S A Mayer

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Nutritional support and brain tissue glucose metabolism in poor-grade SAH: a retrospective observational study
    J Michael Schmidt
    Columbia University, Department of Neurology, Milstein Hospital, 177 Fort Washington, Suite 8 300, New York, NY 10032, USA
    Crit Care 16:R15. 2012
  2. pmc Brain injury clinical trials: new agents or new statistics?
    Joshua Z Willey
    Departments of Neurology and Neurosurgery, The Neurological Institute of New York, Columbia University Medical Center, Milstein Hospital Building, 177 Fort Washington Avenue, Suite 8 300, New York, NY 10032, USA
    Crit Care 15:188. 2011
  3. pmc The effect of window rooms on critically ill patients with subarachnoid hemorrhage admitted to intensive care
    Hannah Wunsch
    Division of Critical Care, Department of Anesthesiology, and Department of Epidemiology, Columbia University, 622 West 168th Street, PH5 527D, New York, NY 10032, USA
    Crit Care 15:R81. 2011
  4. pmc Ethics roundtable: 'Open-ended ICU care: can we afford it?'
    David Crippen
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, 644a Saife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 14:222. 2010
  5. pmc Clinical review: Critical care management of spontaneous intracerebral hemorrhage
    Fred Rincon
    Department of Medicine, Cooper University Hospital, The Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, Camden, NJ 08501, USA
    Crit Care 12:237. 2008
  6. ncbi request reprint Safety and feasibility of recombinant factor VIIa for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stroke 36:74-9. 2005
  7. pmc Can a simple blood test quantify brain injury?
    Stephan A Mayer
    Neurological Intensive Care Unit, Milstein Hospital Building, 177 Fort Washington Avenue, Suite 8 300 Center, New York, NY 10032, USA
    Crit Care 13:166. 2009
  8. ncbi request reprint Quantification of lethargy in the neuro-ICU: the 60-Second Test
    S A Mayer
    Division of Critical Care Neurology, College of Physicians and Surgeons, School of Public Health, Columbia University, New York, NY, USA
    Neurology 61:543-5. 2003
  9. ncbi request reprint Recombinant activated factor VII for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
    N Engl J Med 352:777-85. 2005
  10. ncbi request reprint Can a subset of intracerebral hemorrhage patients benefit from hemostatic therapy with recombinant activated factor VII?
    Stephan A Mayer
    Department of Neurology and Neurosurgery, Columbia University, New York, NY, USA
    Stroke 40:833-40. 2009

Research Grants

  1. New York-Presbyterian NETT Consortium
    Stephan Mayer; Fiscal Year: 2007

Detail Information

Publications122 found, 100 shown here

  1. pmc Nutritional support and brain tissue glucose metabolism in poor-grade SAH: a retrospective observational study
    J Michael Schmidt
    Columbia University, Department of Neurology, Milstein Hospital, 177 Fort Washington, Suite 8 300, New York, NY 10032, USA
    Crit Care 16:R15. 2012
    ..We sought to determine the effect of nutritional support and insulin infusion therapy on serum and brain glucose levels and cerebral metabolic crisis after aneurysmal subarachnoid hemorrhage (SAH)...
  2. pmc Brain injury clinical trials: new agents or new statistics?
    Joshua Z Willey
    Departments of Neurology and Neurosurgery, The Neurological Institute of New York, Columbia University Medical Center, Milstein Hospital Building, 177 Fort Washington Avenue, Suite 8 300, New York, NY 10032, USA
    Crit Care 15:188. 2011
    ..These techniques may soon become commonplace as critical care research increasingly focuses on patient-centered functional outcomes...
  3. pmc The effect of window rooms on critically ill patients with subarachnoid hemorrhage admitted to intensive care
    Hannah Wunsch
    Division of Critical Care, Department of Anesthesiology, and Department of Epidemiology, Columbia University, 622 West 168th Street, PH5 527D, New York, NY 10032, USA
    Crit Care 15:R81. 2011
    ..We hypothesized that receiving care in an intensive care unit (ICU) room with a window might improve outcomes for critically ill patients with acute brain injury...
  4. pmc Ethics roundtable: 'Open-ended ICU care: can we afford it?'
    David Crippen
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, 644a Saife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 14:222. 2010
    ....
  5. pmc Clinical review: Critical care management of spontaneous intracerebral hemorrhage
    Fred Rincon
    Department of Medicine, Cooper University Hospital, The Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, Camden, NJ 08501, USA
    Crit Care 12:237. 2008
    ..Apart from management in a specialized stroke or neurological intensive care unit, no specific medical therapies have been shown to consistently improve outcome after intracerebral hemorrhage...
  6. ncbi request reprint Safety and feasibility of recombinant factor VIIa for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stroke 36:74-9. 2005
    ..Activated recombinant factor VII (rFVIIa) promotes hemostasis at sites of vascular injury and may minimize hematoma growth after ICH...
  7. pmc Can a simple blood test quantify brain injury?
    Stephan A Mayer
    Neurological Intensive Care Unit, Milstein Hospital Building, 177 Fort Washington Avenue, Suite 8 300 Center, New York, NY 10032, USA
    Crit Care 13:166. 2009
    ..Their study suggests that elevation of S-100B reflects the severity of the primary hypoxic-ischemic insult...
