Research Topics
| J H LefkowitchSummaryAffiliation: Columbia University Country: USA Publications
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Detail Information
Publications
Late nonalcoholic fatty liver disease with cirrhosis: a pathologic case of lost or mistaken identityJay H Lefkowitch
Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Semin Liver Dis 32:92-8. 2012..A strategic pathologic approach is discussed, which can be utilized for the pathologic assessment of cirrhosis of unknown cause, particularly when late NAFLD is suspected...
Hepatobiliary pathologyJay H Lefkowitch
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Curr Opin Gastroenterol 21:260-9. 2005....- Hepatobiliary pathologyJay H Lefkowitch
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Curr Opin Gastroenterol 22:198-208. 2006..Publications concerning liver histopathology in fatty liver disease and chronic hepatitis C, iron and copper overload, and liver transplantation from the past year have been surveyed to highlight useful concepts and diagnostic information... - Ground-glass, polyglucosan-like hepatocellular inclusions: A "new" diagnostic entityJay H Lefkowitch
Department of Pathology, Columbia University Medical Center, New York, New York, USA
Gastroenterology 131:713-8. 2006..This study was undertaken to further delineate the clinical and liver pathologic features in such cases and their possible pathogenesis... - Special stains in diagnostic liver pathologyJay H Lefkowitch
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Semin Diagn Pathol 23:190-8. 2006..Diagnostic applications of immunohistochemical stains are also described... - Hepatobiliary pathologyJay H Lefkowitch
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Curr Opin Gastroenterol 23:221-31. 2007..Recent papers on disorders of the liver and biliary tract which clarify their pathogenesis and attendant morphologic changes are highlighted... - Liver biopsy assessment in chronic hepatitisJay H Lefkowitch
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Arch Med Res 38:634-43. 2007.... - Hepatobiliary pathologyJay H Lefkowitch
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, USA
Curr Opin Gastroenterol 24:269-77. 2008..Studies are reviewed from the past year concerning the histopathology of liver and biliary diseases and their pathogenesis... - Recent developments in liver pathologyJay H Lefkowitch
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Hum Pathol 40:445-55. 2009..Genomic and immunohistochemical analysis of liver tumors provides important diagnostic information, particularly regarding the use of glypican-3 in the diagnosis of hepatocellular carcinoma... - Advances in hepatobiliary pathology: update for 2010Jay H Lefkowitch
Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street PH 15 West, Room 1574, New York, NY 10032, USA
Clin Liver Dis 14:747-62. 2010..For benign and malignant liver tumors, immunohistochemistry plays a major diagnostic role, and several recent studies demonstrate the value of immunostains in distinguishing between liver-cell adenoma and focal nodular hyperplasia... - Morphology of alcoholic liver diseaseJay H Lefkowitch
Columbia University, Department of Surgical Pathology, PH 1564W, 630 W 168th Streest, VC 14th Floor, Room 215, New York, NY 10032, USA
Clin Liver Dis 9:37-53. 2005..These features and other less common histopathologic lesions in the liver are reviewed and illustrated... - Biliary atresiaJ H Lefkowitch
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Mayo Clin Proc 73:90-5. 1998.... - Kupffer cell aggregation and perivenular distribution in steatohepatitisJay H Lefkowitch
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Mod Pathol 15:699-704. 2002..These results support the concept that hepatic Kupffer cells are a major immune effector cell in the pathogenesis of steatohepatitis. A potential direct Kupffer cell role in hepatic lipid processing is also postulated... - Diagnostic issues in liver transplantation pathologyJay H Lefkowitch
Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street PH15 West 1574, New York, NY 10032, USA
Clin Liver Dis 6:555-70, ix. 2002..Consensus documents from the Banff international panel provide useful guidelines for the appropriate grading of acute and chronic rejection... - Iron-rich foci in chronic viral hepatitisJ H Lefkowitch
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Hum Pathol 29:116-8. 1998..The possible pathogenesis of IRF and the relationship of iron storage to the outcome of interferon therapy in chronic viral hepatitis are discussed... - Progenitor cell expansion: an important source of hepatocyte regeneration in chronic hepatitisJennifer A Eleazar
Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
J Hepatol 41:983-91. 2004..CONCLUSIONS: Progenitor cell derived hepatocytes accrue in chronic hepatitis, possibly related to native hepatocellular dysfunction. However, the fate of these hepatocytes is unclear... - Histological assessment of cholestasisJay H Lefkowitch
Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, PH 15 West 1574, New York, NY 10032, USA
