H T Lee

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Protecting the kidney during critical illness
    Dean R Jones
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Curr Opin Anaesthesiol 20:106-12. 2007
  2. ncbi request reprint Isoflurane protects against renal ischemia and reperfusion injury and modulates leukocyte infiltration in mice
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 293:F713-22. 2007
  3. ncbi request reprint TGF-beta1 release by volatile anesthetics mediates protection against renal proximal tubule cell necrosis
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032 3784, USA
    Am J Nephrol 27:416-24. 2007
  4. pmc Inhibition of sphingosine 1-phosphate receptor 2 protects against renal ischemia-reperfusion injury
    Sang Wong Park
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    J Am Soc Nephrol 23:266-80. 2012
  5. pmc Acute kidney injury after hepatic ischemia and reperfusion injury in mice
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Lab Invest 89:196-208. 2009
  6. pmc Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia
    Sang W Park
    Department of Anesthesiology, Columbia University, New York, New York 10032 3784, USA
    Kidney Int 82:878-91. 2012
  7. pmc Cytokines induce small intestine and liver injury after renal ischemia or nephrectomy
    Sang Won Park
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Lab Invest 91:63-84. 2011
  8. pmc The volatile anesthetic isoflurane induces ecto-5'-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury
    Mihwa Kim
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, Anesthesiology Research Laboratories, Columbia University, New York, New York, USA
    Kidney Int 84:90-103. 2013
  9. pmc Renalase protects against ischemic AKI
    H Thomas Lee
    Department of Anesthesiology, Anesthesiology Research Laboratories, College of Physicians and Surgeons, Columbia University, P and S Box 46 PH 5, 630 West 168th Street, New York, NY 10032 3784, USA
    J Am Soc Nephrol 24:445-55. 2013
  10. doi request reprint Critical role of interleukin-17A in murine intestinal ischemia-reperfusion injury
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032 3784, USA
    Am J Physiol Gastrointest Liver Physiol 304:G12-25. 2013

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Protecting the kidney during critical illness
    Dean R Jones
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Curr Opin Anaesthesiol 20:106-12. 2007
    ..This review will focus on clinical and basic science research efforts related to the diagnosis, pathophysiology, prevention, and treatment of acute renal failure...
  2. ncbi request reprint Isoflurane protects against renal ischemia and reperfusion injury and modulates leukocyte infiltration in mice
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 293:F713-22. 2007
    ..In particular, neutrophil, macrophage, and NK1.1+ lymphocyte cell modulation may play a significant role in renal protection by isoflurane anesthesia...
  3. ncbi request reprint TGF-beta1 release by volatile anesthetics mediates protection against renal proximal tubule cell necrosis
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032 3784, USA
    Am J Nephrol 27:416-24. 2007
    ....
  4. pmc Inhibition of sphingosine 1-phosphate receptor 2 protects against renal ischemia-reperfusion injury
    Sang Wong Park
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    J Am Soc Nephrol 23:266-80. 2012
    ..Taken together, these data suggest that S1P(2)R may be a therapeutic target to attenuate the effects of renal IR injury...
  5. pmc Acute kidney injury after hepatic ischemia and reperfusion injury in mice
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Lab Invest 89:196-208. 2009
    ..Our murine model of AKI after liver injury closely mimics human AKI associated with ALF and may be useful in delineating the mechanisms and potential therapies for this common clinical condition...
  6. pmc Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia
    Sang W Park
    Department of Anesthesiology, Columbia University, New York, New York 10032 3784, USA
    Kidney Int 82:878-91. 2012
    ..Thus, proximal tubule SK1 has a critical role in A(1)AR-mediated protection against renal ischemia-reperfusion injury...
  7. pmc Cytokines induce small intestine and liver injury after renal ischemia or nephrectomy
    Sang Won Park
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Lab Invest 91:63-84. 2011
    ..Modulation of the inflammatory response and cytokine release in the small intestine after AKI may have important therapeutic implications in reducing complications arising from AKI...
