E D Louis

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Historical underpinnings of the term essential tremor in the late 19th century
    E D Louis
    GH Sergievsky Center, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 71:856-9. 2008
  2. pmc Distinguishing essential tremor from Parkinson's disease: bedside tests and laboratory evaluations
    Mary Ann Thenganatt
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Expert Rev Neurother 12:687-96. 2012
  3. ncbi request reprint Functional correlates and prevalence of mild parkinsonian signs in a community population of older people
    Elan D Louis
    The Gertrude H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, and Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Arch Neurol 62:297-302. 2005
  4. ncbi request reprint Olfaction in essential tremor patients with and without isolated rest tremor
    Elan D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 18:1387-9. 2003
  5. pmc Cancer and blood concentrations of the comutagen harmane in essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 23:1747-51. 2008
  6. pmc Blood harmane, blood lead, and severity of hand tremor: evidence of additive effects
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neurotoxicology 32:227-32. 2011
  7. ncbi request reprint Clinical correlates of action tremor in Parkinson disease
    E D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Arch Neurol 58:1630-4. 2001
  8. pmc Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurotoxicology 29:294-300. 2008
  9. pmc Familial aggregation of cranial tremor in familial essential tremor
    Elan D Louis
    G H Sergievsky Center, New York, N Y, USA
    Neuroepidemiology 41:48-53. 2013
  10. ncbi request reprint Study of possible factors associated with age of onset in essential tremor
    Elan D Louis
    Gertrude H Sergievsky Center, Columbia University, New York, New York, USA
    Mov Disord 21:1980-6. 2006

Collaborators

Detail Information

Publications190 found, 100 shown here

  1. pmc Historical underpinnings of the term essential tremor in the late 19th century
    E D Louis
    GH Sergievsky Center, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 71:856-9. 2008
    ..The term essential tremor has been in regular use since the second half of the 20th century. To modern neurologists, the word "essential" may seem cryptic. The historical underpinnings of this term have not been examined...
  2. pmc Distinguishing essential tremor from Parkinson's disease: bedside tests and laboratory evaluations
    Mary Ann Thenganatt
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Expert Rev Neurother 12:687-96. 2012
    ..These tests have limitations and their diagnostic utility requires additional study...
  3. ncbi request reprint Functional correlates and prevalence of mild parkinsonian signs in a community population of older people
    Elan D Louis
    The Gertrude H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, and Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Arch Neurol 62:297-302. 2005
    ..Mild parkinsonian signs (MPS) are associated with incident dementia and an increased risk of mortality. To our knowledge, the functional correlates of MPS have not been studied...
  4. ncbi request reprint Olfaction in essential tremor patients with and without isolated rest tremor
    Elan D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 18:1387-9. 2003
    ..These data raise the possibility that some ET patients with isolated rest tremor may not have early PD and that the pathological process that is responsible for their ET is also involving the basal ganglia...
  5. pmc Cancer and blood concentrations of the comutagen harmane in essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 23:1747-51. 2008
    ..02). Log blood harmane concentration was highest in ET cases with cancer when compared with other groups (P = 0.009). These links between cancer and ET and between high blood harmane and cancer in ET deserve further study...
  6. pmc Blood harmane, blood lead, and severity of hand tremor: evidence of additive effects
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neurotoxicology 32:227-32. 2011
    ..Harmane (1-methyl-9H-pyrido[3,4-β]indole) is a potent tremor-producing β-carboline alkaloid. Lead is another tremor-producing neurotoxicant. The effects of harmane and lead with respect to tremor have been studied in isolation...
  7. ncbi request reprint Clinical correlates of action tremor in Parkinson disease
    E D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Arch Neurol 58:1630-4. 2001
    ..It is not clear whether this action tremor is a manifestation of the underlying basal ganglia disease...
  8. pmc Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurotoxicology 29:294-300. 2008
    ..43+/-0.45g(-10)/ml) and lowest in controls (0.35+/-0.62g(-10)/ml) (test for trend, p=0.026). Blood harmane appears to be elevated in ET. The higher concentrations in familial ET suggests that the mechanism may involve genetic factors...
  9. pmc Familial aggregation of cranial tremor in familial essential tremor
    Elan D Louis
    G H Sergievsky Center, New York, N Y, USA
    Neuroepidemiology 41:48-53. 2013
    ..Cranial (neck, voice, and jaw) tremor is an important feature of ET. We examined whether cranial tremor aggregates in ET families, after controlling for other factors (age, tremor severity, and duration)...
