RUDOLPH L contact LEIBEL

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi Effects of ambient temperature on adaptive thermogenesis during maintenance of reduced body weight in mice
    Yann Ravussin
    Department of Pediatrics, Division of Molecular Genetics, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Am J Physiol Regul Integr Comp Physiol 303:R438-48. 2012
  2. ncbi Identifying functional relationships among human genes by systematic analysis of biological literature
    Yong Chuan Tao
    Life Science Informatics Unit, Functional Genomics Area, Novartis Pharmaceuticals, Summit, NJ 07901, USA
    BMC Bioinformatics 3:16. 2002
  3. ncbi The molecular genetics of rodent single gene obesities
    R L Leibel
    Columbia University, New York, New York 10032, USA
    J Biol Chem 272:31937-40. 1997
  4. ncbi Molecular physiology of weight regulation in mice and humans
    R L Leibel
    Division of Molecular Genetics and Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Obes (Lond) 32:S98-108. 2008
  5. ncbi Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjects
    Rochelle Goldsmith
    Department of Medicine, Division of Exercise Physiology, New York, New York, USA
    Am J Physiol Regul Integr Comp Physiol 298:R79-88. 2010
  6. ncbi Regulation of Fto/Ftm gene expression in mice and humans
    George Stratigopoulos
    Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1185-96. 2008
  7. ncbi Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice
    Kai Ying Guo
    Division of Molecular Genetics, Columbia Univ, College of Physicians and Surgeons, Russ Berrie Pavilion, 1150 St Nicholas Ave, New York, NY 10032, USA
    Am J Physiol Regul Integr Comp Physiol 287:R112-9. 2004
  8. ncbi The links between obesity, leptin, and prostate cancer
    Wendy K Chung
    Division of Molecular Genetics and the Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, Russ Berrie Medical Science Pavilion, New York, New York 10032, USA
    Cancer J 12:178-81. 2006
  9. ncbi Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys
    Haijun D Sun
    ImClone Systems Inc, 180 Varick St, New York, NY 10014, USA
    Am J Physiol Endocrinol Metab 292:E964-76. 2007
  10. ncbi An apparent role for Alox15 in the pathogenesis of diabetes in the NOD mouse: parsing the supporting genetic data
    Stuart P Weisberg
    Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA
    Diabetes 57:1-2. 2008

Research Grants

  1. Leptin in Human Energy and Neuroendocrine Homeostasis
    Rudolph Leibel; Fiscal Year: 2009
  2. Leptin in Human Energy and Neuroendocrine Homeostasis
    Rudolph Leibel; Fiscal Year: 2006
  3. Cloning of a type 2 diabetes modifier in obese mice
    Rudolph Leibel; Fiscal Year: 2006
  4. MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY
    Rudolph Leibel; Fiscal Year: 2007
  5. MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY
    Rudolph Leibel; Fiscal Year: 2009
  6. Cloning of a type 2 diabetes modifier in obese mice
    Rudolph Leibel; Fiscal Year: 2009
  7. MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY
    RUDOLPH L contact LEIBEL; Fiscal Year: 2010
  8. Cloning of a type 2 diabetes modifier in obese mice
    Rudolph L Leibel; Fiscal Year: 2010
  9. Leptin in Human Energy and Neuroendocrine Homeostasis
    Rudolph L Leibel; Fiscal Year: 2010
  10. MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY
    Rudolph Leibel; Fiscal Year: 2000

