Gilberto Levy

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint A two-stage design for a phase II clinical trial of coenzyme Q10 in ALS
    G Levy
    Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Neurology 66:660-3. 2006
  2. ncbi request reprint Contribution of aging to the severity of different motor signs in Parkinson disease
    Gilberto Levy
    Statistical Analysis Center, Department of Biostatistics, Columbia University, New York, NY 10032, USA
    Arch Neurol 62:467-72. 2005
  3. ncbi request reprint The relationship of Parkinson disease with aging
    Gilberto Levy
    Department of Biostatistics, Columbia University, 722 W 168th St, Sixth Floor, New York, NY 10032, USA
    Arch Neurol 64:1242-6. 2007
  4. ncbi request reprint Memory and executive function impairment predict dementia in Parkinson's disease
    Gilberto Levy
    Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Mov Disord 17:1221-6. 2002
  5. ncbi request reprint Lack of familial aggregation of Parkinson disease and Alzheimer disease
    Gilberto Levy
    Statistical Analysis Center, Department of Biostatistics, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    Arch Neurol 61:1033-9. 2004
  6. ncbi request reprint Combined effect of age and severity on the risk of dementia in Parkinson's disease
    Gilberto Levy
    Gertrude H Sergievsky Center, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Ann Neurol 51:722-9. 2002
  7. ncbi request reprint Familial aggregation of early- and late-onset Parkinson's disease
    Karen Marder
    Department of Neurology, Columbia University, New York, NY, USA
    Ann Neurol 54:507-13. 2003
  8. ncbi request reprint The Saitohin 'Q7R' polymorphism and tau haplotype in multi-ethnic Alzheimer disease and Parkinson's disease cohorts
    Lorraine N Clark
    Department of Pathology, Columbia University, New York, NY, USA
    Neurosci Lett 347:17-20. 2003
  9. ncbi request reprint Diagnosing Parkinson's disease using videotaped neurological examinations: validity and factors that contribute to incorrect diagnoses
    Elan D Louis
    The Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 17:513-7. 2002
  10. ncbi request reprint Body mass index in essential tremor
    Elan D Louis
    Unit 198, Neurological Institute, College of Physicians and Surgeons, Columbia University, 710 W 168th St, New York, NY 10032
    Arch Neurol 59:1273-7. 2002

