Richard P Mayeux

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Biomarkers: potential uses and limitations
    Richard Mayeux
    Gertrude H Sergievsky Center and the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    NeuroRx 1:182-8. 2004
  2. ncbi request reprint Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease
    Nobuto Shibata
    Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, 6 Queen s Park Crescent West, Toronto, Ont, Canada M5S 3H2
    Neurosci Lett 391:142-6. 2006
  3. ncbi request reprint Genetic epidemiology of Alzheimer disease
    Richard Mayeux
    The Taub Institute on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Alzheimer Dis Assoc Disord 20:S58-62. 2006
  4. pmc Genetic variants in the Fat and Obesity Associated (FTO) gene and risk of Alzheimer's disease
    Christiane Reitz
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
    PLoS ONE 7:e50354. 2012
  5. pmc Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP)
    C Reitz
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Transl Psychiatry 3:e256. 2013
  6. pmc Impact of genetic variation in SORCS1 on memory retention
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e24588. 2011
  7. pmc Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts
    Badri Vardarajan
    Department of Medicine Biomedical Genetics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Mol Neurodegener 8:10. 2013
  8. pmc Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
    Karolien Bettens
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, 2610 Antwerpen, Belgium
    Mol Neurodegener 7:3. 2012
  9. pmc Blood-based biomarkers for Alzheimer's disease: plasma Aβ40 and Aβ42, and genetic variants
    Richard Mayeux
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, and the Department of Neurology, Psychiatry, and Epidemiology, Columbia University, New York, NY, USA
    Neurobiol Aging 32:S10-9. 2011
  10. ncbi request reprint Familial Alzheimer disease among Caribbean Hispanics: a reexamination of its association with APOE
    Stavra N Romas
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 59:87-91. 2002

Detail Information

Publications69

  1. pmc Biomarkers: potential uses and limitations
    Richard Mayeux
    Gertrude H Sergievsky Center and the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    NeuroRx 1:182-8. 2004
    ..Causes of variability in the measurement of biomarkers range from the individual to the laboratory. Issues that affect the analysis of biomarkers are discussed along with recommendations on how to deal with bias and confounding...
  2. ncbi request reprint Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease
    Nobuto Shibata
    Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, 6 Queen s Park Crescent West, Toronto, Ont, Canada M5S 3H2
    Neurosci Lett 391:142-6. 2006
    ..Similarly, no association was found in the Caribbean Hispanic families for CH25H. However, we did observe a possible interaction between ABCA1 and APOE in the Hispanics...
  3. ncbi request reprint Genetic epidemiology of Alzheimer disease
    Richard Mayeux
    The Taub Institute on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Alzheimer Dis Assoc Disord 20:S58-62. 2006
  4. pmc Genetic variants in the Fat and Obesity Associated (FTO) gene and risk of Alzheimer's disease
    Christiane Reitz
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
    PLoS ONE 7:e50354. 2012
    ..Recent studies showed that polymorphisms in the Fat and Obesity-Associated (FTO) gene have robust effects on obesity, obesity-related traits and endophenotypes associated with Alzheimer's disease (AD)...
  5. pmc Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP)
    C Reitz
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Transl Psychiatry 3:e256. 2013
    ..More importantly, the results indicate that variants within these genes have epistatic effects on AD risk...
  6. pmc Impact of genetic variation in SORCS1 on memory retention
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e24588. 2011
    ..We now explored the effect of variation in SORCS1 on memory...
  7. pmc Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts
    Badri Vardarajan
    Department of Medicine Biomedical Genetics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Mol Neurodegener 8:10. 2013
    ..Here, we reevaluated tau pathologies in the same TgCRND8 mouse model as the previous studies...
  8. pmc Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
    Karolien Bettens
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, 2610 Antwerpen, Belgium
    Mol Neurodegener 7:3. 2012
    ....
  9. pmc Blood-based biomarkers for Alzheimer's disease: plasma Aβ40 and Aβ42, and genetic variants
    Richard Mayeux
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, and the Department of Neurology, Psychiatry, and Epidemiology, Columbia University, New York, NY, USA
    Neurobiol Aging 32:S10-9. 2011
    ..Thus, there are several types of peripheral biomarkers under investigation, but more work is required before they can be deemed clinically useful...
  10. ncbi request reprint Familial Alzheimer disease among Caribbean Hispanics: a reexamination of its association with APOE
    Stavra N Romas
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 59:87-91. 2002
    ....
