Richard Mann

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Regulation of Ubx expression by epigenetic enhancer silencing in response to Ubx levels and genetic variation
    Michael A Crickmore
    Department of Biological Sciences, Columbia University, New York, New York, United States of America
    PLoS Genet 5:e1000633. 2009
  2. pmc Non-redundant selector and growth-promoting functions of two sister genes, buttonhead and Sp1, in Drosophila leg development
    Carlos Estella
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America
    PLoS Genet 6:e1001001. 2010
  3. pmc Divergent transcriptional regulatory logic at the intersection of tissue growth and developmental patterning
    Matthew Slattery
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America Institute for Genomics and Systems Biology and Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 9:e1003753. 2013
  4. pmc Quantification of gait parameters in freely walking wild type and sensory deprived Drosophila melanogaster
    César S Mendes
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, USA
    elife 2:e00231. 2013
  5. pmc Genome-wide tissue-specific occupancy of the Hox protein Ultrabithorax and Hox cofactor Homothorax in Drosophila
    Matthew Slattery
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e14686. 2011
  6. ncbi request reprint Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins
    R S Mann
    Department of Biochemistry and Molecular Biophysics, Columbia University, NY 10032, USA
    Trends Genet 12:258-62. 1996
  7. ncbi request reprint Molecular mechanisms of selector gene function and evolution
    Richard S Mann
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Curr Opin Genet Dev 12:592-600. 2002
  8. ncbi request reprint The developmental and molecular biology of genes that subdivide the body of Drosophila
    R S Mann
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, New York 10032, USA
    Annu Rev Cell Dev Biol 16:243-71. 2000
  9. ncbi request reprint Why are Hox genes clustered?
    R S Mann
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Bioessays 19:661-4. 1997
  10. pmc Dissecting the functional specificities of two Hox proteins
    Rohit Joshi
    Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
    Genes Dev 24:1533-45. 2010

Collaborators

  • James B Jaynes
  • BRIAN A GEBELEIN
  • Sean B Carroll
  • Pilar Aroca
  • M Affolter
  • Wen Zhang
  • HYUNG D RYOO
  • G Morata
  • Michael A Crickmore
  • Carlos Estella
  • Barry Honig
  • Remo Rohs
  • Alona Sosinsky
  • Matthew Slattery
  • Jill Wildonger
  • Joaquim Culi
  • Rohit Joshi
  • Sean M West
  • Daniel J Mckay
  • Jonathan D Zirin
  • César S Mendes
  • Lijia Ma
  • Kevin P White
  • Nicolas Negre
  • Christopher P Bonin
  • Michael Crickmore
  • H Wayne Peng
  • Myungin Baek
  • Katherine E Stevens
  • Barbara Noro
  • Ryan J Ice
  • Masatomo Kobayashi
  • Zhaohui Wang
  • Jose Bessa
  • Roumen Voutev
  • Imre Bartos
  • Turgay Akay
  • Szabolcs Márka
  • Xiangshu Jin
  • Liping Sun
  • Peng Liu
  • Vikram Ranade
  • Vinitha Jacob
  • Aneel K Aggarwal
  • Rinku Jain
  • Jonathan M Passner
  • Andrea Califano
  • Juan Modolell
  • Scott W Hiebert
  • Timothy A Springer
  • Miki Fujioka
  • Elena N Tolkunova
  • Deepali Deka
  • Muna Abu-Shaar
  • Franck Pichaud
  • Fernando Casares

Detail Information

Publications48

  1. pmc Regulation of Ubx expression by epigenetic enhancer silencing in response to Ubx levels and genetic variation
    Michael A Crickmore
    Department of Biological Sciences, Columbia University, New York, New York, United States of America
    PLoS Genet 5:e1000633. 2009
    ..Together, these findings suggest that enhancer silencing may be used to maintain gene product levels within the correct range in response to natural genetic variation...
  2. pmc Non-redundant selector and growth-promoting functions of two sister genes, buttonhead and Sp1, in Drosophila leg development
    Carlos Estella
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America
    PLoS Genet 6:e1001001. 2010
    ..These observations suggest that an ancient Sp8/Dlx gene cassette was used in an early metazoan for primitive limb-like outgrowths and that this cassette was co-opted multiple times for appendage formation in multiple animal phyla...
