George Z Mentis

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Early functional impairment of sensory-motor connectivity in a mouse model of spinal muscular atrophy
    George Z Mentis
    Section on Developmental Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 69:453-67. 2011
  2. pmc Mechanisms regulating the specificity and strength of muscle afferent inputs in the spinal cord
    George Z Mentis
    Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1198:220-30. 2010
  3. pmc Mechanisms of excitation of spinal networks by stimulation of the ventral roots
    Michael J O'Donovan
    Developmental Neurobiology Section, NINDS, NIH, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1198:63-71. 2010
  4. pmc Primary afferent synapses on developing and adult Renshaw cells
    George Z Mentis
    Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 26:13297-310. 2006
  5. doi request reprint Imaging the spatiotemporal organization of neural activity in the developing spinal cord
    Michael J O'Donovan
    National Institute of Neurological Disorder and Stroke, NIH, Bethesda, Maryland 20892, USA
    Dev Neurobiol 68:788-803. 2008
  6. pmc Noncholinergic excitatory actions of motoneurons in the neonatal mammalian spinal cord
    George Z Mentis
    Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:7344-9. 2005
  7. ncbi request reprint Calcium imaging of network function in the developing spinal cord
    Michael J O'Donovan
    Laboratory of Neural Control, Section on Developmental Neurobiology, NINDS, NIH, Bethesda, MD 20892, USA
    Cell Calcium 37:443-50. 2005
  8. doi request reprint Imaging nervous system activity
    Douglas R Fields
    Section on Nervous System Development and Plasticity, National Institute of Child Health and Human Development NICHD, NIH, Bethesda, Maryland, USA
    Curr Protoc Neurosci . 2009
  9. ncbi request reprint Electroporation loading of calcium-sensitive dyes into the CNS
    Agnes Bonnot
    Laboratory of Neural Control, Section on Developmental Neurobiology, NINDS, National Institutes of Health, 35 Convent Dr, Rm 3C1010, Bethesda, MD 20892, USA
    J Neurophysiol 93:1793-808. 2005
  10. ncbi request reprint Locomotor-like activity generated by the neonatal mouse spinal cord
    Agnes Bonnot
    Laboratory of Neural Control, Section on Developmental Neurobiology, NINDS, NIH, Bethesda, MD 20892, USA
    Brain Res Brain Res Rev 40:141-51. 2002