  11. pmc Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 1
    Richard Mayeux
    Gertrude H Sergievsky Center, Columbia University, New York, NY, USA
    Alzheimers Dement 7:15-34. 2011
    ..Biomarkers for AD could also facilitate studies of the interactions of various forms of neurodegenerative disorders with cerebrovascular disease, resulting in "mixed dementia"...
  12. pmc Alzheimer's disease: advances in trafficking
    Richard Mayeux
    Taub Institute on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Lancet Neurol 7:2-3. 2008
  13. ncbi request reprint The neighborhood as the laboratory: looking for answers by knocking on doors
    Richard Mayeux
    Columbia University Medical Center, Sergievsky Center PH19, New York, NY 10032, USA
    Alzheimer Dis Assoc Disord 21:272-5. 2007
  14. ncbi request reprint Memory performance in healthy elderly without Alzheimer's disease: effects of time and apolipoprotein-E
    R Mayeux
    Gertrude H Sergievsky Center, School of Public Health, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Neurobiol Aging 22:683-9. 2001
    ..Transgenic mice and elderly humans without AD or QD expressing APOE-epsilon4 show a decline in memory performance over time. These observations provide evidence for an APOE-specific effect on memory during senescence...
  15. pmc Chromosome-12 mapping of late-onset Alzheimer disease among Caribbean Hispanics
    R Mayeux
    The Taub Institute on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center and Department of Neurology, School of Public Health, Columbia University, New York, NY 10032, USA
    Am J Hum Genet 70:237-43. 2002
    ..74; P=.013). This study of Caribbean Hispanics with familial AD extends and provides modest evidence of linkage to loci on chromosome 12p. Linkage varied by age at onset of AD and by the presence or absence of the APOE-epsilon 4 allele...
  16. ncbi request reprint A clinicopathological comparison of community-based and clinic-based cohorts of patients with dementia
    F Massoud
    Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons and Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Arch Neurol 56:1368-73. 1999
    ..To compare the sensitivity and specificity of the clinical diagnosis of Alzheimer disease, the distribution of pathological causes, and the demographic and clinical characteristics of 2 different groups of patients with dementia...
  17. ncbi request reprint Stroke and the risk of Alzheimer disease
    Lawrence S Honig
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, Columbia University, New York
    Arch Neurol 60:1707-12. 2003
    ..Alzheimer disease (AD) and stroke are common in elderly individuals, but the relation between these 2 disorders remains uncertain...
  18. ncbi request reprint Epidemiology of neurodegeneration
    Richard Mayeux
    The Gertrude H Sergievsky Center, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Annu Rev Neurosci 26:81-104. 2003
    ..The analysis of behavioral and genetic factors that may lower disease risk has led to clinical trials that are either in progress or being planned with the aim of preventing these disorders...
  19. pmc Mapping the new frontier: complex genetic disorders
    Richard Mayeux
    Gertrude H Sergievsky Center and Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York 10032, USA
    J Clin Invest 115:1404-7. 2005
    ..In this issue, the JCI provides readers with a series dedicated to complex genetic disorders, offering a view of genetic medicine in the 21st century...
  20. pmc Relation of plasma lipids to all-cause mortality in Caucasian, African-American and Hispanic elders
    Jennifer L Akerblom
    Department of Epidemiology, Columbia University, New York, USA
    Age Ageing 37:207-13. 2008
    ..to investigate the relation of plasma lipids to all-cause mortality in a multi-ethnic cohort of non-demented elderly...
  21. ncbi request reprint Preservation of cognitive and functional ability as markers of longevity
    Nicole Schupf
    G H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease, Department of Epidemiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neurobiol Aging 25:1231-40. 2004
    ..The results of the present study identify phenotypes associated with preserved cognitive and functional abilities which may serve as markers for longevity...
  22. ncbi request reprint Implementing diagnostic criteria and estimating frequency of mild cognitive impairment in an urban community
    Jennifer J Manly
    Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 62:1739-46. 2005
    ....
  23. pmc Plasma ß-amyloid and cognitive decline
    Stephanie A Cosentino
    The Gertrude H Sergievsky Center, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 67:1485-90. 2010
    ..To determine if plasma β-amyloid (Aβ) levels (1) can be linked to specific cognitive changes that constitute conversion to Alzheimer disease (AD) and (2) correspond to cognitive change independent of dementia...
