Carol A Mason

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion cells in albino mice
    Punita Bhansali
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, USA
    Neural Dev 9:11. 2014
  2. pmc Specificity and sufficiency of EphB1 in driving the ipsilateral retinal projection
    Timothy J Petros
    Departments of Neuroscience, Pathology and Cell Biology, and Ophthalmology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 29:3463-74. 2009
  3. ncbi request reprint Glia, neurons, and axon pathfinding during optic chiasm development
    C A Mason
    Department of Pathology, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Curr Opin Neurobiol 7:647-53. 1997
  4. ncbi request reprint Temporal regulation of EphA4 in astroglia during murine retinal and optic nerve development
    Timothy J Petros
    Center for Neurobiology and Behavior, Department of Pathology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Mol Cell Neurosci 32:49-66. 2006
  5. ncbi request reprint Zic2 patterns binocular vision by specifying the uncrossed retinal projection
    Eloisa Herrera
    Department of Pathology and Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Cell 114:545-57. 2003
  6. pmc Eye-specific projections of retinogeniculate axons are altered in albino mice
    Alexandra Rebsam
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 32:4821-6. 2012
  7. pmc Switching retinogeniculate axon laterality leads to normal targeting but abnormal eye-specific segregation that is activity dependent
    Alexandra Rebsam
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 29:14855-63. 2009
  8. pmc Zic2 regulates retinal ganglion cell axon avoidance of ephrinB2 through inducing expression of the guidance receptor EphB1
    Ramee Lee
    Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 28:5910-9. 2008
  9. ncbi request reprint A role for Nr-CAM in the patterning of binocular visual pathways
    Scott E Williams
    Center for Neurobiology and Behavior and Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Neuron 50:535-47. 2006
  10. ncbi request reprint Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm
    Scott E Williams
    Departments of Pathology, Anatomy and Cell Biology, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Neuron 39:919-35. 2003

Research Grants

  1. GROWTH AND GUIDANCE OF RETINAL AXONS
    Carol Mason; Fiscal Year: 2005
  2. Role of Zic Genes in Patterning the Binocular Projection
    Carol Mason; Fiscal Year: 2006
  3. GROWTH AND GUIDANCE OF RETINAL AXONS
    Carol Mason; Fiscal Year: 2006
  4. Role of Zic Genes in Patterning the Binocular Projection
    Carol Mason; Fiscal Year: 2007
  5. GROWTH AND GUIDANCE OF RETINAL AXONS
    Carol Mason; Fiscal Year: 2007
  6. Vision Sciences Training Grant
    Carol Mason; Fiscal Year: 2007
  7. The Role of Zic Genes in Patterning the Binocular Projection
    Carol Mason; Fiscal Year: 2009
  8. GROWTH AND GUIDANCE OF RETINAL AXONS
    Carol A Mason; Fiscal Year: 2010
  9. Role of Zic Genes in Patterning the Binocular Projection
    Carol Mason; Fiscal Year: 2005
  10. GROWTH AND GUIDANCE OF RETINAL AXONS
    Carol Mason; Fiscal Year: 2004

