Research Topics
| Rachel L MillerSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
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Detail Information
Publications
Reproducibility and intraindividual variation over days in buccal cell DNA methylation of two asthma genes, interferon γ (IFNγ) and inducible nitric oxide synthase (iNOS)Dz Torrone
Division of Pulmonary, Allergy and Critical Care of Medicine, PH8E, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
Clin Epigenetics 4:3. 2012..19 to 0.56, P = 0.06 to 0.30). Our data reveal DNA methylation as a dynamic epigenetic mechanism that can be accessed safely and reproducibly in an inner city pediatric cohort using non-invasive buccal swabs and pyrosequencing technology...- Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohortRachel L Miller
Division of Pulmonary, Allergy, Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, PH8C, 630 168th Street, New York, NY 10032, USA
Chest 126:1071-8. 2004.... - Environmental epigenetics and asthma: current concepts and call for studiesRachel L Miller
PH8E, 630 W 168th Street, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Am J Respir Crit Care Med 177:567-73. 2008..There is immense promise that the study of environmental epigenetics will help us understand a theoretically preventable environmental disease... - Prenatal maternal diet affects asthma risk in offspringRachel L Miller
Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Invest 118:3265-8. 2008..Site-specific differences in DNA methylation and reduced transcriptional activity were detected. If these findings are confirmed, a new paradigm for asthma pathogenesis may be emerging... - Polycyclic aromatic hydrocarbon metabolite levels and pediatric allergy and asthma in an inner-city cohortRachel L Miller
Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, New York, NY 10032, USA
Pediatr Allergy Immunol 21:260-7. 2010..Levels of PAH metabolites were not associated with respiratory symptoms. Measures of PAH metabolites suggest considerable exposure in an urban pediatric population, and possible associations with allergic sensitization to mouse... - Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring miceLin Lin
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Allergy Asthma Clin Immunol 6:7. 2010..fumigatus) allergen and diesel exhaust particles will be associated with altered IgE production, airway inflammation, airway hyperreactivity (AHR), and airway remodeling of adult offspring... - Cord blood versus age 5 mononuclear cell proliferation on IgE and asthmaCarolyn Chang
Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
Clin Mol Allergy 8:11. 2010..Our objective was to compare indoor allergen-induced CBMC with age 5 peripheral blood mononuclear cell (PBMC) proliferation and determine which may be associated with age 5 allergic immune responses and asthma in an inner city cohort... 
Prenatal exposure, maternal sensitization, and sensitization in utero to indoor allergens in an inner-city cohortR L Miller
Division of Pulmonary, Allergy, Critical Care, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Am J Respir Crit Care Med 164:995-1001. 2001....- Anti-cockroach and anti-mouse IgE are associated with early wheeze and atopy in an inner-city birth cohortKathleen M Donohue
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
J Allergy Clin Immunol 122:914-20. 2008.... - Children's Urinary Phthalate Metabolites and Fractional Exhaled Nitric Oxide in an Urban CohortAllan C Just
722 W 168th Street, 11th Floor, New York, NY 10032
Am J Respir Crit Care Med 186:830-7. 2012..These results suggest that these two ubiquitous phthalates, previously shown to have substantial contributions from inhalation, are positively associated with airway inflammation in children... 
