E D Louis

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Essential tremor
    Elan D Louis
    Department of Neurology, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032, USA
    Clin Geriatr Med 22:843-57, vii. 2006
  2. ncbi request reprint Interest in participating in clinical research: A study of essential tremor patients
    Elan D Louis
    H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 22:133-8. 2007
  3. ncbi request reprint Neuropathological changes in essential tremor: 33 cases compared with 21 controls
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, USA
    Brain 130:3297-307. 2007
  4. pmc Historical underpinnings of the term essential tremor in the late 19th century
    E D Louis
    GH Sergievsky Center, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 71:856-9. 2008
  5. pmc Distinguishing essential tremor from Parkinson's disease: bedside tests and laboratory evaluations
    Mary Ann Thenganatt
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Expert Rev Neurother 12:687-96. 2012
  6. doi request reprint Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in Parkinson's disease
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA Electronic address
    Neurotoxicology 40:52-6. 2014
  7. pmc When do essential tremor patients develop head tremor? Influences of age and duration and evidence of a biological clock
    Elan D Louis
    G H Sergievsky Center, Department of Neurology, Columbia University, New York, NY 10032, USA
    Neuroepidemiology 41:110-5. 2013
  8. doi request reprint Age of onset: can we rely on essential tremor patients to report this? Data from a prospective, longitudinal study
    Elan D Louis
    Department of Neurology, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY, USA
    Neuroepidemiology 40:93-8. 2013
  9. pmc Prevalence and features of unreported dystonia in a family study of "pure" essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Parkinsonism Relat Disord 19:359-62. 2013
  10. doi request reprint High width variability during spiral drawing: further evidence of cerebellar dysfunction in essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Cerebellum 11:872-9. 2012

Collaborators

Detail Information

Publications143 found, 100 shown here

  1. ncbi request reprint Essential tremor
    Elan D Louis
    Department of Neurology, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032, USA
    Clin Geriatr Med 22:843-57, vii. 2006
    ..This article discusses the major clinical features of ET and approaches to its diagnosis and treatment...
  2. ncbi request reprint Interest in participating in clinical research: A study of essential tremor patients
    Elan D Louis
    H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 22:133-8. 2007
    ..These observations should be assessed in additional patient samples. Investigators may use our observations to identify and target patients for clinical trials and other research...
  3. ncbi request reprint Neuropathological changes in essential tremor: 33 cases compared with 21 controls
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, USA
    Brain 130:3297-307. 2007
    ..The majority have cerebellar changes without Lewy bodies; a smaller proportion has brainstem Lewy bodies. The clinical differences between cases with versus without Lewy bodies require additional study...
  4. pmc Historical underpinnings of the term essential tremor in the late 19th century
    E D Louis
    GH Sergievsky Center, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 71:856-9. 2008
    ..The term essential tremor has been in regular use since the second half of the 20th century. To modern neurologists, the word "essential" may seem cryptic. The historical underpinnings of this term have not been examined...
  5. pmc Distinguishing essential tremor from Parkinson's disease: bedside tests and laboratory evaluations
    Mary Ann Thenganatt
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Expert Rev Neurother 12:687-96. 2012
    ..These tests have limitations and their diagnostic utility requires additional study...
  6. doi request reprint Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in Parkinson's disease
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA Electronic address
    Neurotoxicology 40:52-6. 2014
    ..Genetic and environmental factors play an etiological role. Harmane (1-methyl-9H-pyrido[3,4-b]indole) is a potent tremor-producing neurotoxin that shows structural resemblance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)...
  7. pmc When do essential tremor patients develop head tremor? Influences of age and duration and evidence of a biological clock
    Elan D Louis
    G H Sergievsky Center, Department of Neurology, Columbia University, New York, NY 10032, USA
    Neuroepidemiology 41:110-5. 2013
    ....
  8. doi request reprint Age of onset: can we rely on essential tremor patients to report this? Data from a prospective, longitudinal study
    Elan D Louis
    Department of Neurology, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY, USA
    Neuroepidemiology 40:93-8. 2013
    ..As a researcher, one wonders about the quality of this self-report. Is age of onset something which can be reproducibly self-reported by patients? There are few published data to aid researchers...