  8. ncbi request reprint Quantification of lethargy in the neuro-ICU: the 60-Second Test
    S A Mayer
    Division of Critical Care Neurology, College of Physicians and Surgeons, School of Public Health, Columbia University, New York, NY, USA
    Neurology 61:543-5. 2003
    ..The SST is sensitive to subtle alterations in LOC but, like the GCS, may have limitations as a monitoring tool in the neurocritical care setting...
  9. ncbi request reprint Recombinant activated factor VII for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
    N Engl J Med 352:777-85. 2005
    ..We sought to determine whether recombinant activated factor VII (rFVIIa) can reduce hematoma growth after intracerebral hemorrhage...
  10. ncbi request reprint Can a subset of intracerebral hemorrhage patients benefit from hemostatic therapy with recombinant activated factor VII?
    Stephan A Mayer
    Department of Neurology and Neurosurgery, Columbia University, New York, NY, USA
    Stroke 40:833-40. 2009
    ..In this exploratory analysis, we hypothesized that earlier treatment and exclusion of patients with a poor prognosis at baseline might enhance the benefit of rFVIIa treatment...
  11. doi request reprint Factor VIIa for ICH: behind the scenes of an academic-industry collaborative trial
    Stephan A Mayer
    Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Stroke 2:164-8. 2007
  12. ncbi request reprint Treatment of intracerebral haemorrhage
    Stephan A Mayer
    Neurological Intensive Care Unit, Division of Stroke and Critical Care, Department of Neurology Columbia University, New York, NY 10032, USA
    Lancet Neurol 4:662-72. 2005
    ....
  13. doi request reprint Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
    N Engl J Med 358:2127-37. 2008
    ..We performed this phase 3 trial to confirm a previous study in which recombinant activated factor VII (rFVIIa) reduced growth of the hematoma and improved survival and functional outcomes...
  14. ncbi request reprint Ultra-early hemostatic therapy for acute intracerebral hemorrhage
    Stephan A Mayer
    Neurological Intensive Care Unit, Columbia Presbyterian Medical Center, New York, NY, USA
    Semin Hematol 43:S70-6. 2006
    ..This was associated with a significant reduction (38%) in mortality, and improved functional outcomes among survivors. A phase III trial comparing 20 and 80 microg/kg rFVIIa with placebo is now in progress to confirm these results...
  15. doi request reprint Advances in critical care and emergency medicine 2007
    Stephan A Mayer
    Department of Neurology, Columbia University Medical Center, New York, NY, USA
    Stroke 39:261-3. 2008
  16. ncbi request reprint Recombinant activated factor VII for acute intracerebral hemorrhage: US phase IIA trial
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neurocrit Care 4:206-14. 2006
    ..We conducted this trial to evaluate the safety of activated recombinant factor VII (rFVIIa; NovoSeven) for preventing early hematoma growth in acute ICH...
  17. ncbi request reprint Critical care and emergency medicine
    Stephan A Mayer
    Neurological Intensive Care Unit, Departments of Neurolgy and Neurosurgery, Columbia University Medical Center, New York, NY 10032, USA
    Stroke 38:225-8. 2007
  18. ncbi request reprint Recombinant activated factor VII for acute intracerebral hemorrhage
    Stephan A Mayer
    Neurological Intensive Care Unit, Neurological Institute, Columbia University Medical Center, New York, NY 10032, USA
    Stroke 38:763-7. 2007
    ..A large phase III trial (the FAST trial [Factor Seven for Acute Hemorrhagic Stroke Treatment]) is now in progress to confirm these findings...
  19. ncbi request reprint Risk factors for continued cigarette use after subarachnoid hemorrhage
    Jennifer Ballard
    Division of Critical Care Neurology, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stroke 34:1859-63. 2003
    ..Cigarette smoking is a risk factor for the formation and rupture of intracranial aneurysms. Few studies have examined predictors of resumption of cigarette smoking after a first episode of subarachnoid hemorrhage (SAH)...
  20. ncbi request reprint Intracerebral hemorrhage: natural history and rationale of ultra-early hemostatic therapy
    Stephan A Mayer
    Neurologic Intensive Care Unit, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Intensive Care Med 28:S235-40. 2002
    ....
  21. ncbi request reprint Delirium from nicotine withdrawal in neuro-ICU patients
    S A Mayer
    Division of Critical Care Neurology, Department of Neurology, Columbia Presbyterian Medical Center and College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Neurology 57:551-3. 2001
    ..These preliminary observations suggest that nicotine withdrawal may be an under-recognized cause of delirium in patients with acute brain injury...
  22. doi request reprint Clinical practices, complications, and mortality in neurological patients with acute severe hypertension: the Studying the Treatment of Acute hyperTension registry
    Stephan A Mayer
    Columbia University College of Physicians and Surgeons, New York, NY, USA
    Crit Care Med 39:2330-6. 2011
    ..To determine the demographic and clinical features, hospital complications, and predictors of 90-day mortality in neurologic patients with acute severe hypertension...
  23. ncbi request reprint Refractory status epilepticus: frequency, risk factors, and impact on outcome
    Stephan A Mayer
    Division of Critical Care Neurology, Neurological Institute, 710 W 168th St, Unit 39, New York, NY 10032, USA
    Arch Neurol 59:205-10. 2002
    ..How often RSE occurs, risk factors that predispose to this condition, and the effect of failure to control seizures on clinical outcome are poorly defined...
