Research Topics
Species | Karen S MarderSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
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Publications
Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish populationXinmin Liu
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
BMC Med Genet 12:104. 2011..Collectively the associations identified in these GWAS account for only a small proportion of the estimated total heritability of PD suggesting that an 'unknown' component of the genetic architecture of PD remains to be identified...
Relationship between CAG repeat length and late-stage outcomes in Huntington's diseaseK Marder
Department of Neurology, Sergievsky Center, and The Taub Institute, Columbia University, New York, NY 10032, USA
Neurology 59:1622-4. 2002..CAG repeat length was inversely correlated with time to NH admission and PEG (both p < 0.001), independent of age at onset. CAG repeat length may influence disease progression to late-stage outcomes in addition to age at onset...- Predictors of parkin mutations in early-onset Parkinson disease: the consortium on risk for early-onset Parkinson disease studyKaren S Marder
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 W 168th St, Unit 16, New York, NY 10032, USA
Arch Neurol 67:731-8. 2010..Mutations in the parkin gene are the most common genetic cause of early-onset Parkinson disease (PD). Results from a multicenter study of patients with PD systematically sampled by age at onset have not been reported to date... 
Cognitive impairment and dementia in Parkinson's diseaseKaren Marder
Department of Neurology, Columbia University, New York, New York, USA
Mov Disord 25:S110-6. 2010..The FDA has approved a treatment for PDD, and efforts now are directed toward intervention at earlier stages of cognitive impairment...- Dietary intake in adults at risk for Huntington disease: analysis of PHAROS research participantsK Marder
Departments of Neurology and Psychiatry, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
Neurology 73:385-92. 2009..To examine caloric intake, dietary composition, and body mass index (BMI) in participants in the Prospective Huntington At Risk Observational Study (PHAROS)... - Accuracy of family history data on Parkinson's diseaseK Marder
Department of Neurology, Columbia University, New York, USA
Neurology 61:18-23. 2003..Genetic studies of PD frequently rely on family history interviews (FHI), yet the accuracy of data obtained in this way is unclear... - Familial aggregation of early- and late-onset Parkinson's diseaseKaren Marder
Department of Neurology, Columbia University, New York, NY, USA
Ann Neurol 54:507-13. 2003..Genetic factors are important in both early- and late-onset PD, but specific genes and mode of inheritance may differ between the two groups... - Inter-rater reliability of a clinical staging of HIV-associated cognitive impairmentK Marder
Department of Neurology, Sergievsky Center, New York, NY 10032, USA
Neurology 60:1467-73. 2003..To determine the inter-rater reliability of a modification of the Memorial Sloan-Kettering (MSK) Staging for HIV-associated cognitive impairment... - Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's diseaseRoy N Alcalay
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
J Clin Exp Neuropsychol 32:775-9. 2010..GBA carriers reported more impairment, but MMSE performance did not differ among genetic groups. Detailed neuropsychological testing is required to explore the association between cognitive impairment and GBA mutations... - Neuropsychological Profile of Parkin Mutation Carriers with and without Parkinson Disease: The CORE-PD StudyElise Caccappolo
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Int Neuropsychol Soc 17:91-100. 2011..Carriers of parkin mutations, whether or not they have PD, do not perform differently on neuropsychological measures as compared to noncarriers. The cognitive functioning of parkin carriers over time warrants further study... - Spectrum of gait impairments in presymptomatic and symptomatic Huntington's diseaseAshwini K Rao
Program in Physical Therapy, Department of Rehabilitation Medicine, Columbia University Medical Center, New York, NY 10032, USA
Mov Disord 23:1100-7. 2008..Gait measures are sensitive in differentiating between mutation positive and negative individuals even when impairments were not detected by clinical neurological examination. (c) 2008 Movement Disorder Society... - The association between Mediterranean diet adherence and Parkinson's diseaseRoy N Alcalay
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Mov Disord 27:771-4. 2012..Recent studies have demonstrated an association between a Mediterranean-type diet and Alzheimer's risk. We assessed the association between Mediterranean-type diet adherence and Parkinson's disease (PD) status... - Coordination of fingertip forces during precision grip in premanifest Huntington's diseaseAshwini K Rao