Domestic airborne black carbon and exhaled nitric oxide in children in NYCAlexandra G Cornell
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY, USA
J Expo Sci Environ Epidemiol 22:258-66. 2012..020). The association between airborne BC in homes and both neighborhood asthma prevalence and FeNO suggest that further public health interventions on truck emissions standards and residual oil use are warranted...- Childhood exposure to fine particulate matter and black carbon and the development of new wheeze between ages 5 and 7 in an urban prospective cohortKyung Hwa Jung
Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8E, 630 W 168 St New York, NY 10032, USA
Environ Int 45:44-50. 2012..We hypothesized that childhood exposure to PM(2.5) and the soot-BC component would be associated with the report of new wheeze and development of seroatopy in an inner city birth cohort... - Ambient metals, elemental carbon, and wheeze and cough in New York City children through 24 months of ageMolini M Patel
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
Am J Respir Crit Care Med 180:1107-13. 2009..The effects of exposure to specific components of ambient fine particulate matter (PM(2.5)), including metals and elemental carbon (EC), have not been fully characterized in young children... - Traffic density and stationary sources of air pollution associated with wheeze, asthma, and immunoglobulin E from birth to age 5 years among New York City childrenMolini M Patel
Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, College of Physicians and Surgeons, 630 W 168th St, NY 10032, USA
Environ Res 111:1222-9. 2011..These findings may have broad implications for other urban populations that commonly have high asthma prevalence and exposure to a high density of traffic and stationary air pollution sources... - Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohortMatthew S Perzanowski
Columbia Center for Children s Environmental Health CCCEH, New York, NY 10032, USA
Thorax 65:118-23. 2010.... - Fractional exhaled nitric oxide exchange parameters among 9-year-old inner-city childrenMaria Jose Rosa
Columbia Center for Children s Environmental Health CCCEH, Columbia University, New York, New York 10032, USA
Pediatr Pulmonol 46:83-91. 2011..We hypothesized that the flow independent NO parameters would be associated differentially with wheeze and seroatopy... - Neighborhood differences in exposure and sensitization to cockroach, mouse, dust mite, cat, and dog allergens in New York CityOmar Olmedo
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
J Allergy Clin Immunol 128:284-292.e7. 2011..Asthma prevalence varies widely among neighborhoods within New York City. Exposure to mouse and cockroach allergens has been suggested as a cause... - Effects of winter birth season and prenatal cockroach and mouse allergen exposure on indoor allergen-specific cord blood mononuclear cell proliferation and cytokine productionCynthia Lendor
Department of Medicine, Columbia University, New York, New York 10032, USA
Ann Allergy Asthma Immunol 101:193-9. 2008..Relationships among a particular birth season, maternal allergen exposure during the birth season, and childhood development of allergies to allergens in higher concentration during the birth season may be important... - Cat ownership is a risk factor for the development of anti-cat IgE but not current wheeze at age 5 years in an inner-city cohortMatthew S Perzanowski
Columbia Center for Children s Environmental Health, Columbia University, New York, NY 10032, USA
J Allergy Clin Immunol 121:1047-52. 2008..Cat ownership is inversely associated with atopy and asthma in some areas of the world, but the relevance of cat ownership to allergic disease in the inner city is less known... - Endotoxin in inner-city homes: associations with wheeze and eczema in early childhoodMatthew S Perzanowski
Columbia's Center for Children's Environmental Health, Columbia University, New York, NY 10032, USA
J Allergy Clin Immunol 117:1082-9. 2006.... - Spatial and temporal trends of polycyclic aromatic hydrocarbons and other traffic-related airborne pollutants in New York CityRafael F Narváez
Division of Pulmonary, Allergy and Critical Care of Medicine, College of Physicians and Surgeons, Columbia University, PH8E, 630 W 168th St, New York, New York 10032, USA
Environ Sci Technol 42:7330-5. 2008..By contrast PM2.5 levels were highly intercorrelated (values ranged from 0.725 to 0.922, p < 0.01). Further policy initiatives targeting traffic-related air pollutants may be needed for a greater impact on public health... - Repeated exposure to polycyclic aromatic hydrocarbons and asthma: effect of seroatopyKyung Hwa Jung
Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Ann Allergy Asthma Immunol 109:249-54. 2012..Exposure to traffic-related air pollutants, including polycyclic aromatic hydrocarbons (PAHs), can induce asthma. However, the effects of early repeated PAH exposure over time on different asthma phenotypes have not been examined... - Using latent class growth analysis to identify childhood wheeze phenotypes in an urban birth cohortQixuan Chen