Collaborators

Detail Information

Publications38

  1. pmc Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion cells in albino mice
    Punita Bhansali
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, USA
    Neural Dev 9:11. 2014
    ....
  2. pmc Specificity and sufficiency of EphB1 in driving the ipsilateral retinal projection
    Timothy J Petros
    Departments of Neuroscience, Pathology and Cell Biology, and Ophthalmology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 29:3463-74. 2009
    ....
  3. ncbi request reprint Glia, neurons, and axon pathfinding during optic chiasm development
    C A Mason
    Department of Pathology, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Curr Opin Neurobiol 7:647-53. 1997
    ....
  4. ncbi request reprint Temporal regulation of EphA4 in astroglia during murine retinal and optic nerve development
    Timothy J Petros
    Center for Neurobiology and Behavior, Department of Pathology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Mol Cell Neurosci 32:49-66. 2006
    ....
  5. ncbi request reprint Zic2 patterns binocular vision by specifying the uncrossed retinal projection
    Eloisa Herrera
    Department of Pathology and Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Cell 114:545-57. 2003
    ..These data provide evidence for transcriptional coding of axon pathfinding at the midline...
  6. pmc Eye-specific projections of retinogeniculate axons are altered in albino mice
    Alexandra Rebsam
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 32:4821-6. 2012
    ..These results suggest that the defects in afferent targeting and activity-dependent refinement in the albino dLGN arise from RGC misspecification together with potential perturbations of early activity patterns in the albino retina...
  7. pmc Switching retinogeniculate axon laterality leads to normal targeting but abnormal eye-specific segregation that is activity dependent
    Alexandra Rebsam
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 29:14855-63. 2009
    ..These findings implicate molecular determinants for targeting of eye-specific zones that are independent of midline guidance cues and that function in concert with correlated retinal activity to sculpt retinogeniculate projections...
  8. pmc Zic2 regulates retinal ganglion cell axon avoidance of ephrinB2 through inducing expression of the guidance receptor EphB1
    Ramee Lee
    Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 28:5910-9. 2008
    ..Our results demonstrate that Zic2 upregulates EphB1 expression and define a link between a transcription factor and expression of a guidance receptor protein essential for axon guidance at the vertebrate midline...
  9. ncbi request reprint A role for Nr-CAM in the patterning of binocular visual pathways
    Scott E Williams
    Center for Neurobiology and Behavior and Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Neuron 50:535-47. 2006
    ..Finally, we demonstrate that EphB1/ephrin-B2-mediated repulsion and Nr-CAM-mediated attraction comprise distinct molecular programs that each contributes to the proper formation of binocular visual pathways...
  10. ncbi request reprint Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm
    Scott E Williams
    Departments of Pathology, Anatomy and Cell Biology, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Neuron 39:919-35. 2003
    ..EphB1 null mice exhibit a dramatically reduced ipsilateral projection, suggesting that this receptor contributes to the formation of the ipsilateral retinal projection, most likely through its repulsive interaction with ephrin-B2...
  11. ncbi request reprint Retinal axon growth at the optic chiasm: to cross or not to cross
    Timothy J Petros
    Department of Pathology and Cell Biology, Department of Neuroscience, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Annu Rev Neurosci 31:295-315. 2008
    ..Throughout this review, we compare guidance mechanisms at the optic chiasm with those in other midline models and highlight unanswered questions both for retinal axon growth and axon guidance in general...
  12. pmc Differential effects of AMPA receptor activation on survival and neurite integrity during neuronal development
    M Chiara Manzini
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Cell Neurosci 35:328-38. 2007
    ..However, the majority of immature cells that survive excitotoxic treatment bear a degenerating neurite, suggesting that AMPA-R activation can still cause damage in the absence of cell death...
  13. ncbi request reprint A new allele of Gli3 and a new mutation, circletail (Crc), resulting from a single transgenic experiment
    Rivka A Rachel