  24. ncbi request reprint Asymmetry of intracranial hemodynamics as an indicator of mass effect in acute intracerebral hemorrhage. A transcranial Doppler study
    S A Mayer
    Department of Neurology, Columbia Presbyterian Medical Center, New York, NY, USA
    Stroke 27:1788-92. 1996
    ..The goal was to evaluate TCD as a noninvasive method for monitoring compartmentalized mass effect...
  25. ncbi request reprint Withdrawal of life support in the neurological intensive care unit
    S A Mayer
    Department of Neurology, Neurological Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neurology 52:1602-9. 1999
    ....
  26. ncbi request reprint Myocardial injury and left ventricular performance after subarachnoid hemorrhage
    S A Mayer
    Department of Neurology, Columbia Presbyterian Medical Center, New York, NY, USA
    Stroke 30:780-6. 1999
    ..It is not known whether cardiac injury of this type adversely affects cardiovascular hemodynamic performance...
  27. ncbi request reprint Ultra-early hemostatic therapy for intracerebral hemorrhage
    Stephan A Mayer
    Division of Critical Care Neurology, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stroke 34:224-9. 2003
    ..Intracerebral hemorrhage (ICH) causes higher morbidity and mortality than other forms of stroke and has no proven effective treatment. Hematoma volume is a powerful predictor of outcome after ICH...
  28. ncbi request reprint Perilesional blood flow and edema formation in acute intracerebral hemorrhage: a SPECT study
    S A Mayer
    Department of Neurology, Columbia Presbyterian Medical Center, New York, NY, USA
    Stroke 29:1791-8. 1998
    ..We sought to characterize alterations in perilesional blood flow that occur during the acute phase of ICH and to determine whether progressive enlargement of edema surrounding ICH is related to increased or decreased perfusion...
  29. ncbi request reprint Global and domain-specific cognitive impairment and outcome after subarachnoid hemorrhage
    S A Mayer
    Division of Critical Care Neurology, School of Public Health, Columbia University, New York, NY, USA
    Neurology 59:1750-8. 2002
    ..Cognitive dysfunction is the most common form of neurologic impairment after subarachnoid hemorrhage (SAH)...
  30. pmc Multimodality monitoring for cerebral perfusion pressure optimization in comatose patients with intracerebral hemorrhage
    Sang Bae Ko
    Department of Neurology, Columbia University College of Physicians and Surgeons, 177 Fort Washington Ave, New York, NY 10032, USA
    Stroke 42:3087-92. 2011
    ..We sought to determine the feasibility of brain multimodality monitoring for optimizing CPP and potentially reducing secondary brain injury after intracerebral hemorrhage...
  31. ncbi request reprint Effect of cisternal and ventricular blood on risk of delayed cerebral ischemia after subarachnoid hemorrhage: the Fisher scale revisited
    J Claassen
    Department of Neurology, School of Public Health, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stroke 32:2012-20. 2001
    ..We propose a new SAH rating scale that accounts for the independent predictive value of subarachnoid and ventricular blood for DCI...
  32. ncbi request reprint Electrographic seizures and periodic discharges after intracerebral hemorrhage
    J Claassen
    Division of Stroke and Critical Care Neurology, Comprehensive Epilepsy Center, Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Neurology 69:1356-65. 2007
    ..To determine the frequency and significance of electrographic seizures and other EEG findings in patients with intracerebral hemorrhage (ICH)...
  33. ncbi request reprint Predictors and clinical impact of epilepsy after subarachnoid hemorrhage
    J Claassen
    Division of Critical Care Neurology, The Comprehensive Epilepsy Center, Department of Neurology, College of Physicians and Surgeons, School of Public Health, Columbia University, New York, NY, USA
    Neurology 60:208-14. 2003
    ..To determine the frequency, predictors, and impact on outcome of epilepsy developing during the first year after subarachnoid hemorrhage (SAH)...
  34. doi request reprint Systemic glucose and brain energy metabolism after subarachnoid hemorrhage
    Raimund Helbok
    Division of Critical Care Neurology, Department of Neurology, Columbia University Medical Center, Milstein Hospital 8 Center, 177 Fort Washington Ave, New York, NY 10032, USA
    Neurocrit Care 12:317-23. 2010
    ..We sought to determine if MC and LPR elevations after subarachnoid hemorrhage (SAH) are associated with acute reductions in serum glucose...
  35. ncbi request reprint Continuous EEG monitoring and midazolam infusion for refractory nonconvulsive status epilepticus
    J Claassen
    Department of Neurology, Division of Critical Care Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neurology 57:1036-42. 2001
    ..Titrating cIV-MDZ to burst suppression, more aggressive treatment with concurrent AED, or a longer period of initial treatment may reduce the high proportion of patients with RSE who relapse after cIV-MDZ is discontinued...
  36. ncbi request reprint Fever after subarachnoid hemorrhage: risk factors and impact on outcome
    A Fernandez
    Neurological Intensive Care Unit, Division of Stroke and Critical Care, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 68:1013-9. 2007
    ..To identify risk factors for refractory fever after subarachnoid hemorrhage (SAH), and to determine the impact of temperature elevation on outcome...
  37. ncbi request reprint Risk factors for fever in the neurologic intensive care unit
    Christopher Commichau
    Division of Critical Care Neurology, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neurology 60:837-41. 2003
    ..To identify risk factors for fever among patients treated in a neurologic intensive care unit (NICU)...