  24. pmc TP73 allelic expression in human brain and allele frequencies in Alzheimer's disease
    Quanyi Li
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
    BMC Med Genet 5:14. 2004
    ..TP73 mRNA is transcribed from three promoters, termed P1-P3, and there is evidence for an additional complexity in its regulation, namely, a variable allelic expression bias in some human tissues...
  25. pmc Frequency and course of mild cognitive impairment in a multiethnic community
    Jennifer J Manly
    Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY, USA
    Ann Neurol 63:494-506. 2008
    ....
  26. ncbi request reprint Association of C-reactive protein with cognitive impairment
    James M Noble
    Gertrude H Sergievsky Center, Columbia University, New York, New York, USA
    Arch Neurol 67:87-92. 2010
    ..High-sensitivity C-reactive protein (hsCRP) is a biomarker of cardiovascular risk that is suggested to be a biomarker for cognitive impairment...
  27. pmc The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort
    Joseph H Lee
    Taub Institute on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Neurol 64:501-6. 2007
    ..To investigate the association between Alzheimer disease (AD) and variant alleles in SORL1 using a series of single nucleotide polymorphisms (SNPs) in an urban, multiethnic, community-based population...
  28. pmc The heritability of abstract reasoning in Caribbean Latinos with familial Alzheimer disease
    Beverly Johnson
    Taub Institute on Alzheimer s Disease and the Aging Brain, New York, NY, USA
    Dement Geriatr Cogn Disord 24:411-7. 2007
    ..To better understand the genetic influence on component phenotypes of AD, we estimated the heritability (h(2)) of abstract reasoning and examined its relation with apolipoprotein epsilon 4 (APOE-epsilon 4)...
  29. pmc Metabolic syndrome and dementia risk in a multiethnic elderly cohort
    Majon Muller
    Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Dement Geriatr Cogn Disord 24:185-92. 2007
    ..The metabolic syndrome (MeSy) may be related to Alzheimer's disease (AD). Our aims were to investigate the association of the MeSy with incident dementia in a multiethnic elderly cohort in the United States...
  30. pmc Association between genetic variants in sortilin-related receptor 1 (SORL1) and Alzheimer's disease in adults with Down syndrome
    Joseph H Lee
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
    Neurosci Lett 425:105-9. 2007
    ..Thus, further studies are needed to identify functional variants that influence risk for AD in this uniquely vulnerable population...
  31. ncbi request reprint Apolipoprotein E epsilon4 and age at onset of sporadic and familial Alzheimer disease in Caribbean Hispanics
    Lucia Olarte
    Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Neurol 63:1586-90. 2006
    ..The primary effect of the apolipoprotein E epsilon4 (APOE epsilon4) allele is on the age at onset of Alzheimer disease (AD)...
  32. ncbi request reprint Relationship between plasma lipids and all-cause mortality in nondemented elderly
    Nicole Schupf
    G H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Am Geriatr Soc 53:219-26. 2005
    ..To investigate the relationship between plasma lipids and risk of death from all causes in nondemented elderly...
  33. pmc Plasma lipid levels in the elderly are not associated with the risk of mild cognitive impairment
    Christiane Reitz
    Gertrude H Sergievsky Center, Mailman School of Public Health, Columbia University College of Physicians and Surgeons, New York, N Y, USA
    Dement Geriatr Cogn Disord 25:232-7. 2008
    ..Baseline data were collected from 1992 to 1994, follow-up data were collected at 18-month intervals...
  34. pmc Validity of self-reported stroke in elderly African Americans, Caribbean Hispanics, and Whites
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York 10032, USA
    Arch Neurol 66:834-40. 2009
    ..The validity of a self-reported stroke remains inconclusive...
  35. pmc Mediterranean diet and mild cognitive impairment
    Nikolaos Scarmeas
    Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 66:216-25. 2009
    ..Higher adherence to the Mediterranean diet (MeDi) may protect from Alzheimer disease (AD), but its association with mild cognitive impairment (MCI) has not been explored...
  36. pmc Quantitative brain measurements in community-dwelling elderly persons with mild parkinsonian signs
    Elan D Louis
    Unit 198, Department of Neurology, Columbia University, 710 W 168th St, New York, NY 10032, USA
    Arch Neurol 65:1649-54. 2008
    ..Also, if MPS are a marker for developing Alzheimer-type changes, hippocampal volume on MRI might be diminished in individuals with MPS...