  8. pmc The volatile anesthetic isoflurane induces ecto-5'-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury
    Mihwa Kim
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, Anesthesiology Research Laboratories, Columbia University, New York, New York, USA
    Kidney Int 84:90-103. 2013
    ..Modulation of this pathway may have important therapeutic implications to reduce morbidity and mortality arising from ischemic acute kidney injury. ..
  9. pmc Renalase protects against ischemic AKI
    H Thomas Lee
    Department of Anesthesiology, Anesthesiology Research Laboratories, College of Physicians and Surgeons, Columbia University, P and S Box 46 PH 5, 630 West 168th Street, New York, NY 10032 3784, USA
    J Am Soc Nephrol 24:445-55. 2013
    ..Recombinant renalase therapy may have potential for the prevention and treatment of AKI...
  10. doi request reprint Critical role of interleukin-17A in murine intestinal ischemia-reperfusion injury
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032 3784, USA
    Am J Physiol Gastrointest Liver Physiol 304:G12-25. 2013
    ..Taken together, we propose that Paneth cell-derived IL-17A may play a critical role in intestinal I/R injury as well as extraintestinal organ dysfunction...
  11. pmc Interleukin-11 protects against renal ischemia and reperfusion injury
    H Thomas Lee
    Department of Anesthesiology, Anesthesiology Research Laboratories, Columbia University, West 168th St, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 303:F1216-24. 2012
    ..Together, our data show powerful renal protective effects of exogenous IL-11 against IR injury by reducing necrosis, inflammation, and apoptosis through induction of SK1 via HIF-1α...
  12. pmc A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury
    Sang Won Park
    Department of Anesthesiology, Columbia University, 630 W 168th St, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 303:F721-32. 2012
    ..Our findings imply that selectively enhancing A(1)AR activation by locally produced renal adenosine may be a clinically useful therapeutic option to attenuate ischemic acute kidney injury without systemic side effects...
  13. doi request reprint Cytokine elevation and transaminitis after laparoscopic donor nephrectomy
    Steven Yap
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 302:F1104-11. 2012
    ..Further studies are needed to correlate increased urinary NGAL after donor nephrectomy both as a potential marker for renal tubular stress and/or hypertrophy in the contralateral kidney...
  14. ncbi request reprint Sevoflurane-mediated TGF-beta1 signaling in renal proximal tubule cells
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 294:F371-8. 2008
    ..Therefore, we demonstrate in this study that sevoflurane-mediated cytoprotective and anti-inflammatory effects in HK-2 cells are at least partially due to the externalization of PS and activation of TGF-beta1 signaling pathways...
  15. pmc Sevoflurane protects against renal ischemia and reperfusion injury in mice via the transforming growth factor-beta1 pathway
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 295:F128-36. 2008
    ..Therefore, we demonstrate in this study that sevoflurane-mediated renal protection in vivo requires the TGF-beta1-->SMAD3 signaling pathway...
  16. ncbi request reprint A3 adenosine receptor activation decreases mortality and renal and hepatic injury in murine septic peritonitis
    H Thomas Lee
    Department of Anesthesiology, Anesthesiology Research Laboratories, Columbia University, P and S Box 46 PH 5 630 West 168th St, New York, NY 10032 3784, USA
    Am J Physiol Regul Integr Comp Physiol 291:R959-69. 2006
    ..We conclude that endogenous or exogenous A3AR activation confers significant protection from murine septic peritonitis primarily by attenuating the hyperacute inflammatory response in sepsis...
  17. ncbi request reprint Anti-inflammatory and antinecrotic effects of the volatile anesthetic sevoflurane in kidney proximal tubule cells
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 291:F67-78. 2006
    ..These mechanisms may, in part, account for volatile anesthetics' protective effects against renal IR injury...
  18. ncbi request reprint Isoflurane improves survival and protects against renal and hepatic injury in murine septic peritonitis
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032 3784, USA
    Shock 27:373-9. 2007
    ..Therefore, isoflurane anesthesia conferred significant protection against renal and hepatic dysfunction and death after septic peritonitis and attenuated renal inflammation and apoptosis compared with pentobarbital anesthesia...
