JOSEPH JOHN MANN

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint A current perspective of suicide and attempted suicide
    J John Mann
    Columbia University, New York, New York, USA
    Ann Intern Med 136:302-11. 2002
  2. pmc No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover
    J John Mann
    Department of Neuroscience, New York State Psychiatric Institute, NY 10032, USA
    J Affect Disord 106:117-21. 2008
  3. ncbi request reprint The medical management of depression
    J John Mann
    Department of Neuroscience, New York State Psychiatric Institute Columbia University College of Physicians and Surgeons, New York 10032, USA
    N Engl J Med 353:1819-34. 2005
  4. pmc The serotonergic system in mood disorders and suicidal behaviour
    J John Mann
    Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10471, USA
    Philos Trans R Soc Lond B Biol Sci 368:20120537. 2013
  5. pmc Sex genes for genomic analysis in human brain: internal controls for comparison of probe level data extraction
    Hanga C Galfalvy
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    BMC Bioinformatics 4:37. 2003
  6. ncbi request reprint A synthesis of current findings regarding neurobiological correlates and treatment of suicidal behavior
    J J Mann
    Department of Neuroscience, New York State Psychiatric Institute, New York 10032, USA
    Ann N Y Acad Sci 836:352-63. 1997
  7. ncbi request reprint Can biological tests assist prediction of suicide in mood disorders?
    J John Mann
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Int J Neuropsychopharmacol 9:465-74. 2006
  8. ncbi request reprint Family history of suicidal behavior and mood disorders in probands with mood disorders
    J John Mann
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Dr, Box 42, New York, NY 10032, USA
    Am J Psychiatry 162:1672-9. 2005
  9. ncbi request reprint Suicide prevention strategies: a systematic review
    J John Mann
    New York State Psychiatric Institute, Division of Neuroscience, New York, NY 10032, USA
    JAMA 294:2064-74. 2005
  10. ncbi request reprint Neurobiology of suicidal behaviour
    J John Mann
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, Box 42, New York, New York 10032, USA
    Nat Rev Neurosci 4:819-28. 2003

Detail Information

Publications69

  1. ncbi request reprint A current perspective of suicide and attempted suicide
    J John Mann
    Columbia University, New York, New York, USA
    Ann Intern Med 136:302-11. 2002
    ..This review includes a hypothesized stress-diathesis model, which has implications for detection of high-risk patients and treatment interventions, and discusses promising treatment approaches that have been recently identified...
  2. pmc No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover
    J John Mann
    Department of Neuroscience, New York State Psychiatric Institute, NY 10032, USA
    J Affect Disord 106:117-21. 2008
    ..Associations are reported of TPH2 polymorphisms with MDD, bipolar disorder and suicidal behavior. This study examines a single nucleotide polymorphism in the putative promoter region of the TPH2 gene...
  3. ncbi request reprint The medical management of depression
    J John Mann
    Department of Neuroscience, New York State Psychiatric Institute Columbia University College of Physicians and Surgeons, New York 10032, USA
    N Engl J Med 353:1819-34. 2005
  4. pmc The serotonergic system in mood disorders and suicidal behaviour
    J John Mann
    Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10471, USA
    Philos Trans R Soc Lond B Biol Sci 368:20120537. 2013
    ..Thus the serotonin system is involved in both the diathesis for suicidal behaviour in terms of decision-making, and to a major stressor, namely episodes of major depression...
  5. pmc Sex genes for genomic analysis in human brain: internal controls for comparison of probe level data extraction
    Hanga C Galfalvy
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    BMC Bioinformatics 4:37. 2003
    ..We introduce the idea of using sex-chromosome genes as an alternative to spiked-in control genes or simulations for assessment of microarray data and analysis methods...
  6. ncbi request reprint A synthesis of current findings regarding neurobiological correlates and treatment of suicidal behavior
    J J Mann
    Department of Neuroscience, New York State Psychiatric Institute, New York 10032, USA
    Ann N Y Acad Sci 836:352-63. 1997
    ..Such interventions will supplement current treatment strategies that target the associated psychiatric illness and reduce the opportunities to attempt suicide in high-risk patients by hospitalization...