  38. doi request reprint Intracranial multimodal monitoring for acute brain injury: a single institution review of current practices
    R Morgan Stuart
    Department of Neurological Surgery, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neurocrit Care 12:188-98. 2010
    ..Here we review our experience in a consecutive series of acutely brain injured patients who underwent multimodality monitoring...
  39. ncbi request reprint Global cerebral edema after subarachnoid hemorrhage: frequency, predictors, and impact on outcome
    Jan Claassen
    Division of Critical Care Neurology, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stroke 33:1225-32. 2002
    ..Inflammatory or circulatory mechanisms have been postulated to explain this radiographic observation after SAH. We sought to determine the frequency, causes, and impact on outcome of early and delayed global cerebral edema after SAH...
  40. pmc Effect of rebleeding on the course and incidence of vasospasm after subarachnoid hemorrhage
    A S Lord
    Department of Neurology, Columbia University, New York, NY, USA
    Neurology 78:31-7. 2012
    ..Whereas numerous studies have demonstrated the risk factors associated with rebleeding, few data on complications of rebleeding, including its effect on the development of delayed cerebral ischemia (DCI), are available...
  41. ncbi request reprint Detection of electrographic seizures with continuous EEG monitoring in critically ill patients
    J Claassen
    Division of Critical Care Neurology, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 10032, USA
    Neurology 62:1743-8. 2004
    ..To identify patients most likely to have seizures documented on continuous EEG (cEEG) monitoring and patients who require more prolonged cEEG to record the first seizure...
  42. doi request reprint Hypothermia for the treatment of ischemic and hemorrhagic stroke
    Guillermo Linares
    Division of Stroke, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Crit Care Med 37:S243-9. 2009
    ..More research is clearly needed to bring us closer to the successful application of hypothermia in the treatment for stroke...
  43. ncbi request reprint Impact of medical complications on outcome after subarachnoid hemorrhage
    Katja E Wartenberg
    Clinical Neuropsychology, New York Presbyterian Hospital, and Stroke and Critical Care, Columbia University, New York, NY, USA
    Crit Care Med 34:617-23; quiz 624. 2006
    ..Medical complications occur frequently after subarachnoid hemorrhage (SAH). Their impact on outcome remains poorly defined...
  44. pmc Cardiac arrhythmias after subarachnoid hemorrhage: risk factors and impact on outcome
    Jennifer A Frontera
    Neurological Intensive Care Unit, Department of Neurosurgery, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cerebrovasc Dis 26:71-8. 2008
    ..Serious cardiac arrhythmias have been described in approximately 5% of patients after subarachnoid hemorrhage (SAH). The aim of this study was to identify the frequency, risk factors and clinical impact of cardiac arrhythmia after SAH...
  45. doi request reprint Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: a microdialysis study
    Mauro Oddo
    Department of Neurology, Critical Care Division, Columbia University Medical Center, New York, NY, USA
    Crit Care Med 36:3233-8. 2008
    ..To analyze the effect of tight glycemic control with the use of intensive insulin therapy on cerebral glucose metabolism in patients with severe brain injury...
  46. doi request reprint Frequency and clinical impact of asymptomatic cerebral infarction due to vasospasm after subarachnoid hemorrhage
    J Michael Schmidt
    Neurological Intensive Care Unit, Division of Neurocritical Care, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosurg 109:1052-9. 2008
    ..The authors sought to determine frequency, risk factors, and impact on outcome of asymptomatic cerebral infarction due to vasospasm after subarachnoid hemorrhage (SAH)...
  47. doi request reprint Spontaneous hyperventilation and brain tissue hypoxia in patients with severe brain injury
    Emmanuel Carrera
    Department of Neurology, Division of Neurocritical Care, Columbia University Medical Center, 177 Fort Washington Avenue, New York, NY 10032, USA
    J Neurol Neurosurg Psychiatry 81:793-7. 2010
    ..Our aim was to determine whether spontaneous reduction in end-tidal CO(2) (EtCO(2)) was associated with an increased in brain tissue hypoxia (BTH)...
  48. doi request reprint Defining vasospasm after subarachnoid hemorrhage: what is the most clinically relevant definition?
    Jennifer A Frontera
    Mount Sinai School of Medicine, Department of Neurosurgery, One Gustave Levy Place, Box 1136, New York, NY 10029, USA
    Stroke 40:1963-8. 2009
    ..Vasospasm is an important complication of subarachnoid hemorrhage, but is variably defined in the literature...
  49. ncbi request reprint Dynamics of intraventricular hemorrhage in patients with spontaneous intracerebral hemorrhage: risk factors, clinical impact, and effect of hemostatic therapy with recombinant activated factor VII
    Thorsten Steiner
    Department of Neurology, Univesity of Heidelberg, Heidelberg, Germany
    Neurosurgery 59:767-73; discussion 773-4. 2006
    ..To evaluate predictors of intraventricular hemorrhage (IVH) and IVH growth, impact of IVH growth on outcome, and impact of recombinant activated factor VII (rFVIIa) in patients with intracerebral hemorrhage (ICH)...
  50. ncbi request reprint External ventricular drainage response in poor grade aneurysmal subarachnoid hemorrhage: effect on preoperative grading and prognosis
    Evan R Ransom
    Department of Neurological Surgery, Columbia University, College of Physicians and Surgeons, Neurological Institute of New York, 710 W 168th Street, Room 431, New York, NY 10032, USA
    Neurocrit Care 6:174-80. 2007
    ..The effect of EVD response on preoperative grade and prognosis is described...
