Karen S Marder

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population
    Xinmin Liu
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    BMC Med Genet 12:104. 2011
  2. ncbi request reprint Relationship between CAG repeat length and late-stage outcomes in Huntington's disease
    K Marder
    Department of Neurology, Sergievsky Center, and The Taub Institute, Columbia University, New York, NY 10032, USA
    Neurology 59:1622-4. 2002
  3. doi request reprint Cognitive impairment and dementia in Parkinson's disease
    Karen Marder
    Department of Neurology, Columbia University, New York, New York, USA
    Mov Disord 25:S110-6. 2010
  4. pmc Predictors of parkin mutations in early-onset Parkinson disease: the consortium on risk for early-onset Parkinson disease study
    Karen S Marder
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 W 168th St, Unit 16, New York, NY 10032, USA
    Arch Neurol 67:731-8. 2010
  5. pmc Dietary intake in adults at risk for Huntington disease: analysis of PHAROS research participants
    K Marder
    Departments of Neurology and Psychiatry, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Neurology 73:385-92. 2009
  6. ncbi request reprint Familial aggregation of early- and late-onset Parkinson's disease
    Karen Marder
    Department of Neurology, Columbia University, New York, NY, USA
    Ann Neurol 54:507-13. 2003
  7. ncbi request reprint Accuracy of family history data on Parkinson's disease
    K Marder
    Department of Neurology, Columbia University, New York, USA
    Neurology 61:18-23. 2003
  8. ncbi request reprint Inter-rater reliability of a clinical staging of HIV-associated cognitive impairment
    K Marder
    Department of Neurology, Sergievsky Center, New York, NY 10032, USA
    Neurology 60:1467-73. 2003
  9. pmc Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease
    Roy N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Clin Exp Neuropsychol 32:775-9. 2010
  10. pmc Neuropsychological Profile of Parkin Mutation Carriers with and without Parkinson Disease: The CORE-PD Study
    Elise Caccappolo
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Int Neuropsychol Soc 17:91-100. 2011

Research Grants

  1. Genetic Epidemiology of Parkinson's Disease
    Karen Marder; Fiscal Year: 2007
  2. GENETIC EPIDEMIOLOGY OF PARKINSONS DISEASE
    Karen Marder; Fiscal Year: 2003

