Holly Moore

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc The role of rodent models in the discovery of new treatments for schizophrenia: updating our strategy
    Holly Moore
    Department of Integrative Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, Mail Unit 14, New York, NY 10032, USA
    Schizophr Bull 36:1066-72. 2010
  2. pmc Harnessing cognitive neuroscience to develop new treatments for improving cognition in schizophrenia: CNTRICS selected cognitive paradigms for animal models
    Holly Moore
    Department of Psychiatry, Columbia University, New York, NY, USA Department of Integrative Neuroscience, New York State Psychiatric Institute, New York, NY, USA Electronic address
    Neurosci Biobehav Rev 37:2087-91. 2013
  3. pmc A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia
    Holly Moore
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 60:253-64. 2006
  4. pmc Moderate recurrent hypoglycemia during early development leads to persistent changes in affective behavior in the rat
    Holly Moore
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Brain Behav Immun 24:839-49. 2010
  5. pmc Ventral striatum dopamine D2 receptor activity inhibits rat pups' vocalization response to loss of maternal contact
    Jeff M Muller
    New York State Psychiatric Institute, Department of Developmental Neuroscience, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Behav Neurosci 122:119-28. 2008
  6. pmc Interneuron precursor transplants in adult hippocampus reverse psychosis-relevant features in a mouse model of hippocampal disinhibition
    Ahmed I Gilani
    New York State Psychiatric Institute, New York, NY 10032 Department of Biological Sciences, Columbia University, New York, NY 10027 Departments of
    Proc Natl Acad Sci U S A 111:7450-5. 2014
  7. pmc Dopamine's role in social modulation of infant isolation-induced vocalization: II. Maternally modulated infant separation responses are regulated by D1- and D2-family dopamine receptors
    Jeff M Muller
    Division of Developmental Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 40, New York, NY 10032, USA
    Dev Psychobiol 51:158-72. 2009
  8. pmc Effects of excessive glucocorticoid receptor stimulation during early gestation on psychomotor and social behavior in the rat
    Karine Kleinhaus
    Department of Psychiatry New York University Medical Center, New York, NY, USA
    Dev Psychobiol 52:121-32. 2010
  9. pmc Dopamine's role in social modulation of infant isolation-induced vocalization: I. Reunion responses to the dam, but not littermates, are dopamine dependent
    Harry N Shair
    Division of Developmental Neuroscience New York State Psychiatric Institute New York, NY 10032, USA
    Dev Psychobiol 51:131-46. 2009
  10. pmc A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition
    Mirna Kvajo
    Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:7076-81. 2008