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Genesis 33:55-61. 2002
    ..Anatomical evidence from a Crc/Crc; Gli3/+ fetus indicates that these two genes may interact...
  14. pmc Comparative strength and dendritic organization of thalamocortical and corticocortical synapses onto excitatory layer 4 neurons
    Carl E Schoonover
    Department of Neuroscience and Kavli Institute for Brain Science, Columbia University, New York, New York 10032
    J Neurosci 34:6746-58. 2014
    ..We conclude that thalamic effectiveness does not rely on enhanced TC strength, but rather on coincident activation of converging inputs. ..
  15. ncbi request reprint Influence of tyrosinase levels on pigment accumulation in the retinal pigment epithelium and on the uncrossed retinal projection
    Rivka A Rachel
    Center for Neurobiology and Behaviour, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Pigment Cell Res 15:273-81. 2002
    ..Our results suggest that replacing less than 35% of wild-type tyrosinase activity is sufficient to restore normal pigmentation of the RPE, and potentially, to allay visual defects...
  16. ncbi request reprint Domains of regulatory gene expression and the developing optic chiasm: correspondence with retinal axon paths and candidate signaling cells
    R C Marcus
    Department of Pathology, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Comp Neurol 403:346-58. 1999
    ..Together, these data support the hypothesis that molecularly distinct, longitudinally aligned domains in the forebrain regulate the pattern of retinal axon projections in the developing hypothalamus...
  17. pmc Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice
    Mirna Kvajo
    Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 108:E1349-58. 2011
    ..Our results provide support to the notion that modest disturbances of neuronal connectivity and accompanying deficits in short-term synaptic dynamics is a general feature of schizophrenia-predisposing mutations...
  18. pmc Integrins establish dendrite-substrate relationships that promote dendritic self-avoidance and patterning in drosophila sensory neurons
    Michelle E Kim
    Department of Physiology and Cellular Biophysics, Columbia University Medical Center, 630 W 168th St P and S 12 403, New York, NY 10032, USA
    Neuron 73:79-91. 2012
    ....
  19. pmc Development of axon-target specificity of ponto-cerebellar afferents
    Anna Kalinovsky
    Department of Physiology and Cellular Biophysics and Department of Neuroscience, Columbia University, New York, New York, United States of America
    PLoS Biol 9:e1001013. 2011
    ..Moreover, this work establishes BMP4 as a retrograde signal that regulates the axon-target interactions during development...
  20. ncbi request reprint The first retinal axon growth in the mouse optic chiasm: axon patterning and the cellular environment
    R C Marcus
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 15:6389-402. 1995
    ....
  21. ncbi request reprint The optic chiasm as a midline choice point
    Scott E Williams
    Department of Pathology, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, 630 W 168 th Street, New York, NY 10032, USA
    Curr Opin Neurobiol 14:51-60. 2004
    ..In addition, the mechanisms for axon divergence in the optic chiasm are discussed in the context of other popular models for midline axon guidance...
  22. ncbi request reprint The stop signal revised: immature cerebellar granule neurons in the external germinal layer arrest pontine mossy fiber growth
    M Chiara Manzini
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 26:6040-51. 2006
    ..We found that the stop-growing signals are dependent on heparin-binding factors, and we propose that such signals in the EGL restrict the extension of mossy fiber afferents and prevent invasion of proliferative regions...
  23. ncbi request reprint Retinal axon divergence in the optic chiasm: midline cells are unaffected by the albino mutation
    R C Marcus
    Department of Pathology, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York 10032, USA
    Development 122:859-68. 1996
    ....
  24. ncbi request reprint Eph family receptors and their ligands distribute in opposing gradients in the developing mouse retina
    R C Marcus
    Department of Pathology, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, 630 W 168th Street, New York, New York, 10032, USA
    Dev Biol 180:786-9. 1996
    ..The distinct distributions of Eph family members suggest that each subclass specifies positional information along independent retinal axes...
  25. ncbi request reprint Developmental regulation of mossy fiber afferent interactions with target granule cells
    Q Zhang