  19. ncbi request reprint A1 adenosine receptor knockout mice are protected against acute radiocontrast nephropathy in vivo
    H Thomas Lee
    Dept of Anesthesiology, Anesthesiology Research Laboratories, Columbia Univ, College of Physicians and Surgeons, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 290:F1367-75. 2006
    ..Therefore, we conclude that radiocontrast causes acute renal failure via mechanisms dependent on A1AR; however, renal proximal tubule A1AR do not contribute to the direct tubular toxicity of radiocontrast...
  20. ncbi request reprint Renal tubule necrosis and apoptosis modulation by A1 adenosine receptor expression
    H T Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032 3784, USA
    Kidney Int 71:1249-61. 2007
    ..These studies show that endogenous A1AR activation produces cytoprotective effects in renal proximal tubules by modulating HSP27 signaling pathways...
  21. ncbi request reprint A3 adenosine receptor knockout mice are protected against ischemia- and myoglobinuria-induced renal failure
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Am J Physiol Renal Physiol 284:F267-73. 2003
    ..125 mg/kg IB-MECA) exacerbated renal I/R injury in mice. Mice lacking A(3) ARs or blocking A(3) ARs in wild-type mice resulted in significant renal protection from ischemic or myoglobinuric renal failure...
  22. ncbi request reprint Regulation of renal A(1) adenosine receptors in vivo
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Exp Nephrol 10:43-50. 2002
    ..Unlike cardiac and brain A(1) ARs, renal A(1) receptors are not subject to up-regulation following chronic antagonist treatment...
  23. ncbi request reprint Adenosine attenuates oxidant injury in human proximal tubular cells via A(1) and A(2a) adenosine receptors
    H T Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032 3784, USA
    Am J Physiol Renal Physiol 282:F844-52. 2002
    ..We concluded that A(1)- and A(2a)-AR activation protects HK-2 cells against H(2)O(2)-induced injury by means of distinct signaling pathways that require new gene transcription and new protein synthesis...
  24. ncbi request reprint Characterization of adenosine receptors in human kidney proximal tubule (HK-2) cells
    H Thomas Lee
    Department of Anesthesiology, Columbia Presbyterian Meidcal Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032 3784, USA
    Exp Nephrol 10:383-92. 2002
    ..Based on these findings, HK-2 cells are a useful in vitro model to study the signaling cascades of AR-mediated renal protection...
  25. ncbi request reprint Protein kinase C and G(i/o) proteins are involved in adenosine- and ischemic preconditioning-mediated renal protection
    H T Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Am Soc Nephrol 12:233-40. 2001
    ..Unlike cardiac IPC, bradykinin, muscarinic, and opioid receptors do not mediate renal IPC...
  26. ncbi request reprint Preconditioning and adenosine protect human proximal tubule cells in an in vitro model of ischemic injury
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Am Soc Nephrol 13:2753-61. 2002
    ..It is concluded that ATP depletion preconditioning and A(1) and A(2a) adenosine receptor activation protect HK-2 cells against severe ATP depletion injury via distinct signaling pathways...
  27. ncbi request reprint Protective effects of renal ischemic preconditioning and adenosine pretreatment: role of A(1) and A(3) receptors
    H T Lee
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Am J Physiol Renal Physiol 278:F380-7. 2000
    ..Our data suggest that an A(1) adenosine agonist and A(3) adenosine antagonist may have clinically beneficial implications where renal ischemia is unavoidable...
  28. ncbi request reprint Local anesthetics induce human renal cell apoptosis
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Am J Nephrol 23:129-39. 2003
    ..We conclude that local anesthetics induce human renal cell apoptotic signaling by caspase activation and via inhibition of pro-survival signaling pathways...