  7. ncbi request reprint Can biological tests assist prediction of suicide in mood disorders?
    J John Mann
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Int J Neuropsychopharmacol 9:465-74. 2006
    ..Further work on refining biological predictors and integration with clinical predictors is needed to optimize a model to predict suicide in the clinic...
  8. ncbi request reprint Family history of suicidal behavior and mood disorders in probands with mood disorders
    J John Mann
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Dr, Box 42, New York, NY 10032, USA
    Am J Psychiatry 162:1672-9. 2005
    ..This study examined the shared and distinctive factors associated with familial mood disorders and familial suicidal behavior...
  9. ncbi request reprint Suicide prevention strategies: a systematic review
    J John Mann
    New York State Psychiatric Institute, Division of Neuroscience, New York, NY 10032, USA
    JAMA 294:2064-74. 2005
    ..Some developed nations have implemented national suicide prevention plans. Although these plans generally propose multiple interventions, their effectiveness is rarely evaluated...
  10. ncbi request reprint Neurobiology of suicidal behaviour
    J John Mann
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, Box 42, New York, New York 10032, USA
    Nat Rev Neurosci 4:819-28. 2003
  11. ncbi request reprint ACNP Task Force report on SSRIs and suicidal behavior in youth
    J John Mann
    Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 31:473-92. 2006
    ....
  12. ncbi request reprint Toward a clinical model of suicidal behavior in psychiatric patients
    J J Mann
    Mental Health Clinical Research Center for the Study of Suicidal Behavior, Department of Neuroscience, New York State Psychiatric Institute, New York 10032, USA
    Am J Psychiatry 156:181-9. 1999
    ....
  13. pmc Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression
    J J Mann
    Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Box 42, New York, NY 10032, USA
    Eur Psychiatry 25:268-71. 2010
    ..Moreover, the interaction of early-life experiences of adversity and genetic vulnerability is increasingly thought to play a role, including via epigenetic mechanisms...
  14. pmc Candidate endophenotypes for genetic studies of suicidal behavior
    J John Mann
    Department of Psychiatry, NewYork State Psychiatric Institute ColumbiaUniversity, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Psychiatry 65:556-63. 2009
    ..Other candidate endophenotypes requiring further investigation include serotonergic neurotransmission, second messenger systems, and borderline personality disorder traits...
  15. ncbi request reprint A review of prospective studies of biologic predictors of suicidal behavior in mood disorders
    J John Mann
    Department of Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    Arch Suicide Res 11:3-16. 2007
    ..The most promising biologic predictors are low CSF 5-HIAA and HPA axis dysfunction as demonstrated by dexamethasone non-suppression that are each associated with about 4.5 fold greater risk of suicide...
  16. pmc Classification trees distinguish suicide attempters in major psychiatric disorders: a model of clinical decision making
    J John Mann
    Department of Neuroscience, New York State Psychiatric Institute, New York 10032, USA
    J Clin Psychiatry 69:23-31. 2008
    ..Hypothetical decision trees to identify recent and remote suicide attempters, weighted to increase sensitivity, were generated for psychiatric patients using correlates of past suicidal behavior...
  17. ncbi request reprint Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression
    Gil Zalsman
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Dr, Box 42, New York, NY 10032, USA
    Am J Psychiatry 163:1588-93. 2006
    ..The authors examined the relationship of a triallelic 5-HTTLPR polymorphism to stressful life events, severity of major depression, and suicidality...
  18. ncbi request reprint Protective factors against suicidal behavior in depressed adults reporting childhood abuse
    Kanita Dervic
    Department of Neuroscience, New York State Psychiatric Institute, and Columbia University, New York, New York 10032, USA
    J Nerv Ment Dis 194:971-4. 2006
    ..The results of this clinical study add support to previous reports that religious/spiritual coping could serve as an additional resource in prevention of suicidal behavior for subjects with reported childhood abuse...