Collaborators

Detail Information

Publications31

  1. pmc The role of rodent models in the discovery of new treatments for schizophrenia: updating our strategy
    Holly Moore
    Department of Integrative Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, Mail Unit 14, New York, NY 10032, USA
    Schizophr Bull 36:1066-72. 2010
    ....
  2. pmc Harnessing cognitive neuroscience to develop new treatments for improving cognition in schizophrenia: CNTRICS selected cognitive paradigms for animal models
    Holly Moore
    Department of Psychiatry, Columbia University, New York, NY, USA Department of Integrative Neuroscience, New York State Psychiatric Institute, New York, NY, USA Electronic address
    Neurosci Biobehav Rev 37:2087-91. 2013
    ..These paradigms are designed to measure cognitive constructs within the domains of perception, attention, executive function, working memory, object/relational long-term memory, and social/affective processes. ..
  3. pmc A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia
    Holly Moore
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 60:253-64. 2006
    ..Specifically, we tested whether this manipulation leads to disruptions of frontal and limbic corticostriatal circuit function, while producing schizophrenia-like, region-dependent reductions in gray matter in cortex and thalamus...
  4. pmc Moderate recurrent hypoglycemia during early development leads to persistent changes in affective behavior in the rat
    Holly Moore
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Brain Behav Immun 24:839-49. 2010
    ..Importantly, these phenotypes are not reversed with normalization of blood glucose and may persist into adulthood...
  5. pmc Ventral striatum dopamine D2 receptor activity inhibits rat pups' vocalization response to loss of maternal contact
    Jeff M Muller
    New York State Psychiatric Institute, Department of Developmental Neuroscience, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Behav Neurosci 122:119-28. 2008
    ..Because activity level was increased by both dorsal and ventral striatum infusions, activity level can not account for the results...
  6. pmc Interneuron precursor transplants in adult hippocampus reverse psychosis-relevant features in a mouse model of hippocampal disinhibition
    Ahmed I Gilani
    New York State Psychiatric Institute, New York, NY 10032 Department of Biological Sciences, Columbia University, New York, NY 10027 Departments of
    Proc Natl Acad Sci U S A 111:7450-5. 2014
    ....
  7. pmc Dopamine's role in social modulation of infant isolation-induced vocalization: II. Maternally modulated infant separation responses are regulated by D1- and D2-family dopamine receptors
    Jeff M Muller
    Division of Developmental Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 40, New York, NY 10032, USA
    Dev Psychobiol 51:158-72. 2009
    ..We conclude that D2 receptor family activation has a more selective effect of disrupting maternal potentiation than D1 receptor family activation...
  8. pmc Effects of excessive glucocorticoid receptor stimulation during early gestation on psychomotor and social behavior in the rat
    Karine Kleinhaus
    Department of Psychiatry New York University Medical Center, New York, NY, USA
    Dev Psychobiol 52:121-32. 2010
    ..Moreover, some of these deficits may be mediated by alterations in postnatal maternal behavior and physiology produced by early gestational exposure to excess glucocorticoids...
  9. pmc Dopamine's role in social modulation of infant isolation-induced vocalization: I. Reunion responses to the dam, but not littermates, are dopamine dependent
    Harry N Shair
    Division of Developmental Neuroscience New York State Psychiatric Institute New York, NY 10032, USA
    Dev Psychobiol 51:131-46. 2009
    ..This is also the first demonstration that the neurochemical substrates of an infant comfort response to dams differ from a behaviorally similar response to siblings...
  10. pmc A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition
    Mirna Kvajo
    Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:7076-81. 2008
    ..Our results implicate malfunction of neural circuits within the hippocampus and medial prefrontal cortex and selective deficits in WM as contributing to the genetic risk conferred by this gene...
  11. pmc Dopamine d2 receptors regulate the anatomical and functional balance of Basal Ganglia circuitry
    Maxime Cazorla
    Department of Psychiatry, Columbia University, New York, NY 10032, USA Department of Pharmacology, Columbia University, New York, NY 10032, USA Department of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuron 81:153-64. 2014
    ....
  12. pmc Chronic 5-HT transporter blockade reduces DA signaling to elicit basal ganglia dysfunction
    Emanuela Morelli
    Division of Developmental Neuroscience, Department of Psychiatry, Columbia University, New York, New York 10032, USA
    J Neurosci 31:15742-50. 2011
    ..Our data suggest that augmentation of DA signaling would reduce side effects and increase efficacies of SSRI-based therapy...
  13. ncbi request reprint FoxG1 haploinsufficiency results in impaired neurogenesis in the postnatal hippocampus and contextual memory deficits
    Lijian Shen
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York 10021, USA
    Hippocampus 16:875-90. 2006
    ....
  14. pmc Type III neuregulin-1 is required for normal sensorimotor gating, memory-related behaviors, and corticostriatal circuit components
    Ying Jiun J Chen
    Department of Cell Biology and Pathology, School of Pubic Health, Columbia University, New York, New York, USA
    J Neurosci 28:6872-83. 2008
    ..Our findings demonstrate a role of type III Nrg1 signaling in the maintenance of corticostriatal components and in the neural circuits involved in sensorimotor gating and short-term memory...
  15. pmc Prefrontal cortical inputs to the basal amygdala undergo pruning during late adolescence in the rat
    Victoria L Cressman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Comp Neurol 518:2693-709. 2010
    ..Moreover, the structural remodeling within these afferents may be accompanied by significant changes in neurite plasticity within the BA...