  3. pmc Divergent transcriptional regulatory logic at the intersection of tissue growth and developmental patterning
    Matthew Slattery
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America Institute for Genomics and Systems Biology and Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 9:e1003753. 2013
    ....
  4. pmc Quantification of gait parameters in freely walking wild type and sensory deprived Drosophila melanogaster
    César S Mendes
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, USA
    elife 2:e00231. 2013
    ..DOI:http://dx.doi.org/10.7554/eLife.00231.001...
  5. pmc Genome-wide tissue-specific occupancy of the Hox protein Ultrabithorax and Hox cofactor Homothorax in Drosophila
    Matthew Slattery
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e14686. 2011
    ..Together, these data provide the first whole-genome analysis of the binding sites and target genes regulated by Ubx to specify the morphologies of the adult T3 segment of the fly...
  6. ncbi request reprint Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins
    R S Mann
    Department of Biochemistry and Molecular Biophysics, Columbia University, NY 10032, USA
    Trends Genet 12:258-62. 1996
    ....
  7. ncbi request reprint Molecular mechanisms of selector gene function and evolution
    Richard S Mann
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Curr Opin Genet Dev 12:592-600. 2002
    ..Elucidation of the architecture of selector-regulated target gene enhancers and gene networks, and comparative studies of selector protein function are providing important insights into the evolution of development and morphology...
  8. ncbi request reprint The developmental and molecular biology of genes that subdivide the body of Drosophila
    R S Mann
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, New York 10032, USA
    Annu Rev Cell Dev Biol 16:243-71. 2000
    ..Finally, we discuss experiments that address the molecular mechanisms by which selector and selector-like gene products function in the fly...
  9. ncbi request reprint Why are Hox genes clustered?
    R S Mann
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Bioessays 19:661-4. 1997
    ..Moreover, characterizing the activity of one of these mouse enhancers in Drosophila illustrates that despite many similarities, not all Hox clusters are built in the same way...
  10. pmc Dissecting the functional specificities of two Hox proteins
    Rohit Joshi
    Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
    Genes Dev 24:1533-45. 2010
    ....
  11. pmc jing is required for wing development and to establish the proximo-distal axis of the leg in Drosophila melanogaster
    Joaquim Culi
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Genetics 173:255-66. 2006
    ..Together, our data suggest that jing encodes a transcriptional repressor that may participate in a subset of Pc-dependent activities during Drosophila appendage development...
  12. pmc A balance between two nuclear localization sequences and a nuclear export sequence governs extradenticle subcellular localization
    Katherine E Stevens
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Genetics 175:1625-36. 2007
    ..Surprisingly, although these Exd forms are functional, they do not phenocopy Hth overexpression. These findings suggest that Hth is required for Exd activity, not simply for inducing its nuclear localization...
  13. pmc Hox control of organ size by regulation of morphogen production and mobility
    Michael A Crickmore
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Science 313:63-8. 2006
    ..Because morphogens control tissue growth in many contexts, these findings provide a potentially general mechanism for how selector genes modify organ sizes...
  14. pmc Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax
    Barbara Noro
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Genes Dev 20:1636-50. 2006
    ..We further demonstrate that the mouse ortholog of hth, Meis1, also encodes a HDless isoform, suggesting that homeodomain-less variants of this gene family are evolutionarily ancient...
  15. ncbi request reprint Specificity of Distalless repression and limb primordia development by abdominal Hox proteins
    Brian Gebelein
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, HHSC 1104, New York, NY 10032, USA
    Dev Cell 3:487-98. 2002
    ..Instead, an additional alternatively spliced domain in Ubx is required for Distalless repression but not DNA binding. Thus, the functional specificities of Hox proteins depend on both DNA binding-dependent and -independent mechanisms...
  16. ncbi request reprint Requirement for two nearly identical TGIF-related homeobox genes in Drosophila spermatogenesis
    Zhaohui Wang
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, HHSC 1104, New York, NY 10032, USA
    Development 130:2853-65. 2003
    ....