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Dev Biol 195:75-87. 1998
    ..These results indicate that the stop signal, and the response of afferents to it, are developmentally regulated. Moreover, factors within the target region may initiate these interactions...
  26. ncbi request reprint Retinal axon misrouting at the optic chiasm in mice with neural tube closure defects
    R A Rachel
    Center for Neurobiology and Behavior, Columbia University, New York, New York, USA
    Genesis 27:32-47. 2000
    ..This study therefore reveals an unexpected connection between closure of the neural tube at the dorsal midline and development of ventral axon tracts. genesis 27:32-47, 2000...
  27. ncbi request reprint Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits
    L Erskine
    Department of Pathology, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 20:4975-82. 2000
    ....
  28. pmc Reciprocal actions of ATF5 and Shh in proliferation of cerebellar granule neuron progenitor cells
    Hae Young Lee
    Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Dev Neurobiol 72:789-804. 2012
    ..These findings indicate a reciprocal interaction between ATF5 and Shh in which Shh stimulates ATF5 expression and in which ATF5 contributes to Shh-stimulated CGNP expansion...
  29. ncbi request reprint Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retina
    Rivka A Rachel
    Center for Neurobiology and Behavior, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 22:4249-63. 2002
    ..These results point to spatiotemporal defects in neuronal production in the albino retina, which could perturb expression of genes that specify cell fate, number, and/or projection phenotype...
  30. pmc Genetic modulation of BDNF signaling affects the outcome of axonal competition in vivo
    Luxiang Cao
    Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Curr Biol 17:911-21. 2007
    ..However, the molecular pathways that modulate axonal-branch stability or formation in competitive environments remain unknown...
  31. ncbi request reprint Bidirectional regulation of hippocampal mossy fiber filopodial motility by kainate receptors: a two-step model of synaptogenesis
    Ayumu Tashiro
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Neuron 38:773-84. 2003
    ..A two-step model of synaptogenesis can also explain the opposite effects of neuronal activity on the motility of dendritic protrusions...
  32. ncbi request reprint alpha-Internexin is the only neuronal intermediate filament expressed in developing cerebellar granule neurons
    C L Chien
    Department of Pathology, Columbia University College of Physicans and Surgeons, New York, 10032, USA
    J Neurobiol 29:304-18. 1996
    ..Furthermore, alpha-internexin may play a key role in neurite outgrowth and the establishment of neuronal cytoarchitecture...
  33. doi request reprint Otx2's incredible journey
    Alexandra Rebsam
    Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, 630 W 168 th Street, 14 509 P and S Building, New York, NY 10032, USA
    Cell 134:386-7. 2008
    ....
  34. ncbi request reprint Nr-CAM expression in the developing mouse nervous system: ventral midline structures, specific fiber tracts, and neuropilar regions
    M Lustig
    Department of Pharmacology, New York University Medical Center, New York, New York 10016, USA
    J Comp Neurol 434:13-28. 2001
    ..In the hippocampus, however, TAG-1-positive areas are segregated from Nr-CAM-positive areas, suggesting that, in neuropilar regions, Nr-CAM interacts with molecules other than TAG-1...
  35. ncbi request reprint Neuron death in the substantia nigra of weaver mouse occurs late in development and is not apoptotic
    T F Oo
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 16:6134-45. 1996
    ....
  36. ncbi request reprint Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system
    Andrew S Plump
    Department of Anatomy, Howard Hughes Medical Institute, CA, USA
    Neuron 33:219-32. 2002
    ..Our results indicate that Slit proteins repel retinal axons in vivo and cooperate to establish a corridor through which the axons are channeled, thereby helping define the site in the ventral diencephalon where the optic chiasm forms...
  37. ncbi request reprint Mena and vasodilator-stimulated phosphoprotein are required for multiple actin-dependent processes that shape the vertebrate nervous system
    A Sheila Menzies
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    J Neurosci 24:8029-38. 2004
    ..Mena-/-VASP-/- double mutants die perinatally and display defects in neurulation, craniofacial structures, and the formation of several fiber tracts in the CNS and peripheral nervous system...