Detail Information

Publications24

  1. ncbi request reprint A two-stage design for a phase II clinical trial of coenzyme Q10 in ALS
    G Levy
    Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Neurology 66:660-3. 2006
    ..The combination of a small pool of patients at any given time with the availability of many potential neuroprotective agents to be tested in ALS requires efficient phase II trial designs...
  2. ncbi request reprint Contribution of aging to the severity of different motor signs in Parkinson disease
    Gilberto Levy
    Statistical Analysis Center, Department of Biostatistics, Columbia University, New York, NY 10032, USA
    Arch Neurol 62:467-72. 2005
    ..This knowledge may have implications for clinical trials of neuroprotective agents in PD...
  3. ncbi request reprint The relationship of Parkinson disease with aging
    Gilberto Levy
    Department of Biostatistics, Columbia University, 722 W 168th St, Sixth Floor, New York, NY 10032, USA
    Arch Neurol 64:1242-6. 2007
    ....
  4. ncbi request reprint Memory and executive function impairment predict dementia in Parkinson's disease
    Gilberto Levy
    Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Mov Disord 17:1221-6. 2002
    ..Our results indicate that impairment in verbal memory and executive function are associated with the development of dementia in patients with PD...
  5. ncbi request reprint Lack of familial aggregation of Parkinson disease and Alzheimer disease
    Gilberto Levy
    Statistical Analysis Center, Department of Biostatistics, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    Arch Neurol 61:1033-9. 2004
    ..To investigate the risk of Alzheimer disease (AD) in first-degree relatives of patients with Parkinson disease (PD) compared with first-degree relatives of controls...
  6. ncbi request reprint Combined effect of age and severity on the risk of dementia in Parkinson's disease
    Gilberto Levy
    Gertrude H Sergievsky Center, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Ann Neurol 51:722-9. 2002
    ..2) did not. These findings suggest that the increased risk of incident dementia in Parkinson's disease associated with age and severity of extrapyramidal signs is related primarily to their combined effect rather than separate effects...
  7. ncbi request reprint Familial aggregation of early- and late-onset Parkinson's disease
    Karen Marder
    Department of Neurology, Columbia University, New York, NY, USA
    Ann Neurol 54:507-13. 2003
    ..Genetic factors are important in both early- and late-onset PD, but specific genes and mode of inheritance may differ between the two groups...
  8. ncbi request reprint The Saitohin 'Q7R' polymorphism and tau haplotype in multi-ethnic Alzheimer disease and Parkinson's disease cohorts
    Lorraine N Clark
    Department of Pathology, Columbia University, New York, NY, USA
    Neurosci Lett 347:17-20. 2003
    ..7%) and controls (56.6%); however, this difference was not statistically significant (PDD vs. controls OR 2.1; 95% CI: 0.8-5.8, P=0.2)...
  9. ncbi request reprint Diagnosing Parkinson's disease using videotaped neurological examinations: validity and factors that contribute to incorrect diagnoses
    Elan D Louis
    The Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 17:513-7. 2002
    ..A limitation is that patients with milder PD of shorter duration may not be recognized as PD...
  10. ncbi request reprint Body mass index in essential tremor
    Elan D Louis
    Unit 198, Neurological Institute, College of Physicians and Surgeons, Columbia University, 710 W 168th St, New York, NY 10032
    Arch Neurol 59:1273-7. 2002
    ..The pathogenesis of essential tremor (ET) is unknown, but it could be neurodegenerative. Weight loss has been observed in patients with neurodegenerative diseases...
  11. pmc Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III
    Petra Kaufmann
    Department of Neurology, Clinical Coordinating Center, Columbia University, New York, NY 10032, USA
    Ann Neurol 66:235-44. 2009
    ..Our aims were to choose between two high doses of CoQ10 for ALS, and to determine if it merits testing in a Phase III clinical trial...
  12. ncbi request reprint Development and evaluation of a self-administered version of the ALSFRS-R
    J Montes
    Eleanor and Lou Gehrig MDA ALS Research Center, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Neurology 67:1294-6. 2006
    ..The self-administered ALSFRS-R showed excellent reliability (intraclass correlation = 0.93, 95% CI: 088 to 0.96) and similar sensitivity to change over time vs the standard evaluator-administered ALSFRS-R...
  13. ncbi request reprint The ALSFRSr predicts survival time in an ALS clinic population
    P Kaufmann
    Department of Neurology, College of Physicians and Surgeons, The Neurologic Institute, Columbia University, 710 W 168th Street, New York, NY 10032, USA
    Neurology 64:38-43. 2005
    ..To determine whether the Amyotrophic Lateral Sclerosis Functional Rating Scale-revised (ALSFRSr), a predictor of survival time in ALS clinical trials, predicts survival time in an ALS clinic population...
  14. ncbi request reprint Clinical correlates of action tremor in Parkinson disease
    E D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Arch Neurol 58:1630-4. 2001
    ..It is not clear whether this action tremor is a manifestation of the underlying basal ganglia disease...
  15. ncbi request reprint Risk of action tremor in relatives of tremor-dominant and postural instability gait disorder PD
    E D Louis
    G H Sergievsky Center, Taub Institute for Alzheimer s Disease, Columbia University, New York, NY, USA
    Neurology 61:931-6. 2003
    ..This tremor could represent mild PD or essential tremor. An estimate of the risk of this condition in families of patients with PD is important when studying the genetics of PD...
  16. ncbi request reprint Accuracy of family history data on Parkinson's disease
    K Marder
    Department of Neurology, Columbia University, New York, USA
    Neurology 61:18-23. 2003
    ..Genetic studies of PD frequently rely on family history interviews (FHI), yet the accuracy of data obtained in this way is unclear...
  17. pmc Statistical aspects of the TNK-S2B trial of tenecteplase versus alteplase in acute ischemic stroke: an efficient, dose-adaptive, seamless phase II/III design
    Bruce Levin
    Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10025, USA
    Clin Trials 8:398-407. 2011
    ..TNK-S2B, an innovative, randomized, seamless phase II/III trial of tenecteplase versus rt-PA for acute ischemic stroke, terminated for slow enrollment before regulatory approval of use of phase II patients in phase III...
  18. ncbi request reprint Do risk factors for Alzheimer's disease predict dementia in Parkinson's disease? An exploratory study
    Gilberto Levy
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 17:250-7. 2002
    ..The association of smoking with incident dementia in PD deserves further study...
  19. doi request reprint Web-based data management for a phase II clinical trial in ALS
    Richard Buchsbaum
    Department of Biostatistics, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY 10032, USA
    Amyotroph Lateral Scler 10:374-7. 2009
    ..Given sufficient resources, a comprehensive web-based data management system can meet the need for clean, available data in clinical trials in ALS and similar diseases, and can contribute significantly to their efficient execution...
  20. ncbi request reprint The association of incident dementia with mortality in PD
    G Levy
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, New York, USA
    Neurology 59:1708-13. 2002
    ..To evaluate the association of incident dementia with mortality in a cohort of patients with idiopathic PD who were nondemented at baseline evaluation, controlling for extrapyramidal sign (EPS) severity at each study visit...
  21. ncbi request reprint ALS issues in clinical trials. Missing data
    John L P Thompson
    Statistical Analysis Center SAC, Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:48-51. 2004
  22. ncbi request reprint The changing natural history of spinal muscular atrophy type 1
    M Oskoui
    Department of Neurology, Columbia University, New York, NY, USA
    Neurology 69:1931-6. 2007
    ..Noninvasive ventilation has become increasingly available to spinal muscular atrophy (SMA) patients since the early 1990 s. This is expected to have improved survival for SMA type 1 patients...
  23. pmc Influence of leisure activity on the incidence of Alzheimer's disease
    N Scarmeas
    Cognitive Neuroscience Division of the Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neurology 57:2236-42. 2001
    ..CONCLUSIONS: The data suggest that engagement in leisure activities may reduce the risk of incident dementia, possibly by providing a reserve that delays the onset of clinical manifestations of the disease...
  24. ncbi request reprint Dementia in Parkinson's disease challenges the "gold standard"
    Gilberto Levy
    Ann Neurol 58:663-5. 2005