  19. ncbi request reprint Cigarette smoking, suicidal behavior, and serotonin function in major psychiatric disorders
    Kevin M Malone
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, USA
    Am J Psychiatry 160:773-9. 2003
    ..The authors hypothesized that the relationship that may exist between cigarette smoking and suicidal behavior may be associated with lower serotonin function and the presence of impulsive/aggressive traits...
  20. ncbi request reprint Biodistribution and radiation dosimetry of [11C]DASB in baboons
    Marie Jose Belanger
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nucl Med Biol 31:1097-102. 2004
    ..We report on the biodistribution and dosimetry of [(11)C]DASB in the baboon as this species may be a more reliable surrogate for human dosimetry...
  21. ncbi request reprint An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences
    Yung Yu Huang
    Department of Neuroscience, New York State Psychiatric Institute, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 29:1498-505. 2004
    ..The polymorphism may be a marker for impulsivity that in turn may contribute to the risk for abuse. This trait could then be further aggravated by abuse...
  22. ncbi request reprint Human 5-HT1A receptor C(-1019)G polymorphism and psychopathology
    Yung Yu Huang
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Neuropsychopharmacol 7:441-51. 2004
    ..The relationship does not appear to be explained by binding differences, although we cannot rule out altered receptor affinity and transduction...
  23. pmc Familial pathways to early-onset suicidal behavior: familial and individual antecedents of suicidal behavior
    Nadine M Melhem
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Psychiatry 164:1364-70. 2007
    ..The authors sought to identify clinical predictors of new-onset suicidal behavior in children of parents with a history of mood disorder and suicidal behavior...
  24. ncbi request reprint Suicidal behavior and mild traumatic brain injury in major depression
    Maria A Oquendo
    Department of Neuroscience, New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
    J Nerv Ment Dis 192:430-4. 2004
    ..Our data suggest that suicidal behavior and TBI share antecedent risk factors: hostility and aggression. Future studies may yield confirmation using a prospective design...
  25. pmc Clinical correlates of planned, more lethal suicide attempts in major depressive disorder
    Atsuo Nakagawa
    Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY 10032, USA
    J Affect Disord 112:237-42. 2009
    ..The purpose of this study was to investigate clinical correlates of suicide planning in depressed patients...
  26. ncbi request reprint Moral objections to suicide: Can they counteract suicidality in patients with cluster B psychopathology?
    Kanita Dervic
    Department of Neuroscience, Columbia University, New York, NY, USA
    J Clin Psychiatry 67:620-5. 2006
    ..The effect of MOS was then examined in relation to other mechanisms affecting suicide risk including trait aggressivity and the presence of effective coping strategies...
  27. ncbi request reprint Protective factors against suicidal behavior in Latinos
    Maria A Oquendo
    Department of Neuroscience, New York State Psychiatric Institute and Columbia University, New York, NY, USA
    J Nerv Ment Dis 193:438-43. 2005
    ..Further studies to elucidate the impact of these factors on suicidal behavior and their relationship to specific cultural constructs would be of interest...
  28. ncbi request reprint Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder
    Paul H Soloff
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA, USA
    Psychiatry Res 119:11-24. 2003
    ..Impulsivity and aggression were inversely related to delta-prolactin and peak-prolactin responses among male but not female subjects. Gender differences in central serotonergic function may contribute to variations in impulsivity in BPD...
  29. ncbi request reprint Regional brain responses to serotonin in major depressive disorder
    Amy D Anderson
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    J Affect Disord 82:411-7. 2004
    ..Positron Emission Tomography (PET) studies have reported altered resting regional brain glucose metabolism in mood disorders. This study examines the relationship of such changes to serotonin system abnormalities associated with depression...
  30. pmc No association of COMT Val158Met polymorphism with suicidal behavior or CSF monoamine metabolites in mood disorders
    Gil Zalsman
    Department of Psychiatry, Division of Neuroscience, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Arch Suicide Res 12:327-35. 2008
    ..The COMT-V158M polymorphism was not associated with suicidal behavior in a Caucasian sample of mood disorder subjects, or with possible clinical or biological endophenotypes...