  29. ncbi request reprint Local anesthetics worsen renal function after ischemia-reperfusion injury in rats
    H Thomas Lee
    Department of Anesthesiology, Anesthesiology Research Laboratories, Columbia University, P and S Box 46 PH 5, 630 W 168th Street, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 286:F111-9. 2004
    ..Local anesthetic infusion alone without I/R injury had no effect on renal function. We conclude that local anesthetics potentiated renal injury after I/R by increasing necrosis, apoptosis, and inflammation...
  30. ncbi request reprint A1 adenosine receptor knockout mice exhibit increased renal injury following ischemia and reperfusion
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia Univ, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 286:F298-306. 2004
    ..In conclusion, we demonstrate that endogenous or exogenous preischemic activation of A1 ARs protects against renal I/R injury in vivo via mechanisms leading to decreased necrosis and inflammation...
  31. ncbi request reprint A1 adenosine receptor activation inhibits inflammation, necrosis, and apoptosis after renal ischemia-reperfusion injury in mice
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Am Soc Nephrol 15:102-11. 2004
    ..In conclusion, it was demonstrated that endogenous and exogenous preischemic activation of the A(1) AR protects against IR injury in vivo, through mechanisms that reduce inflammation, necrosis, and apoptosis...
  32. ncbi request reprint Differential protective effects of volatile anesthetics against renal ischemia-reperfusion injury in vivo
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Anesthesiology 101:1313-24. 2004
    ....
  33. ncbi request reprint Acute respiratory alkalosis associated with low minute ventilation in a patient with severe hypothyroidism
    H T Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Can J Anaesth 46:185-9. 1999
    ..The purpose of this clinical report is to discuss an interesting and unique anesthetic presentation of a patient with severe hypothyroidism...
  34. ncbi request reprint Systemic adenosine given after ischemia protects renal function via A(2a) adenosine receptor activation
    H T Lee
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Kidney Dis 38:610-8. 2001
    ..Rat kidneys can be protected against reperfusion injury via postischemic A(2a) AR activation or cAMP. These data suggest that A(2a) adenosine agonists may have clinically beneficial implications when renal ischemia is unavoidable...
  35. ncbi request reprint A1 adenosine receptor knockout mice exhibit increased mortality, renal dysfunction, and hepatic injury in murine septic peritonitis
    George Gallos
    Department of Anesthesiology, Columbia University, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 289:F369-76. 2005
    ..We conclude that endogenous A(1)AR activation confers a protective effect in mice from septic peritonitis primarily by attenuating the hyperacute inflammatory response in sepsis...
  36. ncbi request reprint Acute and delayed renal protection against renal ischemia and reperfusion injury with A1 adenosine receptors
    Jin Deok Joo
    Dept of Anesthesiology, Anesthesiology Research Laboratories, Columbia Univ, P and S Box 46 PH 5 630 West 168th St, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 293:F1847-57. 2007
    ..Therefore, transient activation of renal A(1)AR led to acute as well as delayed protective effects against renal IR injury via distinct signaling pathways...
  37. pmc Selective renal overexpression of human heat shock protein 27 reduces renal ischemia-reperfusion injury in mice
    Minjae Kim
    Departments of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032 3784, USA
    Am J Physiol Renal Physiol 299:F347-58. 2010
    ..Taken together, these findings have important clinical implications, as they imply that kidney-specific expression of HSP27 through lentiviral delivery is a viable therapeutic option in attenuating the effects of renal IR...
  38. doi request reprint Endogenous A1 adenosine receptors protect against hepatic ischemia reperfusion injury in mice
    Jeehee Kim
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Liver Transpl 14:845-54. 2008
    ..Harnessing the mechanisms of cytoprotection with endogenous A(1)AR activation may lead to new therapies for perioperative hepatic IR injury...
  39. ncbi request reprint Isoflurane mediates protection from renal ischemia-reperfusion injury via sphingosine kinase and sphingosine-1-phosphate-dependent pathways
    Minjae Kim
    Dept of Anesthesiology, Anesthesiology Research Laboratories, Columbia Univ, P and S Box 46 PH 5 630 West 168th St, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 293:F1827-35. 2007
    ..Our findings may help to unravel the cellular signaling pathways of volatile anesthetic-mediated renal protection and lead to new therapeutic applications of inhalational anesthetics during the perioperative period...