  10. ncbi request reprint Study of possible factors associated with age of onset in essential tremor
    Elan D Louis
    Gertrude H Sergievsky Center, Columbia University, New York, New York, USA
    Mov Disord 21:1980-6. 2006
    ..This study did not detect any other exposures that modified the age of onset of ET. Follow-up studies are needed to examine additional factors of potential interest...
  11. pmc Color vision: a study of essential tremor cases versus normal controls
    E D Louis
    G H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Eur J Neurol 19:1136-9. 2012
    ..e., ET cases with a family history of PD, and ET cases with rest tremor) to determine whether these cases had greater color vision abnormalities than ET cases without those features...
  12. ncbi request reprint Late-life action tremor in a southern sea otter (enhydris lutris nereis)
    Elan D Louis
    Gertrude H Sergievsky Center, Columbia University, New York, New York, USA
    Mov Disord 19:222-6. 2004
    ..5 to 8.5 Hz action tremor of late life that shared several clinical characteristics with essential tremor. The main pathological finding was in the cerebellum, where there was extensive vacuolation of Purkinje cells...
  13. pmc Frailty in elderly persons with essential tremor: a population-based study (NEDICES)
    E D Louis
    The GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Eur J Neurol 18:1251-7. 2011
    ..Frailty has not been studied in ET, and our objective was to address this gap in knowledge. We hypothesized that frailty would be greater in ET cases than in controls...
  14. pmc Philadelphia Geriatric Morale Scale in essential tremor: a population-based study in three Spanish communities
    Elan D Louis
    G H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 23:1435-40. 2008
    ..This lower morale could in part be a proxy for mild, untreated depression. It therefore seems important to detect and then possibly treat this problem to improve the psychological well-being of patients with this disease...
  15. pmc Environmental epidemiology of essential tremor
    Elan D Louis
    GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Neuroepidemiology 31:139-49. 2008
    ..The purpose of this article is to review current knowledge with regards to the environmental epidemiology of ET...
  16. pmc It is time to remove the 'benign' from the essential tremor label
    Elan D Louis
    Department of Neurology, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032, USA
    Parkinsonism Relat Disord 17:516-20. 2011
    ..In those cases with currently-mild tremor, the nosology "mild essential tremor" would be a more accurate reflection of disease...
  17. pmc Does age of onset in essential tremor have a bimodal distribution? Data from a tertiary referral setting and a population-based study
    Elan D Louis
    GH Sergievsky Center, Columbia University, New York, NY, USA
    Neuroepidemiology 29:208-12. 2007
    ..Some data suggest a bimodal distribution and other data 1 late-life peak. We studied age of ET onset in 2 distinct settings: a population-based study and a tertiary referral center...
  18. ncbi request reprint Re-thinking the biology of essential tremor: from models to morphology
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA Electronic address
    Parkinsonism Relat Disord 20:S88-93. 2014
    ..This shift in paradigm opens the door for research that aims to identify the primary set of molecular triggers and the cascade of molecular/cellular events that accompany this disease. ..
  19. pmc Does rate of progression run in essential tremor families? Slower vs. faster progressors
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Parkinsonism Relat Disord 19:363-6. 2013
    ..Do ET families differ from one another with respect to rate of progression? Are some families slower progressors and other families faster progressors? We are unaware of published data...
  20. pmc Structural study of Purkinje cell axonal torpedoes in essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurosci Lett 450:287-91. 2009
    ..It is not known where in the pathogenic cascade these accumulations occur (i.e., whether these accumulations are the primary event or a secondary/downstream event) and this deserves further study...
  21. pmc Factors associated with receptivity to deep brain stimulation surgery among essential tremor cases
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Parkinsonism Relat Disord 17:482-5. 2011
    ..We are unaware of studies that assess ET patients' attitudes toward DBS surgery and the factors that motivate them toward or away from such surgery...
  22. ncbi request reprint Neuropathologic findings in essential tremor
    E D Louis
    GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 66:1756-9. 2006
    ..Six cases (60%) had Lewy bodies vs 2 controls (16.7%) (odds ratio 7.5, 95% CI 1.04 to 54.1; p = 0.035). Four of these six had an atypical distribution of brainstem Lewy bodies. ET may be pathologically heterogeneous...
