J H Lefkowitch

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. doi request reprint Late nonalcoholic fatty liver disease with cirrhosis: a pathologic case of lost or mistaken identity
    Jay H Lefkowitch
    Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Semin Liver Dis 32:92-8. 2012
  2. ncbi request reprint Hepatobiliary pathology
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Curr Opin Gastroenterol 21:260-9. 2005
  3. ncbi request reprint Hepatobiliary pathology
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Curr Opin Gastroenterol 22:198-208. 2006
  4. ncbi request reprint Ground-glass, polyglucosan-like hepatocellular inclusions: A "new" diagnostic entity
    Jay H Lefkowitch
    Department of Pathology, Columbia University Medical Center, New York, New York, USA
    Gastroenterology 131:713-8. 2006
  5. ncbi request reprint Special stains in diagnostic liver pathology
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Semin Diagn Pathol 23:190-8. 2006
  6. ncbi request reprint Hepatobiliary pathology
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Curr Opin Gastroenterol 23:221-31. 2007
  7. ncbi request reprint Liver biopsy assessment in chronic hepatitis
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Arch Med Res 38:634-43. 2007
  8. doi request reprint Hepatobiliary pathology
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, USA
    Curr Opin Gastroenterol 24:269-77. 2008
  9. doi request reprint Recent developments in liver pathology
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Hum Pathol 40:445-55. 2009
  10. doi request reprint Advances in hepatobiliary pathology: update for 2010
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street PH 15 West, Room 1574, New York, NY 10032, USA
    Clin Liver Dis 14:747-62. 2010