  9. pmc Prevalence and features of unreported dystonia in a family study of "pure" essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Parkinsonism Relat Disord 19:359-62. 2013
    ..We sought to determine the prevalence and clinical features of unreported dystonia in a family study of "pure" ET...
  10. doi request reprint High width variability during spiral drawing: further evidence of cerebellar dysfunction in essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Cerebellum 11:872-9. 2012
    ..16, p=0.06). The primary anatomical substrate for ET continues to be a matter of speculation, yet these and other clinical data lend support to the notion that there is an underlying abnormality of the cerebellum and/or its pathways...
  11. pmc Depressive traits in essential tremor: impact on disability, quality of life, and medication adherence
    E D Louis
    G H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Eur J Neurol 19:1349-54. 2012
    ..We assessed whether, independent of tremor severity, patients with more depressive symptoms have more perceived tremor-related disability, lower tremor-related quality of life, and poorer compliance with tremor medication...
  12. pmc Blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor: repeat observation in cases and controls in New York
    Elan D Louis
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Toxicol Environ Health A 75:673-83. 2012
    ..Blood harmane concentration was elevated in ET cases compared to controls when reassessed at a second time point several years later, indicating what seems to be a stable association between this environmental toxin and ET...
  13. pmc Neurofilament protein levels: quantitative analysis in essential tremor cerebellar cortex
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neurosci Lett 518:49-54. 2012
    ..Therefore, further analyses of these NF abnormalities and their mechanisms are important to enhance our understanding of disease pathogenesis in ET...
  14. pmc Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population
    Xinmin Liu
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    BMC Med Genet 12:104. 2011
    ..Collectively the associations identified in these GWAS account for only a small proportion of the estimated total heritability of PD suggesting that an 'unknown' component of the genetic architecture of PD remains to be identified...
  15. doi request reprint How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 25:534-41. 2010
    ....
  16. ncbi request reprint Jaw tremor: prevalence and clinical correlates in three essential tremor case samples
    Elan D Louis
    Gertrude H Sergievsky Center, Columbia University, New York, New York, USA
    Mov Disord 21:1872-8. 2006
    ....
  17. ncbi request reprint Essential tremor associated with pathologic changes in the cerebellum
    Elan D Louis
    Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 710 W 168th Street, New York, NY 10032, USA
    Arch Neurol 63:1189-93. 2006
    ..Although essential tremor (ET) is one of the most common neurologic disorders, there have been few postmortem studies. We recently reported postmortem changes (torpedoes and Bergmann gliosis) in the cerebellar cortex in a few ET cases...
  18. ncbi request reprint History of vascular disease and mild parkinsonian signs in community-dwelling elderly individuals
    Elan D Louis
    The Gertrude H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, and Department of Neurology, College of Physicians and Surgeons, Columbia University, 710 W 168th Street, New York, NY 10032, USA
    Arch Neurol 63:717-22. 2006
    ..If the etiology were vascular, one could hypothesize that individuals with MPS would be more likely to have systemic vascular disease than would their counterparts without these signs...
  19. ncbi request reprint Weir Mitchell's observations on sensory localization and their influence on Jacksonian neurology
    Elan D Louis
    GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 66:1241-4. 2006
    ..Hughlings Jackson, however, did not work in a vacuum. Silas Weir Mitchell (1829-1914), in Philadelphia, published several clinical observations related to localization...
  20. ncbi request reprint The neurologic content of S. Weir Mitchell's fiction
    Elan D Louis
    G H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 66:403-7. 2006
    ..He was also a prolific writer of novels and short stories. The neurologic content of this fiction has not been studied...
  21. pmc Essential tremors: a family of neurodegenerative disorders?
    Elan D Louis
    Gertrude H Sergievsky Center, Department of Neurology, and Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Arch Neurol 66:1202-8. 2009
    ..Furthermore, this aging-associated, progressive disorder is associated with neuronal loss and postmortem changes that occur in traditional neurodegenerative disorders...
  22. ncbi request reprint Functional correlates of mild parkinsonian signs in the community-dwelling elderly: poor balance and inability to ambulate independently
    Elan D Louis
    The Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 21:411-6. 2006
    ..The elderly in whom these signs have been detected are 50% more likely to complain of poor balance and 90% more likely to require a cane, walker, or wheelchair than are their counterparts without these signs...