  51. ncbi request reprint Blood pressure management in patients with intracerebral and subarachnoid hemorrhage
    J Mocco
    Department of Neurological Surgery, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Neurosurg Clin N Am 17:25-40. 2006
  52. doi request reprint Clinical response to hypertensive hypervolemic therapy and outcome after subarachnoid hemorrhage
    Jennifer A Frontera
    Departments of Neurosurgery and Neurology, Neuroscience Intensive Care Unit, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1136, New York, NY 10029, USA
    Neurosurgery 66:35-41; discussion 41. 2010
    ..Hypertensive hypervolemic therapy is widely used to treat symptomatic vasospasm after subarachnoid hemorrhage. Few data exist to support a relationship between early clinical response and mortality or functional outcome...
  53. ncbi request reprint Transcranial Doppler for predicting delayed cerebral ischemia after subarachnoid hemorrhage
    Emmanuel Carrera
    Neurological Intensive Care Unit, Departments of Neurology and Neurosurgery, Columbia University, New York, New York 10032, USA
    Neurosurgery 65:316-23; discussion 323-4. 2009
    ..We sought to determine the prognostic utility of serial TCD examination after SAH...
  54. ncbi request reprint Risk of thromboembolic events in controlled trials of rFVIIa in spontaneous intracerebral hemorrhage
    Michael N Diringer
    Department of Neurology, Campus Box 8111, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Stroke 39:850-6. 2008
    ..Despite low incidences of such events in rFVIIa-treated hemophiliacs, the frequency in older patients with more atherosclerosis and immobility has yet to be defined...
  55. ncbi request reprint Continuous electroencephalographic monitoring in critically ill patients with central nervous system infections
    Emmanuel Carrera
    Comprehensive Epilepsy Center, Columbia University Medical Center, 710 W 168th St, Box NI 135, New York, NY 10032, USA
    Arch Neurol 65:1612-8. 2008
    ..To determine the prevalence, predictors, and clinical significance of electrographic seizures (ESz) and other continuous electroencephalographic monitoring findings in critically ill patients with central nervous system infections...
  56. ncbi request reprint Hyperglycemia after SAH: predictors, associated complications, and impact on outcome
    Jennifer A Frontera
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stroke 37:199-203. 2006
    ..Hyperglycemia is common after subarachnoid hemorrhage (SAH). The extent to which prolonged hyperglycemia contributes to in-hospital complications and poor outcome after SAH is unknown...
  57. doi request reprint Monocyte chemoattractant protein-1 predicts outcome and vasospasm following aneurysmal subarachnoid hemorrhage
    Grace H Kim
    Department of Neurological Surgery, Columbia University, New York, New York 10032, USA
    J Neurosurg 109:38-43. 2008
    ..The authors hypothesized that MCP-1 would be found in increased concentrations in the blood and cerebrospinal fluid (CSF) of patients with ASAH and would correlate with both outcome and the occurrence of vasospasm...
  58. ncbi request reprint Commentary on the Article of C. Woertgen, O. W. Ullrich, R. D. Rothoerl, A. Brawanski: Comparison of the Claassen and Fisher CT classification scale to predict ischemia after aneurysmatic SAH. Zentralbl Neurochir 2003; 64: 104-108
    J Claassen
    Division of Critical Care Neurology, Neurological Institute, Columbia University, New York, New York 10032, USA
    Zentralbl Neurochir 65:95-6; discussion 97. 2004
  59. ncbi request reprint Impact of recombinant activated factor VII on health-related quality of life after intracerebral hemorrhage
    Michael N Diringer
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cerebrovasc Dis 24:219-25. 2007
    ..29%) and poor outcome (modified Rankin Scale, mRS, 4-6, 53 vs. 69%). This analysis was performed to determine the impact of rFVIIa on health-related quality of life (HRQoL) in those patients...
  60. doi request reprint Cerebrovascular carbon dioxide reactivity and delayed cerebral ischemia after subarachnoid hemorrhage
    Emmanuel Carrera
    Division of Neurocritical Care, Department of Neurology, Columbia University Medical Center, New York, New York 10032, USA
    Arch Neurol 67:434-9. 2010
    ..To determine the predictors of impaired cerebrovascular reactivity (CVR) and the value of CVR in predicting delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH)...
  61. ncbi request reprint Nonconvulsive status epilepticus after subarachnoid hemorrhage
    Lyle J Dennis
    Division of Critical Care Neurology, Department of Neurology, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032, USA
    Neurosurgery 51:1136-43; discussion 1144. 2002
    ..We sought to determine the frequency and clinical features of NCSE among comatose patients with SAH...
  62. ncbi request reprint Medical complications after subarachnoid hemorrhage: new strategies for prevention and management
    Katja E Wartenberg
    Neurological Intensive Care Unit, Columbia Presbyterian Medical Center, New York 10032, USA
    Curr Opin Crit Care 12:78-84. 2006
    ..To summarize new concepts regarding the occurrence, prevention, and management of medical complications following subarachnoid hemorrhage...
