Guy M McKhann

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Intraoperative hippocampal electrocorticography to predict the extent of hippocampal resection in temporal lobe epilepsy surgery
    G M McKhann
    Department of Neurological Surgery, University of Washington, Seattle, USA
    J Neurosurg 93:44-52. 2000
  2. ncbi request reprint Novel surgical treatments for epilepsy
    Guy M McKhann
    Department of Neurological Surgery, Columbia University Medical Center, Neurological Institute Room 428, 710 West 168th Street, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 4:335-9. 2004
  3. pmc Hippocampal removal affects visual but not auditory naming
    Marla J Hamberger
    The Neurological Institute, New York, NY 10032, USA
    Neurology 74:1488-93. 2010
  4. ncbi request reprint Randomized study of paclitaxel and tamoxifen deposition into human brain tumors: implications for the treatment of metastatic brain tumors
    Robert L Fine
    Experimental Therapeutics Program, Division of Medical Oncology, Neurological Institute of New York, College of Physicians and Surgeons, Columbia University, 650 West 168th Street, New York, NY 10032, USA
    Clin Cancer Res 12:5770-6. 2006
  5. ncbi request reprint A technique for minimally altering anatomically based subthalamic electrode targeting by microelectrode recording
    Patrick B Senatus
    Department of Neurological Surgery, Neurological Institute of New York, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Neurosurg Focus 20:E8. 2006
  6. pmc Does cortical mapping protect naming if surgery includes hippocampal resection?
    Marla J Hamberger
    Department of Neurology, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032, USA
    Ann Neurol 67:345-52. 2010
  7. ncbi request reprint Critical postcraniotomy cerebrospinal fluid hypovolemia: risk factors and outcome analysis
    Ricardo J Komotar
    Department of Neurosurgery, Columbia University, New York, New York 10032, USA
    Neurosurgery 59:284-90; discussion 284-90. 2006
  8. ncbi request reprint Distribution of auditory and visual naming sites in nonlesional temporal lobe epilepsy patients and patients with space-occupying temporal lobe lesions
    Marla J Hamberger
    Department of Neurology, College of Physicians and Surgeons, Colombia University, New York, NY, USA
    Epilepsia 48:531-8. 2007
  9. doi request reprint The mTOR pathway is activated in glial cells in mesial temporal sclerosis
    Alexander A Sosunov
    Department of Neurosurgery, The Neurological Institute, Columbia University, 710 W 168th Street, New York, NY 10032, U S A
    Epilepsia 53:78-86. 2012
  10. ncbi request reprint Subthalamic stimulation for Parkinson disease: determination of electrode location necessary for clinical efficacy
    Shearwood McClelland
    Department of Neurological Surgery and Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Neurosurg Focus 19:E12. 2005

Research Grants

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Intraoperative hippocampal electrocorticography to predict the extent of hippocampal resection in temporal lobe epilepsy surgery
    G M McKhann
    Department of Neurological Surgery, University of Washington, Seattle, USA
    J Neurosurg 93:44-52. 2000
    ..Whether all patients require a maximal hippocampal resection has not yet been determined...
  2. ncbi request reprint Novel surgical treatments for epilepsy
    Guy M McKhann
    Department of Neurological Surgery, Columbia University Medical Center, Neurological Institute Room 428, 710 West 168th Street, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 4:335-9. 2004
    ..Further surgical developments that will be ready for human application in the near future are highlighted...
  3. pmc Hippocampal removal affects visual but not auditory naming
    Marla J Hamberger
    The Neurological Institute, New York, NY 10032, USA
    Neurology 74:1488-93. 2010
    ..We speculated that unlike visual naming, the hippocampus is not involved in auditory naming, and hypothesized that left AMTLR would not result in auditory naming decline, despite visual naming and verbal memory decline...
  4. ncbi request reprint Randomized study of paclitaxel and tamoxifen deposition into human brain tumors: implications for the treatment of metastatic brain tumors
    Robert L Fine
    Experimental Therapeutics Program, Division of Medical Oncology, Neurological Institute of New York, College of Physicians and Surgeons, Columbia University, 650 West 168th Street, New York, NY 10032, USA
    Clin Cancer Res 12:5770-6. 2006
    ..Tamoxifen is a nontoxic inhibitor of P-glycoprotein. This trial assessed, in primary and metastatic brain tumors, the differential deposition of paclitaxel and whether tamoxifen could increase paclitaxel deposition...
