Beth Levine

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Development by self-digestion: molecular mechanisms and biological functions of autophagy
    Beth Levine
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Dev Cell 6:463-77. 2004
  2. ncbi request reprint Eating oneself and uninvited guests: autophagy-related pathways in cellular defense
    Beth Levine
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75330, USA
    Cell 120:159-62. 2005
  3. pmc Autophagy fights disease through cellular self-digestion
    Noboru Mizushima
    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Nature 451:1069-75. 2008
  4. pmc Autophagy in the pathogenesis of disease
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 132:27-42. 2008
  5. pmc Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    Daniel J Klionsky
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Autophagy 4:151-75. 2008
  6. pmc Viral evasion of autophagy
    Anthony Orvedahl
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Autophagy 4:280-5. 2008
  7. pmc Cardiac autophagy is a maladaptive response to hemodynamic stress
    Hongxin Zhu
    Department of Internal Medicine and Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    J Clin Invest 117:1782-93. 2007
  8. ncbi request reprint How shall I eat thee?
    Daniel J Klionsky
    Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Autophagy 3:413-6. 2007
  9. ncbi request reprint 4th International Symposium on Autophagy: exploiting the frontiers of autophagy research
    Eeva Liisa Eskelinen
    Department of Biological and Environmental Sciences, Division of Biochemistry, University of Helsinki, Helsinki, Finland
    Autophagy 3:166-73. 2007
  10. pmc HIV and CXCR4 in a kiss of autophagic death
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Clin Invest 116:2078-80. 2006

Detail Information

Publications11

  1. ncbi request reprint Development by self-digestion: molecular mechanisms and biological functions of autophagy
    Beth Levine
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Dev Cell 6:463-77. 2004
    ..In this review, we summarize our current knowledge about the molecular machinery of autophagy and the role of the autophagic machinery in eukaryotic development...
  2. ncbi request reprint Eating oneself and uninvited guests: autophagy-related pathways in cellular defense
    Beth Levine
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75330, USA
    Cell 120:159-62. 2005
    ..2005). Other recent studies indicate that the autophagy machinery is also used to degrade foreign microbial invaders (xenophagy)...
  3. pmc Autophagy fights disease through cellular self-digestion
    Noboru Mizushima
    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Nature 451:1069-75. 2008
    ..Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health...
  4. pmc Autophagy in the pathogenesis of disease
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 132:27-42. 2008
    ..This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases...
  5. pmc Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    Daniel J Klionsky
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Autophagy 4:151-75. 2008
    ..In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response...
  6. pmc Viral evasion of autophagy
    Anthony Orvedahl
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Autophagy 4:280-5. 2008
    ..This review will briefly summarize the current understanding of autophagy as an antiviral pathway, and then discuss strategies that viruses may utilize to evade this host defense mechanism...
  7. pmc Cardiac autophagy is a maladaptive response to hemodynamic stress
    Hongxin Zhu
    Department of Internal Medicine and Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    J Clin Invest 117:1782-93. 2007
    ..Taken together, these findings implicate autophagy in the pathogenesis of load-induced heart failure and suggest it may be a target for novel therapeutic intervention...
  8. ncbi request reprint How shall I eat thee?
    Daniel J Klionsky
    Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Autophagy 3:413-6. 2007
  9. ncbi request reprint 4th International Symposium on Autophagy: exploiting the frontiers of autophagy research
    Eeva Liisa Eskelinen
    Department of Biological and Environmental Sciences, Division of Biochemistry, University of Helsinki, Helsinki, Finland
    Autophagy 3:166-73. 2007
    ..Two themes were discussed in many sessions during the symposium: the role of autophagy in the degradation of aggregate-prone proteins and protein aggregates, and the possible role of p62 in autophagy...
  10. pmc HIV and CXCR4 in a kiss of autophagic death
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Clin Invest 116:2078-80. 2006
    ..The HIV envelope glycoprotein interacts with CXC chemokine receptor 4 to activate the lysosomal degradation pathway of autophagy, which is necessary for both apoptotic and nonapoptotic cell death...
  11. pmc The role of autophagy in mammalian development: cell makeover rather than cell death
    Francesco Cecconi
    Dulbecco Telethon Institute at the Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    Dev Cell 15:344-57. 2008
    ..Thus, autophagy is a process of cytosolic "renovation," crucial in cell fate decisions...