  63. ncbi request reprint Cerebral vasospasm after subarachnoid hemorrhage
    Nazli Janjua
    Neurocritical Care, Department of Neurology, Neurological Intensive Care Unit, Columbia Presbyterian Medical Center, Neurological Institute, New York, New York 10032, USA
    Curr Opin Crit Care 9:113-9. 2003
    ..To summarize new pathophysiologic insights and recent advances in the diagnosis and treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage...
  64. ncbi request reprint Predictors of cognitive dysfunction after subarachnoid hemorrhage
    Kurt T Kreiter
    Stroke 33:200-8. 2002
    ..Although several clinical and radiographic findings have been implicated in the pathogenesis of cognitive dysfunction after SAH, few prospective studies have comprehensively and simultaneously evaluated these risk factors...
  65. ncbi request reprint Cerebral abscess and thrombophilia in pregnancy. A case report
    L V Baxi
    Departments of Obstetrics and Gynecology, Neurology and Pathology, College of Physicians and Surgeons, Columbia University, Sloane Hospital for Women, New York Presbyterian Hospital, New York, New York, USA
    J Reprod Med 46:606-8. 2001
    ..Cerebral abscess in pregnancy is a rare event, with the etiology not well described. We present such a case in association with genetic thrombophilia...
  66. pmc Genetic determinants of cerebral vasospasm, delayed cerebral ischemia, and outcome after aneurysmal subarachnoid hemorrhage
    Andrew F Ducruet
    Department of Neurological Surgery, Columbia University, 630 West 168th Street, Room no 5 454, New York, NY 10032, USA
    J Cereb Blood Flow Metab 30:676-88. 2010
    ..In addition, we highlight potential pitfalls in the interpretation of genetic association studies, and call for uniformity of design of larger multicenter studies in the future...
  67. ncbi request reprint Intracortical electroencephalography in acute brain injury
    Allen Waziri
    Department of Neurological Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Ann Neurol 66:366-77. 2009
    ..We hypothesized that bedside placement of an intracortical multicontact electrode would allow for improved monitoring of cortical potentials in critically ill neurological patients...
  68. ncbi request reprint Renal dysfunction as an independent predictor of outcome after aneurysmal subarachnoid hemorrhage: a single-center cohort study
    Brad E Zacharia
    Department of Neurological Surgery, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Stroke 40:2375-81. 2009
    ..We sought to determine the burden of acute kidney injury in patients with aneurysmal subarachnoid hemorrhage and whether this dysfunction affects outcome...
  69. ncbi request reprint Treatment of massive cerebral infarction
    David Palestrant
    Neurological Institute, 710 West 168th Street, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 5:494-502. 2005
    ..To accomplish this there is a growing need for focused specialists in the areas of neurointensive care and stroke...
  70. doi request reprint Exacerbation of perihematomal edema and sterile meningitis with intraventricular administration of tissue plasminogen activator in patients with intracerebral hemorrhage
    Andrew F Ducruet
    Department of Neurological Surgery, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Neurosurgery 66:648-55. 2010
    ..However, recent experimental work has implicated tissue plasminogen activator (tPA) in the pathogenesis of cerebral edema...
  71. doi request reprint Impact of induced normothermia on outcome after subarachnoid hemorrhage: a case-control study
    Neeraj Badjatia
    Department of Neurology, Division of Neurocritical Care, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Neurosurgery 66:696-700; discussion 700-1. 2010
    ..We sought to explore the potential impact of induced normothermia using advanced fever control (AFC) methods on outcome after SAH...
  72. pmc Brain interstitial fluid TNF-alpha after subarachnoid hemorrhage
    Khalid A Hanafy
    Division of Critical Care Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Neurol Sci 291:69-73. 2010
    ....
  73. doi request reprint Doppler ultrasonography screening of poor-grade subarachnoid hemorrhage patients increases the diagnosis of deep venous thrombosis
    William J Mack
    Department of Neurological Surgery, Columbia University College of Physicians and Surgeons, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    Neurol Res 30:889-92. 2008
    ..This study utilizes Doppler USG to examine the prevalence of DVT in a large population of aSAH patients and attempts to identify a high-risk subgroup within this cohort...
  74. ncbi request reprint Effect of acute physiologic derangements on outcome after subarachnoid hemorrhage
    Jan Claassen
    Division of Critical Care Neurology, Department of Neurology, College of Physicians and Surgeons, New York, NY, USA
    Crit Care Med 32:832-8. 2004
    ..To determine the effect that acute physiologic derangements have on outcome after subarachnoid hemorrhage (SAH) and to design a composite score summarizing these abnormalities...
  75. ncbi request reprint Impact of hospital-related factors on outcome after treatment of cerebral aneurysms
    Mitchell F Berman
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Stroke 34:2200-7. 2003
    ..The goal of this study was to examine the impact of hospital characteristics on outcome after the treatment of ruptured and unruptured cerebral aneurysms...
  76. ncbi request reprint Determinants of intracerebral hemorrhage growth: an exploratory analysis
    Joseph P Broderick
    Department of Neurology, The Neuroscience Institute, University of Cincinnati Medical Center, Cincinnati, OH, USA
    Stroke 38:1072-5. 2007
    ..We report an exploratory analysis from a randomized study of recombinant activated factor VII (rFVIIa) in patients with intracerebral hemorrhage (ICH) examining potential factors associated with hemorrhage growth...
