DIANA M MARTINEZ

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi Dopamine type 2/3 receptor availability in the striatum and social status in human volunteers
    Diana Martinez
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 67:275-8. 2010
  2. ncbi Deficits in dopamine D(2) receptors and presynaptic dopamine in heroin dependence: commonalities and differences with other types of addiction
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Biol Psychiatry 71:192-8. 2012
  3. ncbi Imaging dopamine transmission in cocaine dependence: link between neurochemistry and response to treatment
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 168:634-41. 2011
  4. ncbi Imaging neurotransmitter release by drugs of abuse
    Diana Martinez
    NYS Psychiatric Institute, New York, NY 10032, USA
    Curr Top Behav Neurosci 3:219-45. 2010
  5. ncbi Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion
    Diana Martinez
    Department of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 166:1170-7. 2009
  6. ncbi Positron emission tomography imaging of the serotonin transporter and 5-HT(1A) receptor in alcohol dependence
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Psychiatry 65:175-80. 2009
  7. ncbi Imaging the neurochemistry of alcohol and substance abuse
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Box 31, New York, NY 10032, USA
    Neuroimaging Clin N Am 17:539-55, x. 2007
  8. ncbi Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Psychiatry 164:622-9. 2007
  9. ncbi Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Biol Psychiatry 58:779-86. 2005
  10. ncbi Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 29:1190-202. 2004

Research Grants

  1. Imaging the neurochemistry of negative reinforcement in cocaine abuse
    Diana Martinez; Fiscal Year: 2009
  2. PET Imaging of Mesolimbic Dopamine in Heroin Dependence
    Diana Martinez; Fiscal Year: 2007
  3. PET Imaging of Mesolimbic Dopamine in Heroin Dependence
    Diana Martinez; Fiscal Year: 2007
  4. Imaging the Neurobiology of a Behavioral Treatment for Cocaine Dependence
    Diana Martinez; Fiscal Year: 2007
  5. Imaging the Neurochemistry of Binge-Drinking in College-Aged Young Adults
    DIANA M MARTINEZ; Fiscal Year: 2010

Detail Information

Publications14

  1. ncbi Dopamine type 2/3 receptor availability in the striatum and social status in human volunteers
    Diana Martinez
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 67:275-8. 2010
    ..The goal of the present study was to examine this phenomena in human subjects using PET and the radiotracer [(11)C]raclopride...
  2. ncbi Deficits in dopamine D(2) receptors and presynaptic dopamine in heroin dependence: commonalities and differences with other types of addiction
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Biol Psychiatry 71:192-8. 2012
    ..The goal of the present study was to investigate these parameters of striatal dopamine transmission in heroin dependence and their association with drug seeking behavior...
  3. ncbi Imaging dopamine transmission in cocaine dependence: link between neurochemistry and response to treatment
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 168:634-41. 2011
    ..The authors hypothesized that dopamine signaling in the limbic striatum would be associated with response to a behavioral treatment that uses positive reinforcement to replace impulsive cocaine use with constructive personal goals...
  4. ncbi Imaging neurotransmitter release by drugs of abuse
    Diana Martinez
    NYS Psychiatric Institute, New York, NY 10032, USA
    Curr Top Behav Neurosci 3:219-45. 2010
    ..The results of these studies suggest that cocaine and alcohol addiction are associated with a loss of dopamine transmission, and a number of studies show that this loss correlates with severity of disease...
  5. ncbi Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion
    Diana Martinez
    Department of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 166:1170-7. 2009
    ..The purpose of this study was to measure D(2)/D(3) receptors following acute dopamine depletion in cocaine-dependent volunteers relative to healthy comparison subjects...
  6. ncbi Positron emission tomography imaging of the serotonin transporter and 5-HT(1A) receptor in alcohol dependence
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Psychiatry 65:175-80. 2009
    ..This is the first report of combined tracers for pre- and postsynaptic serotonergic transmission in the same alcoholic subjects and the first study of 5-HT(1A) receptors in alcoholism...
  7. ncbi Imaging the neurochemistry of alcohol and substance abuse
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Box 31, New York, NY 10032, USA
    Neuroimaging Clin N Am 17:539-55, x. 2007
    ..This article reviews the literature of radiochemical imaging in cocaine, alcohol, heroin, methamphetamine, MDMA, and ketamine abuse and dependence...
  8. ncbi Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Psychiatry 164:622-9. 2007
    ..Furthermore, the relationship between this dopamine response and the choice to self-administer cocaine in a laboratory model of relapse was investigated...
  9. ncbi Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Biol Psychiatry 58:779-86. 2005
    ..This study measured D2 receptors and dopamine transmission in human alcohol-dependent (AD) subjects using positron emission tomography (PET) and [11C]raclopride...
  10. ncbi Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 29:1190-202. 2004
    ..Additional research is warranted to unravel potential neurobiological traits that might confer vulnerability to relapse in detoxified CCD subjects...
  11. ncbi Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    J Cereb Blood Flow Metab 23:285-300. 2003
    ....
  12. ncbi Imaging neurochemical endophenotypes: promises and pitfalls
    D Martinez
    New York State Psychiatric Institute, 1051 Riverside Drive, Box 31, New York, NY 10032, USA
    Pharmacogenomics 2:223-37. 2001
    ..These studies illustrate the unique opportunities, as well as the pitfalls, generated by combining genetic analysis with brain imaging studies...
  13. ncbi The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporter phenotype in humans
    D Martinez
    Division of Functional Brain Mapping, New York State Psychiatry Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neuropsychopharmacology 24:553-60. 2001
    ..Thus, we did not replicate the findings of two previous studies, which had suggested that the 9 repeat allele was associated with either an increased or decreased DAT expression, albeit in different patient populations...
  14. ncbi Imaging human mesolimbic dopamine transmission with positron emission tomography: I. Accuracy and precision of D(2) receptor parameter measurements in ventral striatum
    O Mawlawi
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Cereb Blood Flow Metab 21:1034-57. 2001
    ....

Research Grants10

  1. Imaging the neurochemistry of negative reinforcement in cocaine abuse
    Diana Martinez; Fiscal Year: 2009
    ..Using both imaging and behavioral studies, this application seeks to further our understanding this important phenomena in relapse. ..
  2. PET Imaging of Mesolimbic Dopamine in Heroin Dependence
    Diana Martinez; Fiscal Year: 2007
    ..abstract_text> ..
  3. PET Imaging of Mesolimbic Dopamine in Heroin Dependence
    Diana Martinez; Fiscal Year: 2007
    ..abstract_text> ..
  4. Imaging the Neurobiology of a Behavioral Treatment for Cocaine Dependence
    Diana Martinez; Fiscal Year: 2007
    ..abstract_text> ..
  5. Imaging the Neurochemistry of Binge-Drinking in College-Aged Young Adults
    DIANA M MARTINEZ; Fiscal Year: 2010
    ..The goal of the present study is to investigate whether these alterations are present in young-adult binge drinkers, and to investigate potential mechanisms behind the disruptions in dopamine transmission. ..