  23. doi request reprint The Knud Krabbe (1885-1961)-Henry Alsop Riley (1887-1966) letters (1929-59): transatlantic friendship fostered by the International Neurological Congresses
    Elan D Louis
    Unit 198, Neurological Institute, 710 West 168th Street, New York, NY 10032, USA
    J Med Biogr 19:26-31. 2011
    ..It shows how the INCs, on a human level, resulted in links between the vanguards of neurology in different countries, thus helping to foster the development of neurology as an independent medical discipline during the 20th century...
  24. doi request reprint Tremor severity and age: a cross-sectional, population-based study of 2,524 young and midlife normal adults
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 26:1515-20. 2011
    ..These data suggest that age-dependent increase in tremor amplitude is not restricted to older people but occurs in all adult age groups...
  25. ncbi request reprint Community-based data on associations of disease duration and age with severity of essential tremor: implications for disease pathophysiology
    Elan D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 18:90-3. 2003
    ....
  26. pmc Rejected applications: An early American Academy of Neurology struggles to define its membership
    Elan D Louis
    From the GH Sergievsky Center, The Department of Neurology, and the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, and the Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY
    Neurology 83:359-63. 2014
    ..To review membership application materials (especially rejected applications) to the American Academy of Neurology (AAN) during its formative years (1947-1953)...
  27. pmc Kinetic tremor: differences between smokers and non-smokers
    Elan D Louis
    Gertrude H Sergievsky Center, and Department of Neurology, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032, USA
    Neurotoxicology 28:569-75. 2007
    ..These results suggest that smoking habits should be considered carefully in order to avoid over- or underestimating the effects of occupational and non-occupational exposures to other tremor-producing neurotoxins...
  28. pmc Essential tremor followed by progressive supranuclear palsy: postmortem reports of 11 patients
    Elan D Louis
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Neuropathol Exp Neurol 72:8-17. 2013
    ..e. et + psp)...
  29. doi request reprint The early struggles of the fledgling American Academy of Neurology: resistance from the old guard of American neurology
    Elan D Louis
    GH Sergievsky Centre, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Brain 136:343-54. 2013
    ..The struggle involved the rise of democratic medical populism in the country's Midwest versus establishment medicine (mainly situated in the Northeast), and perhaps, the rise of the middle class versus the aristocrats...
  30. pmc Embarrassment in essential tremor: prevalence, clinical correlates and therapeutic implications
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Parkinsonism Relat Disord 15:535-8. 2009
    ..Embarrassment is a commonly described feature of essential tremor (ET) but has not been the focus of clinical research...
  31. pmc Essential tremor as a neuropsychiatric disorder
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Neurol Sci 289:144-8. 2010
    ..Further study of these non-motor phenomena will advance our understanding of disease mechanisms and enhance the quality of clinical interactions with patients...
  32. ncbi request reprint Mild tremor in relatives of patients with essential tremor: what does this tell us about the penetrance of the disease?
    E D Louis
    Gertrude H Sergievsky Center, Columbia University, New York, NY, USA
    Arch Neurol 58:1584-9. 2001
    ..Mild tremor may occur in relatives of patients with essential tremor (ET). However, this phenomenon has not been studied quantitatively or with a comparison group. Such a study may provide information on the penetrance of ET...
  33. pmc Isolated head tremor: part of the clinical spectrum of essential tremor? Data from population-based and clinic-based case samples
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 24:2281-5. 2009
    ..Head tremor in the complete absence of arm tremor was not observed in any cases (0.0%). These clinical data may be of value to clinicians in practice settings and researchers in phenotyping efforts in the emerging field of ET genetics...
  34. pmc From neurons to neuron neighborhoods: the rewiring of the cerebellar cortex in essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Cerebellum 13:501-12. 2014
    ....
  35. ncbi request reprint Cognitive and motor functional activity in non-demented community-dwelling essential tremor cases
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, USA
    J Neurol Neurosurg Psychiatry 81:997-1001. 2010
    ..Also, there are very few data in which functional activity in ET has been divided into cognitively based activities (remembering appointments) versus motor-based activities (writing cheques)...