  23. ncbi request reprint Blood harmane concentrations and dietary protein consumption in essential tremor
    E D Louis
    The Gertrude H Sergievsky Center, Department of Neurology, Taub Institute for Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 65:391-6. 2005
    ..Whether this difference is due to greater animal protein consumption by patients or their failure to metabolize harmane is unknown...
  24. ncbi request reprint Essential tremor
    Elan D Louis
    G H Sergievsky Center, Department of Neurology, and the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Lancet Neurol 4:100-10. 2005
    ..These insights also have the potential to form the basis for neuroprotective therapies...
  25. ncbi request reprint John Adams' essential tremor
    Elan D Louis
    Gertrude H Sergievsky Center, Columbia University, New York, New York 10032, USA
    Mov Disord 20:1537-42. 2005
    ..This finding raises some speculation as to whether Adams could have been developing some parkinsonism, although the evidence in favor of this is not compelling. The most likely diagnosis was essential tremor...
  26. ncbi request reprint Essential tremor centralized brain repository: diagnostic validity and clinical characteristics of a highly selected group of essential tremor cases
    Elan D Louis
    Gertude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 20:1361-5. 2005
    ....
  27. ncbi request reprint Interaction between blood lead concentration and delta-amino-levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor
    Elan D Louis
    Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Mov Disord 20:1170-7. 2005
    ..The presence of increased circulating BPb concentrations along with a greater potential for lead toxicity (ALAD-2 allele) could result in greater cerebellar damage, thereby increasing the risk of developing tremor...
  28. doi request reprint Essential tremor: evolving clinicopathological concepts in an era of intensive post-mortem enquiry
    Elan D Louis
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Lancet Neurol 9:613-22. 2010
    ..However, with more controlled, tissue-based studies being done, it is hoped that these mechanisms will be elucidated, thereby laying the foundation for the development of more targeted, effective pharmacotherapeutic interventions...
  29. ncbi request reprint Factor structure of motor signs in essential tremor
    Elan D Louis
    G H Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neuroepidemiology 25:42-7. 2005
    ..The demonstration of these four factors will be of potential use for pathological and genetic studies as well as interventional studies, as will be discussed...
  30. pmc Subclinical tremor in normal controls with versus without a family history of essential tremor: data from the United States and Turkey
    E D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Eur J Neurol 17:607-11. 2010
    ..We determined whether normal controls who report a family history of ET have greater action tremor than normal controls who do not report such a history...
  31. ncbi request reprint Essential tremor: occupational exposures to manganese and organic solvents
    E D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 63:2162-4. 2004
    ..Using lifetime occupational histories, the authors demonstrated that occupational exposures were similar in cases and controls, which does not support an etiologic link between occupational exposures to these chemicals and ET...
  32. ncbi request reprint Self-reported depression and anti-depressant medication use in essential tremor: cross-sectional and prospective analyses in a population-based study
    E D Louis
    G H Sergievsky Center, Department of Neurology and Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Eur J Neurol 14:1138-46. 2007
    ..Rather than being totally benign, ET seems to be associated with a mood disorder. Furthermore, as well as being a secondary response to disease manifestations, this mood disorder may be a primary feature of the underlying disease...
  33. pmc Quantitative brain measurements in community-dwelling elderly persons with mild parkinsonian signs
    Elan D Louis
    Unit 198, Department of Neurology, Columbia University, 710 W 168th St, New York, NY 10032, USA
    Arch Neurol 65:1649-54. 2008
    ..Also, if MPS are a marker for developing Alzheimer-type changes, hippocampal volume on MRI might be diminished in individuals with MPS...
  34. pmc Prevalence of essential tremor in a multiethnic, community-based study in northern Manhattan, New York, N.Y
    Elan D Louis
    G H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Neuroepidemiology 32:208-14. 2009
    ..Y., USA; (2) compare prevalence across ethnic groups, and (3) provide prevalence estimates for the oldest old...
  35. pmc Population-based prospective study of cigarette smoking and risk of incident essential tremor
    Elan D Louis
    G H Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neurology 70:1682-7. 2008
    ..One study showed an association between smoking and lower ET prevalence. We now study whether baseline smoking is associated with lower risk of incident ET...
  36. pmc Population-based study of baseline ethanol consumption and risk of incident essential tremor
    E D Louis
    GH Sergievsky Center, Columbia University, New York, NY 10032, USA
    J Neurol Neurosurg Psychiatry 80:494-7. 2009
    ..Toxic exposures that compromise cerebellar tissue could lower the threshold for developing ET. Ethanol is a well-established cerebellar toxin, resulting in Purkinje cell loss...