  77. ncbi request reprint Predictors and clinical implications of shivering during therapeutic normothermia
    Neeraj Badjatia
    Department of Neurology, Columbia University College of Physicians and Surgeons, 710 W 168th Street, New York, NY 10032, USA
    Neurocrit Care 6:186-91. 2007
    ..Shivering during induced normothermia (IN) remains a therapeutic limitation. We investigated potential risk factors and clinical implications of shivering during IN...
  78. ncbi request reprint Potential mechanisms and clinical significance of global cerebral edema following aneurysmal subarachnoid hemorrhage
    J Mocco
    Department of Neurosurgery, Columbia University, New York, New York 10032, USA
    Neurosurg Focus 22:E7. 2007
    ..Further investigation is needed to gain a full understanding of edema development following SAH, with the hope that the knowledge can be used to influence treatment positively and improve outcome...
  79. ncbi request reprint Outcome prediction with serum intercellular adhesion molecule-1 levels after aneurysmal subarachnoid hemorrhage
    William J Mack
    Department of Neurology and Neurological Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosurg 96:71-5. 2002
    ....
  80. pmc Cerebral perfusion pressure thresholds for brain tissue hypoxia and metabolic crisis after poor-grade subarachnoid hemorrhage
    J Michael Schmidt
    Neurological Intensive Care Unit, Department of Neurology, Columbia University Medical Center, and Milstein Hospital, 177 Fort Washington, 8 300, New York, NY 10032, USA
    Stroke 42:1351-6. 2011
    ..To identify a minimally acceptable cerebral perfusion pressure threshold above which the risks of brain tissue hypoxia (BTH) and oxidative metabolic crisis are reduced for patients with subarachnoid hemorrhage (SAH)...
  81. ncbi request reprint The impact of microsurgical fenestration of the lamina terminalis on shunt-dependent hydrocephalus and vasospasm after aneurysmal subarachnoid hemorrhage
    Ricardo J Komotar
    Department of Neurological Surgery, Columbia University, New York, New York 10032, USA
    Neurosurgery 62:123-32; discussion 132-4. 2008
    ..We reviewed a single-surgeon series to compare postsurgical outcomes of patients who underwent fenestration of the lamina terminalis against those who did not...
  82. ncbi request reprint Far lateral suboccipital approach for the treatment of proximal posteroinferior cerebellar artery aneurysms: surgical results and long-term outcome
    Anthony L D'Ambrosio
    Department of Neurological Surgery, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Neurosurgery 55:39-50; discussion 50-4. 2004
    ..We describe the perioperative course and long-term clinical outcomes obtained via a far lateral suboccipital approach in 20 consecutive proximal PICA aneurysms...
  83. doi request reprint Quantitative analysis of hemorrhage volume for predicting delayed cerebral ischemia after subarachnoid hemorrhage
    Sang Bae Ko
    Department of Neurology, Columbia University College of Physicians and Surgeons, Milstein Hospital Building 8 Center, 177 Fort Washington Avenue, New York, NY 10032, USA
    Stroke 42:669-74. 2011
    ..Quantification of hemorrhage on digitized images may be a more accurate method for predicting DCI than qualitative scales...
  84. ncbi request reprint Critical postcraniotomy cerebrospinal fluid hypovolemia: risk factors and outcome analysis
    Ricardo J Komotar
    Department of Neurosurgery, Columbia University, New York, New York 10032, USA
    Neurosurgery 59:284-90; discussion 284-90. 2006
    ..We sought to identify risk factors for critical CSF hypovolemia and determine this syndrome's effect on clinical outcome...
  85. doi request reprint Effect of mannitol on brain metabolism and tissue oxygenation in severe haemorrhagic stroke
    Raimund Helbok
    Division of Neurocritical Care, Department of Neurology, Columbia University Medical Center, Milstein Hospital 8 300 Center, New York, NY 10032, USA
    J Neurol Neurosurg Psychiatry 82:378-83. 2011
    ..The authors examined if mannitol treatment of raised intracranial pressure will result in an improvement in brain metabolism together with the expected drop in intracranial pressure (ICP)...
  86. ncbi request reprint Continuous electroencephalographic monitoring in neurocritical care
    Jan Claassen
    Division of Critical Care Neurology, Columbia University, Neurological Institute, Box NI 1, 710 West 168th Street, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 2:534-40. 2002
    ..New technologic developments include continuous digital video EEG, automated seizure-detection software, and user-friendly online quantitative EEG analysis...
  87. ncbi request reprint Predictors of global cognitive impairment 1 year after subarachnoid hemorrhage
    Mellanie V Springer
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA
    Neurosurgery 65:1043-50; discussion 1050-1. 2009
    ..We sought to determine the frequency, risk factors, and impact on functional outcome and quality of life (QOL) of global cognitive impairment 1 year after subarachnoid hemorrhage...
  88. ncbi request reprint Continuous EEG monitoring in patients with subarachnoid hemorrhage
    Jan Claassen
    Comprehensive Epilepsy Center, Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Neurophysiol 22:92-8. 2005
    ..CEEG findings may lead to therapeutic (e.g., antiepileptic medication, hypertensive therapy, angioplasty) or additional diagnostic interventions such as angiography, CT or MRI...
  89. pmc Cerebral inflammatory response and predictors of admission clinical grade after aneurysmal subarachnoid hemorrhage
    Khalid A Hanafy
    Department of Neurology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    J Clin Neurosci 17:22-5. 2010
    ..Strategies for mitigating the inflammatory response to aneurysmal rupture in the hyper-acute setting may improve the admission clinical grade, which may in turn improve outcomes...