  5. ncbi request reprint A technique for minimally altering anatomically based subthalamic electrode targeting by microelectrode recording
    Patrick B Senatus
    Department of Neurological Surgery, Neurological Institute of New York, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Neurosurg Focus 20:E8. 2006
    ....
  6. pmc Does cortical mapping protect naming if surgery includes hippocampal resection?
    Marla J Hamberger
    Department of Neurology, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032, USA
    Ann Neurol 67:345-52. 2010
    ..We sought to determine whether preservation of visual naming sites identified via cortical stimulation mapping protects against naming decline when resection includes the hippocampal region...
  7. ncbi request reprint Critical postcraniotomy cerebrospinal fluid hypovolemia: risk factors and outcome analysis
    Ricardo J Komotar
    Department of Neurosurgery, Columbia University, New York, New York 10032, USA
    Neurosurgery 59:284-90; discussion 284-90. 2006
    ..We sought to identify risk factors for critical CSF hypovolemia and determine this syndrome's effect on clinical outcome...
  8. ncbi request reprint Distribution of auditory and visual naming sites in nonlesional temporal lobe epilepsy patients and patients with space-occupying temporal lobe lesions
    Marla J Hamberger
    Department of Neurology, College of Physicians and Surgeons, Colombia University, New York, NY, USA
    Epilepsia 48:531-8. 2007
    ..We sought to determine whether space-occupying temporal lobe lesions are associated with a similar topography of language sites, as this information would be useful in surgical planning...
  9. doi request reprint The mTOR pathway is activated in glial cells in mesial temporal sclerosis
    Alexander A Sosunov
    Department of Neurosurgery, The Neurological Institute, Columbia University, 710 W 168th Street, New York, NY 10032, U S A
    Epilepsia 53:78-86. 2012
    ..These findings suggest that the astroglial "scar" in sclerotic MTLE has active, ongoing cellular changes. Targeting mTOR in MTLE may provide new pathways for the medical therapy of epilepsy...
  10. ncbi request reprint Subthalamic stimulation for Parkinson disease: determination of electrode location necessary for clinical efficacy
    Shearwood McClelland
    Department of Neurological Surgery and Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Neurosurg Focus 19:E12. 2005
    ..This study was performed to examine these issues...
  11. ncbi request reprint [Disparities in access to deep brain stimulation surgery for Parkinson disease: interaction between African American race and Medicaid use]
    Andrew K Chan
    Department of Neurological Surgery, Columbia University Medical Center, New York, New York
    JAMA Neurol 71:291-9. 2014
    ..To improve health care in this patient population, it is important to recognize and study the potential factors limiting access to care...
  12. doi request reprint The survival impact of postoperative infection in patients with glioblastoma multiforme
    Leif Erik Bohman
    Department of Neurological Surgery, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Neurosurgery 64:828-34; discussion 834-5. 2009
    ..This association has not been explored in a larger series of patients with malignant glioma with postoperative infections...
  13. ncbi request reprint Microelectrode recording-determined subthalamic nucleus length not predictive of stimulation-induced side effects
    Shearwood McClelland
    Department of Neurological Surgery, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Neurosurg Focus 19:E13. 2005
    ..This study was performed to evaluate the relationship between mapping of the STN by using MER and postoperative stimulation-induced side effects...
  14. pmc Mechanisms underlying selective neuronal tracking of attended speech at a "cocktail party"
    Elana M Zion Golumbic
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuron 77:980-91. 2013
    ..In higher-order regions, the representation appears to become more "selective," in that there is no detectable tracking of ignored speech. This selectivity itself seems to sharpen as a sentence unfolds...
  15. pmc Motor deficits correlate with resting state motor network connectivity in patients with brain tumours
    Marc L Otten
    Department of Neurosurgery, Columbia University, 710 West 168th Street, Suite 4 404, New York, NY 10032, USA
    Brain 135:1017-26. 2012
    ..Motor networks become weaker as the subjects become weaker, and may become strong again during motor recovery...
  16. doi request reprint Cervical spine disease may result in a negative lumbar spinal drainage trial in normal pressure hydrocephalus: case report
    Ricardo J Komotar
    Department of Neurosurgery, Columbia University, New York, New York 10032, USA
    Neurosurgery 63:315; discussion 315. 2008
    ..In this case report, we present a patient with normal pressure hydrocephalus in whom a lumbar drainage trial yielded a false-negative result secondary to cervical spondylosis...
