Cathy Mendelsohn

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Stromal cells mediate retinoid-dependent functions essential for renal development
    C Mendelsohn
    Columbia University, Department of Urology, New York, NY 10032, USA
    Development 126:1139-48. 1999
  2. pmc The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface
    Lorraine Clark
    Institute for Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, NY, USA
    BMC Genet 3:11. 2002
  3. pmc Going in circles: conserved mechanisms control radial patterning in the urinary and digestive tracts
    Cathy Mendelsohn
    Department of Urology, Columbia University, New York, New York 10032, USA
    J Clin Invest 116:635-7. 2006
  4. pmc Functional obstruction: the renal pelvis rules
    Cathy Mendelsohn
    Department of Urology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 113:957-9. 2004
  5. ncbi request reprint Stromal progenitors are important for patterning epithelial and mesenchymal cell types in the embryonic kidney
    Randy Levinson
    Department of Urology, Columbia University, 650 West 168th Street, New York, NY 10032, USA
    Semin Cell Dev Biol 14:225-31. 2003
  6. pmc Non-cell-autonomous retinoid signaling is crucial for renal development
    Carolina Rosselot
    Department of Urology, Columbia University, New York, New York 10032 USA
    Development 137:283-92. 2010
  7. pmc Retinoid signaling in progenitors controls specification and regeneration of the urothelium
    Devangini Gandhi
    Departments of Urology, Genetics, and Development and Pathology, Columbia University, 1130 St Nicholas Avenue, New York, NY 10032, USA
    Dev Cell 26:469-82. 2013
  8. pmc Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice
    Ian Chia
    Department of Urology, Columbia University, 1130 St Nicholas Avenue, New York, NY 10032, USA
    Development 138:2089-97. 2011
  9. pmc Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis
    Xuan Chi
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Dev Cell 17:199-209. 2009
  10. ncbi request reprint Retinoid inactivation: survival factor for male germ cells
    William S Blaner
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Endocrinology 148:4557-9. 2007

Research Grants

  1. CORE--ANIMAL FACILITY
    Cathy Mendelsohn; Fiscal Year: 2002
  2. Molecular Events in Urinary Tract Formation
    Cathy Mendelsohn; Fiscal Year: 2009
  3. Molecular Events in Urinary Tract Formation
    Cathy Mendelsohn; Fiscal Year: 2009
  4. Molecular Events in Urinary Tract Formation
    Cathy Mendelsohn; Fiscal Year: 2007
  5. Molecular Events in Urinary Tract Formation
    Cathy Mendelsohn; Fiscal Year: 2006
  6. Molecular Events in Urinary Tract Formation
    Cathy Mendelsohn; Fiscal Year: 2005
  7. Molecular Events in Urinary Tract Formation
    Cathy Mendelsohn; Fiscal Year: 2004
  8. Molecular Events in Urinary Tract Formation
    Cathy Mendelsohn; Fiscal Year: 2003
  9. Molecular Events in Urinary Tract Formation
    Cathy L Mendelsohn; Fiscal Year: 2010