  37. pmc Mild parkinsonian signs are associated with increased risk of dementia in a prospective, population-based study of elders
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 25:172-8. 2010
    ..Baseline MPS seems to be a predictor of incident dementia. These motor signs might, therefore, serve as a useful biomarker for emerging dementia...
  38. pmc Telephone-based identification of mild cognitive impairment and dementia in a multicultural cohort
    Jennifer J Manly
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, 630 W 168th Street, New York, NY 10032, USA
    Arch Neurol 68:607-14. 2011
    ..Telephone-based interviews can be used for screening and to obtain key study outcomes when participants in longitudinal studies die or cannot be seen in person, but must be validated among ethnically and educationally diverse people...
  39. pmc Association of higher levels of high-density lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer disease
    Christiane Reitz
    Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Arch Neurol 67:1491-7. 2010
    ..To reexamine the association of lipid levels with Alzheimer disease (AD) using Cox proportional hazards models...
  40. pmc Physical activity, diet, and risk of Alzheimer disease
    Nikolaos Scarmeas
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain and Department of Neurology, Columbia University Medical Center, 622 W 168th St, New York, NY 10032, USA
    JAMA 302:627-37. 2009
    ..Both higher adherence to a Mediterranean-type diet and more physical activity have been independently associated with lower Alzheimer disease (AD) risk but their combined association has not been investigated...
  41. pmc A summary risk score for the prediction of Alzheimer disease in elderly persons
    Christiane Reitz
    The Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Arch Neurol 67:835-41. 2010
    ..To develop a simple summary risk score for the prediction of Alzheimer disease in elderly persons based on their vascular risk profiles...
  42. pmc Essential tremor is associated with dementia: prospective population-based study in New York
    Sujata P Thawani
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Neurology 73:621-5. 2009
    ..Furthermore, an association between ET and dementia has been reported in a single population-based study in Spain. This has not been confirmed elsewhere...
  43. pmc Long-term blood pressure fluctuation and cerebrovascular disease in an elderly cohort
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Arch Neurol 67:564-9. 2010
    ..Elevated blood pressure (BP) and fluctuation in BP may lead to cerebrovascular disease through ischemic changes and compromised cerebral autoregulation...
  44. pmc Hormonal influences on cognition and risk for Alzheimer's disease
    Sarah C Janicki
    G H Sergievsky Center, Columbia University Medical Center, 622 West 168th Street, PH 19, New York, NY 10019, USA
    Curr Neurol Neurosci Rep 10:359-66. 2010
    ..Future trials are needed to determine whether alternate timing, dosage, formulation, or method of administration of hormone replacement can reduce the risk of dementia...
  45. pmc Olfactory identification deficits and MCI in a multi-ethnic elderly community sample
    D P Devanand
    Division of Geriatric Psychiatry, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neurobiol Aging 31:1593-600. 2010
    ..These findings indicate that the predictive utility of olfactory identification deficits for decline from no MCI to MCI and AD needs to be assessed in longitudinal studies of elderly community samples...
  46. ncbi request reprint Functional correlates of mild parkinsonian signs in the community-dwelling elderly: poor balance and inability to ambulate independently
    Elan D Louis
    The Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 21:411-6. 2006
    ..The elderly in whom these signs have been detected are 50% more likely to complain of poor balance and 90% more likely to require a cane, walker, or wheelchair than are their counterparts without these signs...
  47. ncbi request reprint Onset of dementia is associated with age at menopause in women with Down's syndrome
    Nicole Schupf
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Ann Neurol 54:433-8. 2003
    ..Our findings support the hypothesis that reductions in estrogens after menopause contribute to the cascade of pathological processes leading to AD...
  48. ncbi request reprint Genetic influences on life span and survival among elderly African-Americans, Caribbean Hispanics, and Caucasians
    Joseph H Lee
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York 10032, USA
    Am J Med Genet A 128:159-64. 2004
    ..Identifying the genes associated with life span and survival will provide insight into how the genes interact with environment to influence aging in humans...
  49. ncbi request reprint Incidence and prevalence of dementia in elderly adults with mental retardation without down syndrome
    Warren B Zigman
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA
    Am J Ment Retard 109:126-41. 2004
    ....
  50. ncbi request reprint Cognitive decline and literacy among ethnically diverse elders
    Jennifer J Manly
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    J Geriatr Psychiatry Neurol 18:213-7. 2005
    ..The results of this study suggest that in an ethnically diverse cohort, literacy level should be considered as a mediator of the interactions of biological and environmental factors on cognitive decline...