  36. ncbi request reprint Parkinsonian signs in older people in a community-based study: risk of incident dementia
    Elan D Louis
    The Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Arch Neurol 61:1273-6. 2004
    ..Mild parkinsonian signs occur in 30% to 40% of community-dwelling older people. In a cross-sectional study, the severity of these signs was greater in people with dementia than in people without dementia...
  37. ncbi request reprint Case-control study of nutritional antioxidant intake in essential tremor
    Elan D Louis
    G H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Neuroepidemiology 24:203-8. 2005
    ..There was no evidence that current nutritional antioxidant exposure differs in ET cases and controls. This does not exclude the possibility that nutritional antioxidant exposure was lower in ET cases prior to their disease onset...
  38. ncbi request reprint Association between mild parkinsonian signs and mild cognitive impairment in a community
    E D Louis
    The Gertrude H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease, New York, NY, USA
    Neurology 64:1157-61. 2005
    ..Mild parkinsonian signs (MPS) are associated with prevalent and incident dementia but it is not known whether they are associated with mild cognitive impairment (MCI)...
  39. ncbi request reprint Association between male gender and pediatric essential tremor
    Elan D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 20:904-6. 2005
    ..Whether this association between male gender and pediatric ET represents a selection bias or a true gender-mediated biological difference in disease expression is not known, although some data support the latter possibility...
  40. doi request reprint Rest tremor in advanced essential tremor: a post-mortem study of nine cases
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, USA 10032, USA
    J Neurol Neurosurg Psychiatry 82:261-5. 2011
    ..Here we report the clinical and post-mortem findings of nine ET cases with upper-extremity rest tremor in the absence of other parkinsonian features...
  41. ncbi request reprint Essential tremor associated with focal nonnigral Lewy bodies: a clinicopathologic study
    Elan D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Arch Neurol 62:1004-7. 2005
    ..Essential tremor is one of the most common neurological diseases. Its links with Parkinson disease (PD) are often debated. There have been few published postmortem studies...
  42. pmc Tremor in school-aged children: a cross-sectional study of tremor in 819 boys and girls in Burgos, Spain
    Elan D Louis
    GH Sergievsky Center, Columbia University, New York, NY, USA
    Neuroepidemiology 37:90-5. 2011
    ..Mild hand tremor occurs in most normal adults. There are no surveys of the prevalence or clinical correlates of such tremor among children...
  43. pmc The emerging neuropathology of essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 23:174-82. 2008
    ..These types of investigations are likely to lead the way to additional insights into the pathophysiology of ET and guide the development of therapies for this common movement disorder...
  44. ncbi request reprint Organochlorine pesticide exposure in essential tremor: a case-control study using biological and occupational exposure assessments
    Elan D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurotoxicology 27:579-86. 2006
    ..Our data suggest that these tremor-producing chemicals are not of major etiological importance in our patients with ET...
  45. ncbi request reprint Parkinsonism, dysautonomia, and intranuclear inclusions in a fragile X carrier: a clinical-pathological study
    Elan Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 21:420-5. 2006
    ..Further studies of clinical-pathological correlation in a larger sample of brains would provide additional insight into the mechanisms of the tremor, ataxia, and parkinsonism in these patients...
  46. pmc Dietary epidemiology of essential tremor: meat consumption and meat cooking practices
    Elan D Louis
    G H Sergievsky Center, New York, NY, USA
    Neuroepidemiology 30:161-6. 2008
    ..We tested the hypothesis that meat consumption and level of meat doneness are higher in ET cases than in controls...
  47. pmc Elevated brain harmane (1-methyl-9H-pyrido[3,4-b]indole) in essential tremor cases vs. controls
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA Electronic address
    Neurotoxicology 38:131-5. 2013
    ..controls, all work to date has involved blood samples...
  48. pmc How are we doing with the treatment of essential tremor (ET)?: Persistence of patients with ET on medication: data from 528 patients in three settings
    E D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Eur J Neurol 17:882-4. 2010
    ..There are only two first-line medications and troublesome side effects are common. It is not uncommon for patients to simply stop taking medication. Yet, no published data substantiate or quantify this anecdotal impression...
  49. pmc Mirror movements in patients with essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 24:2211-7. 2009
    ..Whether, as in PD, MMs in ET represent a failure of subcortical structures to support the cortical network involved with the initiation of unilateral motor activity, requires future neurophysiological investigation...