  17. pmc Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc
    H Wayne Peng
    Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
    Genes Dev 23:2307-19. 2009
    ..In the eye disc, Hth and Tsh provide spatial information to this pathway, promoting cell proliferation and survival in the progenitor domain...
  18. pmc Lozenge directly activates argos and klumpfuss to regulate programmed cell death
    Jill Wildonger
    Center for Neurobiology and Behavior, Howard Hughes Medical Institute, Columbia University Medical School, New York, NY 10032, USA
    Genes Dev 19:1034-9. 2005
    ..These results provide novel insights into the control of programmed cell death (PCD) by Lz during Drosophila eye development...
  19. pmc The origins of the Drosophila leg revealed by the cis-regulatory architecture of the Distalless gene
    Daniel J Mckay
    Department of Biochemistry and Molecular Biophysics, Integrated Program in Cellular, Molecular, Structural and Genetic Studies, Columbia University, 701 W 168th Street, HHSC 1104, New York, NY 10032, USA
    Development 136:61-71. 2009
    ..Together, these findings provide a complete and high-resolution fate map of the Drosophila appendage primordia, linking the primary domains to specific cis-regulatory elements in Dll...
  20. ncbi request reprint Differing strategies for the establishment and maintenance of teashirt and homothorax repression in the Drosophila wing
    Jonathan D Zirin
    Department of Biological Sciences, Columbia University, 701 West 168th Street, HHSC 1104, New York, NY 10032, USA
    Development 131:5683-93. 2004
    ..Thus, despite their overall similar expression patterns, tsh and hth repression in the wing disc is controlled by two very different mechanisms...
  21. ncbi request reprint Direct integration of Hox and segmentation gene inputs during Drosophila development
    Brian Gebelein
    Department of Biochemistry and Molecular Biophysics and Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, HHSC 1104, New York, New York 10032, USA
    Nature 431:653-9. 2004
    ..Our results suggest that these two classes of proteins may collaborate to directly control gene expression at many downstream target genes...
  22. pmc Functional specificity of a Hox protein mediated by the recognition of minor groove structure
    Rohit Joshi
    Department of Biochemistry and Molecular Biophysics, Columbia University, HHSC 1104, New York, NY 10032, USA
    Cell 131:530-43. 2007
    ..Our results suggest that these residues, which are conserved in a paralog-specific manner, confer specificity by recognizing a sequence-dependent DNA structure instead of directly reading a specific DNA sequence...
  23. pmc Nubbin and Teashirt mark barriers to clonal growth along the proximal-distal axis of the Drosophila wing
    Jonathan D Zirin
    Department of Biological Sciences, Columbia University, 701 West 168th Street, HHSC 1104, New York, NY 10032, USA
    Dev Biol 304:745-58. 2007
    ..Thus, like the vein/intervein divisions of the wing and mammalian rhombomeres, the Nub and Tsh domains share some of the attributes of classical compartments, but lack their stringent and immobile boundaries...
  24. pmc Hox specificity unique roles for cofactors and collaborators
    Richard S Mann
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA
    Curr Top Dev Biol 88:63-101. 2009
    ....
  25. pmc Logic of Wg and Dpp induction of distal and medial fates in the Drosophila leg
    Carlos Estella
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, HHSC 1104, New York, NY 10032, USA
    Development 135:627-36. 2008
    ..Based on these results, we present a model for how Dpp and Wg, which are present as dorsal and ventral gradients, respectively, induce nearly circular domains of gene expression along the PD axis...
  26. ncbi request reprint Evidence that nervy, the Drosophila homolog of ETO/MTG8, promotes mechanosensory organ development by enhancing Notch signaling
    Jill Wildonger
    Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Dev Biol 286:507-20. 2005
    ..We propose a model in which nvy acts downstream of ac and sc to promote the SOP fate by transiently strengthening the Dl signal emanating from the SOP...
  27. pmc A piggyBac transposon gene trap for the analysis of gene expression and function in Drosophila
    Christopher P Bonin
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Genetics 167:1801-11. 2004
    ..These experiments highlight the utility of the PBss system for expanding the functional genomics tools that are available in Drosophila...