  31. ncbi request reprint Molecular aging in human prefrontal cortex is selective and continuous throughout adult life
    Loubna Erraji-Benchekroun
    Department of Psychiatry, Columbia University, New York, New York, USA
    Biol Psychiatry 57:549-58. 2005
    ..Aging leads to morphologic and functional changes in the brain and is associated with increased risk for psychiatric and neurological disorders...
  32. ncbi request reprint Sadness and loss: toward a neurobiopsychosocial model
    Peter J Freed
    Department of Psychiatry, Columbia University, and the Department of Neuroscience, New York State Psychiatric Institute, Unit 42, 1051 Riverside Dr, New York, NY 10032, USA
    Am J Psychiatry 164:28-34. 2007
  33. pmc Synthesis, in vitro and in vivo evaluation of [11C]MMTP: a potential PET ligand for mGluR1 receptors
    Jaya Prabhakaran
    Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University, USA
    Bioorg Med Chem Lett 20:3499-501. 2010
    ..These findings suggest [(11)C]1 is a promising PET radiotracer candidate for mGluR1...
  34. ncbi request reprint Applications of positron emission tomography in psychiatry
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Semin Nucl Med 33:129-35. 2003
    ..In that way PET scanning can contribute to both therapeutics and to drug development by more rapid identification of the likely therapeutic dose range compared with conventional parallel group dose comparisons or dose ranging studies...
  35. ncbi request reprint A comparison of the medical lethality of suicide attempts in bipolar and major depressive disorders
    Gil Zalsman
    Division of Neuroscience, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    Bipolar Disord 8:558-65. 2006
    ....
  36. ncbi request reprint In vivo assessment of [11C]MRB as a prospective PET ligand for imaging the norepinephrine transporter
    Alin J Severance
    Division of Brain Imaging, Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, P O Box 42, New York, NY 10032, USA
    Eur J Nucl Med Mol Imaging 34:688-93. 2007
    ..S,S)-Methylreboxetine (MRB) is among the more promising ligands recently adapted for positron emission tomography (PET), and the present study aimed to evaluate its potential for use in higher primates...
  37. ncbi request reprint More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicides
    Maura Boldrini
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Brain Res 1041:19-28. 2005
    ..More TPH may be an upregulatory homeostatic response to impaired serotonin release or less autoreceptor activation. Alternatively, the serotonin impairment in suicide may be due to hypofunctional serotonin-synthesizing enzyme...
  38. ncbi request reprint Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism
    Yung Yu Huang
    Department of Neuroscience, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Neuropsychopharmacology 28:163-9. 2003
    ..This preliminary result will need replication, given the limitations of association studies...
  39. ncbi request reprint Association of serotonin 5-HT2A receptor binding and the T102C polymorphism in depressed and healthy Caucasian subjects
    Vadim D Khait
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 30:166-72. 2005
    ..The TT genotype appears associated with higher platelet 5-HT2A Bmax in the healthy population, but this genotypic effect appears absent in mood disorders and unrelated to psychopathology...
  40. ncbi request reprint Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide
    Helene Bach-Mizrachi
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 31:814-24. 2006
    ..Higher TPH2 mRNA expression may explain more TPH protein observed in depressed suicides and reflect a homeostatic response to deficient brain serotonergic transmission...
  41. pmc Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model
    Fabiola Souza
    Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Invest 116:1506-13. 2006
    ..These studies suggest that PET-based quantitation of VMAT2 receptors provides a noninvasive measurement of BCM that could be used to study the pathogenesis of diabetes and to monitor therapeutic interventions...
  42. ncbi request reprint Volumetric analysis of the prefrontal cortex, amygdala, and hippocampus in major depression
    Ramin S Hastings
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 29:952-9. 2004
    ..The biology of mood disorders in females may differ in some aspects from males, and may contribute to the higher rate of depression in women...
  43. pmc Serotonin-1A autoreceptor binding in the dorsal raphe nucleus of depressed suicides
    Maura Boldrini
    Department of Psychiatry, Division of Neuroscience, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, P O Box 42, New York, NY 10032, USA
    J Psychiatr Res 42:433-42. 2008
    ..More autoreceptor binding in rostral DRN might contribute to deficient serotonin release in ventromedial prefrontal cortex by lower neuronal firing...