  37. ncbi request reprint Mild parkinsonian signs and plasma homocysteine concentration in community-dwelling elderly individuals
    Elan D Louis
    The Gertrude H Sergievsky Center, Department of Neurology, Columbia University, New York, NY 10032, USA
    Arch Neurol 64:1646-51. 2007
    ..To determine whether plasma homocysteine (Hcy) concentration is associated with mild parkinsonian signs (MPS) in community-dwelling elderly individuals...
  38. ncbi request reprint Young-onset Parkinson's disease: hospital utilization and medical comorbidity in a nationwide survey
    Elan D Louis
    GH Sergievsky Center, New York, NY, USA
    Neuroepidemiology 29:39-43. 2007
    ..10% of Parkinson's disease (PD) patients have young-onset PD (YOPD). We compared YOPD patients to control patients in terms of hospital utilization and outcomes and medical comorbidities during hospitalization...
  39. pmc Older onset essential tremor: More rapid progression and more degenerative pathology
    Elan D Louis
    GH Sergievsky Center, Columbia University, New York, New York, USA
    Mov Disord 24:1606-12. 2009
    ..In a brain bank, older age of onset was associated with more degenerative pathology in the cerebellum. As in several neurodegenerative disorders, in older onset cases, it is possible that the disease advances more rapidly...
  40. ncbi request reprint Blood harmane is correlated with cerebellar metabolism in essential tremor: a pilot study
    Elan D Louis
    Gertrude H Sergievsky Center, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 69:515-20. 2007
    ..Harmane, which is present in the human diet, is a potent tremor-producing neurotoxin. Blood harmane concentrations seem to be elevated in ET...
  41. ncbi request reprint ICD-9 CM code 333.1 as an identifier of patients with essential tremor: a study of the positive predictive value of this code
    Elan D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, USA
    Neuroepidemiology 28:181-5. 2007
    ..The utility of the code for essential tremor (ET), 333.1, remains untested. We determined the positive predictive value (PPV) of the code 333.1...
  42. ncbi request reprint Mild Parkinsonian signs: An overview of an emerging concept
    Elan D Louis
    G H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 22:1681-8. 2007
    ....
  43. ncbi request reprint Silas Weir Mitchell's essential tremor
    Elan D Louis
    G H Sergievsky Center and Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 22:1217-22. 2007
    ..The likely diagnosis was essential tremor. Curiously, Mitchell rarely alluded to tremor in personal writings and tremor was not prominently featured in his scientific or fictional works...
  44. ncbi request reprint Prevalence of essential tremor in patients with Parkinson's disease vs. Parkinson-plus syndromes
    Elan D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 22:1402-7. 2007
    ..Patients with PD were three to thirteen times more likely to have diagnoses of ET than were patients with Parkinson-plus syndromes. These data further confirm the link between ET and PD, and possibly, between ET and Lewy body disease...
  45. pmc Fertility in essential tremor. Data from population-based and clinical sources
    Elan D Louis
    GH Sergievsky Center, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neuroepidemiology 31:185-90. 2008
    ..The objective was to determine whether ET cases and controls differ in terms of number of children...
  46. pmc Antihypertensive agents and risk of Parkinson's disease, essential tremor and dementia: a population-based prospective study (NEDICES)
    Elan D Louis
    Department of Neurology, GH Sergievsky Center, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neuroepidemiology 33:286-92. 2009
    ..A modest literature, with mixed results, has examined whether these medications might lower the odds or risk of Parkinson's disease (PD) or dementia. There are no data for essential tremor (ET)...
  47. pmc Higher blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations correlate with lower olfactory scores in essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurotoxicology 29:460-5. 2008
    ..Harmane and related chemicals are toxic to the cerebellum. Whether it is through this mechanism (cerebellar toxicity) that harmane leads to ET is unknown. Impaired olfaction may be a feature of cerebellar disease...
  48. ncbi request reprint Unraveling the neuron jungle: the 1879-1886 publications by Wilhelm His on the embryological development of the human brain
    E D Louis
    Gertrude H Sergievsky Center, New York, NY, USA
    Arch Neurol 58:1932-5. 2001
    ..Although this age-based embryological approach seems relatively straightforward by today's standards, few other researchers were using it at the time...