Clin Liver Dis 8:27-40, v. 2004..The histologic assessment of cholestasis, in broad terms, therefore, is a morphologic approach to distinguish between medical jaundice and surgical jaundice... - Utility of liver allograft biopsy obtained at procurementIrene J Lo
Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA
Liver Transpl 14:639-46. 2008..Implementation of a universal FS worksheet could standardize histologic reporting and facilitate data collection, allocation, and research... - Steatohepatitic hepatocellular carcinoma (SH-HCC): a distinctive histological variant of HCC in hepatitis C virus-related cirrhosis with associated NAFLD/NASHMarcela Salomao
Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA
Am J Surg Pathol 34:1630-6. 2010..6% of cases. These results suggest a possible NAFLD/NASH pathway leading to SH-HCC in the setting of HCV-C which requires further investigation in the future... - Mitochondrial DNA dysfunction in oncocytic hepatocytesKurenai Tanji
Department of Pathology, College of Physicians and Surgeons, Columbia University, NY, New York 10032, USA
Liver Int 23:397-403. 2003..In conclusion, hepatic oncocytes demonstrate significant deficiencies of mtDNA and mtDNA-encoded respiratory chain enzymes. We propose that mtDNA depletion plays an important role in hepatocellular oncocytic transformation... - Therapeutic plasmapheresis as a bridge to liver transplantation in fulminant Wilson diseaseJeffrey S Jhang
College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
J Clin Apher 22:10-4. 2007.... - Hepatitis C-associated granulomas after liver transplantation: morphologic spectrum and clinical implicationsEfsevia Vakiani
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Am J Clin Pathol 127:128-34. 2007..Our study suggests that a granulomatous response to HCV infection occurs in a subset of patients after transplantation; however, this histologic finding does not portend a worse clinical outcome... - Three cases of autoimmune hepatitis in HIV-infected patientsYoram A Puius
Division of Infectious Diseases, Department of Pathology, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
J Clin Gastroenterol 42:425-9. 2008..The clinical course of these cases also suggests that standard immunosuppressive therapy for AIH remains the optimal treatment regimen, even in HIV-positive patients... - Multiple cutaneous infantile hemangiomas associated with hepatic angiosarcoma: case report and review of the literatureKristin M Nord
Department of Dermatology, Columbia University, New York, New York 10032, USA
Pediatrics 118:e907-13. 2006..We report this case and a review of the literature on pediatric angiosarcoma of the liver associated with cutaneous infantile hemangiomas... - Cholesterol 7-hydroxylase knockout mouse: a model for monohydroxy bile acid-related neonatal cholestasisR Arnon
Division of Pediatric Gastroenterology and Nutrition, Columbia College of Physicians and Surgeons, Columbia University, New York, NY, USA
Gastroenterology 115:1223-8. 1998..Because 7alpha-hydroxylation is not the initial step in this metabolic pathway, we tested the hypothesis that cholesterol 27-hydroxylase is expressed at an earlier step and leads to the production of monohydroxy bile acids... - Hepatitis B virus reactivation after kidney transplantation and new onset lymphomaAlberto Larghi
Department of Medicine, College of Physicians and Seurgeons, Columbia University, New York, New York 10032, USA
J Clin Gastroenterol 36:276-80. 2003..In this setting, periodic follow-up of HBV serology in patients at highest risk for HBV reactivation to allow for early diagnosis and prompt treatment with lamivudine is highly recommended... - Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human liversTania A Roskams
Department of Pathology, University Hospitals, University of Leuven, Leuven, Belgium
Hepatology 39:1739-45. 2004.... - Mixed hepatocellular-cholestatic liver injury after pioglitazone therapyLouis D May
Good Samaritan Hospital, Suffern, NY 10901, USA
Ann Intern Med 136:449-52. 2002..After treatment with pioglitazone was discontinued, liver enzyme values returned to normal. CONCLUSION: Patients receiving pioglitazone may develop serious liver injury and should be observed for evidence of hepatitis... - Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathwayYongjun Wang
Department of Medicine and Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Biol Chem 281:15258-67. 2006..Toxic liver injury is, therefore, associated with JNK over-activation and mediated by JNK2 promotion of caspase-8 activation and the TNF mitochondrial death pathway through a mechanism independent of c-Jun kinase activity... - JNK1 but not JNK2 promotes the development of steatohepatitis in miceJörn M Schattenberg
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Hepatology 43:163-72. 2006..These findings also provide additional support for the critical mechanistic involvement of JNK1 overactivation in conditions associated with insulin resistance and the metabolic syndrome... - Liver histopathologyJay H Lefkowitch
Clin Liver Dis 6:xv-xix. 2002