  40. pmc Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
    Kiyoshi Mori
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 115:610-21. 2005
    ..We reveal what we believe to be a novel pathway of iron traffic that is activated in human and mouse renal diseases, and it provides a unique method for their treatment...
  41. pmc Protection against acute kidney injury via A(1) adenosine receptor-mediated Akt activation reduces liver injury after liver ischemia and reperfusion in mice
    Sang Won Park
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032 3784, USA
    J Pharmacol Exp Ther 333:736-47. 2010
    ..Taken together, we show that endogenous and exogenous activation of renal A(1)ARs protect against liver and kidney injury after liver IR in vivo via pathways involving Akt activation...
  42. doi request reprint Selective intrarenal human A1 adenosine receptor overexpression reduces acute liver and kidney injury after hepatic ischemia reperfusion in mice
    Sang Won Park
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Lab Invest 90:476-95. 2010
    ..Therefore, our findings show that protecting the kidney reduces liver IR injury and selective overexpression of cytoprotective A(1)ARs in the kidney leads to protection of both liver and kidney after hepatic IR...
  43. doi request reprint A comparison of urinary neutrophil gelatinase-associated lipocalin in patients undergoing on- versus off-pump coronary artery bypass graft surgery
    Gebhard Wagener
    Department of Anesthesiology, College of Physicians and Surgeons, New York, NY, USA
    J Cardiothorac Vasc Anesth 23:195-9. 2009
    ..The purpose of this study was to compare urinary neutrophil gelatinase-associated lipocalin (NGAL) levels in off-pump and on-pump coronary artery bypass graft (CABG) surgery...
  44. ncbi request reprint Local anesthetics reduce mortality and protect against renal and hepatic dysfunction in murine septic peritonitis
    George Gallos
    Department of Anesthesiology, Columbia University, 630 West 168th Street, New York, NY 10032 3784, USA
    Anesthesiology 101:902-11. 2004
    ..In the current study, the ability of local anesthetic infusions to protect against sepsis-induced mortality, as well as renal and hepatic dysfunction after cecal ligation and puncture, was investigated...
  45. ncbi request reprint Lipopolysaccharide-induced sensitization of adenylyl cyclase activity in murine macrophages
    Y Osawa
    Dept of Anesthesiology, College of Physicians and Surgeons, Columbia Univ, 630 W 168th St, P and S Box 46, New York, NY 10032, USA
    Am J Physiol Cell Physiol 290:C143-51. 2006
    ..Taken together, these findings indicate that LPS induces sensitization of AC activity by augmenting the stimulatory effect of CaM and attenuating the inhibitory effect of CaMKII on isoforms of AC that are CaMK sensitive...
  46. pmc beta-Adrenoceptor blockers protect against staurosporine-induced apoptosis in SH-SY5Y neuroblastoma cells
    Maya Mikami
    Department of Anesthesiology, Columbia University P and S, New York, NY 10032, USA
    Eur J Pharmacol 589:14-21. 2008
    ....
  47. pmc Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation
    Sang Won Park
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Lab Invest 90:1209-24. 2010
    ....
  48. pmc Mice that overexpress human heat shock protein 27 have increased renal injury following ischemia reperfusion
    Sean W C Chen
    Department of Anesthesiology, Anesthesiology Research Laboratories, College of Physicians and Surgeons, Columbia University, New York, New York 10032 3784, USA
    Kidney Int 75:499-510. 2009
    ..Our study shows that induction of HSP27 in renal tubular cells protects against necrosis in vitro, but its systemic increase counteracts this protection by exacerbating renal and systemic inflammation in vivo...