  28. pmc Target Explorer: An automated tool for the identification of new target genes for a specified set of transcription factors
    Alona Sosinsky
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, USA
    Nucleic Acids Res 31:3589-92. 2003
    ..It was specifically designed for the well-annotated Drosophila melanogaster genome, but most options can be used for sequences from other genomes as well. Target Explorer is available at http://trantor.bioc.columbia.edu/Target_Explorer/..
  29. ncbi request reprint The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor
    Jill Wildonger
    Center for Neurobiology and Behavior, Columbia University Medical School, New York, NY 10032, USA
    Development 132:2263-72. 2005
    ..Instead, our data suggest that AML1-ETO acts as a constitutive transcriptional repressor...
  30. ncbi request reprint Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila
    Joaquim Culi
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, HHSC 1104, New York, NY 10032, USA
    Cell 112:343-54. 2003
    ..Consequently, boca is an essential component of the Wingless pathway but is more generally required for the activities of multiple LDL receptor family members...
  31. pmc Electrostatic interactions between arginines and the minor groove in the nucleosome
    Sean M West
    Howard Hughes Medical Institute, Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biophysics, Columbia University, 1130 St Nicholas Avenue, New York, NY 10032, USA
    J Biomol Struct Dyn 27:861-6. 2010
    ..Our results extend and generalize our previous observation that the interaction of arginines with narrow minor grooves plays an important role in stabilizing the deformed DNA in the nucleosome...
  32. pmc Origins of specificity in protein-DNA recognition
    Remo Rohs
    Howard Hughes Medical Institute, Center for Computational Biology and Bioinformatics, Columbia University, New York, NY 10032, USA
    Annu Rev Biochem 79:233-69. 2010
    ....
  33. ncbi request reprint A new chisel for sculpting Darwin's endless forms
    Michael Crickmore
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, New York, USA
    Nat Cell Biol 12:528-9. 2010
    ..Pentagone has been identified as a secreted factor that controls the distribution of the morphogen Decapentaplegic (Dpp) in the Drosophila melanogaster wing...
  34. pmc Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins
    Joaquim Culi
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    EMBO J 23:1372-80. 2004
    ..We also show that Boca-dependent beta-propeller/EGF modules are found not only throughout the LDLR family but also in the precursor to the mammalian EGF ligand...
  35. pmc The role of DNA shape in protein-DNA recognition
    Remo Rohs
    Howard Hughes Medical Institute, Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biophysics, Columbia University, 1130 Saint Nicholas Avenue, New York, New York 10032, USA
    Nature 461:1248-53. 2009
    ....
  36. pmc The control of size in animals: insights from selector genes
    Michael A Crickmore
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY, USA
    Bioessays 30:843-53. 2008
    ..We integrate these results with other pathways known to regulate organ size in developing a comprehensive model for organ size control...
  37. doi request reprint Lineage and birth date specify motor neuron targeting and dendritic architecture in adult Drosophila
    Myungin Baek
    Department of Biological Sciences, Columbia University, New York, New York 10032, USA
    J Neurosci 29:6904-16. 2009
    ..Thus, although Drosophila uses a lineage-based method to generate leg motor neurons, individual lineages are not dedicated to generate neurons that target a single leg segment or muscle type...
  38. ncbi request reprint Hox control of morphogen mobility and organ development through regulation of glypican expression
    Michael A Crickmore
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Development 134:327-34. 2007
    ..Our results suggest that Dpp mobility is biased towards cells with higher levels of Dally and that selector genes modulate organ development by regulating glypican levels...
  39. pmc Molecular integration of wingless, decapentaplegic, and autoregulatory inputs into Distalless during Drosophila leg development
    Carlos Estella
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Dev Cell 14:86-96. 2008
    ..The "trigger-maintenance" model describes a mechanism by which secreted morphogens act combinatorially to induce the stable expression of target genes...
  40. ncbi request reprint Two Pax are better than one
    Richard S Mann
    Nat Genet 36:10-1. 2004
  41. doi request reprint A lexicon for homeodomain-DNA recognition
    Markus Affolter
    Growth and Development, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Cell 133:1133-5. 2008
    ..2008) provides individual specificities for nearly all Drosophila and mouse homeodomains, key DNA-binding domains in many transcription factors. The data underscore the complexity of determining target specificities in vivo...