  50. pmc Torpedoes in Parkinson's disease, Alzheimer's disease, essential tremor, and control brains
    Elan D Louis
    GH Sergievsky Center, Columbia University, New York, New York, USA
    Mov Disord 24:1600-5. 2009
    ..Although torpedoes are increased in AD and PD, as well as cerebellar ET, the magnitude of increase in cerebellar ET is greater, and cannot be accounted for by concomitant AD or PD pathology...
  51. ncbi request reprint Factors associated with increased risk of head tremor in essential tremor: a community-based study in northern Manhattan
    Elan D Louis
    The Gertrude H Sergievsky Center, Columbia University, New York, New York, USA
    Mov Disord 18:432-6. 2003
    ..These disease associations require further exploration, and might provide insight into the mechanisms underlying head tremor...
  52. pmc Relationship between blood harmane and harmine concentrations in familial essential tremor, sporadic essential tremor and controls
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurotoxicology 31:674-9. 2010
    ....
  53. doi request reprint Weir Mitchell's 1859 demonstration of "a peculiar contraction" produced by a percussion hammer
    Elan D Louis
    G H Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 70:969-73. 2008
    ..The 1875 publications of Erb and Westphal brought widespread attention to the percussion of muscle stretch reflexes. Although the maneuver may have been observed before 1875, there is little concrete evidence of this...
  54. pmc Factor analysis of motor and nonmotor signs in essential tremor: are these signs all part of the same underlying pathogenic process?
    Elan D Louis
    GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuroepidemiology 33:41-6. 2009
    ..Age loaded with cognitive test scores, further raising the possibility that age-related processes (e.g. Alzheimer-type changes) could underlie cognitive changes in ET...
  55. pmc Functional correlates of gait and balance difficulty in essential tremor: balance confidence, near misses and falls
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Gait Posture 35:43-7. 2012
    ..In this study, we assessed whether ET patients subjectively experience more gait difficulty, more falls or near misses than controls...
  56. pmc Blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentration in essential tremor cases in Spain
    Elan D Louis
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurotoxicology 34:264-8. 2013
    ..controls, and especially in familial ET cases. These findings, however, have been derived from a study of cases ascertained through a single tertiary referral center in New York...
  57. pmc The primary type of tremor in essential tremor is kinetic rather than postural: cross-sectional observation of tremor phenomenology in 369 cases
    E D Louis
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Eur J Neurol 20:725-7. 2013
    ..Essential tremor (ET) is amongst the most commonly misdiagnosed neurological diseases. The current aim was to provide observational data on a basic characteristic of ET, namely, the relative severity of postural to kinetic tremor...
  58. pmc Mild parkinsonian signs are associated with increased risk of dementia in a prospective, population-based study of elders
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 25:172-8. 2010
    ..Baseline MPS seems to be a predictor of incident dementia. These motor signs might, therefore, serve as a useful biomarker for emerging dementia...
  59. ncbi request reprint Semiquantitative study of current coffee, caffeine, and ethanol intake in essential tremor cases and controls
    Elan D Louis
    The Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 19:499-504. 2004
    ..A prospective study is needed to explore whether decreased caffeine consumption is a risk factor for ET...
  60. ncbi request reprint Feasibility and validity of a modified finger-nose-finger test
    Elan D Louis
    G H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 20:636-9. 2005
    ..The mFNF may be used to collect valuable data on tremor severity in pathological, genetic, and epidemiological field studies of ET, in which in-person or videotaped neurological examinations are not possible...
  61. pmc Apathy in essential tremor, dystonia, and Parkinson's disease: a comparison with normal controls
    Elan D Louis
    G H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Mov Disord 27:432-4. 2012
    ..Apathy, defined as decreased goal-directed activity, has been observed in Parkinson's disease. A number of cognitive/psychiatric features have been documented in essential tremor, yet we are unaware of studies of apathy...
  62. ncbi request reprint James Ramsay Hunt (1874-1937)
    Elan D Louis
    Gertrude H Sergievsky Center and Department of Neurology, College of Physicians and Surgeons, Columbia University, Unit 198, Neurological Institute, 710 West 168th Street, New York, NY 10032, USA
    J Neurol 251:240-1. 2004
  63. pmc Mild Parkinsonian signs are associated with lower olfactory test scores in the community-dwelling elderly
    Elan D Louis
    The Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 23:524-30. 2008
    ..MPS were associated with a mild reduction in olfactory function. These observations further support the view of MPS as a marker of emerging degenerative brain pathologies...