Department of Biostatistics, Mailman School of Public Health, Columbia University, 722 W 168th St, New York, NY 10032, USA
Ann Allergy Asthma Immunol 108:311-315.e1. 2012.... - Relationship between maternal demoralization, wheeze, and immunoglobulin E among inner-city childrenMarilyn Reyes
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY, USA
Ann Allergy Asthma Immunol 107:42-49.e1. 2011..However, this relationship has not been examined in inner-city African Americans and Hispanics, populations at high risk for asthma... - Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivoJinming Liu
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Toxicol Sci 102:76-81. 2008..This study is the first to demonstrate that inhaled environmental exposures influence methylation of Th genes in vivo, supporting a new paradigm in asthma pathogenesis... - Prenatal exposure to polycyclic aromatic hydrocarbons, environmental tobacco smoke and asthmaMaria Jose Rosa
Division of Pulmonary, Allergy, Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, NY 10032, USA
Respir Med 105:869-76. 2011..Here, we hypothesized that children exposed to both prenatal PAH and ETS may be at greater risk of asthma and seroatopy at ages 5-6 years, after controlling for current pollution exposure... - Prevalence of allergy symptoms and total IgE in a New York City cohort and their association with birth orderInge F Goldstein
Columbia s Children s Center for Environmental Health CCCEH, Columbia University, New York, NY, USA
Int Arch Allergy Immunol 137:249-57. 2005..As part of an ongoing prospective birth cohort study, the prevalence of early phenotypes of asthma and/or allergy was compared with those reported in other studies, and the association with birth order was evaluated... - Assessment of benzo(a)pyrene-equivalent carcinogenicity and mutagenicity of residential indoor versus outdoor polycyclic aromatic hydrocarbons exposing young children in New York CityKyung Hwa Jung
Division of Pulmonary, Allergy and Critical Care of Medicine, College of Physicians and Surgeons, Columbia University, PH8E, New York, NY 10032, USA
Int J Environ Res Public Health 7:1889-900. 2010..01). These findings suggest that at levels encountered in New York City air, especially during the heating season, residential exposure to PAH may pose an increased risk of cancer and mutation... 
The challenge of preventing environmentally related disease in young children: community-based research in New York CityFrederica P Perera
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, 60 Haven Avenue, New York, NY 10032, USA
Environ Health Perspect 110:197-204. 2002..In turn, communities become better equipped to relay environmental health concerns to policy makers. In this paper we describe the center's research and its academic-community partnership and present some preliminary findings...- Urinary naphthol metabolites and chromosomal aberrations in 5-year-old childrenManuela A Orjuela
Department of Pediatrics, Columbia University, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 21:1191-202. 2012..Although prenatal (maternal) PAH exposure predicts chromosomal aberrations in cord blood, few studies have examined chromosomal aberrations in school-age children and none has examined their association with metabolites of specific PAHs... - Distribution and determinants of mouse allergen exposure in low-income New York City apartmentsGinger L Chew
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
Environ Health Perspect 111:1348-51. 2003..However, high levels of mouse allergen were also found in many homes where mothers reported never seeing mice... - Exercise-induced wheeze, urgent medical visits, and neighborhood asthma prevalenceTimothy R Mainardi
Department of Environmental Health Sciences, 722 W 168th St, 11th Floor, New York, New York 10032
Pediatrics 131:e127-35. 2013..Among these asthmatics, we hypothesized that EIW would be associated with urgent medical visits and a child's neighborhood asthma prevalence... - Prenatal exposure to butylbenzyl phthalate and early eczema in an urban cohortAllan C Just
Columbia Center for Children s Environmental Health, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Health Perspect 120:1475-80. 2012..Recent cross-sectional studies suggest a link between butylbenzyl phthalate (BBzP) in house dust and childhood eczema... - Methods for detecting interactions between imprinted genes and environmental exposures using birth cohort designs with mother-offspring pairsShuang Wang
Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Hum Hered 71:196-208. 2011.... - Antigen-specific immune responses to influenza vaccine in uteroDeepa Rastogi
Children s Hospital at Montefiore, Albert Einstein College of Medicine, New York, New York, USA