  42. ncbi request reprint Comment on "Nervy links protein kinase A to plexin-mediated semaphorin repulsion"
    Ryan J Ice
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Science 309:558; author reply 558. 2005
  43. pmc Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila
    Masatomo Kobayashi
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 130:741-51. 2003
    ..These studies expand the functional requirements for extradenticle and homothorax beyond the Hox proteins to a larger family of non-Hox homeodomain proteins...
  44. pmc Combinatorial control of Drosophila eye development by eyeless, homothorax, and teashirt
    Jose Bessa
    Instituto de Biologia Molecular e Celular IBMC, 4150 180 Porto, Portugal
    Genes Dev 16:2415-27. 2002
    ..A key step in the transition from an immature proliferative state to a committed state in eye development is the repression of hth by the BMP-4 homolog Decapentaplegic (Dpp)...
  45. pmc Compartmental modulation of abdominal Hox expression by engrailed and sloppy-paired patterns the fly ectoderm
    Brian Gebelein
    Division of Developmental Biology, Cincinnati Children s Hospital, 3333 Burnet Ave, MLC 7007, Cincinnati, OH 45229, USA
    Dev Biol 308:593-605. 2007
    ....
  46. ncbi request reprint Developmental biology: morphogens hitch a greasy ride
    Richard S Mann
    Nature 435:30-3. 2005
  47. pmc Discovering transcriptional regulatory regions in Drosophila by a nonalignment method for phylogenetic footprinting
    Alona Sosinsky
    Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:6305-10. 2007
    ..Our results demonstrate that comparative genomic analysis of multiple closely related species has substantial power to identify key functional elements without additional biological knowledge...
  48. ncbi request reprint Developmental biology: signalling legacies
    Richard S Mann
    Nature 418:737-9. 2002

Research Grants38

  1. Development and function of an adult locomotion circuit in Drosophila
    Richard S Mann; Fiscal Year: 2010
    ....
  2. MOLECULAR GENETICS OF SEGMENT IDENTITY
    Richard Mann; Fiscal Year: 2005
    ..Other proteins are hypothesized to act as Hox cofactors in these cells, and experiments are designed to identify and test the function of these putative cofactors in vivo. ..
  3. Proximo-distal patterning in the Drosophila appendages
    Richard Mann; Fiscal Year: 2006
    ..An understanding of their basic functions in fly development should therefore generate information that is relevant to leukemia, as well as to defects that can occur in vertebrate limb development. ..
  4. MOLECULAR GENETICS OF SEGMENT IDENTITY
    Richard Mann; Fiscal Year: 2006
    ..Other proteins are hypothesized to act as Hox cofactors in these cells, and experiments are designed to identify and test the function of these putative cofactors in vivo. ..
  5. MOLECULAR GENETICS OF SEGMENT IDENTITY
    Richard Mann; Fiscal Year: 2007
    ..Other proteins are hypothesized to act as Hox cofactors in these cells, and experiments are designed to identify and test the function of these putative cofactors in vivo. ..
  6. Integrated Approcahes to Find Hox-regulated DNA Elements
    Richard Mann; Fiscal Year: 2007
    ..Once these methods are worked out, they will be applicable to a wide variety of problems in biology. ..
  7. Proximo-distal Patterning inthe Drosophila appendeges
    Richard Mann; Fiscal Year: 2007
    ....
  8. Proximo-distal patterning in the Drosophila appendages
    Richard Mann; Fiscal Year: 2007
    ..abstract_text> ..
  9. Proximo-distal Patterning inthe Drosophila appendeges
    Richard Mann; Fiscal Year: 2007
    ..abstract_text> ..
  10. Proximo-distal Patterning inthe Drosophila appendeges
    Richard Mann; Fiscal Year: 2009
    ..abstract_text> ..
