Research Topics
| José Alejandro LuchsingerSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
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Detail Information
Publications
Metabolic syndrome and dementia risk in a multiethnic elderly cohortMajon Muller
Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
Dement Geriatr Cogn Disord 24:185-92. 2007..The metabolic syndrome (MeSy) may be related to Alzheimer's disease (AD). Our aims were to investigate the association of the MeSy with incident dementia in a multiethnic elderly cohort in the United States...- Type 2 diabetes and cognitive impairment: linking mechanismsJose A Luchsinger
Division of General Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
J Alzheimers Dis 30:S185-98. 2012..Given the epidemic of T2D in the world, it is important to elucidate whether the association between T2D and cognitive impairment, particularly LOAD, is causal, and if so, what the mechanisms are... - Adiponectin and all-cause mortality in elderly people with type 2 diabetesJessica R Singer
Department of Medicine, Columbia University, New York, NY, USA
Diabetes Care 35:1858-63. 2012..Because of the insulin-sensitizing, anti-inflammatory, and antiatherogenic effects of adiponectin, we hypothesized that higher adiponectin level would be associated with lower all-cause mortality... - Central obesity in the elderly is related to late-onset Alzheimer diseaseJose A Luchsinger
Departments of Neurology, Joseph P Mailman School of Public Health, Columbia University, New York, NY, USA
Alzheimer Dis Assoc Disord 26:101-5. 2012..Our results support the notion that central obesity is related to a higher risk of LOAD... - Measures of adiposity and dementia risk in elderly personsJose A Luchsinger
Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Columbia University, 630 W 168th St, New York, NY 10032, USA
Arch Neurol 64:392-8. 2007.... 
Relation of diabetes to mild cognitive impairmentJose A Luchsinger
Department of Medicine, Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
Arch Neurol 64:570-5. 2007..Type 2 diabetes mellitus is an important risk factor for Alzheimer disease and is more prevalent in elderly minority persons compared with non-Hispanic white persons...- Adiposity and Alzheimer's diseaseJose A Luchsinger
Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
Curr Alzheimer Res 4:127-34. 2007..Being overweight or obese is increasing in children and adults, thus understanding the association between adiposity and AD has important public health implications... - Glycemic load and risk of Alzheimer's diseaseJ A Luchsinger
Taub University in Alzheimer s Disease and the aging Brain, Columbia University, New York, NY, USA
J Nutr Health Aging 11:238-41. 2007..to explore the relation of glycemic load (GL) with Alzheimer's disease (AD) risk... - Diet and Alzheimer's diseaseJose A Luchsinger
Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Columbia University, PH9E 105, 630 West 168th Street, New York, NY 10032, USA
Curr Neurol Neurosci Rep 7:366-72. 2007..The existing evidence does not support the recommendation of specific supplements, foods, or diets for the prevention of AD... - Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease: an epidemiological perspectiveJosé Alejandro Luchsinger
Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
Eur J Pharmacol 585:119-29. 2008..However, if proven causal, these associations also present a unique opportunity for prevention and treatment of Alzheimer's disease... - Body mass index, dementia, and mortality in the elderlyJ A Luchsinger
Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
J Nutr Health Aging 12:127-31. 2008..To explore the association between body mass index and mortality in the elderly taking the diagnosis of dementia into account... - Depressive symptoms, vascular risk factors, and Alzheimer's diseaseJose A Luchsinger
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, USA
Int J Geriatr Psychiatry 23:922-8. 2008..We sought to determine whether the association between depressive symptoms and AD is explained by a history of vascular risk factors and stroke... - Adiposity and Alzheimer's diseaseJose A Luchsinger
Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Curr Opin Clin Nutr Metab Care 12:15-21. 2009..This topic is of enormous public health importance given the global epidemic of high adiposity and its consequences... - Adiposity, type 2 diabetes, and Alzheimer's diseaseJose A Luchsinger
Gertrude H Sergievsky Center, New York, NY 10032, USA
J Alzheimers Dis 16:693-704. 2009..Several studies in the prevention and treatment of T2D are currently conducting, or have planned, cognition ancillary studies. In addition, clinical trials using insulin sensitizers in the treatment or prevention of AD are under way... - Subclinical cerebrovascular disease in mild cognitive impairmentJ A Luchsinger
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
Neurology 73:450-6. 2009..Cerebrovascular disease (CVD) may contribute to mild cognitive impairment (MCI). We sought to determine the relation of white matter hyperintensity (WMH) volume and infarcts in brain MRI to MCI in a community-based sample... 