  51. pmc Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21
    Chi Ming Li
    Institute for Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, NY, USA
    BMC Med Genet 7:24. 2006
    ..Down syndrome (DS) is caused by trisomy 21 (+21), but the aberrations in gene expression resulting from this chromosomal aneuploidy are not yet completely understood...
  52. ncbi request reprint Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia
    Lawrence S Honig
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain and the Gertrude H Sergievsky Center, New York, NY, USA
    Ann Neurol 60:181-7. 2006
    ..Reduced telomere length may be a marker of biological aging. We hypothesized that telomere length might thus relate to increased risk for dementia and mortality...
  53. ncbi request reprint Bioavailable estradiol and age at onset of Alzheimer's disease in postmenopausal women with Down syndrome
    Nicole Schupf
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Neurosci Lett 406:298-302. 2006
    ..Our findings support the hypothesis that reductions in estrogen following menopause can contribute to the cascade of pathological processes leading to AD...
  54. pmc Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern Manhattan
    Adam M Brickman
    Departmentof Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Arch Neurol 65:1053-61. 2008
    ..Aging is accompanied by a decrease in brain volume and by an increase in cerebrovascular disease...
  55. ncbi request reprint Genetic and host factors for dementia in Down's syndrome
    Nicole Schupf
    Laboratory of Epidemiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Br J Psychiatry 180:405-10. 2002
    ..The high risk for dementia in adults with Down's syndrome has been attributed to triplication and overexpression of the gene for amyloid precursor protein (APP). But the wide variation in age at onset must be due to other risk factors...
  56. ncbi request reprint Combined effect of age and severity on the risk of dementia in Parkinson's disease
    Gilberto Levy
    Gertrude H Sergievsky Center, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Ann Neurol 51:722-9. 2002
    ..2) did not. These findings suggest that the increased risk of incident dementia in Parkinson's disease associated with age and severity of extrapyramidal signs is related primarily to their combined effect rather than separate effects...
  57. pmc Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, G H Sergievsky Center, New York, NY, USA
    Dement Geriatr Cogn Disord 25:476-82. 2008
    ..Two tightly linked polymorphisms (PvuII and XbaI) in the first intron of estrogen receptor 1 (ESR1), the gene for ER-alpha, have been reported to influence estrogen receptor expression and may influence the risk of AD...
  58. ncbi request reprint Mild parkinsonian signs and plasma homocysteine concentration in community-dwelling elderly individuals
    Elan D Louis
    The Gertrude H Sergievsky Center, Department of Neurology, Columbia University, New York, NY 10032, USA
    Arch Neurol 64:1646-51. 2007
    ..To determine whether plasma homocysteine (Hcy) concentration is associated with mild parkinsonian signs (MPS) in community-dwelling elderly individuals...
  59. pmc Elevated plasma beta-amyloid peptide Abeta(42) levels, incident dementia, and mortality in Down syndrome
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, PO Box 16, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 64:1007-13. 2007
    ..Individuals with Down syndrome have increased levels of beta-amyloid peptides and an increased risk for AD...
  60. pmc Measures of adiposity and dementia risk in elderly persons
    Jose A Luchsinger
    Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 64:392-8. 2007
    ....
  61. ncbi request reprint Functional correlates and prevalence of mild parkinsonian signs in a community population of older people
    Elan D Louis
    The Gertrude H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, and Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Arch Neurol 62:297-302. 2005
    ..Mild parkinsonian signs (MPS) are associated with incident dementia and an increased risk of mortality. To our knowledge, the functional correlates of MPS have not been studied...
  62. ncbi request reprint Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer disease
    Eleni S Athan
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Arch Neurol 59:1793-9. 2002
    ..Missense mutations in the amyloid precursor protein (APP) gene cause early-onset Alzheimer disease (AD). However, little is known regarding the effects of polymorphisms in regulatory sequences of APP on AD susceptibility...
  63. pmc Do neuropsychological tests have the same meaning in Spanish speakers as they do in English speakers?
    Karen L Siedlecki
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
    Neuropsychology 24:402-11. 2010
    ..The purpose of this study was to examine whether neuropsychological tests translated into Spanish measure the same cognitive constructs as the original English versions...
  64. pmc Altered DNA methylation in leukocytes with trisomy 21
    Kristi Kerkel
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY, USA
    PLoS Genet 6:e1001212. 2010
    ..We conclude that altered gene-specific DNA methylation is a recurrent and functionally relevant downstream response to trisomy 21 in human cells...