  64. pmc Essential tremor 10, 20, 30, 40: clinical snapshots of the disease by decade of duration
    E D Louis
    G H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Eur J Neurol 20:949-54. 2013
    ..e. < 10, 10-19, 20-29, 30-39, ≥ 40 years). We hope these data will be of value in clinical-prognostic settings both to patients and their treating physicians...
  65. pmc Torpedo formation and Purkinje cell loss: modeling their relationship in cerebellar disease
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Cerebellum 13:433-9. 2014
    ..With more severe cerebellar disease, torpedoes can be quite numerous and are likely a common feature of surviving PCs, but eventually, dramatic loss of PC leads to a paradoxical reduction in observable torpedoes...
  66. ncbi request reprint Matching asymmetry of tremor with asymmetry of postmortem cerebellar hemispheric changes in essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Cerebellum 13:462-70. 2014
    ....
  67. pmc Elevated blood lead concentrations in essential tremor: a case-control study in Mersin, Turkey
    Okan Dogu
    Department of Neurology, Faculty of Medicine, Mersin University, Mersin, Turkey
    Environ Health Perspect 115:1564-8. 2007
    ..A recent study in New York City found blood lead concentrations to be elevated in ET cases compared with matched controls. Chronic exposure to lead produces cerebellar damage, and this could predispose individuals to develop ET...
  68. pmc Blood harmane concentrations in 497 individuals relative to coffee, cigarettes, and food consumption on the morning of testing
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, Unit 198, Neurological Institute, 710 West 168th Street, New York, NY 10032 2699, USA
    J Toxicol 2011:628151. 2011
    ..BHCs in this sample of ~500 individuals did not covary with recent smoking, coffee, or food consumption, suggesting that our inability to withhold these exposures on the morning of phlebotomy was not reflected in the BHCs we measured...
  69. pmc Postural and Intention Tremors: A Detailed Clinical Study of Essential Tremor vs. Parkinson's Disease
    Eliezer J Sternberg
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University New York, NY, USA Tufts University School of Medicine Boston, MA, USA
    Front Neurol 4:51. 2013
    ..We hope that detailed phenomenological data on tremor in ET and PD will help practicing physicians delineate the two diseases...
  70. pmc Macroautophagy abnormality in essential tremor
    Sheng Han Kuo
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
    PLoS ONE 7:e53040. 2012
    ..This provides a possible means by which perturbed macroautophagy could contribute to PC pathology in ET...
  71. pmc Treatment of Essential Tremor: Are there Issues We are Overlooking?
    Elan D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University New York, NY, USA
    Front Neurol 2:91. 2011
    ..Further discussion of the issues raised here may lead to improvements in clinical trial methodologies as well as facilitate the development of fresh approaches to pharmacotherapy...
  72. pmc Essential tremor with ubiquitinated intranuclear inclusions and cerebellar degeneration
    Elan D Louis
    GH Sergievsky Center
    Clin Neuropathol 31:119-26. 2012
    ..Yet until recently, there had been few postmortem examinations so that the full range of pathological changes associated with this disease has not been catalogued...
  73. pmc Understanding essential tremor: progress on the biological front
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Curr Neurol Neurosci Rep 14:450. 2014
    ..Hence, there is a renewed interest in the science behind the biology of ET. How the new understanding of ET will translate into treatment changes is an open question. ..
  74. pmc Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in Parkinson's disease
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA Electronic address
    Neurotoxicology 40:52-6. 2014
    ..Genetic and environmental factors play an etiological role. Harmane (1-methyl-9H-pyrido[3,4-b]indole) is a potent tremor-producing neurotoxin that shows structural resemblance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)...
  75. pmc When do essential tremor patients develop head tremor? Influences of age and duration and evidence of a biological clock
    Elan D Louis
    G H Sergievsky Center, Department of Neurology, Columbia University, New York, NY 10032, USA
    Neuroepidemiology 41:110-5. 2013
    ....
  76. pmc Age of onset: can we rely on essential tremor patients to report this? Data from a prospective, longitudinal study
    Elan D Louis
    Department of Neurology, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY, USA
    Neuroepidemiology 40:93-8. 2013
    ..As a researcher, one wonders about the quality of this self-report. Is age of onset something which can be reproducibly self-reported by patients? There are few published data to aid researchers...