  49. pmc Estimating annual rate of decline: prospective, longitudinal data on arm tremor severity in two groups of essential tremor cases
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Neurol Neurosurg Psychiatry 82:761-5. 2011
    ..Patients themselves often want to know from their treating physician whether and by how much their tremor is expected to worsen over time...
  50. ncbi request reprint Vaccines to treat encephalitis lethargica: human experiments at the Neurological Institute of New York, 1929-1940
    Elan D Louis
    Unit No 198, Neurological Institute of New York, 710 West 168th St, New York, NY 10032, USA
    Arch Neurol 59:1486-90. 2002
    ..Encephalitis lethargica, first observed in 1915, became a pandemic. Because of its presumed infectious basis, there were early attempts to treat it with vaccines. The history of the use of these vaccines has not been analyzed...
  51. pmc Purkinje cell loss is a characteristic of essential tremor
    Elan D Louis
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Parkinsonism Relat Disord 17:406-9. 2011
    ....
  52. ncbi request reprint The James Ramsay Hunt case books
    Elan D Louis
    Gerturde H Sergievsky Center, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Hist Neurosci 12:34-43. 2003
    ..These Case Books provide a valuable perspective of the practice of neurology in early-twentieth-century America...
  53. ncbi request reprint Samuel Adams' tremor
    E D Louis
    Gertrude H Sergievsky Center and the Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 56:1201-5. 2001
    ..Samuel Adams (1722--1803), the American Revolutionist and brewer, is said to have had a tremor. There has not been a formal study of the clinical characteristics and progression of his tremor...
  54. doi request reprint Torpedoes in the cerebellar vermis in essential tremor cases vs. controls
    Elan D Louis
    G H Sergievsky Center, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032, USA
    Cerebellum 10:812-9. 2011
    ..These data further confirm the central role of the cerebellum in the underlying pathophysiology of this common neurological disorder...
  55. ncbi request reprint Risk of tremor and impairment from tremor in relatives of patients with essential tremor: a community-based family study
    E D Louis
    Gertrude H Sergievsky Center, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Ann Neurol 49:761-9. 2001
    ..The majority of the affected relatives can expect to experience impairment resulting from tremor...
  56. ncbi request reprint A population-based study of mortality in essential tremor
    Elan D Louis
    G H Sergievsky Center and Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 69:1982-9. 2007
    ..Because ET is common, particularly among older adults, an influence of ET on the life span would have important public health implications. The authors compared the risks of mortality in patients with ET and control subjects without ET...
  57. ncbi request reprint Elevation of blood beta-carboline alkaloids in essential tremor
    E D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Neurology 59:1940-4. 2002
    ..beta-Carboline alkaloids are normal body constituents but are also potent tremor-producing chemicals that are naturally present in the food chain...
  58. ncbi request reprint Olfactory dysfunction in essential tremor: a deficit unrelated to disease duration or severity
    Elan D Louis
    Gertrude H Sergievsky Center and the Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 59:1631-3. 2002
    ..Mean score was lower in cases than in control subjects (29.0 +/- 6.1 vs 31.9 +/- 4.6, p = 0.02) and was not correlated with tremor severity or duration...
  59. ncbi request reprint Metabolic abnormality in the cerebellum in patients with essential tremor: a proton magnetic resonance spectroscopic imaging study
    Elan D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neurosci Lett 333:17-20. 2002
    ..59, P = 0.02). The reduction in cerebellar cortical NAA/tCR indicates that there is neuronal damage or loss in ET, suggesting that ET may be a neurodegenerative disease...
  60. ncbi request reprint Body mass index in essential tremor
    Elan D Louis
    Unit 198, Neurological Institute, College of Physicians and Surgeons, Columbia University, 710 W 168th St, New York, NY 10032
    Arch Neurol 59:1273-7. 2002
    ..The pathogenesis of essential tremor (ET) is unknown, but it could be neurodegenerative. Weight loss has been observed in patients with neurodegenerative diseases...
  61. ncbi request reprint Diagnosing Parkinson's disease using videotaped neurological examinations: validity and factors that contribute to incorrect diagnoses
    Elan D Louis
    The Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 17:513-7. 2002
    ..A limitation is that patients with milder PD of shorter duration may not be recognized as PD...