Detail Information

Publications29

  1. pmc Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population
    Xinmin Liu
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    BMC Med Genet 12:104. 2011
    ..Collectively the associations identified in these GWAS account for only a small proportion of the estimated total heritability of PD suggesting that an 'unknown' component of the genetic architecture of PD remains to be identified...
  2. ncbi request reprint Relationship between CAG repeat length and late-stage outcomes in Huntington's disease
    K Marder
    Department of Neurology, Sergievsky Center, and The Taub Institute, Columbia University, New York, NY 10032, USA
    Neurology 59:1622-4. 2002
    ..CAG repeat length was inversely correlated with time to NH admission and PEG (both p < 0.001), independent of age at onset. CAG repeat length may influence disease progression to late-stage outcomes in addition to age at onset...
  3. doi request reprint Cognitive impairment and dementia in Parkinson's disease
    Karen Marder
    Department of Neurology, Columbia University, New York, New York, USA
    Mov Disord 25:S110-6. 2010
    ..The FDA has approved a treatment for PDD, and efforts now are directed toward intervention at earlier stages of cognitive impairment...
  4. pmc Predictors of parkin mutations in early-onset Parkinson disease: the consortium on risk for early-onset Parkinson disease study
    Karen S Marder
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 W 168th St, Unit 16, New York, NY 10032, USA
    Arch Neurol 67:731-8. 2010
    ..Mutations in the parkin gene are the most common genetic cause of early-onset Parkinson disease (PD). Results from a multicenter study of patients with PD systematically sampled by age at onset have not been reported to date...
  5. pmc Dietary intake in adults at risk for Huntington disease: analysis of PHAROS research participants
    K Marder
    Departments of Neurology and Psychiatry, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Neurology 73:385-92. 2009
    ..To examine caloric intake, dietary composition, and body mass index (BMI) in participants in the Prospective Huntington At Risk Observational Study (PHAROS)...
  6. ncbi request reprint Familial aggregation of early- and late-onset Parkinson's disease
    Karen Marder
    Department of Neurology, Columbia University, New York, NY, USA
    Ann Neurol 54:507-13. 2003
    ..Genetic factors are important in both early- and late-onset PD, but specific genes and mode of inheritance may differ between the two groups...
  7. ncbi request reprint Accuracy of family history data on Parkinson's disease
    K Marder
    Department of Neurology, Columbia University, New York, USA
    Neurology 61:18-23. 2003
    ..Genetic studies of PD frequently rely on family history interviews (FHI), yet the accuracy of data obtained in this way is unclear...
  8. ncbi request reprint Inter-rater reliability of a clinical staging of HIV-associated cognitive impairment
    K Marder
    Department of Neurology, Sergievsky Center, New York, NY 10032, USA
    Neurology 60:1467-73. 2003
    ..To determine the inter-rater reliability of a modification of the Memorial Sloan-Kettering (MSK) Staging for HIV-associated cognitive impairment...
  9. pmc Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease
    Roy N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Clin Exp Neuropsychol 32:775-9. 2010
    ..GBA carriers reported more impairment, but MMSE performance did not differ among genetic groups. Detailed neuropsychological testing is required to explore the association between cognitive impairment and GBA mutations...
  10. pmc Neuropsychological Profile of Parkin Mutation Carriers with and without Parkinson Disease: The CORE-PD Study
    Elise Caccappolo
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Int Neuropsychol Soc 17:91-100. 2011
    ..Carriers of parkin mutations, whether or not they have PD, do not perform differently on neuropsychological measures as compared to noncarriers. The cognitive functioning of parkin carriers over time warrants further study...
  11. doi request reprint Cognitive and motor function in long-duration PARKIN-associated Parkinson disease
    Roy N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York2Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York
    JAMA Neurol 71:62-7. 2014
    ..Data on the long-term cognitive outcomes of patients with PARKIN-associated Parkinson disease (PD) are unknown but may be useful when counseling these patients...
  12. doi request reprint Spectrum of gait impairments in presymptomatic and symptomatic Huntington's disease
    Ashwini K Rao
    Program in Physical Therapy, Department of Rehabilitation Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Mov Disord 23:1100-7. 2008
    ..Gait measures are sensitive in differentiating between mutation positive and negative individuals even when impairments were not detected by clinical neurological examination. (c) 2008 Movement Disorder Society...
  13. pmc Lack of association between cancer history and PARKIN genotype: a family based study in PARKIN/Parkinson's families
    Roy N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Genes Chromosomes Cancer 51:1109-13. 2012
    ..We conclude that although Parkin may exert a suppressive effect in mice, further studies are required prior to assigning a TS function to PARKIN in humans...
  14. pmc The association between Mediterranean diet adherence and Parkinson's disease
    Roy N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 27:771-4. 2012
    ..Recent studies have demonstrated an association between a Mediterranean-type diet and Alzheimer's risk. We assessed the association between Mediterranean-type diet adherence and Parkinson's disease (PD) status...
  15. pmc Coordination of fingertip forces during precision grip in premanifest Huntington's disease
    Ashwini K Rao
    Program in Physical Therapy, Department of Rehabilitation and Regenerative Medicine, Columbia University Medical Center, New York, New York, USA