  49. doi request reprint alpha2-Adrenergic agonists protect against radiocontrast-induced nephropathy in mice
    F T Billings
    Department of Anesthesiology, Anesthesiology Research Laboratories, Columbia University, 630 West 168th St, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 295:F741-8. 2008
    ..As alpha(2)-agonists are widely utilized during the perioperative period, our findings may have significant clinical relevance to improving outcomes following radiocontrast exposure...
  50. ncbi request reprint Oxidant preconditioning protects human proximal tubular cells against lethal oxidant injury via p38 MAPK and heme oxygenase-1
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Am J Nephrol 23:324-33. 2003
    ..We conclude that oxidant preconditioning protects HK-2 cells against more severe oxidant injury via activation of signaling pathways that include p38 MAPK and increased synthesis of HO-1...
  51. pmc Sphinganine-1-phosphate attenuates both hepatic and renal injury induced by hepatic ischemia and reperfusion in mice
    Sang Won Park
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Shock 33:31-42. 2010
    ..Harnessing the mechanisms of cytoprotection with sphinganine-1-phosphate activation may lead to new therapies for perioperative hepatic I/R injury and subsequent remote organ injury...
  52. pmc Human heat shock protein 27-overexpressing mice are protected against acute kidney injury after hepatic ischemia and reperfusion
    Sang Won Park
    Dept of Anesthesiology, Anesthesiology Research Laboratories, Columbia Univ, P and S Box 46 PH 5 630 W 168th St, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 297:F885-94. 2009
    ..Harnessing the mechanisms of cytoprotection with renal HSP27 may lead to new therapies for the perioperative AKI and liver injury associated with liver IRI...
  53. pmc Kidney-specific reconstitution of the A1 adenosine receptor in A1 adenosine receptor knockout mice reduces renal ischemia-reperfusion injury
    Minjae Kim
    Department of Anesthesiology, Columbia University, New York, NY, USA
    Kidney Int 75:809-23. 2009
    ..Our findings suggest that selective expression of cytoprotective A(1)ARs in the kidney can attenuate renal injury...
  54. ncbi request reprint Inhibition of geranylgeranylation blocks agonist-induced actin reorganization in human airway smooth muscle cells
    R E Lesh
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Am J Physiol Lung Cell Mol Physiol 281:L824-31. 2001
    ..These results demonstrate that selective GGTIs can inhibit agonist-induced actin reorganization...
  55. pmc Adenosine regulation of alveolar fluid clearance
    Phillip Factor
    Pulmonary, Allergy, and Critical Care Medicine, Columbia University, 639 West 168th Street, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 104:4083-8. 2007
    ....
  56. pmc Urinary neutrophil gelatinase-associated lipocalin as a marker of acute kidney injury after orthotopic liver transplantation
    Gebhard Wagener
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Nephrol Dial Transplant 26:1717-23. 2011
    ..It predicts acute kidney injury (AKI) in multiple clinical scenarios. We hypothesized that urinary NGAL can predict AKI after liver transplantation...
  57. ncbi request reprint Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery
    Gebhard Wagener
    Department of Anesthesiology, Columbia University, NY 10032 3784, USA
    Anesthesiology 105:485-91. 2006
    ..The authors hypothesized that postoperative urinary NGAL concentrations are increased in adult patients developing ARD after cardiac surgery compared with patients without ARD...
  58. pmc Neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery: the effect of baseline renal function on diagnostic performance
    David R McIlroy
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, PH 5, Suite 523, New York, New York 10032, USA
    Clin J Am Soc Nephrol 5:211-9. 2010
    ..We hypothesized the relationship between urinary NGAL and AKI would vary with baseline renal function, allowing a stratified analysis to improve diagnostic performance of this novel biomarker...
  59. doi request reprint Increased incidence of acute kidney injury with aprotinin use during cardiac surgery detected with urinary NGAL
    Gebhard Wagener
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032 3784, USA
    Am J Nephrol 28:576-82. 2008
    ..Urinary NGAL may be able to detect renal injury caused by aprotinin. This study determined if the use of aprotinin is associated with an increased incidence of acute kidney injury and increased levels of urinary NGAL...