  44. pmc Does first episode polarity predict risk for suicide attempt in bipolar disorder?
    Sadia R Chaudhury
    Department of Neuroscience, New York State Psychiatric Institute and Columbia University, 1051 Riverside Drive, Box 42, New York, NY 10032, United States
    J Affect Disord 104:245-50. 2007
    ..We tested the hypothesis that the polarity of a patient's first mood episode would be a marker for BD subtypes with differential risk for suicidality...
  45. doi request reprint Norepinephrine and serotonin imbalance in the locus coeruleus in bipolar disorder
    Anna K Wiste
    Department of Psychiatry, Columbia College of Physicians and Surgeons, New York, NY, USA
    Bipolar Disord 10:349-59. 2008
    ....
  46. pmc Family history of suicidal behavior and early traumatic experiences: additive effect on suicidality and course of bipolar illness?
    Juan J Carballo
    Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, United States
    J Affect Disord 109:57-63. 2008
    ..Bipolar disorder (BD) is associated with a high prevalence of suicide attempt and completion. Family history of suicidal behavior and personal history of childhood abuse are reported risk factors for suicide among BD subjects...
  47. ncbi request reprint Attenuated 5-HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen-activated protein kinase
    Shu chi Hsiung
    Department of Neuroscience, New York State Psychiatric Institute, New York, USA
    J Neurochem 87:182-94. 2003
    ....
  48. ncbi request reprint Differentiating depressed adolescent 24 h cortisol secretion in light of their adult clinical outcome
    Sanjay J Mathew
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, USA
    Neuropsychopharmacology 28:1336-43. 2003
    ..Dysregulation of the HPA axis, combined with dysfunction of sleep-onset mechanisms previously reported in this same cohort, might serve as premorbid biological substrates that predict suicide attempts during follow-up...
  49. ncbi request reprint Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims
    Ilona Gurevich
    Mount Sinai Graduate School of Biological Sciences, New York, NY 10029, USA
    Neuron 34:349-56. 2002
    ..Thus, one outcome of fluoxetine treatment may be to reverse the abnormalities in 5-HT2C pre-mRNA editing seen in depressed suicide victims...
  50. pmc 11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls
    Robin Goland
    Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, New York, USA
    J Nucl Med 50:382-9. 2009
    ..We evaluated the feasibility of (11)C-dihydrotetrabenazine PET quantification of pancreatic VMAT2 binding in healthy subjects and patients with long-standing type 1 diabetes...
  51. doi request reprint Synthesis and in vivo evaluation of [11C]MPTQ: a potential PET tracer for alpha2A-adrenergic receptors
    Jaya Prabhakaran
    Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University, New York, USA
    Bioorg Med Chem Lett 20:3654-7. 2010
    ..The total synthesis time was 30 min from EOB. PET studies in anesthetized baboon show that [(11)C]1 penetrates BBB and accumulates in alpha2A-AR enriched brain areas...
  52. ncbi request reprint Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand
    Jaya Prabhakaran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, NY 10032, USA
    Bioorg Med Chem Lett 16:2101-4. 2006
    ..PET studies in baboon show that [11C]5 penetrates the blood-brain barrier but, because of low specific binding and fast clearance of radioactivity it is not a suitable PET tracer for the in vivo quantification of 5-HT1AR...
  53. ncbi request reprint Optimal metabolite curve fitting for kinetic modeling of 11C-WAY-100635
    Songmei Wu
    New York City Department of Health and Mental Hygiene, New York, New York, USA
    J Nucl Med 48:926-31. 2007
    ..11)C-WAY 100635 is a rapidly metabolized radioligand used extensively in mapping the 5-hydroxytryptamine receptor 1A system...
  54. ncbi request reprint Religious affiliation and suicide attempt
    Kanita Dervic
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Dr, Unit Number 42, New York, NY 10032, USA
    Am J Psychiatry 161:2303-8. 2004
    ..The relationship between religion and suicide attempts has received even less attention...