  17. pmc Initial surgical experience with a dense cortical microarray in epileptic patients undergoing craniotomy for subdural electrode implantation
    Allen Waziri
    Department of Neurosurgery, The Neurological Institute, Columbia University, New York, New York 10032, USA
    Neurosurgery 64:540-5; discussion 545. 2009
    ..Salt Lake City, UT) in a series of patients undergoing subdural electrode implantation for epilepsy monitoring...
  18. pmc Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
    Heng Du
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:18670-5. 2010
    ....
  19. pmc Ictal high frequency oscillations distinguish two types of seizure territories in humans
    Shennan A Weiss
    1 Department of Neurology, Columbia University, New York, NY, USA
    Brain 136:3796-808. 2013
    ..Our observations suggest that it may be possible to reduce substantially the extent of cortical resections in epilepsy surgery procedures without compromising seizure control. ..
  20. doi request reprint Features and timing of the response of single neurons to novelty in the substantia nigra
    Charles B Mikell
    Columbia University Medical Center, Department of Neurological Surgery, 710W 168th Street, New York, NY 10032, United States Electronic address
    Brain Res 1542:79-84. 2014
    ..Our data provide human validation of the purported role of dopamine neurons in novelty detection and suggest modifications to proposed models of novelty detection circuitry...
  21. pmc Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease
    Alexander A Sosunov
    Department of Neurosurgery and Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
    J Neurosci 33:7439-50. 2013
    ....
  22. ncbi request reprint Postoperative hydrocephalus in patients undergoing decompressive hemicraniectomy for ischemic or hemorrhagic stroke
    Allen Waziri
    Department of Neurological Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Neurosurgery 61:489-93; discussion 493-4. 2007
    ....
  23. ncbi request reprint Lack of B7 expression, not human leukocyte antigen expression, facilitates immune evasion by human malignant gliomas
    Richard C E Anderson
    Department of Neurological Surgery, The Neurological Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Neurosurgery 60:1129-36; discussion 1136. 2007
    ..Lack of human leukocyte antigens and costimulatory molecules have been suggested as mechanisms by which human malignant gliomas avoid immune recognition and elimination...
  24. doi request reprint Tuberous sclerosis: a primary pathology of astrocytes?
    Alexander A Sosunov
    Neurological Surgery, Columbia University, New York, New York 10032, USA
    Epilepsia 49:53-62. 2008
    ..We hypothesize that the development of astrogliosis in cortical tubers constitutes a primary pathology of astrocytes and is directly related to TSC 1/2 mutations...
  25. ncbi request reprint Ventriculoperitoneal shunting of idiopathic normal pressure hydrocephalus increases midbrain size: a potential mechanism for gait improvement
    J Mocco
    Department of Neurological Surgery, Columbia University, New York, New York 10032, USA
    Neurosurgery 59:847-50; discussion 850-1. 2006
    ..The current study was undertaken to determine the effect of ventriculoperitoneal shunt placement on midbrain dimensions in INPH patients...
  26. doi request reprint Identification of A2B5+CD133- tumor-initiating cells in adult human gliomas
    Alfred T Ogden
    Department of Neurological Surgery, The Neurological Institute, Columbia University, New York, New York 10032, USA
    Neurosurgery 62:505-14; discussion 514-5. 2008
    ..However, human gliomas also contain an abundance of cells that closely resemble more differentiated glial progenitors. Animal model studies have shown that these cells also possess the capacity to form malignant gliomas...
  27. ncbi request reprint Radiographic characteristics fail to predict clinical course after subdural electrode placement
    J Mocco
    Department of Neurological Surgery, Columbia University, New York Presbyterian Hospital, New York, New York, USA
    Neurosurgery 58:120-5; discussion 120-5. 2006
    ..To facilitate treatment decision-making in postoperative subdural electrode patients, we reviewed and compared the computed tomographic (CT) features of postelectrode placement EACs in asymptomatic and symptomatic patients...
  28. pmc Alexander disease mutant glial fibrillary acidic protein compromises glutamate transport in astrocytes
    Rujin Tian
    Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA
    J Neuropathol Exp Neurol 69:335-45. 2010
    ..These results indicate that aberrant astrocytes have decreased glutamate uptake, which may play an important role in the pathogenesis of neuronal and oligodendrocyte injury and death in AxD...
  29. ncbi request reprint Brain stimulation reveals critical auditory naming cortex
    Marla J Hamberger
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Brain 128:2742-9. 2005
    ..These findings not only have potentially critical clinical significance, but also argue for modality specificity, with considerable integration within the semantic system...