  60. doi request reprint Urinary neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery
    Gebhard Wagener
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032 3784, USA
    Am J Kidney Dis 52:425-33. 2008
    ..We report the association of urinary NGAL with indexes of intraoperative renal hypoperfusion (cardiopulmonary bypass time and aortic cross-clamp time) and acute kidney injury (AKI) after adult cardiac surgery...
  61. doi request reprint Vasopressin decreases portal vein pressure and flow in the native liver during liver transplantation
    Gebhard Wagener
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032 3784, USA
    Liver Transpl 14:1664-70. 2008
    ..07, mean +/- SD, P < 0.0001). In conclusion, vasopressin significantly decreased portal vein pressure and flow of the native liver without decreasing cardiac output or intestinal perfusion in patients undergoing liver transplantations...
  62. doi request reprint Human activated protein C attenuates both hepatic and renal injury caused by hepatic ischemia and reperfusion injury in mice
    Sang Won Park
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032 3784, USA
    Kidney Int 76:739-50. 2009
    ....
  63. pmc Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation
    Mihwa Kim
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Am J Nephrol 31:353-62. 2010
    ..In this study, we tested the hypothesis that isoflurane directly targets renal proximal tubule cells via SK activation, S1P synthesis and activation of S1P receptors to initiate cytoprotective signaling...
  64. ncbi request reprint Perioperative renal protection
    Dean R Jones
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Best Pract Res Clin Anaesthesiol 22:193-208. 2008
    ..This review will address the definition and diagnosis of AKI, identify patients at risk of AKI, and critically appraise management options for perioperative renal protection...
  65. ncbi request reprint Ischemic preconditioning provides both acute and delayed protection against renal ischemia and reperfusion injury in mice
    Jin Deok Joo
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    J Am Soc Nephrol 17:3115-23. 2006
    ..Therefore, this study demonstrated that acute or delayed IPC provides renal protection against IR injury in mice but involves distinct signaling pathways...
  66. pmc Human heat shock protein 27 overexpressing mice are protected against hepatic ischemia and reperfusion injury
    Sean W C Chen
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    Transplantation 87:1478-87. 2009
    ..Our laboratory previously demonstrated that exogenous A1 adenosine receptor activation protects against renal IRI by upregulation and phosphorylation of heat shock protein 27 (HSP27)...
  67. pmc Isoflurane via TGF-beta1 release increases caveolae formation and organizes sphingosine kinase signaling in renal proximal tubules
    Joseph H Song
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, 630 West 168th St, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 298:F1041-50. 2010
    ..Our findings may help to unravel the cellular signaling pathways of volatile anesthetic-mediated renal protection and lead to new therapeutic applications of inhalational anesthetics during the perioperative period...
  68. doi request reprint Hypothermic machine preservation in human liver transplantation: the first clinical series
    J V Guarrera
    Center for Liver Disease and Transplantation, Department of Surgery, Columbia University Medical Center, New York, NY, USA
    Am J Transplant 10:372-81. 2010
    ..9 +/- 4.7 days vs. 15.3 +/- 4.9 days in the CS group, p = 0.006). HMP of donor livers provided safe and reliable preservation in this pilot case-controlled series. Further multicenter HMP trials are now warranted...
  69. doi request reprint Surgery in the patient with renal dysfunction
    Dean R Jones
    Department of Anesthesiology, Columbia University, PH 5 133, New York, NY 10032, USA
    Med Clin North Am 93:1083-93. 2009
    ..This article focuses on defining the population at risk, a framework for preoperative evaluation, and developments in the area of perioperative renal protection...
  70. pmc Isoflurane activates intestinal sphingosine kinase to protect against bilateral nephrectomy-induced liver and intestine dysfunction
    Minjae Kim
    Department of Anesthesiology, College of Physicians and Surgeons, Anesthesiology Research Laboratories, Columbia University, P and S Box 46 PH 5 630 West 168th St, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 300:F167-76. 2011
    ....