Detail Information

Publications15

  1. pmc Early functional impairment of sensory-motor connectivity in a mouse model of spinal muscular atrophy
    George Z Mentis
    Section on Developmental Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 69:453-67. 2011
    ..Deafferentation of motor neurons is an early event in SMA and may be a primary cause of motor dysfunction that is amenable to therapeutic intervention...
  2. pmc Mechanisms regulating the specificity and strength of muscle afferent inputs in the spinal cord
    George Z Mentis
    Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1198:220-30. 2010
    ....
  3. pmc Mechanisms of excitation of spinal networks by stimulation of the ventral roots
    Michael J O'Donovan
    Developmental Neurobiology Section, NINDS, NIH, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1198:63-71. 2010
    ..However, motoneurons do not exhibit short latency excitatory potentials in response to ventral root stimulation indicating that the excitatory effects are mediated polysynaptically. We discuss the significance of these findings...
  4. pmc Primary afferent synapses on developing and adult Renshaw cells
    George Z Mentis
    Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 26:13297-310. 2006
    ..Similar synaptic weight shifts on interneurons may be involved in the maturation of motor reflexes and locomotor circuitry...
  5. doi request reprint Imaging the spatiotemporal organization of neural activity in the developing spinal cord
    Michael J O'Donovan
    National Institute of Neurological Disorder and Stroke, NIH, Bethesda, Maryland 20892, USA
    Dev Neurobiol 68:788-803. 2008
    ..In the last part of the review, we discuss some of the exciting new prospects for the future...
  6. pmc Noncholinergic excitatory actions of motoneurons in the neonatal mammalian spinal cord
    George Z Mentis
    Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:7344-9. 2005
    ..Our results raise the possibility that motoneurons release an excitatory amino acid in addition to acetylcholine and that they may be more directly involved in the genesis of mammalian locomotion than previously believed...
  7. ncbi request reprint Calcium imaging of network function in the developing spinal cord
    Michael J O'Donovan
    Laboratory of Neural Control, Section on Developmental Neurobiology, NINDS, NIH, Bethesda, MD 20892, USA
    Cell Calcium 37:443-50. 2005
    ..This finding raises the possibility that the activation of mammalian motoneurons during locomotion may share some of the same rostrocaudally organized mechanisms that evolved to control swimming in fishes...
  8. doi request reprint Imaging nervous system activity
    Douglas R Fields
    Section on Nervous System Development and Plasticity, National Institute of Child Health and Human Development NICHD, NIH, Bethesda, Maryland, USA
    Curr Protoc Neurosci . 2009
    ..Although the protocols described here concern spinal networks in culture or an intact in vitro preparation, they can be, and have been, widely used in other parts of the nervous system...
  9. ncbi request reprint Electroporation loading of calcium-sensitive dyes into the CNS
    Agnes Bonnot
    Laboratory of Neural Control, Section on Developmental Neurobiology, NINDS, National Institutes of Health, 35 Convent Dr, Rm 3C1010, Bethesda, MD 20892, USA
    J Neurophysiol 93:1793-808. 2005
    ..We show that these different motor behaviors are characterized by distinct patterns of activation among the labeled populations of cells...
  10. ncbi request reprint Locomotor-like activity generated by the neonatal mouse spinal cord
    Agnes Bonnot
    Laboratory of Neural Control, Section on Developmental Neurobiology, NINDS, NIH, Bethesda, MD 20892, USA
    Brain Res Brain Res Rev 40:141-51. 2002
    ..Finally, our data are discussed in the context of other models of locomotion in lower and higher vertebrates...
  11. ncbi request reprint Transduction of motor neurons and muscle fibers by intramuscular injection of HIV-1-based vectors pseudotyped with select rabies virus glycoproteins
    George Z Mentis
    Developmental Neurobiology Section, Basic Neuroscience Program, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 3700, USA
    J Neurosci Methods 157:208-17. 2006
    ..These transduction efficiencies may allow novel approaches to functional studies of the motor system and the treatment of neuromuscular disease...
  12. pmc Ventrolateral origin of each cycle of rhythmic activity generated by the spinal cord of the chick embryo
    Yoshiyasu Arai
    Laboratory of Neural Control, Section on Developmental Neurobiology, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland, United States of America
    PLoS ONE 2:e417. 2007
    ..Here we investigate whether the activity of motoneurons occurs before other neuronal populations at the beginning of each cycle of rhythmic discharge...
  13. pmc Functionally reduced sensorimotor connections form with normal specificity despite abnormal muscle spindle development: the role of spindle-derived neurotrophin 3
    Neil A Shneider
    Section on Developmental Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 29:4719-35. 2009
    ..These findings indicate that spindle-derived factors regulate the strength of the connections but not their initial formation or their specificity...
  14. ncbi request reprint Chloride-sensitive MEQ fluorescence in chick embryo motoneurons following manipulations of chloride and during spontaneous network activity
    Nikolai Chub
    Laboratory of Neural Control, NINDS NIH, Rm 3BC911, 35 Convent Dr, Bethesda, MD 20892 3700, USA
    J Neurophysiol 95:323-30. 2006
    ....
  15. ncbi request reprint Spatiotemporal pattern of motoneuron activation in the rostral lumbar and the sacral segments during locomotor-like activity in the neonatal mouse spinal cord
    Agnes Bonnot
    Laboratory of Neural Control, Section on Developmental Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 22:RC203. 2002
    ..It is hypothesized that this behavior may simplify the appropriate sequencing of motoneurons during locomotion...