  65. pmc Peripheral Abeta subspecies as risk biomarkers of Alzheimer's disease
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:14052-7. 2008
    ..Our results suggest individuals with elevated plasma Abeta42 are at increased risk of AD and that with the onset of disease, the decline in some forms of Abeta may reflect compartmentalization of Abeta peptides in the brain...
  66. doi request reprint Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation
    Kristi Kerkel
    Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA
    Nat Genet 40:904-8. 2008
    ..This recurrent phenomenon of sequence-dependent ASM has practical implications for mapping and interpreting associations of noncoding SNPs and haplotypes with human phenotypes...
  67. pmc Familial aggregation of dementia with Lewy bodies
    Angela Nervi
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Arch Neurol 68:90-3. 2011
    ..Familial aggregation of dementia with Lewy bodies (DLB) remains unclear...
  68. pmc Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals
    Joseph H Lee
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 68:320-8. 2011
    ....
  69. pmc Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study
    Alexis Elbaz
    INSERM, Unit 708, Paris, France
    Lancet Neurol 5:917-23. 2006
    ..Small-scale replication studies were largely non-confirmatory, but a meta-analysis that included data from the original study could not exclude all SNP associations, leaving relevance of several markers uncertain...

Research Grants19

  1. GENETIC EPIDEMIOLOGY OF ALZHEIMER'S DISEASE IN HISPANICS
    Richard Mayeux; Fiscal Year: 2007
    ..Further we will make cells lines and clinical information available to others through the National Cell Repository for Alzheimer's Disease. ..
  2. GENETIC EPIDEMIOLOGY OF ALZHEIMERS DISEASE IN HISPANICS
    Richard Mayeux; Fiscal Year: 1999
    ..The ultimate goal of this project is to chromosomally localize genes that may increase the risk of AD among the Caribbean Hispanic ethnic group. ..
  3. Genetic Consortium for Late Onset Alzheimer's Disease
    Richard Mayeux; Fiscal Year: 2007
    ..background, significance, and innovation ..
  4. Multicenter Study on Exceptional Survival in Families
    Richard Mayeux; Fiscal Year: 2007
    ..Identifying genes associated with ES will be an important step in understanding the processes underlying successful aging. ..
  5. Genetic Consortium for Late Onset Alzheimer's Disease
    Richard Mayeux; Fiscal Year: 2005
    ..background, significance, and innovation ..
  6. GENETIC EPIDEMIOLOGY OF ALZHEIMERS DISEASE IN HISPANICS
    Richard Mayeux; Fiscal Year: 2003
    ..The ultimate goal of this project is to chromosomally localize genes that may increase the risk of AD among the Caribbean Hispanic ethnic group. ..
  7. GENETIC EPIDEMIOLOGY OF AGING IN A MULTIETHNIC COMMUNITY
    Richard Mayeux; Fiscal Year: 2002
    ....
  8. GENETIC EPIDEMIOLOGY OF ALZHEIMERS DISEASE IN HISPANICS
    Richard Mayeux; Fiscal Year: 2002
    ..The ultimate goal of this project is to chromosomally localize genes that may increase the risk of AD among the Caribbean Hispanic ethnic group. ..
  9. GENETIC EPIDEMIOLOGY OF AGING IN A MULTIETHNIC COMMUNITY
    Richard Mayeux; Fiscal Year: 2001
    ....
  10. GENETIC EPIDEMIOLOGY OF ALZHEIMERS DISEASE IN HISPANICS
    Richard Mayeux; Fiscal Year: 2001
    ..The ultimate goal of this project is to chromosomally localize genes that may increase the risk of AD among the Caribbean Hispanic ethnic group. ..
  11. GENETIC EPIDEMIOLOGY OF AGING IN A MULTIETHNIC COMMUNITY
    Richard Mayeux; Fiscal Year: 2000
    ....
  12. GENETIC EPIDEMIOLOGY OF ALZHEIMERS DISEASE IN HISPANICS
    Richard Mayeux; Fiscal Year: 2000
    ..The ultimate goal of this project is to chromosomally localize genes that may increase the risk of AD among the Caribbean Hispanic ethnic group. ..
  13. Epidemiology of Biomarkers of Risk and Progression in LOAD
    Nicole Schupf; Fiscal Year: 2010
    ..Therefore the potential public health impact of developing reliable and valid biomarkers in a multi-ethnic community is a major benefit of this proposed investigation. ..