  55. ncbi request reprint Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice
    Noelia V Weisstaub
    Department of Biology, Columbia University and the New York State Psychiatric Institute, New York, NY 10032, USA
    Science 313:536-40. 2006
    ..These findings indicate a specific role for cortical 5HT2AR function in the modulation of conflict anxiety, consistent with models of cortical, "top-down" influences on risk assessment...
  56. pmc Decreased suicidal ideation in depressed patients with or without comorbid posttraumatic stress disorder treated with selective serotonin reuptake inhibitors: an open study
    Leo Sher
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Psychiatry Res 196:261-6. 2012
    ..Our finding has not supported the hypothesis that a response to treatment is poorer in the PTSD-MDD group which may indicate that sicker patients benefit more from the treatment...
  57. ncbi request reprint Brain serotonin1A receptor binding in major depression is related to psychic and somatic anxiety
    Gregory M Sullivan
    Division of Neuroscience, Department of Psychiatry, New York 10032, USA
    Biol Psychiatry 58:947-54. 2005
    ..We investigated the relationship of anxiety expressed in major depressive disorder (MDD) to regional 5-HT1A binding...
  58. ncbi request reprint Higher cerebrospinal fluid homovanillic acid levels in depressed patients with comorbid posttraumatic stress disorder
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
    Eur Neuropsychopharmacol 15:203-9. 2005
    ..Higher dopaminergic activity may contribute to alterations in memory and other cognitive functions, anhedonia, and hypervigilance observed in PTSD...
  59. doi request reprint Nucleotide variation in central nervous system genes among male suicide attempters
    Enrique Baca-Garcia
    Department of Psychiatry at Fundacion Jimenez Diaz Hospital, Autonoma University, Madrid, Spain
    Am J Med Genet B Neuropsychiatr Genet 153:208-13. 2010
    ..This strategy may uncover new pathophysiological pathways regarding the neurobiology of suicidal acts...
  60. pmc Pretreatment regional brain glucose uptake in the midbrain on PET may predict remission from a major depressive episode after three months of treatment
    Matthew S Milak
    Department of Psychiatry, Columbia University, New York, NY, United States
    Psychiatry Res 173:63-70. 2009
    ..Prospective studies are needed to replicate these findings and determine whether outcome prediction is limited to a specific class of antidepressants...
  61. ncbi request reprint Determination of volume of distribution using likelihood estimation in graphical analysis: elimination of estimation bias
    Ramin V Parsey
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    J Cereb Blood Flow Metab 23:1471-8. 2003
    ..As predicted by simulations, LEGA eliminates the noise-dependent bias associated with GA using OLS. This method is a valuable addition to the tools available for the quantification of radioligand binding data in PET and SPECT...
  62. ncbi request reprint Relationship of MAO-A promoter (u-VNTR) and COMT (V158M) gene polymorphisms to CSF monoamine metabolites levels in a psychiatric sample of caucasians: A preliminary report
    Gil Zalsman
    Department of Neuroscience, New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, Box 42, New York, NY 10032, USA
    Am J Med Genet B Neuropsychiatr Genet 132:100-3. 2005
    ..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299:1/suppmat/index.html...
  63. pmc Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls
    Leo Sher
    Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, NY 10032, USA
    Eur Neuropsychopharmacol 18:692-9. 2008
    ..The difference in prolactin responses between MDD/AUD and MDD only could be attributed to higher aggression scores in the MDD/AUD group compared to the MDD group...
  64. ncbi request reprint Suicidal behavior in schizophrenia and schizoaffective disorder: examining the role of depression
    Jill M Harkavy-Friedman
    New York State Psychiatric Institute and Columbia University, New York, NY 10032, USA
    Suicide Life Threat Behav 34:66-76. 2004
    ..Clinicians should remember that even without a depressive episode there is still a significant risk for suicidal behavior in schizophrenia...