Collaborators

Detail Information

Publications43

  1. ncbi Effects of ambient temperature on adaptive thermogenesis during maintenance of reduced body weight in mice
    Yann Ravussin
    Department of Pediatrics, Division of Molecular Genetics, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Am J Physiol Regul Integr Comp Physiol 303:R438-48. 2012
    ....
  2. ncbi Identifying functional relationships among human genes by systematic analysis of biological literature
    Yong Chuan Tao
    Life Science Informatics Unit, Functional Genomics Area, Novartis Pharmaceuticals, Summit, NJ 07901, USA
    BMC Bioinformatics 3:16. 2002
    ....
  3. ncbi The molecular genetics of rodent single gene obesities
    R L Leibel
    Columbia University, New York, New York 10032, USA
    J Biol Chem 272:31937-40. 1997
  4. ncbi Molecular physiology of weight regulation in mice and humans
    R L Leibel
    Division of Molecular Genetics and Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Obes (Lond) 32:S98-108. 2008
    ..This paper reviews the history of the rationale and methodology of the cloning of leptin (Lep) and the leptin receptor (Lepr), and describes some of the clinical investigation characterizing this axis...
  5. ncbi Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjects
    Rochelle Goldsmith
    Department of Medicine, Division of Exercise Physiology, New York, New York, USA
    Am J Physiol Regul Integr Comp Physiol 298:R79-88. 2010
    ....
  6. ncbi Regulation of Fto/Ftm gene expression in mice and humans
    George Stratigopoulos
    Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1185-96. 2008
    ..quot; FTM has recently been shown to be a ciliary basal body protein...
  7. ncbi Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice
    Kai Ying Guo
    Division of Molecular Genetics, Columbia Univ, College of Physicians and Surgeons, Russ Berrie Pavilion, 1150 St Nicholas Ave, New York, NY 10032, USA
    Am J Physiol Regul Integr Comp Physiol 287:R112-9. 2004
    ....
  8. ncbi The links between obesity, leptin, and prostate cancer
    Wendy K Chung
    Division of Molecular Genetics and the Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, Russ Berrie Medical Science Pavilion, New York, New York 10032, USA
    Cancer J 12:178-81. 2006
  9. ncbi Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys
    Haijun D Sun
    ImClone Systems Inc, 180 Varick St, New York, NY 10014, USA
    Am J Physiol Endocrinol Metab 292:E964-76. 2007
    ..Our data suggest that FGF signaling through FGFR1c may play a physiological role in hypothalamic feeding circuit and that blocking it leads to hypophagia and weight loss...
  10. ncbi An apparent role for Alox15 in the pathogenesis of diabetes in the NOD mouse: parsing the supporting genetic data
    Stuart P Weisberg
    Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA
    Diabetes 57:1-2. 2008
  11. ncbi Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli
    Michael Rosenbaum
    Department of Pediatrics, Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University Medical Center New York Presbyterian Medical Center, New York, New York, USA
    J Clin Invest 118:2583-91. 2008
    ..These data are consistent with a model of the weight-reduced state as one of relative leptin deficiency...
  12. ncbi Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight
    Michael Rosenbaum
    Columbia University College of Physicians and Surgeons, New York Presbyterian Medical Center, New York, NY 10032, USA
    Am J Clin Nutr 88:906-12. 2008
    ..An important clinical issue is whether this reduction, which predisposes to weight regain, persists over time...
  13. ncbi Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling
    George Stratigopoulos
    Division of Molecular Genetics, Department of Pediatrics and Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA
    J Biol Chem 286:2155-70. 2011
    ....
  14. ncbi Considerations regarding the genetics of obesity
    Wendy K Chung
    Division of Molecular Genetics, Department of Pediatrics, Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Obesity (Silver Spring) 16:S33-9. 2008
    ..New analytic tools will have to be developed to permit the necessary analysis of the gene x gene interactions that must ultimately convey aggregate genetic effects on adiposity...
  15. ncbi Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations
    Wendy K Chung
    Columbia University Medical Center, New York, NY 10032, USA
    Hum Hered 67:193-205. 2009
    ..Human adiposity is highly heritable, but few of the genes that predispose to obesity in most humans are known. We tested candidate genes in pathways related to food intake and energy expenditure for association with measures of adiposity...
  16. ncbi Energy intake in weight-reduced humans
    Michael Rosenbaum
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Brain Res 1350:95-102. 2010
    ..Much of this biological opposition to sustained weight loss is mediated by the adipocyte-derived hormone "leptin."..
  17. ncbi The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity