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Stromal cells mediate retinoid-dependent functions essential for renal development
    C Mendelsohn
    Columbia University, Department of Urology, New York, NY 10032, USA
    Development 126:1139-48. 1999
    ..Since c-ret signaling is required for ureteric bud morphogenesis, loss of c-ret expression is a likely cause of impaired ureteric bud branching in RARalpha beta2(-) mutants...
  2. pmc The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface
    Lorraine Clark
    Institute for Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, NY, USA
    BMC Genet 3:11. 2002
    ..Although other genes in this chromosomal region show conserved synteny with genes on human Chr11p15.5, there are no obvious human orthologues of Tnfrh1 or Tnfrh2...
  3. pmc Going in circles: conserved mechanisms control radial patterning in the urinary and digestive tracts
    Cathy Mendelsohn
    Department of Urology, Columbia University, New York, New York 10032, USA
    J Clin Invest 116:635-7. 2006
    ..Deletion of Tbx18 resulted in defective urothelial differentiation at the level of the ureter, suggesting that Tbx18 acts via mesenchyme as an important regulator of A-P patterning in the urinary tract...
  4. pmc Functional obstruction: the renal pelvis rules
    Cathy Mendelsohn
    Department of Urology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 113:957-9. 2004
    ..New animal models reveal molecular pathways important for peristalsis and point to the central role of the renal pelvis in urine transport...
  5. ncbi request reprint Stromal progenitors are important for patterning epithelial and mesenchymal cell types in the embryonic kidney
    Randy Levinson
    Department of Urology, Columbia University, 650 West 168th Street, New York, NY 10032, USA
    Semin Cell Dev Biol 14:225-31. 2003
    ....
  6. pmc Non-cell-autonomous retinoid signaling is crucial for renal development
    Carolina Rosselot
    Department of Urology, Columbia University, New York, New York 10032 USA
    Development 137:283-92. 2010
    ....
  7. pmc Retinoid signaling in progenitors controls specification and regeneration of the urothelium
    Devangini Gandhi
    Departments of Urology, Genetics, and Development and Pathology, Columbia University, 1130 St Nicholas Avenue, New York, NY 10032, USA
    Dev Cell 26:469-82. 2013
    ..These observations have important implications for tissue engineering and repair and, ultimately, may lead to treatments that prevent loss of the urothelial barrier, a major cause of voiding dysfunction and bladder pain syndrome. ..
  8. pmc Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice
    Ian Chia
    Department of Urology, Columbia University, 1130 St Nicholas Avenue, New York, NY 10032, USA
    Development 138:2089-97. 2011
    ....
  9. pmc Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis
    Xuan Chi
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Dev Cell 17:199-209. 2009
    ..Thus, both Ret-dependent cell movements and Ret-independent changes in the Wolffian duct epithelium contribute to ureteric bud formation...
  10. ncbi request reprint Retinoid inactivation: survival factor for male germ cells
    William S Blaner
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Endocrinology 148:4557-9. 2007
  11. ncbi request reprint Formation and regeneration of the urothelium
    Tammer Yamany
    aDepartment of Urology bDepartment of Genetics and Development cDepartment of Pathology, Columbia University, New York, New York, USA
    Curr Opin Organ Transplant 19:323-30. 2014
    ..Understanding urothelial differentiation will be important in the push to find new methods of bladder reconstruction and augmentation, as well as identification of bladder cancer stem cells...
  12. pmc A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse
    Francesca Lugani
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, United States of America
    PLoS Genet 9:e1003206. 2013
    ..This striking example of an enhancer mutation resulting in profound developmental defects suggests that disruption of conserved regulatory elements may also contribute to human malformation syndromes...
  13. pmc Stromal protein Ecm1 regulates ureteric bud patterning and branching
    Suneeta S Paroly
    Department of Urology, Irving Cancer Research Center, Columbia University, New York, New York, United States of America
    PLoS ONE 8:e84155. 2013
    ..We propose a model in which retinoid signaling in the stroma activates expression of Ecm1, which in turn down-regulates Ret expression in the ureteric bud cleft, where bifurcation normally occurs and normal branching progresses. ..
  14. ncbi request reprint Regulated expression of ATF5 is required for the progression of neural progenitor cells to neurons
    James M Angelastro
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 23:4590-600. 2003
    ..These findings indicate that ATF5 blocks the differentiation of neuroprogenitor cells into neurons and must be downregulated to permit this process to occur...
  15. ncbi request reprint The development of the bladder trigone, the center of the anti-reflux mechanism
    Renata Viana
    Columbia University, Department of Urology, 650 West 168th Street, New York, NY 10032, USA
    Development 134:3763-9. 2007
    ..These studies suggest that urinary tract development occurs differently than previously thought, providing new insights into the mechanisms underlying normal and abnormal development...
  16. ncbi request reprint Lack of major involvement of human uroplakin genes in vesicoureteral reflux: implications for disease heterogeneity
    Songshan Jiang
    Epithelial Biology Unit, Ronald O Perelman Department of Dermatology, Kaplan Comprehensive Cancer Center, New York University Medical School, New York, New York, USA
    Kidney Int 66:10-9. 2004
    ..Recent studies indicate that genetic ablation of mouse uroplakin (UP) III gene, which encodes a 47 kD urothelial-specific integral membrane protein forming urothelial plaques, causes VUR and hydronephrosis...
  17. ncbi request reprint Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency
    Loredana Quadro
    Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Endocrinology 146:4479-90. 2005
    ..Finally, we demonstrate that accumulation of embryonic vitamin A stores does not depend on the expression of RBP in the fetal liver...
  18. ncbi request reprint Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development
    Randy S Levinson
    Department of Urology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Development 132:529-39. 2005
    ....
  19. ncbi request reprint Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development
    Akio Kobayashi
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 132:2809-23. 2005
    ..We also demonstrate that the nephric duct is essential for the elongation and maintenance of the adjacent Mullerian duct, the anlage of the female reproductive tract...
  20. ncbi request reprint c-kit delineates a distinct domain of progenitors in the developing kidney
    Kai M Schmidt-Ott
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Dev Biol 299:238-49. 2006
    ..These data suggest that ureteric bud-derived SCF elicits growth-promoting effects in the metanephric kidney by expanding one or more components of the interstitial c-kit-positive progenitor pool...
  21. ncbi request reprint Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret
    Ekatherina Batourina
    Department of Urology, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Nat Genet 32:109-15. 2002
    ..Our studies indicate that formation of the trigonal wedge may be essential for correct insertion of the distal ureters into the bladder, and that these events are mediated by the vitamin A and Ret signaling pathways...
  22. ncbi request reprint Apoptosis induced by vitamin A signaling is crucial for connecting the ureters to the bladder
    Ekatherina Batourina
    Columbia University, Department of Urology, 650 West 168th Street, New York, New York 10032, USA
    Nat Genet 37:1082-9. 2005
    ..These studies provide an explanation for ureter defects underlying some forms of obstruction in humans and redefine the current model of ureter maturation...