J Clin Invest 117:1637-46. 2007..These results suggest that B and T cell immune responses occur in the fetus following vaccination against influenza and have important implications for determining when immune responses to environmental exposures begin... - Prenatal exposure to pesticide ingredient piperonyl butoxide and childhood cough in an urban cohortBian Liu
Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168 Street, PH8E 101, New York, NY 10032, USA
Environ Int 48:156-61. 2012..Further, we explored the associations between these pesticide measures and wheeze, asthma, seroatopy, and fractional exhaled nitric oxide (FeNO)... - Polycyclic aromatic hydrocarbons impair function of β2-adrenergic receptors in airway epithelial and smooth muscle cellsPhillip Factor
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Hospital, New York, NY 10003, USA
Am J Respir Cell Mol Biol 45:1045-9. 2011.... - Children's environmental health research--highlights from the Columbia Center for Children's Environmental HealthFrederica Perera
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Ann N Y Acad Sci 1076:15-28. 2006..This article summarizes the recent findings from the Center's projects in the context of current research in children's environmental health... - Anaphylaxis in the United States: an investigation into its epidemiologyA I Neugut
Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th St, Room PH18 127, New York, NY 10032, USA
Arch Intern Med 161:15-21. 2001..Anaphylaxis is a severe, life-threatening allergic reaction that affects both children and adults in the United States. However, data regarding the incidence and prevalence of anaphylaxis and the number of deaths caused by it are limited... - T-helper type 2 polarization among asthmatics during and following pregnancyD Rastogi
Division of Pulmonary, Allergy, Critical Care, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Clin Exp Allergy 36:892-8. 2006..CONCLUSION: IP10/eotaxin declined over the course of pregnancy and was associated with worse asthma symptoms. Alterations of Th1/Th2 chemokine balance during pregnancy may identify women prone to more severe asthma during pregnancy... - Air pollution and childhood asthma: recent advances and future directionsMolini M Patel
Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University College of Physicians and Surgeons, 630 W 168th Street, New York, NY 10032, USA
Curr Opin Pediatr 21:235-42. 2009.... - T-cell responses and hypersensitivity to influenza and egg antigens among adults with asthma immunized with the influenza vaccineRachel L Miller
Division of Pulmonary, Allergy, Critical Care, Department of Medicine, Columbia University College of Physicians and Surgeons, 630 W. 168th Street, New York, NY 10032, USA
J Allergy Clin Immunol 112:606-8. 2003..CONCLUSIONS: Episodes of bronchospasm after influenza vaccination do not seem related to hypersensitivity to the vaccine... - A SOCS-1 promoter variant is associated with total serum IgE levelsJustin Mostecki
Department of Microbiology, Columbia University, New York, NY 10032, USA
J Immunol 187:2794-802. 2011..These data suggest that genetic variation in the SOCS-1 promoter may affect IgE production... - Epidemiology of anaphylaxis: findings of the American College of Allergy, Asthma and Immunology Epidemiology of Anaphylaxis Working GroupPhil Lieberman
Division of Allergy Immunology, Department of Medicine, University of Tennessee College of Medicine, Germantown, Tennessee, USA
Ann Allergy Asthma Immunol 97:596-602. 2006..To improve understanding of the epidemiology of anaphylaxis... - Modifications improve an offline exhaled nitric oxide collection device for use with young childrenMatthew S Perzanowski
J Allergy Clin Immunol 122:213; author reply 214. 2008
Research Grants
- INDUCIBLE DOMINANT NEGATIVE OF STAT 6 IN MEMORY IGERachel Miller; Fiscal Year: 2002..Both the memory allergic response to antigenic stimulation and the polyclonal IgE response will be studied. In addition, the components of the memory response that are affected by Stat6 activity will be analyzed. (End of Abstract) ..
- Prenatal diesel exposure and adult onset asthmaRachel Miller; Fiscal Year: 2006..Aim 4: Determine a) the differential gene expression following in utero diesel exposure, and b) whether differential gene expression following prenatal diesel exposure is associated with adult asthma. ..
- Urban Diesel Exposure and Inner City AsthmaRachel Miller; Fiscal Year: 2007..The primary goals are to determine whether diesel-related exposure can induce the development of allergy and/or asthma, and to identify its contribution relative to other urban exposures. ..
- Urban Diesel Exposure and Inner City AsthmaRachel Miller; Fiscal Year: 2009..The primary goals are to determine whether diesel-related exposure can induce the development of allergy and/or asthma, and to identify its contribution relative to other urban exposures. ..