Research Grants27

  1. GROWTH AND GUIDANCE OF RETINAL AXONS
    Carol Mason; Fiscal Year: 2005
    ..Such studies are important for understanding how visual pathways form, key for aiding RGC regeneration after perturbation to the visual system. ..
  2. Role of Zic Genes in Patterning the Binocular Projection
    Carol Mason; Fiscal Year: 2006
    ..This analysis should shed light on patterning the binocular pathway and should apply to the establishment of bilateral sensory pathways elsewhere in the nervous system. ..
  3. GROWTH AND GUIDANCE OF RETINAL AXONS
    Carol Mason; Fiscal Year: 2006
    ..Such studies are important for understanding how visual pathways form, key for aiding RGC regeneration after perturbation to the visual system. ..
  4. Role of Zic Genes in Patterning the Binocular Projection
    Carol Mason; Fiscal Year: 2007
    ..This analysis should shed light on patterning the binocular pathway and should apply to the establishment of bilateral sensory pathways elsewhere in the nervous system. ..
  5. GROWTH AND GUIDANCE OF RETINAL AXONS
    Carol Mason; Fiscal Year: 2007
    ..Such studies are important for understanding how visual pathways form, key for aiding RGC regeneration after perturbation to the visual system. ..
  6. Vision Sciences Training Grant
    Carol Mason; Fiscal Year: 2007
    ....
  7. The Role of Zic Genes in Patterning the Binocular Projection
    Carol Mason; Fiscal Year: 2009
    ..This work investigates the genes that pattern the retina into sectors giving rise to crossed and uncrossed projections and that drive expression of guidance receptors to enable retinal axons to take the appropriate route. ..
  8. GROWTH AND GUIDANCE OF RETINAL AXONS
    Carol A Mason; Fiscal Year: 2010
    ..These studies use this model to investigate the molecular factors that help guide axons to their appropriate route and synaptic targets in the brain. ..
  9. Role of Zic Genes in Patterning the Binocular Projection
    Carol Mason; Fiscal Year: 2005
    ..This analysis should shed light on patterning the binocular pathway and should apply to the establishment of bilateral sensory pathways elsewhere in the nervous system. ..
  10. GROWTH AND GUIDANCE OF RETINAL AXONS
    Carol Mason; Fiscal Year: 2004
    ..Such studies are important for understanding how visual pathways form, key for aiding RGC regeneration after perturbation to the visual system. ..
  11. Role of Zic Genes in Patterning the Binocular Projection
    Carol Mason; Fiscal Year: 2004
    ..This analysis should shed light on patterning the binocular pathway and should apply to the establishment of bilateral sensory pathways elsewhere in the nervous system. ..
  12. AXON TARGET INTERACTIONS IN THE DEVELOPING CEREBELLUM
    Carol Mason; Fiscal Year: 1999
    ..These studies should suggest molecular mechanisms underlying synaptogenesis in the mammalian CNS, important for understanding neurological disease, and for devising approaches to ensure neural process regrowth after injury. ..
  13. The Role of Zic Genes in Patterning the Binocular Projection
    Carol A Mason; Fiscal Year: 2010
    ..This work investigates the genes that pattern the retina into sectors giving rise to crossed and uncrossed projections and that drive expression of guidance receptors to enable retinal axons to take the appropriate route. ..
  14. AXON TARGET INTERACTIONS IN THE DEVELOPING CEREBELLUM
    Carol Mason; Fiscal Year: 2000
    ....
  15. GROWTH AND GUIDANCE OF RETINAL AXONS
    Carol Mason; Fiscal Year: 2001
    ..This work should elucidate the signalling mechanisms used for axon navigation in this CNS pathway, a model for the patterning of bilateral projections, and provide a dynamic analysis of growth cone kinetics and interactions. ..
  16. AXON TARGET INTERACTIONS IN THE DEVELOPING CEREBELLUM
    Carol Mason; Fiscal Year: 2001
    ....
  17. GROWTH AND GUIDANCE OF RETINAL AXONS
    Carol Mason; Fiscal Year: 2003
    ..This work should elucidate the signalling mechanisms used for axon navigation in this CNS pathway, a model for the patterning of bilateral projections, and provide a dynamic analysis of growth cone kinetics and interactions. ..
  18. GROWTH AND GUIDANCE OF RETINAL AXONS
    Carol Mason; Fiscal Year: 2002
    ..This work should elucidate the signalling mechanisms used for axon navigation in this CNS pathway, a model for the patterning of bilateral projections, and provide a dynamic analysis of growth cone kinetics and interactions. ..
  19. AXON TARGET INTERACTIONS IN THE DEVELOPING CEREBELLUM
    Carol Mason; Fiscal Year: 2002
    ....
  20. GROWTH AND GUIDANCE OF RETINAL AXONS
    Carol Mason; Fiscal Year: 2009
    ..These studies use this model to investigate the molecular factors that help guide axons to their appropriate route and synaptic targets in the brain. ..
  21. The Role of Zic Genes in Patterning the Binocular Projection
    Carol A Mason; Fiscal Year: 2010
    ..This work investigates the genes that pattern the retina into sectors giving rise to crossed and uncrossed projections and that drive expression of guidance receptors to enable retinal axons to take the appropriate route. ..
  22. GROWTH AND GUIDANCE OF RETINAL AXONS
    Carol Mason; Fiscal Year: 2000
    ..This work should elucidate the signalling mechanisms used for axon navigation in this CNS pathway, a model for the patterning of bilateral projections, and provide a dynamic analysis of growth cone kinetics and interactions. ..