Robert B MacArthur

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Pharmacokinetics of sodium phenylacetate and sodium benzoate following intravenous administration as both a bolus and continuous infusion to healthy adult volunteers
    Robert B MacArthur
    CPMC Research Pharmacy, Columbia University and New York State Psychiatric Institute Pharmacy, New York, NY 10032, USA
    Mol Genet Metab 81:S67-73. 2004
  2. ncbi request reprint Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial
    Paul H Gordon
    Department of Neurology, Columbia University, New York, NY, USA
    Lancet Neurol 6:1045-53. 2007
  3. ncbi request reprint O-desulfated heparin improves outcome after rat cerebral ischemia/reperfusion injury
    J Mocco
    Department of Neurological Surgery, Columbia University, New York, New York 10032, USA
    Neurosurgery 61:1297-303; discussion 1303-4. 2007
  4. doi request reprint A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS
    Paul H Gordon
    Department of Neurology, Columbia University, New York, USA
    Amyotroph Lateral Scler 9:212-22. 2008
  5. doi request reprint The Neuroprotection with Statin Therapy for Acute Recovery Trial (NeuSTART): an adaptive design phase I dose-escalation study of high-dose lovastatin in acute ischemic stroke
    Mitchell S V Elkind
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Int J Stroke 3:210-8. 2008
  6. pmc High-dose lovastatin for acute ischemic stroke: results of the phase I dose escalation neuroprotection with statin therapy for acute recovery trial (NeuSTART)
    Mitchell S V Elkind
    Department of Neurology, College of Physicians and Surgeons, New York, N Y, USA
    Cerebrovasc Dis 28:266-75. 2009
  7. pmc A dosing algorithm for erythropoietin alpha in older adults with heart failure and a preserved ejection fraction
    Arman Altincatal
    Columbia University Medical Center, New York, NY 10034, USA
    Cardiovasc Ther 31:92-9. 2013
  8. ncbi request reprint Titrimetric method for determination of O-desulfated heparin in physiological samples using protamine-sensitive membrane electrode as endpoint detector
    Stacey A Buchanan
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Anal Biochem 346:241-5. 2005

Detail Information

Publications8

  1. ncbi request reprint Pharmacokinetics of sodium phenylacetate and sodium benzoate following intravenous administration as both a bolus and continuous infusion to healthy adult volunteers
    Robert B MacArthur
    CPMC Research Pharmacy, Columbia University and New York State Psychiatric Institute Pharmacy, New York, NY 10032, USA
    Mol Genet Metab 81:S67-73. 2004
    ..A pharmacokinetic study of sodium phenylacetate/sodium benzoate (NAPA/NABZ) was performed in two groups of normal healthy volunteers, following the dosing regimen used to treat hyperammonemia...
  2. ncbi request reprint Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial
    Paul H Gordon
    Department of Neurology, Columbia University, New York, NY, USA
    Lancet Neurol 6:1045-53. 2007
    ..Several trials are planned or are in progress to assess whether minocycline slows human neurodegeneration. We aimed to test the efficacy of minocycline as a treatment for amyotrophic lateral sclerosis (ALS)...
  3. ncbi request reprint O-desulfated heparin improves outcome after rat cerebral ischemia/reperfusion injury
    J Mocco
    Department of Neurological Surgery, Columbia University, New York, New York 10032, USA
    Neurosurgery 61:1297-303; discussion 1303-4. 2007
    ....
  4. doi request reprint A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS
    Paul H Gordon
    Department of Neurology, Columbia University, New York, USA
    Amyotroph Lateral Scler 9:212-22. 2008
    ..This phase II design was efficient, leading to treatment selection after just 60 patients, and can be used in other phase II trials to assess different agents...
  5. doi request reprint The Neuroprotection with Statin Therapy for Acute Recovery Trial (NeuSTART): an adaptive design phase I dose-escalation study of high-dose lovastatin in acute ischemic stroke
    Mitchell S V Elkind
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Int J Stroke 3:210-8. 2008
    ..The presently described trial represents a new approach for treatment of acute ischemic stroke, as well as a novel way of conducting a phase I trial, evaluating safety and determining an optimal dose of a potential neuroprotectant drug...
  6. pmc High-dose lovastatin for acute ischemic stroke: results of the phase I dose escalation neuroprotection with statin therapy for acute recovery trial (NeuSTART)
    Mitchell S V Elkind
    Department of Neurology, College of Physicians and Surgeons, New York, N Y, USA
    Cerebrovasc Dis 28:266-75. 2009
    ..We sought to determine whether lovastatin at doses above those currently approved can be administered safely within 24 h after an acute ischemic stroke...
  7. pmc A dosing algorithm for erythropoietin alpha in older adults with heart failure and a preserved ejection fraction
    Arman Altincatal
    Columbia University Medical Center, New York, NY 10034, USA
    Cardiovasc Ther 31:92-9. 2013
    ..We evaluated a dosing algorithm and potential confounders' effect on Hb and blood pressure (BP) in a clinical trial...
  8. ncbi request reprint Titrimetric method for determination of O-desulfated heparin in physiological samples using protamine-sensitive membrane electrode as endpoint detector
    Stacey A Buchanan
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Anal Biochem 346:241-5. 2005
    ..39 microg protamine/microg ODSH in plasma. This technology is further applied to a toxicokinetic study of ODSH in an animal model, demonstrating the ability to detect the changes in ODSH concentrations in biological samples...