  30. doi request reprint Epidermoid tumors of the temporal lobe as epileptogenic foci
    Simon J Hanft
    Department of Neurological Surgery, Columbia University, New York, NY, USA
    J Clin Neurosci 18:1396-9. 2011
    ..Our clinical experience and review of the literature indicate that gross total resection of these lesions confers control of localization-related epilepsy...
  31. ncbi request reprint Defective receptor expression and dendritic cell differentiation of monocytes in glioblastomas
    Alfred T Ogden
    Department of Neurological Surgery, The Neurological Institute, Columbia University, New York, New York 10032, USA
    Neurosurgery 59:902-9; discussion 909-10. 2006
    ..This study seeks to develop understanding of the phenotypic changes that occur in circulating monocytes of patients with intracranial cancer and to assess the ability of these cells to differentiate into mature dendritic cells...
  32. pmc Tuning of the human neocortex to the temporal dynamics of attended events
    Julien Besle
    Department of Psychiatry, Columbia University, New York, New York 10032, USA
    J Neurosci 31:3176-85. 2011
    ..Thus, attentional entrainment appears to tune a network of brain areas to the temporal dynamics of behaviorally relevant event streams, contributing to its perceptual and behavioral selection...
  33. doi request reprint Pre-operative intracranial meningioma embolization
    Jason A Ellis
    Department of Neurological Surgery, Neurological Institute of New York, Columbia University Medical Center, 710 West 168th Street, New York, NY 10032, USA
    Expert Rev Neurother 11:545-56. 2011
    ..In this article, we examine the principles of meningioma embolization, emphasizing the indications, risks and benefits associated with its use in the pre-operative setting...
  34. ncbi request reprint Herniation secondary to critical postcraniotomy cerebrospinal fluid hypovolemia
    Ricardo J Komotar
    Department of Neurosurgery, Columbia University, New York, New York 10032, USA
    Neurosurgery 57:286-92; discussion 286-92. 2005
    ..This article describes the clinical features of brain sag after craniotomy in an attempt to increase recognition of this syndrome...
  35. ncbi request reprint Clinicopathological review: tumefactive demyelination in a 12-year-old girl
    Richard C E Anderson
    Division of Pediatric Neurosurgery, Primary Children s Medical Center and the University of Utah, Salt Lake City, Utah, USA
    Neurosurgery 56:1051-7; discussion 1051-7. 2005
  36. ncbi request reprint Evidence for cortical reorganization of language in patients with hippocampal sclerosis
    Marla J Hamberger
    Department of Neurology, College of Physicians and Surgeons, Columbia University, USA
    Brain 130:2942-50. 2007
    ..The different patterns of naming areas identified in patients with and without HS may also carry clinical implications, potentially improving efficiency during the time-constrained process of stimulation mapping...
  37. doi request reprint Inferior short-term safety profile of endoscopic third ventriculostomy compared with ventriculoperitoneal shunt placement for idiopathic normal-pressure hydrocephalus: a population-based study
    Andrew K Chan
    Department of Neurological Surgery, Columbia University Medical Center, New York, New York
    Neurosurgery 73:951-60; discussion 960-1. 2013
    ..Therefore, some clinicians have advocated for ETV to avoid the potential long-term complications associated with VPS. Complication rates for these procedures vary widely based on limited small series data...
  38. doi request reprint Beneficial use of a new hand-held CO2 laser fiber in resection of a calcified and vascular intraventricular tumor
    Hani R Malone
    Department of Neurosurgery, Columbia University Medical Center, Columbia University, College of Physicians and Surgeons, New York City, New York, USA
    World Neurosurg 78:191.E9-14. 2012
    ....
  39. ncbi request reprint Novel surgical therapies for epilepsy
    Guy M McKhann
    Department of Neurological Surgery, Columbia University, New York Presbyterian Hospital, New York, New York, USA
    Clin Neurosurg 53:179-84. 2006
  40. ncbi request reprint Functional separation of languages in the bilingual brain: a comparison of electrical stimulation language mapping in 25 bilingual patients and 117 monolingual control patients
    Timothy H Lucas
    Department of Neurological Surgery, University of Washington, Seattle, Washington 98195 6470, USA
    J Neurosurg 101:449-57. 2004
    ..Sites were photographically recorded and plotted onto an anatomically referenced grid system. Language organization in bilinguals was then compared with that in 117 monolinguals and 11 monolingual children...