    Loan K Phan
    Department of Pediatrics, Columbia University, New York, NY, USA
    Am J Physiol Endocrinol Metab 291:E611-20. 2006
    ..The effect of Mgrn1(md) on insulin sensitivity of Mc4r-null mice suggests that Mgrn1(md) may be increasing insulin sensitivity via the hypothalamic melanocortin-3 receptor pathway...
  18. ncbi Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight
    Michael Rosenbaum
    Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 115:3579-86. 2005
    ..These responses suggest that the weight-reduced state may be regarded as a condition of relative leptin insufficiency. Prevention of weight regain might be achievable by strategies relevant to reversing this leptin-insufficient state...
  19. ncbi Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects
    Michael Rosenbaum
    Div of Molecular Genetics, Russ Berrie Medical Science Pavilion, 6th Fl, 1150 St Nicholas Ave, New York, NY 10032, USA
    Am J Physiol Regul Integr Comp Physiol 285:R183-92. 2003
    ..8 (20.5)%, P = 0.043]. Changes in muscle efficiency at altered body weight accounted for 35% of the change in daily energy expended in physical activity...
  20. ncbi Molecular physiology of syndromic obesities in humans
    Wendy K Chung
    Division of Molecular Genetics and the Naomi Berrie Diabetes Center, Columbia University Medical College, Russell Berrie Medical Science Pavilion, Room 620, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Trends Endocrinol Metab 16:267-72. 2005
    ..Although rare, the study of syndromic forms of obesity provides insight into underlying molecular and physiological mechanisms by which adiposity is regulated through food intake, energy expenditure and partitioning of stored calories...
  21. ncbi Body fat redistribution after weight gain in women with anorexia nervosa
    Laurel Mayer
    Department of Psychiatry, Columbia University, New York, NY, USA
    Am J Clin Nutr 81:1286-91. 2005
    ..Increasing evidence suggests that the fat distribution immediately after weight restoration in patients with AN differs from the distribution typical of healthy adult women...
  22. ncbi Determinants of leptin gene expression in fat depots of lean mice
    Yiying Zhang
    Division of Molecular Genetics, Department of Pediatrics, and the Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York 10032, USA
    Am J Physiol Regul Integr Comp Physiol 282:R226-34. 2002
    ..The strong correlation between leptin gene expression and adipocyte volume supports leptin's physiological role as a humoral signal of fat mass...
  23. ncbi Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones
    Michael Rosenbaum
    Columbia University, New York, New York, USA
    J Clin Endocrinol Metab 87:2391-4. 2002
    ..These data indicate that decrease leptin concentrations resulting from loss of fat mass account for some aspects of the endocrine/metabolic phenotype associated with the weight-reduced state...
  24. ncbi Obesity is associated with macrophage accumulation in adipose tissue
    Stuart P Weisberg
    Division of Moleuclar Genetics, Department of Pediatrics, Columbia University, New York, New York 10032, USA
    J Clin Invest 112:1796-808. 2003
    ..Adipose tissue macrophage numbers increase in obesity and participate in inflammatory pathways that are activated in adipose tissues of obese individuals...
  25. ncbi Functional consequences of the human leptin receptor (LEPR) Q223R transversion
    George Stratigopoulos
    Department of Pediatrics, Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University, New York, New York, USA
    Obesity (Silver Spring) 17:126-35. 2009
    ..We conclude that Q223R is unlikely to play a significant role in regulation of human adiposity. This approach to vetting of human allelic variation might be more widely used...
  26. ncbi The role of leptin in the control of body weight
    Rudolph L Leibel
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nutr Rev 60:S15-9; discussion S68-84, 85-7. 2002
    ..High concentrations often produce minimal effects, whereas low concentrations provoke strong counterregulatory responses. A model and rationale for the physiology is presented...
  27. ncbi To eat or not to eat - how the gut talks to the brain
    Judith Korner
    College of Physicians and Surgeons, Columbia University, New York, USA
    N Engl J Med 349:926-8. 2003
  28. ncbi CCR2 modulates inflammatory and metabolic effects of high-fat feeding
    Stuart P Weisberg
    Department of Medicine, Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 116:115-24. 2006
    ....
  29. ncbi The molecular genetics of the melanocortin pathway and energy homeostasis
    Rudolph L Leibel
    Columbia University, Division of Molecular Genetics and Naomi Berrie Diabetes Center, 1150 St Nicholas Avenue, Room 620, New York, New York 10032, USA
    Cell Metab 3:79-81. 2006
    ..Two papers in this issue of Cell Metabolism, Lee et al., 2006 and Biebermann et al., 2006, suggest that beta MSH--a product of POMC processing--plays an unanticipated role in this pathway in humans...
