Igor Matushansky

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. doi request reprint Adjuvant chemotherapy in 2011 for patients with soft-tissue sarcoma
    Igor Matushansky
    Division of Medical Oncology, Department of Medicine, Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center, 177 Fort Washington Avenue, Milstein Hospital Building 6 435, New York, NY 10032, USA
    Nat Rev Clin Oncol 8:434-8. 2011
  2. pmc MFH classification: differentiating undifferentiated pleomorphic sarcoma in the 21st Century
    Igor Matushansky
    Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    Expert Rev Anticancer Ther 9:1135-44. 2009
  3. ncbi request reprint A context dependent role for Wnt signaling in tumorigenesis and stem cells
    Igor Matushansky
    Department of Medicine, Columbia University, New York, New York, USA
    Cell Cycle 7:720-4. 2008
  4. pmc Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway
    Igor Matushansky
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Clin Invest 117:3248-57. 2007
  5. pmc A developmental model of sarcomagenesis defines a differentiation-based classification for liposarcomas
    Igor Matushansky
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, 1130 St Nicholas Avenue, New York, NY 10032, USA
    Am J Pathol 172:1069-80. 2008
  6. pmc PPARĪ³ agonists enhance ET-743-induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcoma
    Elizabeth Charytonowicz
    Department of Pathology, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Invest 122:886-98. 2012
  7. ncbi request reprint The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas
    Eva Hernando
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Med 13:748-53. 2007
  8. pmc Hiwi mediated tumorigenesis is associated with DNA hypermethylation
    Sara Siddiqi
    Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, United States of America
    PLoS ONE 7:e33711. 2012
  9. pmc Epigenetic remodeling of chromatin architecture: exploring tumor differentiation therapies in mesenchymal stem cells and sarcomas
    Sara Siddiqi
    Integrated Program, Graduate School of Arts and Sciences, New York, USA
    Curr Stem Cell Res Ther 5:63-73. 2010
  10. pmc Chromatin structure predicts epigenetic therapy responsiveness in sarcoma
    Joslyn Mills
    Department of Pathology, Columbia University, New York, NY, USA
    Mol Cancer Ther 10:313-24. 2011