  71. doi request reprint Anesthetic management of renal transplantation in a patient with familial dysautonomia
    Gen Koshibe
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032 3784, USA
    J Anesth 23:579-82. 2009
    ..The clinical manifestations of this disease and rationale of our anesthetic management are discussed...
  72. ncbi request reprint Renal protection with isoflurane
    H Thomas Lee
    Anesth Analg 103:1053-4; author reply 1054. 2006
  73. ncbi request reprint Protection against proximal tubule necrosis with 11-deoxy-16,16-dimethyl prostaglandin E2 in vitro
    H Thomas Lee
    Am J Physiol Renal Physiol 287:F1111-2. 2004
  74. doi request reprint Aprotinin and urinary neutrophil gelatinase-associated lipocalin after cardiac surgery
    Gebhard Wagener
    Anesth Analg 106:1593. 2008

Research Grants18

  1. Mechanism of renal protection with volatile anesthetics
    H Lee; Fiscal Year: 2007
    ..abstract_text> ..
  2. Renal Protection With A1 Adenosine Receptors
    H Thomas Lee; Fiscal Year: 2010
    ..This, in turn, will contribute to improved therapeutic regimens for the protection of renal function in patients. ..
  3. Mechanism of renal protection with volatile anesthetics
    H Thomas Lee; Fiscal Year: 2010
    ..Our studies will mechanistically advance our understanding of volatile anesthetic-mediated renal tubule protection, leukocyte modulation and improved outcome after renal IR injury. ..
  4. Renal Protection With A1 Adenosine Receptors
    H Lee; Fiscal Year: 2007
    ..This, in turn, will contribute to improved therapeutic regimens for the protection of renal function in patients. ..
  5. Renal Protection With A1 Adenosine Receptors
    H Lee; Fiscal Year: 2006
    ..This, in turn, will contribute to improved therapeutic regimens for the protection of renal function in patients. ..
  6. Mechanism of renal protection with volatile anethetics
    H Lee; Fiscal Year: 2005
    ..abstract_text> ..
  7. Mechanism of renal protection with volatile anesthetics
    H Lee; Fiscal Year: 2004
    ..abstract_text> ..
  8. PROTECTIVE EFFECTS OF ADENOSINE RECEPTOR MODULATION
    H Lee; Fiscal Year: 2002
    ..This, in turn, will contribute to improved therapeutic regimens for the protection of renal function in patients. ..
  9. Mechanism of renal protection with volatile anethetics
    H Lee; Fiscal Year: 2006
    ..abstract_text> ..
  10. PROTECTIVE EFFECTS OF ADENOSINE RECEPTOR MODULATION
    H Lee; Fiscal Year: 2005
    ..This, in turn, will contribute to improved therapeutic regimens for the protection of renal function in patients. ..
  11. PROTECTIVE EFFECTS OF ADENOSINE RECEPTOR MODULATION
    H Lee; Fiscal Year: 2004
    ..This, in turn, will contribute to improved therapeutic regimens for the protection of renal function in patients. ..
  12. PROTECTIVE EFFECTS OF ADENOSINE RECEPTOR MODULATION
    H Lee; Fiscal Year: 2001
    ..This, in turn, will contribute to improved therapeutic regimens for the protection of renal function in patients. ..
  13. Renal Protection With A1 Adenosine Receptors
    H Lee; Fiscal Year: 2009
    ..This, in turn, will contribute to improved therapeutic regimens for the protection of renal function in patients. ..
  14. Mechanism of renal protection with volatile anesthetics
    H Lee; Fiscal Year: 2009
    ..Our studies will mechanistically advance our understanding of volatile anesthetic-mediated renal tubule protection, leukocyte modulation and improved outcome after renal IR injury. ..
  15. PROTECTIVE EFFECTS OF ADENOSINE RECEPTOR MODULATION
    H Lee; Fiscal Year: 2003
    ..This, in turn, will contribute to improved therapeutic regimens for the protection of renal function in patients. ..