  65. pmc Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography
    Maria A Oquendo
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Gen Psychiatry 64:201-8. 2007
    ..Associations of serotonin transporter promoter polymorphisms and bipolarity have been reported; however, research on alterations in serotonergic neurotransmission in bipolar depression remains scant...
  66. pmc Familial transmission of suicidal behavior: factors mediating the relationship between childhood abuse and offspring suicide attempts
    Beth S Brodsky
    Department of Psychiatry, Columbia University New York State Psychiatric Institute, New York 10032, USA
    J Clin Psychiatry 69:584-96. 2008
    ..The current study investigates the relationship between reported childhood abuse and the familial transmission of suicidal behavior and other related risk factors...
  67. ncbi request reprint Higher cortisol levels in spring and fall in patients with major depression
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:529-34. 2005
    ..This study sought to determine whether there is a seasonal effect on clinical parameters, baseline cortisol and prolactin levels, and cortisol and prolactin responses to fenfluramine administration in subjects with major depression...
  68. doi request reprint Family history of alcoholism is associated with lower 5-HT2A receptor binding in the prefrontal cortex
    Mark D Underwood
    Department of Psychiatry, Columbia College of Physicians and Surgeons, New York State Psychiatric Institute, New York 10032, USA
    Alcohol Clin Exp Res 32:593-9. 2008
    ..We sought to determine postmortem whether 5-HT(2A) receptors are altered in the prefrontal cortex (PFC) of alcoholics...
  69. pmc Personality disorder assessments in acute depressive episodes: stability at follow-up
    Jorge Lopez-Castroman
    Department of Psychiatry, Fundacion Jimenez Diaz, Madrid, Spain
    J Nerv Ment Dis 200:526-30. 2012
    ..Axis II diagnoses in acutely depressed patients reassessed after 3 months are often stable and not associated with remission of or improvement in major depression...

Research Grants37

  1. 2/2 - Familial Pathways to Early-Onset Suicide Attempts
    JOSEPH JOHN MANN; Fiscal Year: 2010
    ....
  2. PSYCHOBIOLOGICAL PREDICTORS OF SUICIDAL BEHAVIOR IN MDE
    JOSEPH MANN; Fiscal Year: 2006
    ..We will also replicate and integrate previous predictors with newly confirmed predictors. ..
  3. FAMILIAL PATHWAYS TO EARLY-ONSET SUICIDE ATTEMPTS
    JOSEPH MANN; Fiscal Year: 2006
    ..This study should lead to an empirical basis for the prevention and treatment of suicidal behavior. ..
  4. Neurobiology of Depression and Antidepressants
    JOSEPH MANN; Fiscal Year: 2007
    ..We propose to test these hypotheses directly in vivo using PET and the ligand [11C]WAY-100635, and to quantify the 5- HT1A receptor in healthy volunteers and patients with a major depressive episode. ..
  5. THE NEUROBIOLOGY OF SUICIDAL BEHAVIOR
    JOSEPH MANN; Fiscal Year: 2007
    ....
  6. 2/2 - Familial Pathways to Early-Onset Suicide Attempts
    JOSEPH MANN; Fiscal Year: 2009
    ....
  7. Neurobiology of Depression and Antidepressants
    JOSEPH JOHN MANN; Fiscal Year: 2010
    ....
  8. NEUROBIOLOGICAL STUDIES OF ECT IN DEPRESSION
    JOSEPH MANN; Fiscal Year: 2001
    ..Elucidation of the mechanism and locus of antidepressant action of ECT compared to SSRIs may ultimately lead to improved antidepressant mediation and better understanding of the pathophysiology of depression. ..
  9. PSYCHOBIOLOGICAL PREDICTORS OF SUICIDAL BEHAVIOR IN MDE
    JOSEPH MANN; Fiscal Year: 2002
    ..An expanded study population will permit comprehensive hypothesis testing and comparison of predictors. ..
  10. Suicidal Behavior in Mood Disorders:Genes and Intermediate Phenotypes
    JOSEPH JOHN MANN; Fiscal Year: 2010
    ..This study will screen the genome in the largest collection of samples ever assembled for such a study of suicidal behavior in order to identify the responsible genes. ..