  90. doi request reprint Anemia is associated with metabolic distress and brain tissue hypoxia after subarachnoid hemorrhage
    Pedro Kurtz
    Division of Critical Care Neurology, Department of Neurology, Columbia University, Milstein Hospital 8 Center, New York, NY 10032, USA
    Neurocrit Care 13:10-6. 2010
    ..The objective of this study is to assess whether there is an association between anemia and metabolic distress or brain tissue hypoxia in patients with subarachnoid hemorrhage...
  91. doi request reprint Medical complications after subarachnoid hemorrhage
    Katja E Wartenberg
    Department of Neurology, Neurologic Intensive Care Unit, Martin Luther University, Halle Wittenberg, Leipzig, Germany
    Neurosurg Clin N Am 21:325-38. 2010
    ..There are promising strategies to minimize these complications. Randomized controlled trials are needed to evaluate the risks and benefits of these and other medical management strategies after SAH...
  92. ncbi request reprint Clinical trial of a novel surface cooling system for fever control in neurocritical care patients
    Stephan A Mayer
    Neurological Intensive Care Unit, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Crit Care Med 32:2508-15. 2004
    ..To compare the efficacy of a novel water-circulating surface cooling system with conventional measures for treating fever in neuro-intensive care unit patients...
  93. doi request reprint The incidence of heparin-induced thrombocytopenia Type II in patients with subarachnoid hemorrhage treated with heparin versus enoxaparin
    Grace H Kim
    Department of Neurological Surgery, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    J Neurosurg 110:50-7. 2009
    ..In this study, the authors investigated the effect of heparin compared with enoxaparin on the incidence of HIT II in patients with aSAH...
  94. ncbi request reprint Impact of a protocol for acute antifibrinolytic therapy on aneurysm rebleeding after subarachnoid hemorrhage
    Robert M Starke
    Department of Neurosurgery, Columbia University, 710 West 168th St, Room 431, New York, NY 10032, USA
    Stroke 39:2617-21. 2008
    ..Although studies have found that a decrease in rebleeding with long-term antifibrinolytic therapy is offset by an increase in ischemic deficits, more recent studies have indicated that early, short-term therapy may be beneficial...
  95. doi request reprint Metabolic impact of shivering during therapeutic temperature modulation: the Bedside Shivering Assessment Scale
    Neeraj Badjatia
    Departments of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stroke 39:3242-7. 2008
    ..We sought to validate a grading scale to assist in the monitoring and control of shivering...
  96. ncbi request reprint Hyperosmolar agents in neurosurgical practice: the evolving role of hypertonic saline
    Alfred T Ogden
    The Neurological Institute, Department of Neurological Surgery, Columbia University, New York, New York 10032, USA
    Neurosurgery 57:207-15; discussion 207-15. 2005
    ..Hypertonic saline is emerging as an alternative to mannitol. Early data suggest that indications for each agent may ultimately depend on ICP etiology...
  97. ncbi request reprint Intensive care unit management of interventional neuroradiology patients
    E Sander Connolly
    Department of Neurological Surgery, Columbia University Medical Center and New York Presbyterian Hospital, 710 West 168th Street, Room 435, New York, NY 10032, USA
    Neurosurg Clin N Am 16:541-5, vi. 2005
    ..Having said this, there are some special considerations that require special mention when it comes to managing patients after catheter-based procedures...
  98. ncbi request reprint Effect of prior statin use on functional outcome and delayed vasospasm after acute aneurysmal subarachnoid hemorrhage: a matched controlled cohort study
    Augusto Parra
    Department of Neurology, Division of Stroke and Critical Care Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Neurosurgery 56:476-84; discussion 476-84. 2005
    ..The effect of prior statin use on 14-day functional outcome and on prevention of vasospasm-induced delayed cerebral ischemia (DCI) or stroke during hospitalization was analyzed...
  99. ncbi request reprint Prognostic significance of continuous EEG monitoring in patients with poor-grade subarachnoid hemorrhage
    Jan Claassen
    Division of Stroke and Critical Care Neurology, Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Neurocrit Care 4:103-12. 2006
    ..The objective of this study was to determine if continuous electroencephalogram (cEEG) monitoring results are predictive of 3-month outcome in critically ill patients with SAH...
  100. ncbi request reprint Quantitative continuous EEG for detecting delayed cerebral ischemia in patients with poor-grade subarachnoid hemorrhage
    Jan Claassen
    The Division of Stroke and Critical Care Neurology, Department of Neurology, Neurological Institute, Columbia University, New York, NY 10032, USA
    Clin Neurophysiol 115:2699-710. 2004
    ..The purpose of this study was to identify quantitative EEG (qEEG) parameters that are most sensitive and specific for the detection of DCI in stuporous or comatose SAH patients...
  101. ncbi request reprint Herniation secondary to critical postcraniotomy cerebrospinal fluid hypovolemia
    Ricardo J Komotar
    Department of Neurosurgery, Columbia University, New York, New York 10032, USA
    Neurosurgery 57:286-92; discussion 286-92. 2005
    ..This article describes the clinical features of brain sag after craniotomy in an attempt to increase recognition of this syndrome...

Research Grants2

  1. New York-Presbyterian NETT Consortium
    Stephan Mayer; Fiscal Year: 2007
    ....