Elizabeth A Miller

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc COPII - a flexible vesicle formation system
    Elizabeth A Miller
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Curr Opin Cell Biol 25:420-7. 2013
  2. pmc Regulation of coat assembly--sorting things out at the ER
    Elizabeth A Miller
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Curr Opin Cell Biol 22:447-53. 2010
  3. ncbi request reprint Vesicle tethering: TRAPPing transport carriers
    Elizabeth A Miller
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Curr Biol 17:R211-3. 2007
  4. pmc Functional rescue of a misfolded eukaryotic ATP-binding cassette transporter by domain replacement
    Raymond J Louie
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 285:36225-34. 2010
  5. pmc ER cargo properties specify a requirement for COPII coat rigidity mediated by Sec13p
    Alenka Copic
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Science 335:1359-62. 2012
  6. pmc Genetic analysis of yeast Sec24p mutants suggests cargo binding is not co-operative during ER export
    Roy Buchanan
    Department of Biological Sciences, Columbia University, New York, NY, USA
    Traffic 11:1034-43. 2010
  7. pmc Intragenic suppressing mutations correct the folding and intracellular traffic of misfolded mutants of Yor1p, a eukaryotic drug transporter
    Silvere Pagant
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 285:36304-14. 2010
  8. pmc Genomewide analysis reveals novel pathways affecting endoplasmic reticulum homeostasis, protein modification and quality control
    Alenka Copic
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Genetics 182:757-69. 2009
  9. pmc Mapping of interdomain interfaces required for the functional architecture of Yor1p, a eukaryotic ATP-binding cassette (ABC) transporter
    Silvere Pagant
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 283:26444-51. 2008
  10. ncbi request reprint Molecular mechanisms of COPII vesicle formation
    Marcus C S Lee
    Department of Microbiology, Columbia University, New York, NY, United States
    Semin Cell Dev Biol 18:424-34. 2007

Collaborators

  • Marcus C S Lee
  • Charles Barlowe
  • Eugene Futai
  • David A Fidock
  • Joel D Ernst
  • Randy W Schekman
  • Silvere Pagant
  • Jennifer G D'Arcangelo
  • Alenka Copic
  • Roy Buchanan
  • John J Halliday
  • Leslie F Kung
  • Amanda D Gillon
  • Catherine F Latham
  • Raymond J Louie
  • MARIANA DORRINGTON
  • Kyle R Stahmer
  • John C Dittmar
  • Susan Hamamoto
  • Rodney Rothstein
  • Max A Horlbeck
  • Erik L Snapp
  • Robert J D Reid
  • Christos Kougentakis
  • Andrew Kaufman
  • Leslie Kung-Tran
  • Ji Young Youn
  • Gregory Huyer
  • Susan Michaelis
  • John L Hartman
  • Indira Singh
  • Justine Barry
  • Ethan Y Brovman
  • Leslie Kung