  41. pmc The hippocampus and nucleus accumbens as potential therapeutic targets for neurosurgical intervention in schizophrenia
    Charles B Mikell
    Department of Neurological Surgery, Columbia University, New York, NY 10032, USA
    Stereotact Funct Neurosurg 87:256-65. 2009
    ..Thus, we suggest a direction for further experimentation aimed at developing neurosurgical therapeutic approaches for this devastating disease...
  42. pmc An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
    Ana C Pereira
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:5638-43. 2007
    ....
  43. ncbi request reprint Decompressive hemicraniectomy for poor-grade aneurysmal subarachnoid hemorrhage patients with associated intracerebral hemorrhage: clinical outcome and quality of life assessment
    Anthony L D'Ambrosio
    Department of Neurological Surgery, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Neurosurgery 56:12-9; dicussion 19-20. 2005
    ..Although hemicraniectomy improves overall survival rates, the long-term quality of life (QoL) for survivors in this patient population has not been reported...
  44. pmc Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
    Heng Du
    Department of Surgery, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Nat Med 14:1097-105. 2008
    ..Blockade of CypD may be a therapeutic strategy in Alzheimer's disease...
  45. doi request reprint Intra-abdominal vascular injury during trocar-assisted ventriculoperitoneal shunting: case report
    Deepa Danan
    Department of Neurological Surgery, Columbia University Medical Center, New York, New York 10032, USA
    Neurosurgery 63:E613; discussion E613. 2008
    ..To increase awareness of this very serious risk, we report a case of intra-abdominal vascular injury during a shunt procedure involved with a common neurosurgical procedure...
  46. ncbi request reprint Epilepsy surgery: indications, approaches, and results
    Guy M McKhann
    Department of Neurological Surgery, Columbia University, New York, New York, USA
    Semin Neurol 22:269-78. 2002
    ..Newer surgical techniques including vagus nerve and deep brain stimulation and gamma knife radiosurgery are also discussed...
  47. ncbi request reprint Implantation of bilateral deep brain stimulators in patients with Parkinson disease and preexisting cardiac pacemakers. Report of two cases
    Patrick B Senatus
    Department of Neurological Surgery, Columbia College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosurg 101:1073-7. 2004
    ..To our knowledge, this is the first report on patients with cardiac pacemakers undergoing brain stimulator implantation...
  48. ncbi request reprint Tamoxifen paradoxically decreases paclitaxel deposition into cerebrospinal fluid of brain tumor patients
    Johnson Chen
    Experimental Therapeutics Program, Division of Medical Oncology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Neurooncol 76:85-92. 2006
    ..We conducted a prospective, randomized study to assess if Pgp inhibition by TAM alters deposition of paclitaxel in cerebrospinal fluid (CSF)...
  49. ncbi request reprint Salomón Hakim and the discovery of normal-pressure hydrocephalus
    Matthew B Wallenstein
    Department of Neurological Surgery, The Neurological Institute, Columbia University, 710 W 168th St, New York, NY 10032, USA
    Neurosurgery 67:155-9; discussion 159. 2010
    ..Salomón Hakim first identified the syndrome in 1957 at the Hospital San Juan de Dios in Bogotá, Colombia. Even after decades of international focus and thousands of publications on his disorder, Hakim's story remains largely untold...
  50. ncbi request reprint Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain
    Martha S Windrem
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York 10021, USA
    J Neurosci Res 69:966-75. 2002
    ..This being the case, they may constitute appropriate vectors for cell-based remyelination strategies...
  51. ncbi request reprint Diffusion- and perfusion-weighted magnetic resonance imaging of the brain before and after coronary artery bypass grafting surgery
    Lucas Restrepo
    Departments of Neurology, Zanvyl Krieger Mind Brain Institute, Johns Hopkins University, Baltimore, MD, USA
    Stroke 33:2909-15. 2002
    ..We sought to determine whether focal PWI and DWI abnormalities could occur after CABG, particularly in patients without any measurable neurological deterioration...
  52. ncbi request reprint Electrophysiological and morphological characterization of dentate astrocytes in the hippocampus
    Masako Isokawa
    Department of Physiology, University of Maryland, 655 W Baltimore Street, Baltimore, Maryland 21201, USA
    J Neurobiol 65:125-34. 2005
    ..Dentate astrocytes may possess a distinct current profile that is different from those in CA1/3 Ammon's horn...
  53. ncbi request reprint Neurocognitive complications after coronary artery bypass surgery
    Ola A Selnes
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Ann Neurol 57:615-21. 2005
    ..Thus, whereas both short- and long-term postoperative cognitive changes have been associated with CABG, only the short-term, transient changes appear to be directly related to the use of cardiopulmonary bypass...