Type 2 diabetes, related conditions, in relation and dementia: an opportunity for prevention?Jose A Luchsinger
Gertrude H Sergievsky Center, Columbia University, New York, NY, USA
J Alzheimers Dis 20:723-36. 2010..Several studies in the prevention and treatment of T2D are currently measuring cognitive outcomes and will provide information on whether T2D treatment and prevention can prevent cognitive decline and dementia...- Improved diabetes control in the elderly delays global cognitive declineJ A Luchsinger
Department of Medicine, Columbia University, Division of General Medicine, PH9East 105, 630 West 168th Street, New York, NY 10032, USA
J Nutr Health Aging 15:445-9. 2011..To examine whether improved diabetes control is related to better cognitive outcomes... - Relation of higher folate intake to lower risk of Alzheimer disease in the elderlyJose A Luchsinger
Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Joseph P Mailman School of Public Health, Columbia University, New York, NY, USA
Arch Neurol 64:86-92. 2007..Higher intake of folate and vitamins B6 (pyridoxine hydrochloride) and B12 (cyanocobalamin) may decrease the risk of Alzheimer disease (AD) through the lowering of homocysteine levels... - Diabetes, related conditions, and dementiaJose A Luchsinger
Division of General Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
J Neurol Sci 299:35-8. 2010..Several studies in the prevention and treatment of T2D are currently measuring cognitive outcomes and will provide information on whether T2D treatment and prevention can prevent cognitive decline and dementia... - Relation of antibiotic use to risk of myocardial infarction in the general populationJose A Luchsinger
Division of General Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
Am J Cardiol 89:18-21. 2002..pneumoniae within each group were similar. Use of antibiotics with activity against C. pneumoniae does not reduce the risk of myocardial infarction in the general population... - A work in progress: the metabolic syndromeJose A Luchsinger
Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
Sci Aging Knowledge Environ 2006:pe19. 2006..However, rigorous lifestyle interventions are difficult to implement outside of a clinical trial setting, especially among elderly patients... - Cardiovascular risk factors and Alzheimer's diseaseJose A Luchsinger
Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Columbia University, PH9E 105, 630 West 168th Street, New York, NY 10032, USA
Curr Atheroscler Rep 6:261-6. 2004..Studies have also indicated that hypertension, hyperlipidemia, hyperhomocysteinemia, and smoking are potentially important risk factors for Alzheimer's disease... - Aggregation of vascular risk factors and risk of incident Alzheimer diseaseJ A Luchsinger
Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
Neurology 65:545-51. 2005..The prevalence of Alzheimer disease (AD) is increasing in the elderly, and vascular risk factors may increase its risk... - Relation of plasma lipids to all-cause mortality in Caucasian, African-American and Hispanic eldersJennifer L Akerblom
Department of Epidemiology, Columbia University, New York, USA
Age Ageing 37:207-13. 2008..to investigate the relation of plasma lipids to all-cause mortality in a multi-ethnic cohort of non-demented elderly... - Relation between vascular risk factors and neuropsychological test performance among elderly persons with Alzheimer's diseaseChristiane Reitz
The Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
J Neurol Sci 257:194-201. 2007..Vascular risk factors increase the risk of Alzheimer's disease (AD). The mechanisms for these associations are unclear, and may be due to misdiagnosis of a vascular dementia syndrome as AD... - Hyperinsulinemia and risk of Alzheimer diseaseJose A Luchsinger
Taub Institute for Research of Alzheimer's Disease and the Aging Brain, Joseph P. Mailman School of Public Health, Columbia University, New York, USA
Neurology 63:1187-92. 2004..Hyperinsulinemia was also related to a significant decline in memory-related cognitive scores, but not to decline in other cognitive domains. CONCLUSIONS: Hyperinsulinemia is associated with a higher risk of AD and decline in memory... - Hypertension and the risk of mild cognitive impairmentChristiane Reitz
The Gertrude H Sergievsky Center, Columbia University Medical Center, Columbia University, New York, NY 10706, USA
Arch Neurol 64:1734-40. 2007..To explore whether hypertension is associated with the risk of mild cognitive impairment (MCI), an intermediate stage of dementia, because there are conflicting data relating hypertension to the risk of Alzheimer disease... - Plasma homocysteine and risk of mild cognitive impairmentChristiane Reitz
The Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, N Y, USA
Dement Geriatr Cogn Disord 27:11-7. 2009..We sought to explore whether fasting plasma homocysteine is associated with the risk of mild cognitive impairment (MCI), an intermediate stage to dementia... - Frequency of subclinical heart disease in elderly persons with dementiaChristiane Reitz
Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
Am J Geriatr Cardiol 16:183-8. 2007..With the increasing prevalence of Alzheimer's disease and vascular dementia, clinicians have to be more attentive to the presence of structural heart disease and its complications in persons with these conditions... - Contribution of vascular risk factors to the progression in Alzheimer diseaseElizabeth P Helzner
Gertrude H Sergievsky Center, Columbia University Medical Center, NY, New York, USA
Arch Neurol 66:343-8. 2009.... - Food combination and Alzheimer disease risk: a protective dietYian Gu
The Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
Arch Neurol 67:699-706. 2010..Because foods are not consumed in isolation, dietary pattern (DP) analysis of food combination, taking into account the interactions among food components, may offer methodological advantages... - Stroke and memory performance in elderly persons without dementiaChristiane Reitz
Gertrude H. Sergievsky Center, The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, 630 W. 168th Street, New York, NY 10032, USA
Arch Neurol 63:571-6. 2006..CONCLUSION: A history of stroke is related to a progressive decline in memory and abstract/visuospatial performance, especially among men and those without an APOEepsilon4 allele... - Plasma lipid levels in the elderly are not associated with the risk of mild cognitive impairmentChristiane Reitz
Gertrude H Sergievsky Center, Mailman School of Public Health, Columbia University College of Physicians and Surgeons, New York, N Y, USA
Dement Geriatr Cogn Disord 25:232-7. 2008..Baseline data were collected from 1992 to 1994, follow-up data were collected at 18-month intervals... - Alcohol intake and risk of dementiaJose A Luchsinger
Taub Institute for Research of Alzheimer's Disease and the Aging Brain, and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Am Geriatr Soc 52:540-6. 2004..CONCLUSIONS: Consumption of up to three servings of wine daily is associated with a lower risk of AD in elderly individuals without the APOE epsilon-4 allele... - Association of C-reactive protein with cognitive impairmentJames M Noble
Gertrude H Sergievsky Center, Columbia University, New York, New York, USA
Arch Neurol 67:87-92. 2010..High-sensitivity C-reactive protein (hsCRP) is a biomarker of cardiovascular risk that is suggested to be a biomarker for cognitive impairment... - Relation of plasma homocysteine to plasma amyloid beta levelsJose A Luchsinger
Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
Neurochem Res 32:775-81. 2007..Elevated plasma homocysteine and amyloid beta (Abeta) have been associated with Alzheimer's disease (AD). We investigated the cross-sectional association between these biomarkers... - Semiquantitative study of current coffee, caffeine, and ethanol intake in essential tremor cases and controlsElan D Louis
The Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Mov Disord 19:499-504. 2004..A prospective study is needed to explore whether decreased caffeine consumption is a risk factor for ET... - Mediterranean diet, Alzheimer disease, and vascular mediationNikolaos Scarmeas
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
Arch Neurol 63:1709-17. 2006..To examine the association between the Mediterranean diet (MeDi) and Alzheimer disease (AD) in a different AD population and to investigate possible mediation by vascular pathways. Design, Setting, Patients, and.. - The effect of body mass index on complications from cardiac surgery in the oldest oldMathew S Maurer
Department of Medicine, Division of Circulatory Physiology, Columbia University, College of Physicians and Surgeons, New York, NY, USA
J Am Geriatr Soc 50:988-94. 2002..In older people, an increased risk of adverse events was observed in leaner and overweight older subjects. We evaluated the association between BMI and cardiac surgery complications in subjects aged 75 and older... - Caloric intake and the risk of Alzheimer diseaseJose A Luchsinger
Taub Institute for Research of Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St, New York, NY 10032, USA
Arch Neurol 59:1258-63. 2002..83 and P =.61, respectively). CONCLUSION: Higher intake of calories and fats may be associated with higher risk of AD in individuals carrying the apolipoprotein E epsilon4 allele... - Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular diseaseNikolaos Scarmeas
Taub Institute for Research in Alzheimer s Disease and the Aging Brain, University of California at Davis, Sacramento, USA
Ann Neurol 69:257-68. 2011..Cerebrovascular disease is 1 of the possible mechanisms of the previously reported relationship between Mediterranean-type diet (MeDi) and Alzheimer's disease (AD). We sought to investigate the association between MeDi and MRI infarcts... - Association of higher levels of high-density lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer diseaseChristiane Reitz
Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
Arch Neurol 67:1491-7. 2010..To reexamine the association of lipid levels with Alzheimer disease (AD) using Cox proportional hazards models... - History of vascular disease and mild parkinsonian signs in community-dwelling elderly individualsElan D Louis
The Gertrude H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, and Department of Neurology, College of Physicians and Surgeons, Columbia University, 710 W 168th Street, New York, NY 10032, USA
Arch Neurol 63:717-22. 2006..If the etiology were vascular, one could hypothesize that individuals with MPS would be more likely to have systemic vascular disease than would their counterparts without these signs... - A summary risk score for the prediction of Alzheimer disease in elderly personsChristiane Reitz
The Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
Arch Neurol 67:835-41. 2010..To develop a simple summary risk score for the prediction of Alzheimer disease in elderly persons based on their vascular risk profiles... - Long-term blood pressure fluctuation and cerebrovascular disease in an elderly cohortAdam M Brickman
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Arch Neurol 67:564-9. 2010..Elevated blood pressure (BP) and fluctuation in BP may lead to cerebrovascular disease through ischemic changes and compromised cerebral autoregulation... - Antioxidant vitamin intake and risk of Alzheimer diseaseJose A Luchsinger
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY, USA
Arch Neurol 60:203-8. 2003..CONCLUSION: Neither dietary, supplemental, nor total intake of carotenes and vitamins C and E was associated with a decreased risk of AD in this study... - Mediterranean diet and risk for Alzheimer's diseaseNikolaos Scarmeas
Taub Institute for Research in Alzheimer s Disease and the Aging Brain, New York, NY 10032, USA
Ann Neurol 59:912-21. 2006..We sought to investigate the association between MeDi and risk for AD... - Mediterranean diet and Alzheimer disease mortalityNikolaos Scarmeas
Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
Neurology 69:1084-93. 2007..We previously reported that the Mediterranean diet (MeDi) is related to lower risk for Alzheimer disease (AD). Whether MeDi is associated with subsequent AD course and outcomes has not been investigated... - Parkinsonian signs in older people: prevalence and associations with smoking and coffeeElan D Louis
Gertrude H Sergievsky Center, Columbia University, New York, NY, USA
Neurology 61:24-8. 2003..Cigarette smoking and coffee consumption may reduce the risk of PD. Parkinsonian signs (tremor, rigidity, bradykinesia) occur in 30 to 40% of the elderly... - Validity of self-reported stroke in elderly African Americans, Caribbean Hispanics, and WhitesChristiane Reitz
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York 10032, USA
Arch Neurol 66:834-40. 2009..The validity of a self-reported stroke remains inconclusive... - Mild parkinsonian signs and plasma homocysteine concentration in community-dwelling elderly individualsElan D Louis
The Gertrude H Sergievsky Center, Department of Neurology, Columbia University, New York, NY 10032, USA
Arch Neurol 64:1646-51. 2007..To determine whether plasma homocysteine (Hcy) concentration is associated with mild parkinsonian signs (MPS) in community-dwelling elderly individuals... - Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern ManhattanAdam M Brickman
Departmentof Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032
Arch Neurol 65:1053-61. 2008..Aging is accompanied by a decrease in brain volume and by an increase in cerebrovascular disease... - Mediterranean diet and mild cognitive impairmentNikolaos Scarmeas
Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
Arch Neurol 66:216-25. 2009..Higher adherence to the Mediterranean diet (MeDi) may protect from Alzheimer disease (AD), but its association with mild cognitive impairment (MCI) has not been explored... - Physical activity, diet, and risk of Alzheimer diseaseNikolaos Scarmeas
Taub Institute for Research in Alzheimer s Disease and the Aging Brain and Department of Neurology, Columbia University Medical Center, 622 W 168th St, New York, NY 10032, USA
JAMA 302:627-37. 2009..Both higher adherence to a Mediterranean-type diet and more physical activity have been independently associated with lower Alzheimer disease (AD) risk but their combined association has not been investigated... - Antihypertensive medication class and pulse pressure in the elderly: analysis based on the third National Health and Nutrition Examination SurveyJoseph J Chang
Division of General Medicine, Department of Medicine, New York Medical College, New York, USA
Am J Med 115:536-42. 2003..These findings lend support to recommendations for use of diuretics in older hypertensive patients...
Research Grants
- Vascular factors, amyloid beta, and Alzheimer's diseaseJose Luchsinger; Fiscal Year: 2004..abstract_text> ..
- Pilot Trial of Metformin in Amnestic MCIJose A Luchsinger; Fiscal Year: 2010....