Collaborators

Detail Information

Publications31

  1. doi request reprint Late nonalcoholic fatty liver disease with cirrhosis: a pathologic case of lost or mistaken identity
    Jay H Lefkowitch
    Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Semin Liver Dis 32:92-8. 2012
    ..A strategic pathologic approach is discussed, which can be utilized for the pathologic assessment of cirrhosis of unknown cause, particularly when late NAFLD is suspected...
  2. ncbi request reprint Hepatobiliary pathology
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Curr Opin Gastroenterol 21:260-9. 2005
    ....
  3. ncbi request reprint Hepatobiliary pathology
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Curr Opin Gastroenterol 22:198-208. 2006
    ..Publications concerning liver histopathology in fatty liver disease and chronic hepatitis C, iron and copper overload, and liver transplantation from the past year have been surveyed to highlight useful concepts and diagnostic information...
  4. ncbi request reprint Ground-glass, polyglucosan-like hepatocellular inclusions: A "new" diagnostic entity
    Jay H Lefkowitch
    Department of Pathology, Columbia University Medical Center, New York, New York, USA
    Gastroenterology 131:713-8. 2006
    ..This study was undertaken to further delineate the clinical and liver pathologic features in such cases and their possible pathogenesis...
  5. ncbi request reprint Special stains in diagnostic liver pathology
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Semin Diagn Pathol 23:190-8. 2006
    ..Diagnostic applications of immunohistochemical stains are also described...
  6. ncbi request reprint Hepatobiliary pathology
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Curr Opin Gastroenterol 23:221-31. 2007
    ..Recent papers on disorders of the liver and biliary tract which clarify their pathogenesis and attendant morphologic changes are highlighted...
  7. ncbi request reprint Liver biopsy assessment in chronic hepatitis
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Arch Med Res 38:634-43. 2007
    ....
  8. doi request reprint Hepatobiliary pathology
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, USA
    Curr Opin Gastroenterol 24:269-77. 2008
    ..Studies are reviewed from the past year concerning the histopathology of liver and biliary diseases and their pathogenesis...
  9. doi request reprint Recent developments in liver pathology
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Hum Pathol 40:445-55. 2009
    ..Genomic and immunohistochemical analysis of liver tumors provides important diagnostic information, particularly regarding the use of glypican-3 in the diagnosis of hepatocellular carcinoma...
  10. doi request reprint Advances in hepatobiliary pathology: update for 2010
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street PH 15 West, Room 1574, New York, NY 10032, USA
    Clin Liver Dis 14:747-62. 2010
    ..For benign and malignant liver tumors, immunohistochemistry plays a major diagnostic role, and several recent studies demonstrate the value of immunostains in distinguishing between liver-cell adenoma and focal nodular hyperplasia...
  11. ncbi request reprint Morphology of alcoholic liver disease
    Jay H Lefkowitch
    Columbia University, Department of Surgical Pathology, PH 1564W, 630 W 168th Streest, VC 14th Floor, Room 215, New York, NY 10032, USA
    Clin Liver Dis 9:37-53. 2005
    ..These features and other less common histopathologic lesions in the liver are reviewed and illustrated...
  12. ncbi request reprint Biliary atresia
    J H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Mayo Clin Proc 73:90-5. 1998
    ....
  13. ncbi request reprint Kupffer cell aggregation and perivenular distribution in steatohepatitis
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mod Pathol 15:699-704. 2002
    ..These results support the concept that hepatic Kupffer cells are a major immune effector cell in the pathogenesis of steatohepatitis. A potential direct Kupffer cell role in hepatic lipid processing is also postulated...
  14. ncbi request reprint Diagnostic issues in liver transplantation pathology
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street PH15 West 1574, New York, NY 10032, USA
    Clin Liver Dis 6:555-70, ix. 2002
    ..Consensus documents from the Banff international panel provide useful guidelines for the appropriate grading of acute and chronic rejection...
  15. ncbi request reprint Iron-rich foci in chronic viral hepatitis
    J H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Hum Pathol 29:116-8. 1998
    ..The possible pathogenesis of IRF and the relationship of iron storage to the outcome of interferon therapy in chronic viral hepatitis are discussed...
  16. ncbi request reprint Progenitor cell expansion: an important source of hepatocyte regeneration in chronic hepatitis
    Jennifer A Eleazar
    Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    J Hepatol 41:983-91. 2004
    ....
  17. ncbi request reprint Histological assessment of cholestasis
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, PH 15 West 1574, New York, NY 10032, USA
    Clin Liver Dis 8:27-40, v. 2004
    ..The histologic assessment of cholestasis, in broad terms, therefore, is a morphologic approach to distinguish between medical jaundice and surgical jaundice...
  18. doi request reprint Utility of liver allograft biopsy obtained at procurement
    Irene J Lo
    Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Liver Transpl 14:639-46. 2008
    ..Implementation of a universal FS worksheet could standardize histologic reporting and facilitate data collection, allocation, and research...
  19. doi request reprint Steatohepatitic hepatocellular carcinoma (SH-HCC): a distinctive histological variant of HCC in hepatitis C virus-related cirrhosis with associated NAFLD/NASH
    Marcela Salomao
    Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA
    Am J Surg Pathol 34:1630-6. 2010
    ..6% of cases. These results suggest a possible NAFLD/NASH pathway leading to SH-HCC in the setting of HCV-C which requires further investigation in the future...
  20. ncbi request reprint Mitochondrial DNA dysfunction in oncocytic hepatocytes
    Kurenai Tanji
    Department of Pathology, College of Physicians and Surgeons, Columbia University, NY, New York 10032, USA
    Liver Int 23:397-403. 2003
    ..In conclusion, hepatic oncocytes demonstrate significant deficiencies of mtDNA and mtDNA-encoded respiratory chain enzymes. We propose that mtDNA depletion plays an important role in hepatocellular oncocytic transformation...
  21. ncbi request reprint Therapeutic plasmapheresis as a bridge to liver transplantation in fulminant Wilson disease
    Jeffrey S Jhang
    College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Clin Apher 22:10-4. 2007
    ....
  22. ncbi request reprint Hepatitis C-associated granulomas after liver transplantation: morphologic spectrum and clinical implications
    Efsevia Vakiani
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Am J Clin Pathol 127:128-34. 2007
    ..Our study suggests that a granulomatous response to HCV infection occurs in a subset of patients after transplantation; however, this histologic finding does not portend a worse clinical outcome...
  23. doi request reprint Three cases of autoimmune hepatitis in HIV-infected patients
    Yoram A Puius
    Division of Infectious Diseases, Department of Pathology, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    J Clin Gastroenterol 42:425-9. 2008
    ..The clinical course of these cases also suggests that standard immunosuppressive therapy for AIH remains the optimal treatment regimen, even in HIV-positive patients...
  24. ncbi request reprint Multiple cutaneous infantile hemangiomas associated with hepatic angiosarcoma: case report and review of the literature
    Kristin M Nord
    Department of Dermatology, Columbia University, New York, New York 10032, USA
    Pediatrics 118:e907-13. 2006
    ..We report this case and a review of the literature on pediatric angiosarcoma of the liver associated with cutaneous infantile hemangiomas...
  25. ncbi request reprint Cholesterol 7-hydroxylase knockout mouse: a model for monohydroxy bile acid-related neonatal cholestasis
    R Arnon
    Division of Pediatric Gastroenterology and Nutrition, Columbia College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Gastroenterology 115:1223-8. 1998
    ..Because 7alpha-hydroxylation is not the initial step in this metabolic pathway, we tested the hypothesis that cholesterol 27-hydroxylase is expressed at an earlier step and leads to the production of monohydroxy bile acids...
  26. ncbi request reprint Hepatitis B virus reactivation after kidney transplantation and new onset lymphoma
    Alberto Larghi
    Department of Medicine, College of Physicians and Seurgeons, Columbia University, New York, New York 10032, USA
    J Clin Gastroenterol 36:276-80. 2003
    ..In this setting, periodic follow-up of HBV serology in patients at highest risk for HBV reactivation to allow for early diagnosis and prompt treatment with lamivudine is highly recommended...
  27. ncbi request reprint Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers
    Tania A Roskams
    Department of Pathology, University Hospitals, University of Leuven, Leuven, Belgium
    Hepatology 39:1739-45. 2004
    ....
  28. ncbi request reprint Mixed hepatocellular-cholestatic liver injury after pioglitazone therapy
    Louis D May
    Good Samaritan Hospital, Suffern, NY 10901, USA
    Ann Intern Med 136:449-52. 2002
    ..Pioglitazone is an oral hypoglycemic agent in the thiazolidinedione class. Only one case of hepatotoxicity related to this agent has previously been reported...
  29. pmc Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway
    Yongjun Wang
    Department of Medicine and Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 281:15258-67. 2006
    ..Toxic liver injury is, therefore, associated with JNK over-activation and mediated by JNK2 promotion of caspase-8 activation and the TNF mitochondrial death pathway through a mechanism independent of c-Jun kinase activity...
  30. ncbi request reprint JNK1 but not JNK2 promotes the development of steatohepatitis in mice
    Jörn M Schattenberg
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 43:163-72. 2006
    ..These findings also provide additional support for the critical mechanistic involvement of JNK1 overactivation in conditions associated with insulin resistance and the metabolic syndrome...
  31. ncbi request reprint Liver histopathology
    Jay H Lefkowitch
    Clin Liver Dis 6:xv-xix. 2002