  62. ncbi request reprint Correlates of functional disability in essential tremor
    E D Louis
    The Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 16:914-20. 2001
    ....
  63. ncbi request reprint Regional and racial differences in the prevalence of physician-diagnosed essential tremor in the United States
    Elan D Louis
    College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 18:1035-40. 2003
    ..Caucasians were five times more likely to have physician-diagnosed ET than were African Americans. This study does not provide an explanation for this difference, which deserves further study...
  64. ncbi request reprint Risk of action tremor in relatives of tremor-dominant and postural instability gait disorder PD
    E D Louis
    G H Sergievsky Center, Taub Institute for Alzheimer s Disease, Columbia University, New York, NY, USA
    Neurology 61:931-6. 2003
    ..This tremor could represent mild PD or essential tremor. An estimate of the risk of this condition in families of patients with PD is important when studying the genetics of PD...
  65. pmc Beta-carboline alkaloids and essential tremor: exploring the environmental determinants of one of the most prevalent neurological diseases
    Elan D Louis
    GH Sergievsky Center, Columbia University, New York, USA
    ScientificWorldJournal 10:1783-94. 2010
    ..Studies of harmane and its possible association with ET have been intriguing. Additional studies are needed to establish more definitively whether these toxic exposures are associated with ET and are of etiological importance...
  66. pmc Tandem gait performance in essential tremor: clinical correlates and association with midline tremors
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 25:1633-8. 2010
    ..Tandem gait difficulty and cranial tremors in ET may both be symptomatic of the same underlying pathophysiology, a disturbance of cerebellar regulation of the midline, which is distinct from its regulation of the limbs...
  67. pmc What is the functional significance of nondominant arm tremor in essential tremor?
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 25:2674-8. 2010
    ..In 5% of patients, tremor in the nondominant arm was the likely motivator for seeking care, which is another indication of its functional significance. © 2010 Movement Disorder Society...
  68. ncbi request reprint Factor structure of parkinsonian signs in the community-dwelling elderly
    Elan D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 19:268-72. 2004
    ..These data support the view that Parkinsonian signs in older adults might be due to basal ganglia dysfunction, a possibility that requires further exploration...
  69. ncbi request reprint A biography of James Ramsay Hunt (1874-1937)
    Elan D Louis
    Gertrude H Sergievsky Center, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Hist Neurosci 12:266-75. 2003
    ....
  70. pmc Association between essential tremor and blood lead concentration
    Elan D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Environ Health Perspect 111:1707-11. 2003
    ..We report an association between BPb concentration and ET. Determining whether this association is due to increased exposure to lead or a difference in lead kinetics in ET patients requires further investigation...
  71. ncbi request reprint Cerebellar metabolic symmetry in essential tremor studied with 1H magnetic resonance spectroscopic imaging: implications for disease pathology
    Elan D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 19:672-7. 2004
    ..7%, P = 0.027). These data suggest that pathological lesions in ET patients, which remain elusive, might be distributed similarly in each cerebellar cortex. Postmortem studies are needed to confirm these preliminary imaging results...
  72. pmc Faster rate of cognitive decline in essential tremor cases than controls: a prospective study
    E D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Eur J Neurol 17:1291-7. 2010
    ..This study provides evidence that cognitive deficits in ET are not static, and they appear to be progressing at a faster rate than in elders without this disease...
  73. ncbi request reprint Whipple disease
    Elan D Louis
    Neurological Institute, Columbia University College of Physicians and Surgeons, 710 West 168th Street, Unit 198, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 3:470-5. 2003
    ..Although the organism historically has been difficult to culture, several recent attempts have been successful. Antibiotic treatment is recommended for 1 year while monitoring the clinical signs and cerebrospinal fluid PCR results...
  74. pmc Risk of Parkinson disease in carriers of parkin mutations: estimation using the kin-cohort method
    Yuanjia Wang
    Department of Biostatistics, Mailman School of Public Health, New York, New York, USA
    Arch Neurol 65:467-74. 2008
    ..To estimate the risk of Parkinson disease (PD) in individuals with mutations in the Parkin gene...
  75. pmc Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease
    Roy N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Clin Exp Neuropsychol 32:775-9. 2010
    ..GBA carriers reported more impairment, but MMSE performance did not differ among genetic groups. Detailed neuropsychological testing is required to explore the association between cognitive impairment and GBA mutations...