  11. MOLECULAR GENETICS OF SEGMENT IDENTITY
    Richard Mann; Fiscal Year: 2009
    ..Thus, a mechanistic understanding of how these transcription factors regulate their target genes will impact our understanding of many aspects of developmental and disease biology. ..
  12. Proximo-distal Patterning inthe Drosophila appendeges
    Richard S Mann; Fiscal Year: 2010
    ..abstract_text> ..
  13. MOLECULAR GENETICS OF SEGMENT IDENTITY
    Richard S Mann; Fiscal Year: 2010
    ..Thus, a mechanistic understanding of how these transcription factors regulate their target genes will impact our understanding of many aspects of developmental and disease biology. ..
  14. MOLECULAR GENETICS OF SEGMENT IDENTITY
    Richard Mann; Fiscal Year: 2004
    ..Other proteins are hypothesized to act as Hox cofactors in these cells, and experiments are designed to identify and test the function of these putative cofactors in vivo. ..
  15. DISSECTION OF ONCOGENIC PATHWAYS USING DROSOPHILA
    Richard Mann; Fiscal Year: 2004
    ..The use of Drosophila genetics is proposed to help make connections between genetic functions that cannot be easily identified in mammalian experimental systems. ..
  16. POSTTRANSCRIPTIONAL MECHANISMS CONTROLLING DEVELOPMENT
    Richard Mann; Fiscal Year: 1999
    ..Characterizing these developmental mechanisms will shed light on how the vertebrate versions of these proteins, when altered, can cause cancer and human birth defects. ..
  17. MOLECULAR GENETICS OF SEGMENT IDENTITY
    Richard Mann; Fiscal Year: 1999
    ..These experiments will determine if particular mutations affect Ultrabithorax functions by affecting their ability to bind DNA or by affecting some other property, such as specific protein-protein interactions. ..
  18. POSTTRANSCRIPTIONAL MECHANISMS CONTROLLING DEVELOPMENT
    Richard Mann; Fiscal Year: 2000
    ..Characterizing these developmental mechanisms will shed light on how the vertebrate versions of these proteins, when altered, can cause cancer and human birth defects. ..
  19. DISSECTION OF ONCOGENIC PATHWAYS USING DROSOPHILA
    Richard Mann; Fiscal Year: 2000
    ..The use of Drosophila genetics is proposed to help make connections between genetic functions that cannot be easily identified in mammalian experimental systems. ..
  20. POSTTRANSCRIPTIONAL MECHANISMS CONTROLLING DEVELOPMENT
    Richard Mann; Fiscal Year: 2001
    ..Characterizing these developmental mechanisms will shed light on how the vertebrate versions of these proteins, when altered, can cause cancer and human birth defects. ..
  21. DISSECTION OF ONCOGENIC PATHWAYS USING DROSOPHILA
    Richard Mann; Fiscal Year: 2001
    ..The use of Drosophila genetics is proposed to help make connections between genetic functions that cannot be easily identified in mammalian experimental systems. ..
  22. POSTTRANSCRIPTIONAL MECHANISMS CONTROLLING DEVELOPMENT
    Richard Mann; Fiscal Year: 2002
    ..Characterizing these developmental mechanisms will shed light on how the vertebrate versions of these proteins, when altered, can cause cancer and human birth defects. ..
  23. DISSECTION OF ONCOGENIC PATHWAYS USING DROSOPHILA
    Richard Mann; Fiscal Year: 2002
    ..The use of Drosophila genetics is proposed to help make connections between genetic functions that cannot be easily identified in mammalian experimental systems. ..
  24. Proximo-distal patterning in the Drosophila appendages
    Richard Mann; Fiscal Year: 2003
    ..An understanding of their basic functions in fly development should therefore generate information that is relevant to leukemia, as well as to defects that can occur in vertebrate limb development. ..
  25. DISSECTION OF ONCOGENIC PATHWAYS USING DROSOPHILA
    Richard Mann; Fiscal Year: 2003
    ..The use of Drosophila genetics is proposed to help make connections between genetic functions that cannot be easily identified in mammalian experimental systems. ..
  26. Proximo-distal Patterning inthe Drosophila appendeges
    Richard Mann; Fiscal Year: 2009
    ..abstract_text> ..