at Davis, Sacramento, California, USA
Biol Psychiatry 70:7-12. 2011..This overview article describes the background and goals of the meeting together with a summary of the major issues discussed in more detail in the accompanying articles appearing in this issue of Biological Psychiatry...
- Presynaptic regulation of dopamine transmission in schizophreniaGholson J Lyon
Department of Psychiatry, Columbia University, New York City, NY 10032, USA
Schizophr Bull 37:108-17. 2011..New laboratory approaches are elucidating mechanisms that control the level of presynaptic DA stores, thus contributing to fundamental understanding of the basic pathophysiologic mechanism in schizophrenia...
- Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disordersScott A Schobel
Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, USA
Arch Gen Psychiatry 66:938-46. 2009..Because schizophrenia and related disorders have a chronic time course and subtle histopathology, it is difficult to identify which brain regions are differentially targeted...
- The prefrontal cortex regulates lateral amygdala neuronal plasticity and responses to previously conditioned stimuliJ Amiel Rosenkranz
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 23:11054-64. 2003..This may be attributable to the loss of PFC-imposed inhibition of the emotional response to a stimulus but may also include the formation or diminished extinction of inappropriate associations...
- Hippocampal neurogenesis is not required for behavioral effects of environmental enrichmentDar Meshi
Department of Biological Sciences, Columbia University, New York, New York 10027, USA
Nat Neurosci 9:729-31. 2006..We report that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these effects of enrichment...
- Prefrontal DA transmission at D1 receptors and the pathology of schizophreniaAnissa Abi-Dargham
Department of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, NY 10032, USA
Neuroscientist 9:404-16. 2003..The impact of antipsychotic drugs on prefrontal DA function will also be reviewed. We will conclude with the formulation of several models of altered prefrontal DA transmission at D1 receptors in schizophrenia...
- Maternally modulated infant separation responses are regulated by D2-family dopamine receptorsJeff M Muller
Department of Developmental Psychobiology, New York State Psychiatric Institute, New York, NY 10032, USA
Behav Neurosci 119:1384-8. 2005..This result was not explained by quinpirole's effects on body temperature or locomotion. The results are consistent with a role for dopamine in infant social behavior...
- Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmissionStan B Floresco
Department of Neuroscienc, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, Pennsylvania 15260, USA
Nat Neurosci 6:968-73. 2003....
- Selective cortical interneuron and GABA deficits in cyclin D2-null miceSara B Glickstein
Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA
Development 134:4083-93. 2007..We propose that cD2 promotes transit-amplifying divisions in the SVZ and that these ensure proper output of at least a subset of PV interneurons...
- A role for electrotonic coupling in the striatum in the expression of dopamine receptor-mediated stereotypiesHolly Moore
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neuropsychopharmacology 27:980-92. 2002..These results may be relevant to diseases and pharmacotherapies associated with disruptions of motor and possibly cognitive sequencing...
- Cholinergic agonists as novel treatments for schizophrenia: the promise of rational drug development for psychiatryJeffrey A Lieberman
Am J Psychiatry 165:931-6. 2008
- Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disordersKristine Roy
Neurobiology Program, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:8131-6. 2007..These results indicate that defects in white matter can cause alterations in dopaminergic function and behavior relevant to neuropsychiatric disorders...