  76. pmc Frequency of known mutations in early-onset Parkinson disease: implication for genetic counseling: the consortium on risk for early onset Parkinson disease study
    Roy N Alcalay
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Arch Neurol 67:1116-22. 2010
    ..To assess the frequency and clinical characteristics of carriers of previously identified mutations in 6 genes associated with early-onset Parkinson disease (PD) and provide empirical data that can be used to inform genetic counseling...
  77. ncbi request reprint Do risk factors for Alzheimer's disease predict dementia in Parkinson's disease? An exploratory study
    Gilberto Levy
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 17:250-7. 2002
    ..The association of smoking with incident dementia in PD deserves further study...
  78. pmc Reduced Purkinje cell number in essential tremor: a postmortem study
    Jordan E Axelrad
    Gertrude H Sergievsky Center, Columbia University, New York, New York, USA
    Arch Neurol 65:101-7. 2008
    ..In recent postmortem studies, we documented increased numbers of torpedoes (Purkinje cell axonal swellings) in ET patients without Lewy bodies. Purkinje cell loss, however, has never been rigorously assessed...
  79. ncbi request reprint Essential tremor: mild olfactory dysfunction in a cerebellar disorder
    Lakeisha M Applegate
    Gertude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Parkinsonism Relat Disord 11:399-402. 2005
    ..04). These findings: suggest that olfactory dysfunction in ET patients occurs independently of mild cognitive deficits and support recent work that the cerebellum may play a role in central olfactory processing...
  80. pmc Motor phenotype of LRRK2 G2019S carriers in early-onset Parkinson disease
    Roy N Alcalay
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Arch Neurol 66:1517-22. 2009
    ....
  81. ncbi request reprint Memory and executive function impairment predict dementia in Parkinson's disease
    Gilberto Levy
    Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Mov Disord 17:1221-6. 2002
    ..Our results indicate that impairment in verbal memory and executive function are associated with the development of dementia in patients with PD...
  82. ncbi request reprint Neuropathologic findings in essential tremor
    E D Louis
    GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 66:1756-9. 2006
    ..Six cases (60%) had Lewy bodies vs 2 controls (16.7%) (odds ratio 7.5, 95% CI 1.04 to 54.1; p = 0.035). Four of these six had an atypical distribution of brainstem Lewy bodies. ET may be pathologically heterogeneous...
  83. ncbi request reprint Essential tremor in childhood: a series of nineteen cases
    E D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 16:921-3. 2001
    ..A paucity of childhood cases with head tremor suggests that the neuropathological changes in ET may evolve somatotopically. Head tremor may require midline or more extensive bilateral pathology which may only occur later in the disease...
  84. ncbi request reprint Mild tremor in relatives of patients with essential tremor: what does this tell us about the penetrance of the disease?
    E D Louis
    Gertrude H Sergievsky Center, Columbia University, New York, NY, USA
    Arch Neurol 58:1584-9. 2001
    ..Mild tremor may occur in relatives of patients with essential tremor (ET). However, this phenomenon has not been studied quantitatively or with a comparison group. Such a study may provide information on the penetrance of ET...
  85. ncbi request reprint The association of incident dementia with mortality in PD
    G Levy
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, New York, USA
    Neurology 59:1708-13. 2002
    ..To evaluate the association of incident dementia with mortality in a cohort of patients with idiopathic PD who were nondemented at baseline evaluation, controlling for extrapyramidal sign (EPS) severity at each study visit...
  86. ncbi request reprint Association between mild parkinsonian signs and mild cognitive impairment in a community
    E D Louis
    The Gertrude H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease, New York, NY, USA
    Neurology 64:1157-61. 2005
    ..Mild parkinsonian signs (MPS) are associated with prevalent and incident dementia but it is not known whether they are associated with mild cognitive impairment (MCI)...
  87. pmc How are we doing with the treatment of essential tremor (ET)?: Persistence of patients with ET on medication: data from 528 patients in three settings
    E D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Eur J Neurol 17:882-4. 2010
    ..There are only two first-line medications and troublesome side effects are common. It is not uncommon for patients to simply stop taking medication. Yet, no published data substantiate or quantify this anecdotal impression...