  30. ncbi Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice
    Marija Dokmanovic-Chouinard
    Naomi Berrie Diabetes Center, Columbia University, New York, New York, USA
    PLoS Genet 4:e1000137. 2008
    ..D congenic lines. The human ortholog, C1orf32, is in the middle of a 30-Mb region of Chr1q23-25 that has been repeatedly associated with type 2 diabetes...
  31. ncbi Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4
    Sara Bretschger Seidelmann
    Division of Molecular Medicine, Columbia University, New York, USA
    Arterioscler Thromb Vasc Biol 25:204-10. 2005
    ....
  32. ncbi Effects of chronic weight perturbation on energy homeostasis and brain structure in mice
    Y Ravussin
    1Department of Pediatrics, Division of Molecular Genetics, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Am J Physiol Regul Integr Comp Physiol 300:R1352-62. 2011
    ..The mouse model described here could help to identify the molecular/cellular mechanisms underlying both the defense mechanisms against sustained weight loss and the upward resetting of those mechanisms following sustained weight gain...
  33. ncbi The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein
    Loan K Phan
    Division of Molecular Genetics, Department of Pediatrics, Institute of Human Nutrition, Columbia University, New York, New York, USA
    J Clin Invest 110:1449-59. 2002
    ..Mahoganoid effects on energy homeostasis are, therefore, most evident in the circumstances of epistasis to hypothalamic overexpression of ASP in A(y) and possible other obesity-causing mutations...
  34. ncbi Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2
    Wendy K Chung
    Division of Molecular Genetics and the Naomi Berrie Diabetes Center, Columbia University Medical College, Russell Berrie Medical Science Pavilion, Room 620, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Neurobiol Dis 33:499-508. 2009
    ..These findings help elucidate basic mechanisms of absence epilepsy and suggest HCN2 may be a target for therapeutic intervention...
  35. ncbi Haplotype analysis of the growth hormone releasing hormone receptor locus in three apparently unrelated kindreds from the indian subcontinent with the identical mutation in the GHRH receptor
    Michael P Wajnrajch
    Division of Pediatric Endocrinology, Department of Pediatrics, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Am J Med Genet A 120:77-83. 2003
    ..5 centimorgan (cM) region around GHRHR on chromosome 7p15. We conclude that the affected individuals share a common ancestor, and we use the association with linked markers to estimate the age of this unique mutation...
  36. ncbi 11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls
    Robin Goland
    Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, New York, USA
    J Nucl Med 50:382-9. 2009
    ..We evaluated the feasibility of (11)C-dihydrotetrabenazine PET quantification of pancreatic VMAT2 binding in healthy subjects and patients with long-standing type 1 diabetes...
  37. ncbi Is the energy homeostasis system inherently biased toward weight gain?
    Michael W Schwartz
    Department of Medicine, University of Washington, Seattle, USA
    Diabetes 52:232-8. 2003
    ..Teleological, molecular, physiological, and clinical aspects of this hypothesis are presented, along with a discussion of currently available supporting evidence...
  38. ncbi Dietary fat is not a major determinant of body fat
    Walter C Willett
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Med 113:47S-59S. 2002
    ..Diets high in fat do not appear to be the primary cause of the high prevalence of excess body fat in our society, and reductions in fat will not be a solution...
  39. ncbi Waist circumference and cardiometabolic risk: a consensus statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American Society for Nutrition; and the American Diabetes Associat
    Samuel Klein
    Center for Human Nutrition and the Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 85:1197-202. 2007
  40. ncbi Toward optimal health: the experts discuss advances in diabetes management in women. Interview by Jodi Godfrey
    David Matthew Nathan
    J Womens Health (Larchmt) 13:365-70. 2004
  41. ncbi Waist Circumference and Cardiometabolic Risk: a Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Associat
    Samuel Klein
    Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, Saint Louis, Missouri 63110, USA
    Obesity (Silver Spring) 15:1061-7. 2007
  42. ncbi Waist circumference and cardiometabolic risk: a consensus statement from shaping America's health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Associat
    Samuel Klein
    Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Diabetes Care 30:1647-52. 2007
  43. ncbi Location, location, location
    Ruth B S Harris
    Department of Foods and Nutrition, University of Georgia, Athens, GA 30602, USA
    Cell Metab 7:359-61. 2008
    ..While subcutaneous fat seems to confer metabolic benefits, species differences in adipose biology justify caution in interpreting the results...