  54. ncbi request reprint Stroke and encephalopathy after cardiac surgery: an update
    Guy M McKhann
    Department of Neurology, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Stroke 37:562-71. 2006
    ..As surgical mortality has declined in recent years, attention has focused on the complications of stroke and encephalopathy after cardiac surgery...
  55. ncbi request reprint Self-reported memory symptoms with coronary artery disease: a prospective study of CABG patients and nonsurgical controls
    Ola A Selnes
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cogn Behav Neurol 17:148-56. 2004
    ..We compared the incidence of self-reported memory symptoms at 3 and 12 months after CABG with that of a control group of patients with comparable risk factors for coronary artery disease but without surgery...
  56. ncbi request reprint Cognitive outcomes three years after coronary artery bypass surgery: a comparison of on-pump coronary artery bypass graft surgery and nonsurgical controls
    Ola A Selnes
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 1910, USA
    Ann Thorac Surg 79:1201-9. 2005
    ....
  57. ncbi request reprint Watershed strokes after cardiac surgery: diagnosis, etiology, and outcome
    Rebecca F Gottesman
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Stroke 37:2306-11. 2006
    ..We investigated the role of intraoperative blood pressure in the development of watershed strokes and used MRI to evaluate diagnosis and outcomes associated with this stroke subtype...
  58. ncbi request reprint Clinicopathological review: primary angiitis of the central nervous system in association with cerebral amyloid angiopathy
    Rafael J Tamargo
    Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, Maryland, USA
    Neurosurgery 53:136-43; discussion 143. 2003
  59. ncbi request reprint Cognitive changes with coronary artery disease: a prospective study of coronary artery bypass graft patients and nonsurgical controls
    Ola A Selnes
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ann Thorac Surg 75:1377-84; discussion 1384-6. 2003
    ..We compared changes in cognitive performance at 3 and 12 months after CABG with those in a control group of patients with comparable risk factors for coronary artery disease (CAD) who had not undergone surgery...
  60. ncbi request reprint Differential distribution of HLA-DQ beta/DR beta epitopes in the two forms of Guillain-Barré syndrome, acute motor axonal neuropathy and acute inflammatory demyelinating polyneuropathy (AIDP): identification of DQ beta epitopes associated with susceptibil
    Eleni E Magira
    Department of Pediatrics, University of Pennsylvania School of Medicine and Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Immunol 170:3074-80. 2003
    ....
  61. ncbi request reprint Encephalopathy and stroke after coronary artery bypass grafting: incidence, consequences, and prediction
    Guy M McKhann
    Zanvyl Krieger Mind Brain Institute, The Johns Hopkins University, 338 Krieger Hall, 3400 N Charles St, Baltimore, MD 21218 2685, USA
    Arch Neurol 59:1422-8. 2002
    ..In contrast to perioperative stroke, much less attention has been paid to those with evidence of diffuse brain encephalopathy, presenting as delirium, confusion, coma, and seizures in the immediate postoperative period...
  62. ncbi request reprint Staged bilateral thalamic electrode implantation utilizing frameless stereotactic guidance
    Shearwood McClelland
    Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    J Clin Neurosci 14:791-3. 2007
    ..We present a report indicating that staged deep brain electrode placement can be accurate and efficacious using a frameless skull-mounted guide...
  63. ncbi request reprint Early postoperative cognitive dysfunction and blood pressure during coronary artery bypass graft operation
    Rebecca F Gottesman
    Department of Neurology, Johns Hopkins University School of Medicine, Phipps 126, 600 N Wolfe St, Baltimore, MD 21287, USA
    Arch Neurol 64:1111-4. 2007
    ..To determine the relationship between change in blood pressure during coronary artery bypass graft operations and early cognitive dysfunction...
  64. ncbi request reprint Neurocognitive outcomes 3 years after coronary artery bypass graft surgery: a controlled study
    Ola A Selnes
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ann Thorac Surg 84:1885-96. 2007
    ..Because most studies did not include a control group, a causal link of such decline with the use of cardiopulmonary bypass has not been established...

Research Grants2

  1. Adult Subventricular Zone Gliogenesis in Limbic Epilepsy
    Guy McKhann; Fiscal Year: 2007
    ..Specific Aim 3: To determine whether selective disruption of cellular proliferation in the SVZ and the hippocampus influences glial development and epileptogenesis. ..