Research Grants11

  1. CORE--ANIMAL FACILITY
    Cathy Mendelsohn; Fiscal Year: 2002
    ..To facilitate the sharing of animals, data and ideas between the individual research projects. ..
  2. Molecular Events in Urinary Tract Formation
    Cathy Mendelsohn; Fiscal Year: 2009
    ..Understanding the normal mechanism by which RA and Ret regulate ureter insertion will lead to a deeper understand of the causes of LUT obstruction in humans. ..
  3. Molecular Events in Urinary Tract Formation
    Cathy Mendelsohn; Fiscal Year: 2009
    ..These findings should help in our general understanding of the abnormalities underlying urinary tract birth defects in humans and may help to identify new ways to intervene or repair urinary tract malformations in newborns. ..
  4. Molecular Events in Urinary Tract Formation
    Cathy Mendelsohn; Fiscal Year: 2007
    ..Results of these experiments will ultimately provide insight into the cellular and molecular defects causing urogenital abnormalities. ..
  5. Molecular Events in Urinary Tract Formation
    Cathy Mendelsohn; Fiscal Year: 2006
    ..Results of these experiments will ultimately provide insight into the cellular and molecular defects causing urogenital abnormalities. ..
  6. Molecular Events in Urinary Tract Formation
    Cathy Mendelsohn; Fiscal Year: 2005
    ..Results of these experiments will ultimately provide insight into the cellular and molecular defects causing urogenital abnormalities. ..
  7. Molecular Events in Urinary Tract Formation
    Cathy Mendelsohn; Fiscal Year: 2004
    ..Results of these experiments will ultimately provide insight into the cellular and molecular defects causing urogenital abnormalities. ..
  8. Molecular Events in Urinary Tract Formation
    Cathy Mendelsohn; Fiscal Year: 2003
    ..Results of these experiments will ultimately provide insight into the cellular and molecular defects causing urogenital abnormalities. ..
  9. Molecular Events in Urinary Tract Formation
    Cathy L Mendelsohn; Fiscal Year: 2010
    ..These findings should help in our general understanding of the abnormalities underlying urinary tract birth defects in humans and may help to identify new ways to intervene or repair urinary tract malformations in newborns. ..