  16. ncbi request reprint Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning
    Christoph Kellendonk
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, New York 10032, USA
    Neuron 49:603-15. 2006
    ..We found that D2R overexpression in the striatum impacts dopamine levels, rates of dopamine turnover, and activation of D1 receptors in the prefrontal cortex, measures that are critical for working memory...
  17. pmc Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver
    Scott A Schobel
    Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 78:81-93. 2013
    ..These findings show that hippocampal hypermetabolism leads to atrophy in psychotic disorder and suggest glutamate as a pathogenic driver...
  18. pmc The hippocampus and nucleus accumbens as potential therapeutic targets for neurosurgical intervention in schizophrenia
    Charles B Mikell
    Department of Neurological Surgery, Columbia University, New York, NY 10032, USA
    Stereotact Funct Neurosurg 87:256-65. 2009
    ..Thus, we suggest a direction for further experimentation aimed at developing neurosurgical therapeutic approaches for this devastating disease...
  19. pmc Dopamine neurons control striatal cholinergic neurons via regionally heterogeneous dopamine and glutamate signaling
    Nao Chuhma
    Department of Psychiatry, Columbia University, New York, NY 10032, USA Department of Molecular Therapeutics, NYS Psychiatric Institute, New York, NY 10032, USA Electronic address
    Neuron 81:901-12. 2014
    ..Overall, the present data indicate that dopamine neurons control striatal circuit function via discrete, plastic connections with cholinergic interneurons. ..
  20. pmc Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia II: developing imaging biomarkers to enhance treatment development for schizophrenia and related disorders
    Cameron S Carter
    Department of Psychiatry, University of California at Davis, Sacramento, California, USA
    Biol Psychiatry 70:7-12. 2011
    ..This overview article describes the background and goals of the meeting together with a summary of the major issues discussed in more detail in the accompanying articles appearing in this issue of Biological Psychiatry...
  21. pmc Presynaptic regulation of dopamine transmission in schizophrenia
    Gholson J Lyon
    Department of Psychiatry, Columbia University, New York City, NY 10032, USA
    Schizophr Bull 37:108-17. 2011
    ..New laboratory approaches are elucidating mechanisms that control the level of presynaptic DA stores, thus contributing to fundamental understanding of the basic pathophysiologic mechanism in schizophrenia...
  22. pmc Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disorders
    Scott A Schobel
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Arch Gen Psychiatry 66:938-46. 2009
    ..Because schizophrenia and related disorders have a chronic time course and subtle histopathology, it is difficult to identify which brain regions are differentially targeted...
  23. ncbi request reprint The prefrontal cortex regulates lateral amygdala neuronal plasticity and responses to previously conditioned stimuli
    J Amiel Rosenkranz
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 23:11054-64. 2003
    ..This may be attributable to the loss of PFC-imposed inhibition of the emotional response to a stimulus but may also include the formation or diminished extinction of inappropriate associations...
  24. ncbi request reprint Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment
    Dar Meshi
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nat Neurosci 9:729-31. 2006
    ..We report that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these effects of enrichment...
  25. ncbi request reprint Prefrontal DA transmission at D1 receptors and the pathology of schizophrenia
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, NY 10032, USA
    Neuroscientist 9:404-16. 2003
    ..The impact of antipsychotic drugs on prefrontal DA function will also be reviewed. We will conclude with the formulation of several models of altered prefrontal DA transmission at D1 receptors in schizophrenia...
  26. ncbi request reprint Maternally modulated infant separation responses are regulated by D2-family dopamine receptors
    Jeff M Muller
    Department of Developmental Psychobiology, New York State Psychiatric Institute, New York, NY 10032, USA
    Behav Neurosci 119:1384-8. 2005
    ..This result was not explained by quinpirole's effects on body temperature or locomotion. The results are consistent with a role for dopamine in infant social behavior...
  27. ncbi request reprint Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission
    Stan B Floresco
    Department of Neuroscienc, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, Pennsylvania 15260, USA
    Nat Neurosci 6:968-73. 2003
    ....
  28. pmc Selective cortical interneuron and GABA deficits in cyclin D2-null mice
    Sara B Glickstein
    Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA
    Development 134:4083-93. 2007
    ..We propose that cD2 promotes transit-amplifying divisions in the SVZ and that these ensure proper output of at least a subset of PV interneurons...
  29. ncbi request reprint A role for electrotonic coupling in the striatum in the expression of dopamine receptor-mediated stereotypies
    Holly Moore
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 27:980-92. 2002
    ..These results may be relevant to diseases and pharmacotherapies associated with disruptions of motor and possibly cognitive sequencing...
  30. doi request reprint Cholinergic agonists as novel treatments for schizophrenia: the promise of rational drug development for psychiatry
    Jeffrey A Lieberman
    Am J Psychiatry 165:931-6. 2008
  31. pmc Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders
    Kristine Roy
    Neurobiology Program, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:8131-6. 2007
    ..These results indicate that defects in white matter can cause alterations in dopaminergic function and behavior relevant to neuropsychiatric disorders...