Program in Physical Therapy, Department of Rehabilitation and Regenerative Medicine, Columbia University Medical Center, New York, New York, USA
Mov Disord 26:862-9. 2011..Force and temporal variability may be good markers of disease severity because they were correlated with predicted onset of disease... - Motor phenotype of LRRK2 G2019S carriers in early-onset Parkinson diseaseRoy N Alcalay
Department of Neurology, Columbia University, New York, NY 10032, USA
Arch Neurol 66:1517-22. 2009.... - Clinical assessment of mobility and balance impairments in pre-symptomatic Huntington's diseaseAshwini K Rao
Department of Rehabilitation Medicine, Columbia University Medical Center, New York, NY 10032, USA
Gait Posture 30:391-3. 2009..Given the ease of administering clinical tests, and the importance of assessing mobility and balance, we examined whether clinical tests can detect motor impairments in individuals with pre-symptomatic HD... - Clinical and pathological characteristics of LRRK2 G2019S patients with PDMarkos Poulopoulos
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
J Mol Neurosci 47:139-43. 2012..However, the extent of cortical involvement is variable. Larger longitudinal follow-up of LRRK2 G2019S mutation carriers is required to assess for risk factors for cortical involvement and dementia... - RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease riskDavid A MacLeod
Department of Neurology and Taub Institute, Columbia University, Black Building 1208, 650 West 168th Street, New York, NY 10032, USA
Neuron 77:425-39. 2013..Expression of wild-type VPS35, but not a familial PD-associated mutant form, rescued these defects. Taken together, these studies implicate retromer and lysosomal pathway alterations in PD risk... - A comparison of self-report and caregiver assessment of depression, apathy, and irritability in Huntington's diseaseAnjan Chatterjee
Department of Neurology and Psychiatry, College of Physicians and Surgeons, Columbia University, NY, NY 10032, USA
J Neuropsychiatry Clin Neurosci 17:378-83. 2005..Caregiver assessment of patients' moods and apathy may be an acceptable alternative to patient self-report as patients' cognitive status worsens... - Clinical measurement of mobility and balance impairments in Huntington's disease: validity and responsivenessAshwini K Rao
Department of Rehabilitation Medicine, Columbia University Medical Center, United States
Gait Posture 29:433-6. 2009..These tests may not be optimal because they are scored on an ordinal scale and do not test anticipatory balance. We tested the validity and responsiveness of three clinical tests of mobility and balance... - Dementia in Parkinson's diseaseGregory A Rippon
Department of Neurology, Columbia University, New York, New York, USA
Adv Neurol 96:95-113. 2005..Further research is needed to elucidate the relationship of PDD to DLB and AD in hopes of developing and using appropriate therapeutic measures designed to address the underlying disease process... - Lack of association between cancer history and PARKIN genotype: a family based study in PARKIN/Parkinson's familiesRoy N Alcalay
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Genes Chromosomes Cancer 51:1109-13. 2012..We conclude that although Parkin may exert a suppressive effect in mice, further studies are required prior to assigning a TS function to PARKIN in humans... - Genetic aspects of Alzheimer diseaseJennifer Williamson
Taub Institute for Research on Alzheimer Disease and the Aging Brain and the Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, Department of Neurology, New York, NY 10032, USA
Neurologist 15:80-6. 2009.... - Association of life activities with cerebral blood flow in Alzheimer disease: implications for the cognitive reserve hypothesisNikolaos Scarmeas
Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Arch Neurol 60:359-65. 2003..This has been interpreted as suggesting that cognitive reserve allows these patients to cope better with the pathologic changes in AD... - Reliability of spatiotemporal gait outcome measures in Huntington's diseaseAshwini K Rao
Program in Physical Therapy, Department of Rehabilitation Medicine, Columbia University Medical Center, New York, New York, USA
Mov Disord 20:1033-7. 2005..Our data on high test-retest reliability and sensitivity extends the utility of the GAITRite to the HD population... - Olfaction in Parkin heterozygotes and compound heterozygotes: the CORE-PD studyR N Alcalay
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Neurology 76:319-26. 2011..Whether olfaction differs between Parkin mutation heterozygotes and carriers of 2 Parkin mutations (compound heterozygotes) is unknown...
Research Grants
- Genetic Epidemiology of Parkinson's DiseaseKaren Marder; Fiscal Year: 2007....
- GENETIC EPIDEMIOLOGY OF PARKINSONS DISEASEKaren Marder; Fiscal Year: 2003..The investigators will use segregation analysis to determine the most likely mode of inheritance of these clinical phenotypes in order to determine the optimal strategy for a future genetic linkage study. ..