Research Grants34

  1. Leptin in Human Energy and Neuroendocrine Homeostasis
    Rudolph Leibel; Fiscal Year: 2009
    ..The goal of the proposed studies is to understand the relevant biology sufficiently well to be able to modify or prevent such compensation, thereby enabling successful maintenance of therapeutic weight loss. ..
  2. Leptin in Human Energy and Neuroendocrine Homeostasis
    Rudolph Leibel; Fiscal Year: 2006
    ..The results of these studies will further delineate the physiology of body weight regulation and of leptin. ..
  3. Cloning of a type 2 diabetes modifier in obese mice
    Rudolph Leibel; Fiscal Year: 2006
    ..Such a gene could be used for anticipatory diagnosis and prevention, and the design of therapeutic agents. ..
  4. MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY
    Rudolph Leibel; Fiscal Year: 2007
    ..These numbers will likely be required to detect sequence variants with specific effects on particular subphenotypes, small phenotypic effects, ethnically-specific genotypes or epistatic interactions among genes. ..
  5. MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY
    Rudolph Leibel; Fiscal Year: 2009
    ..Success in this endeavor will impact diagnosis, treatment and prevention of obesity and its associated co-morbidities such as diabetes and heart disease. ..
  6. Cloning of a type 2 diabetes modifier in obese mice
    Rudolph Leibel; Fiscal Year: 2009
    ..This project will analyze the molecular function of a newly discovered gene that may account for some aspects of diabetes susceptibility in humans. ..
  7. MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY
    RUDOLPH L contact LEIBEL; Fiscal Year: 2010
    ..Success in this endeavor will impact diagnosis, treatment and prevention of obesity and its associated co-morbidities such as diabetes and heart disease. ..
  8. Cloning of a type 2 diabetes modifier in obese mice
    Rudolph L Leibel; Fiscal Year: 2010
    ..This project will analyze the molecular function of a newly discovered gene that may account for some aspects of diabetes susceptibility in humans. ..
  9. Leptin in Human Energy and Neuroendocrine Homeostasis
    Rudolph L Leibel; Fiscal Year: 2010
    ..The goal of the proposed studies is to understand the relevant biology sufficiently well to be able to modify or prevent such compensation, thereby enabling successful maintenance of therapeutic weight loss. ..
  10. MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY
    Rudolph Leibel; Fiscal Year: 2000
    ..Ultimately, this genetic resource can also be used to search for loci linked to specific aspects of phenotype using linked clones spanning the genome. ..
  11. ENERGY HOMEOSTASIS IN HUMAN OBESITY
    Rudolph Leibel; Fiscal Year: 2001
    ..The goal is to identify the cellular and molecular mechanism(s) responsible for the changes in energy metabolism which accompany weight perturbation. ..
  12. Conference on Obesity
    Rudolph Leibel; Fiscal Year: 2004
    ....
  13. MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY
    David B Allison; Fiscal Year: 2011
    ..Success in this endeavor will impact diagnosis, treatment and prevention of obesity and its associated co-morbidities such as diabetes and heart disease. ..