    Mov Disord 26:862-9. 2011
    ..Force and temporal variability may be good markers of disease severity because they were correlated with predicted onset of disease...
  16. pmc Motor phenotype of LRRK2 G2019S carriers in early-onset Parkinson disease
    Roy N Alcalay
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Arch Neurol 66:1517-22. 2009
    ....
  17. doi request reprint Clinical assessment of mobility and balance impairments in pre-symptomatic Huntington's disease
    Ashwini K Rao
    Department of Rehabilitation Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Gait Posture 30:391-3. 2009
    ..Given the ease of administering clinical tests, and the importance of assessing mobility and balance, we examined whether clinical tests can detect motor impairments in individuals with pre-symptomatic HD...
  18. pmc Clinical and pathological characteristics of LRRK2 G2019S patients with PD
    Markos Poulopoulos
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Mol Neurosci 47:139-43. 2012
    ..However, the extent of cortical involvement is variable. Larger longitudinal follow-up of LRRK2 G2019S mutation carriers is required to assess for risk factors for cortical involvement and dementia...
  19. pmc RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk
    David A MacLeod
    Department of Neurology and Taub Institute, Columbia University, Black Building 1208, 650 West 168th Street, New York, NY 10032, USA
    Neuron 77:425-39. 2013
    ..Expression of wild-type VPS35, but not a familial PD-associated mutant form, rescued these defects. Taken together, these studies implicate retromer and lysosomal pathway alterations in PD risk...
  20. ncbi request reprint A comparison of self-report and caregiver assessment of depression, apathy, and irritability in Huntington's disease
    Anjan Chatterjee
    Department of Neurology and Psychiatry, College of Physicians and Surgeons, Columbia University, NY, NY 10032, USA
    J Neuropsychiatry Clin Neurosci 17:378-83. 2005
    ..Caregiver assessment of patients' moods and apathy may be an acceptable alternative to patient self-report as patients' cognitive status worsens...
  21. doi request reprint Clinical measurement of mobility and balance impairments in Huntington's disease: validity and responsiveness
    Ashwini K Rao
    Department of Rehabilitation Medicine, Columbia University Medical Center, United States
    Gait Posture 29:433-6. 2009
    ..These tests may not be optimal because they are scored on an ordinal scale and do not test anticipatory balance. We tested the validity and responsiveness of three clinical tests of mobility and balance...
  22. doi request reprint Parkinson's disease with Lewy bodies associated with a heterozygous PARKIN dosage mutation
    Madeleine E Sharp
    Department of Neurology, Columbia University, New York, New York, USA
    Mov Disord 29:566-8. 2014
    ..Only one other heterozygote PARKIN carrier with autopsy findings has been described. Our case adds to the broadening pathological and clinical phenotype of PARKIN-related disease...
  23. ncbi request reprint Dementia in Parkinson's disease
    Gregory A Rippon
    Department of Neurology, Columbia University, New York, New York, USA
    Adv Neurol 96:95-113. 2005
    ..Further research is needed to elucidate the relationship of PDD to DLB and AD in hopes of developing and using appropriate therapeutic measures designed to address the underlying disease process...
  24. doi request reprint Knowledge of and interest in genetic results among Parkinson disease patients and caregivers
    Karina Sakanaka
    Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA
    J Genet Couns 23:114-20. 2014
    ..6 % of caregivers knew that "scientists have identified genes associated with a higher risk of developing PD." PD patients may benefit from education and genetic counseling on the implications of genetic testing. ..
  25. pmc Genetic aspects of Alzheimer disease
    Jennifer Williamson
    Taub Institute for Research on Alzheimer Disease and the Aging Brain and the Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, Department of Neurology, New York, NY 10032, USA
    Neurologist 15:80-6. 2009
    ....
  26. pmc Parkinson disease phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations
    Roy N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 28:1966-71. 2013
    ..PD in AJ LRRK2 G2019S mutation carriers is similar to idiopathic PD but is characterized by more frequent lower extremity involvement at onset and PIGD without the associated cognitive impairment...
  27. pmc Association of life activities with cerebral blood flow in Alzheimer disease: implications for the cognitive reserve hypothesis
    Nikolaos Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Arch Neurol 60:359-65. 2003
    ..This has been interpreted as suggesting that cognitive reserve allows these patients to cope better with the pathologic changes in AD...
  28. ncbi request reprint Reliability of spatiotemporal gait outcome measures in Huntington's disease
    Ashwini K Rao
    Program in Physical Therapy, Department of Rehabilitation Medicine, Columbia University Medical Center, New York, New York, USA
    Mov Disord 20:1033-7. 2005
    ..Our data on high test-retest reliability and sensitivity extends the utility of the GAITRite to the HD population...
  29. pmc Olfaction in Parkin heterozygotes and compound heterozygotes: the CORE-PD study
    R N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neurology 76:319-26. 2011
    ..Whether olfaction differs between Parkin mutation heterozygotes and carriers of 2 Parkin mutations (compound heterozygotes) is unknown...

Research Grants11

  1. Genetic Epidemiology of Parkinson's Disease
    Karen Marder; Fiscal Year: 2007
    ....
  2. GENETIC EPIDEMIOLOGY OF PARKINSONS DISEASE
    Karen Marder; Fiscal Year: 2003
    ..The investigators will use segregation analysis to determine the most likely mode of inheritance of these clinical phenotypes in order to determine the optimal strategy for a future genetic linkage study. ..