  77. pmc Prevalence and features of unreported dystonia in a family study of "pure" essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Parkinsonism Relat Disord 19:359-62. 2013
    ..We sought to determine the prevalence and clinical features of unreported dystonia in a family study of "pure" ET...
  78. doi request reprint High width variability during spiral drawing: further evidence of cerebellar dysfunction in essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Cerebellum 11:872-9. 2012
    ..16, p=0.06). The primary anatomical substrate for ET continues to be a matter of speculation, yet these and other clinical data lend support to the notion that there is an underlying abnormality of the cerebellum and/or its pathways...
  79. pmc Depressive traits in essential tremor: impact on disability, quality of life, and medication adherence
    E D Louis
    G H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Eur J Neurol 19:1349-54. 2012
    ..We assessed whether, independent of tremor severity, patients with more depressive symptoms have more perceived tremor-related disability, lower tremor-related quality of life, and poorer compliance with tremor medication...
  80. pmc Blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor: repeat observation in cases and controls in New York
    Elan D Louis
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Toxicol Environ Health A 75:673-83. 2012
    ..Blood harmane concentration was elevated in ET cases compared to controls when reassessed at a second time point several years later, indicating what seems to be a stable association between this environmental toxin and ET...
  81. pmc Neurofilament protein levels: quantitative analysis in essential tremor cerebellar cortex
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neurosci Lett 518:49-54. 2012
    ..Therefore, further analyses of these NF abnormalities and their mechanisms are important to enhance our understanding of disease pathogenesis in ET...
  82. pmc Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population
    Xinmin Liu
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    BMC Med Genet 12:104. 2011
    ..Collectively the associations identified in these GWAS account for only a small proportion of the estimated total heritability of PD suggesting that an 'unknown' component of the genetic architecture of PD remains to be identified...
  83. pmc Essential tremors: a family of neurodegenerative disorders?
    Elan D Louis
    Gertrude H Sergievsky Center, Department of Neurology, and Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Arch Neurol 66:1202-8. 2009
    ..Furthermore, this aging-associated, progressive disorder is associated with neuronal loss and postmortem changes that occur in traditional neurodegenerative disorders...
  84. pmc Purkinje cell loss is a characteristic of essential tremor
    Elan D Louis
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Parkinsonism Relat Disord 17:406-9. 2011
    ....
  85. ncbi request reprint Olfactory dysfunction in essential tremor: a deficit unrelated to disease duration or severity
    Elan D Louis
    Gertrude H Sergievsky Center and the Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 59:1631-3. 2002
    ..Mean score was lower in cases than in control subjects (29.0 +/- 6.1 vs 31.9 +/- 4.6, p = 0.02) and was not correlated with tremor severity or duration...
  86. pmc Population-based study of baseline ethanol consumption and risk of incident essential tremor
    E D Louis
    GH Sergievsky Center, Columbia University, New York, NY 10032, USA
    J Neurol Neurosurg Psychiatry 80:494-7. 2009
    ..Toxic exposures that compromise cerebellar tissue could lower the threshold for developing ET. Ethanol is a well-established cerebellar toxin, resulting in Purkinje cell loss...
  87. doi request reprint Torpedoes in the cerebellar vermis in essential tremor cases vs. controls
    Elan D Louis
    G H Sergievsky Center, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032, USA
    Cerebellum 10:812-9. 2011
    ..These data further confirm the central role of the cerebellum in the underlying pathophysiology of this common neurological disorder...
  88. pmc Estimating annual rate of decline: prospective, longitudinal data on arm tremor severity in two groups of essential tremor cases
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Neurol Neurosurg Psychiatry 82:761-5. 2011
    ..Patients themselves often want to know from their treating physician whether and by how much their tremor is expected to worsen over time...
  89. pmc Beta-carboline alkaloids and essential tremor: exploring the environmental determinants of one of the most prevalent neurological diseases
    Elan D Louis
    GH Sergievsky Center, Columbia University, New York, USA
    ScientificWorldJournal 10:1783-94. 2010
    ..Studies of harmane and its possible association with ET have been intriguing. Additional studies are needed to establish more definitively whether these toxic exposures are associated with ET and are of etiological importance...