Research Grants

Collaborators

Detail Information

Publications20

  1. doi request reprint Adjuvant chemotherapy in 2011 for patients with soft-tissue sarcoma
    Igor Matushansky
    Division of Medical Oncology, Department of Medicine, Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center, 177 Fort Washington Avenue, Milstein Hospital Building 6 435, New York, NY 10032, USA
    Nat Rev Clin Oncol 8:434-8. 2011
    ..This Perspectives article examines data that support or refute the use of adjuvant chemotherapy in the treatment of soft-tissue sarcomas...
  2. pmc MFH classification: differentiating undifferentiated pleomorphic sarcoma in the 21st Century
    Igor Matushansky
    Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    Expert Rev Anticancer Ther 9:1135-44. 2009
    ..This manuscript will highlight MFH's troubled history, discuss recent advances, and comment as to what the coming years may promise and what further needs to be done to make sure that progress continues...
  3. ncbi request reprint A context dependent role for Wnt signaling in tumorigenesis and stem cells
    Igor Matushansky
    Department of Medicine, Columbia University, New York, New York, USA
    Cell Cycle 7:720-4. 2008
    ..In this review, we will highlight the diverse effect of Wnt signaling on three types of tissue stem cells and their corresponding malignancies...
  4. pmc Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway
    Igor Matushansky
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Clin Invest 117:3248-57. 2007
    ..Our results provide mechanistic insights regarding the cell of origin of MFH, establish what we believe is a novel tumor suppressor role for Wnt signaling, and identify a potential therapeutic differentiation strategy for sarcomas...
  5. pmc A developmental model of sarcomagenesis defines a differentiation-based classification for liposarcomas
    Igor Matushansky
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, 1130 St Nicholas Avenue, New York, NY 10032, USA
    Am J Pathol 172:1069-80. 2008
    ..Our results indicate that a degree of developmental maturity can be quantitatively assigned to solid tumors, supporting the notion that transformation of a solid tumor stem cell can occur at distinct stages of maturation...
  6. pmc PPARĪ³ agonists enhance ET-743-induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcoma
    Elizabeth Charytonowicz
    Department of Pathology, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Invest 122:886-98. 2012
    ....
  7. ncbi request reprint The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas
    Eva Hernando
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Med 13:748-53. 2007
    ....
  8. pmc Hiwi mediated tumorigenesis is associated with DNA hypermethylation
    Sara Siddiqi
    Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, United States of America
    PLoS ONE 7:e33711. 2012
    ....
  9. pmc Epigenetic remodeling of chromatin architecture: exploring tumor differentiation therapies in mesenchymal stem cells and sarcomas
    Sara Siddiqi
    Integrated Program, Graduate School of Arts and Sciences, New York, USA
    Curr Stem Cell Res Ther 5:63-73. 2010
    ..This review will focus on the importance of epigenetic chromatin remodeling in the context of mesenchymal stem cells, sarcoma tumorigenesis and differentiation therapy...
  10. pmc Chromatin structure predicts epigenetic therapy responsiveness in sarcoma
    Joslyn Mills
    Department of Pathology, Columbia University, New York, NY, USA
    Mol Cancer Ther 10:313-24. 2011
    ..Our results provide the first demonstration of a gene set that can predict responsiveness to HDACI/DNA-MI and links this responsiveness mechanistically to the baseline chromatin structure...
  11. pmc Characterization and comparison of the properties of sarcoma cell lines in vitro and in vivo
    Joslyn Mills
    Department of Pathology, Columbia University, New York, New York 10032, USA
    Hum Cell 22:85-93. 2009
    ..Integration of functional genomics or other more sophisticated assays of cell lines may help bridge the differences in vitro and in vivo...
  12. pmc A transgenic, mesodermal specific, Dkk1 mouse model recapitulates a spectrum of human congenital limb reduction defects
    Filemon Dela Cruz
    Division of Pediatric Oncology, Department of Pediatrics, Columbia University Medical Center, 161 Fort Washington Ave, IP 7, New York, NY 10032, USA
    Differentiation 83:220-30. 2012
    ..We believe Prx1-Dkk1 mice may prove useful in the future to study the mechanisms underlying the development of congenital limb reduction defects...
  13. pmc Solid tumor differentiation therapy - is it possible?
    Filemon Dela Cruz
    Division of Pediatric Oncology, Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Oncotarget 3:559-67. 2012
    ....
  14. doi request reprint Chemotherapy use in elderly patients with soft tissue sarcoma: a population-based study
    Igor Matushansky
    Departments of Medicine, Columbia University, NY, USA
    Cancer Invest 31:83-91. 2013
    ..Consistent with clinical trials, we found minimal use of chemotherapy. Clinical factors were associated with chemotherapy receipt in nonmetastatic STS...
  15. doi request reprint Piwis and piwi-interacting RNAs in the epigenetics of cancer
    Sara Siddiqi
    Integrated Program, Graduate School of Arts and Sciences, Columbia University, New York, New York, USA
    J Cell Biochem 113:373-80. 2012
    ..This review will highlight the current evidence supporting the importance of Piwi and piRNAs in the epigenetics of cancer and provide a potential model for the role of Piwi and piRNAs in tumorigenesis...
  16. ncbi request reprint MicroRNAs in chromosomal translocation-associated solid tumors: learning from sarcomas
    Filemon Dela Cruz
    Division of Pediatric Oncology, Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York 10032, USA
    Discov Med 12:307-17. 2011
    ..The methodological approaches utilized in the study of miR biology and development of miR-based treatment regimens can serve as a paradigm for future investigations in other translocation-associated solid tumors...
  17. ncbi request reprint Mechanisms of sarcomagenesis
    Igor Matushansky
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Hematol Oncol Clin North Am 19:427-49, v. 2005
    ..Finally, the ways in which these advances in basic science are translating into and redefining clinical practice are highlighted...
  18. ncbi request reprint CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells
    Igor Matushansky
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Oncogene 22:4143-9. 2003
    ..Our findings suggest that studying the relative roles of CDK6 and CDK4 in other types of malignant cells will be important in designing approaches for cell cycle inhibition and differentiation therapy in cancer...
  19. pmc PU.1 and pRB interact and cooperate to repress GATA-1 and block erythroid differentiation
    Natasha Rekhtman
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 23:7460-74. 2003
    ..1 antagonizes GATA-1 is by binding to it at GATA-1 target genes and tethering to these sites a corepressor that blocks transcriptional activity and thereby erythroid differentiation...
  20. ncbi request reprint Reversal of tumorigenicity and the block to differentiation in erythroleukemia cells by GATA-1
    Kevin S Choe
    Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cancer Res 63:6363-9. 2003
    ..We also show that the gene for the cell cycle inhibitor p21 is transcriptionally regulated by GATA-1 and is a likely downstream effector of GATA-1 that helps to promote differentiation and proliferation arrest...

Research Grants2

  1. Beta-catenin as a tumor suppressor in sarcomagenesis.
    Igor Matushansky; Fiscal Year: 2006
    ....