Detail Information

Publications20

  1. pmc COPII - a flexible vesicle formation system
    Elizabeth A Miller
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Curr Opin Cell Biol 25:420-7. 2013
    ....
  2. pmc Regulation of coat assembly--sorting things out at the ER
    Elizabeth A Miller
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Curr Opin Cell Biol 22:447-53. 2010
    ..The COPII budding machinery is further organized into higher-order structures at transitional zones on the ER surface where the large multi-domain Sec16 protein appears to perform a central function...
  3. ncbi request reprint Vesicle tethering: TRAPPing transport carriers
    Elizabeth A Miller
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Curr Biol 17:R211-3. 2007
    ..Transport vesicles must dock with the appropriate acceptor membrane to ensure faithful protein delivery. Recent work identifies some of the molecular mechanisms that contribute to the specificity of this reaction...
  4. pmc Functional rescue of a misfolded eukaryotic ATP-binding cassette transporter by domain replacement
    Raymond J Louie
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 285:36225-34. 2010
    ..Together, our genetic and biochemical data reveal that it is possible to modulate activity of ABC transporters by physically replacing dysfunctional domains...
  5. pmc ER cargo properties specify a requirement for COPII coat rigidity mediated by Sec13p
    Alenka Copic
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Science 335:1359-62. 2012
    ..Thus, Sec13p may rigidify the COPII cage and increase its membrane-bending capacity; this function could be bypassed when a bst mutation renders the membrane more deformable...
  6. pmc Genetic analysis of yeast Sec24p mutants suggests cargo binding is not co-operative during ER export
    Roy Buchanan
    Department of Biological Sciences, Columbia University, New York, NY, USA
    Traffic 11:1034-43. 2010
    ..Our findings suggest that co-operativity does not influence cargo capture at these sites, and that Sec22p rescue occurs via its function as a retrograde SNARE...
  7. pmc Intragenic suppressing mutations correct the folding and intracellular traffic of misfolded mutants of Yor1p, a eukaryotic drug transporter
    Silvere Pagant
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 285:36304-14. 2010
    ....
  8. pmc Genomewide analysis reveals novel pathways affecting endoplasmic reticulum homeostasis, protein modification and quality control
    Alenka Copic
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Genetics 182:757-69. 2009
    ..Finally, the variant histone, Htz1p, and its acetylation state seem to play an important role in maintaining ER retrieval pathways, suggesting a surprising link between chromatin remodeling and ER homeostasis...
  9. pmc Mapping of interdomain interfaces required for the functional architecture of Yor1p, a eukaryotic ATP-binding cassette (ABC) transporter
    Silvere Pagant
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 283:26444-51. 2008
    ....
  10. ncbi request reprint Molecular mechanisms of COPII vesicle formation
    Marcus C S Lee
    Department of Microbiology, Columbia University, New York, NY, United States
    Semin Cell Dev Biol 18:424-34. 2007
    ....
  11. pmc Vesicle-mediated export from the ER: COPII coat function and regulation
    Jennifer G D'Arcangelo
    Department of Biological Sciences, Columbia University, New York, NY, USA
    Biochim Biophys Acta 1833:2464-72. 2013
    ..Together, these factors work in concert to ensure proper cargo movement in this first step of the secretory pathway. This article is part of a Special Issue entitled: Functional and structural diversity of endoplasmic reticulum. ..
  12. pmc Vesicle-mediated ER export of proteins and lipids
    Amanda D Gillon
    Department of Biological Sciences, Columbia University, New York, NY, USA
    Biochim Biophys Acta 1821:1040-9. 2012
    ..This article is part of a Special Issue entitled Lipids and Vesicular Transport...
  13. pmc Plasmodium falciparum Sec24 marks transitional ER that exports a model cargo via a diacidic motif
    Marcus C S Lee
    Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Microbiol 68:1535-46. 2008
    ..Furthermore, the number and position of tER sites with respect to the cis-Golgi suggests a co-ordinated biogenesis of these domains...
  14. pmc Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat
    Leslie F Kung
    Department of Biological Sciences, Columbia University, New York, NY, USA
    EMBO J 31:1014-27. 2012
    ....
  15. pmc Inhibiting endoplasmic reticulum (ER)-associated degradation of misfolded Yor1p does not permit ER export despite the presence of a diacidic sorting signal
    Silvere Pagant
    Department of Biological Sciences, Columbia University, New York, NY 10027 6902, USA
    Mol Biol Cell 18:3398-413. 2007
    ..We propose that the ER quality control checkpoint engages misfolded Yor1p even after it has been stabilized by inhibition of the degradative pathway...
  16. pmc A sustained passion for intracellular trafficking
    Elizabeth A Miller
    Department of Biological Sciences, Columbia University, New York, NY 10027
    Mol Biol Cell 24:3270-2. 2013
    ..Simply following one's interests and passions can sustain a career, even though it may involve some migration. ..
  17. pmc Anti-TNF immunotherapy and tuberculosis reactivation: another mechanism revealed
    Elizabeth A Miller
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Clin Invest 119:1079-82. 2009
    ..The study provides insight into host defense mechanisms that act to control TB infection and how they are affected during anti-TNF immunotherapy for autoimmune disease...
  18. ncbi request reprint Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles
    Elizabeth A Miller
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell 114:497-509. 2003
    ..Together, our data support a model whereby Sec24p proteins contain multiple independent cargo binding domains that allow for recognition of a diverse set of sorting signals...
  19. pmc ER-Golgi transport defects are associated with mutations in the Sed5p-binding domain of the COPII coat subunit, Sec24p
    Elizabeth A Miller
    Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA 94702, USA
    Mol Biol Cell 16:3719-26. 2005
    ..We propose that the A-site of Sec24p is a multipurpose cargo-binding site that must recognize additional unidentified cargo proteins, at least one of which is essential at a late stage of vesicle fusion...
  20. ncbi request reprint Bi-directional protein transport between the ER and Golgi
    Marcus C S Lee
    Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA
    Annu Rev Cell Dev Biol 20:87-123. 2004
    ..We review the mechanisms that govern coat recruitment to the membrane, cargo capture into a transport vesicle, and accurate delivery to the target organelle...