  88. pmc Frailty in elderly persons with essential tremor: a population-based study (NEDICES)
    E D Louis
    The GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Eur J Neurol 18:1251-7. 2011
    ..Frailty has not been studied in ET, and our objective was to address this gap in knowledge. We hypothesized that frailty would be greater in ET cases than in controls...
  89. ncbi request reprint Clinical correlates of action tremor in Parkinson disease
    E D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Arch Neurol 58:1630-4. 2001
    ..It is not clear whether this action tremor is a manifestation of the underlying basal ganglia disease...
  90. pmc Kinetic tremor: differences between smokers and non-smokers
    Elan D Louis
    Gertrude H Sergievsky Center, and Department of Neurology, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032, USA
    Neurotoxicology 28:569-75. 2007
    ..These results suggest that smoking habits should be considered carefully in order to avoid over- or underestimating the effects of occupational and non-occupational exposures to other tremor-producing neurotoxins...
  91. pmc Mirror movements in patients with essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 24:2211-7. 2009
    ..Whether, as in PD, MMs in ET represent a failure of subcortical structures to support the cortical network involved with the initiation of unilateral motor activity, requires future neurophysiological investigation...
  92. ncbi request reprint Community-based data on associations of disease duration and age with severity of essential tremor: implications for disease pathophysiology
    Elan D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 18:90-3. 2003
    ....
  93. pmc Essential tremor is associated with dementia: prospective population-based study in New York
    Sujata P Thawani
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Neurology 73:621-5. 2009
    ..Furthermore, an association between ET and dementia has been reported in a single population-based study in Spain. This has not been confirmed elsewhere...
  94. ncbi request reprint Erb and Westphal: simultaneous discovery of the deep tendon reflexes
    Elan D Louis
    The Neurological Institute, Columbia University, New York, New York 10032 2603, USA
    Semin Neurol 22:385-90. 2002
    ..By 1885, the maneuver was used in Europe and across the Atlantic in America. By then, the DTRs had become one of the cardinal features of the neurological examination...
  95. ncbi request reprint Essential tremor associated with focal nonnigral Lewy bodies: a clinicopathologic study
    Elan D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Arch Neurol 62:1004-7. 2005
    ..Essential tremor is one of the most common neurological diseases. Its links with Parkinson disease (PD) are often debated. There have been few published postmortem studies...
  96. ncbi request reprint Testosterone therapy in men with Parkinson disease: results of the TEST-PD Study
    Michael S Okun
    Department of Neurology, University of Florida Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA
    Arch Neurol 63:729-35. 2006
    ..Previously, we reported that testosterone deficiency is more common in patients with PD compared with age-matched control subjects, and we also reported in 2 small open-label studies that some nonmotor symptoms responded favorably to TT...
  97. pmc Philadelphia Geriatric Morale Scale in essential tremor: a population-based study in three Spanish communities
    Elan D Louis
    G H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 23:1435-40. 2008
    ..This lower morale could in part be a proxy for mild, untreated depression. It therefore seems important to detect and then possibly treat this problem to improve the psychological well-being of patients with this disease...
  98. pmc Embarrassment in essential tremor: prevalence, clinical correlates and therapeutic implications
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Parkinsonism Relat Disord 15:535-8. 2009
    ..Embarrassment is a commonly described feature of essential tremor (ET) but has not been the focus of clinical research...
  99. pmc Mild parkinsonian signs are associated with increased risk of dementia in a prospective, population-based study of elders
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 25:172-8. 2010
    ..Baseline MPS seems to be a predictor of incident dementia. These motor signs might, therefore, serve as a useful biomarker for emerging dementia...
  100. pmc Factor analysis of motor and nonmotor signs in essential tremor: are these signs all part of the same underlying pathogenic process?
    Elan D Louis
    GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuroepidemiology 33:41-6. 2009
    ..Age loaded with cognitive test scores, further raising the possibility that age-related processes (e.g. Alzheimer-type changes) could underlie cognitive changes in ET...
  101. pmc Isolated head tremor: part of the clinical spectrum of essential tremor? Data from population-based and clinic-based case samples
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 24:2281-5. 2009
    ..Head tremor in the complete absence of arm tremor was not observed in any cases (0.0%). These clinical data may be of value to clinicians in practice settings and researchers in phenotyping efforts in the emerging field of ET genetics...