MARC A LARUELLE

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Vulnerability of positron emission tomography radiotracers to endogenous competition. New insights
    M Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, NY 10032, USA
    Q J Nucl Med 45:124-38. 2001
  2. ncbi request reprint Positron emission tomography: imaging and quantification of neurotransporter availability
    Marc Laruelle
    Department of Psychiatry and Department of Radiology, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Unit 31, New York, New York 10032, USA
    Methods 27:287-99. 2002
  3. doi request reprint Schizophrenia: from dopaminergic to glutamatergic interventions
    Marc Laruelle
    New Medicines Neurosciences Therapeutic Area Head, UCB Pharma, S A, Belgium Electronic address
    Curr Opin Pharmacol 14:97-102. 2014
  4. ncbi request reprint Relationships between radiotracer properties and image quality in molecular imaging of the brain with positron emission tomography
    Marc Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Mol Imaging Biol 5:363-75. 2003
  5. ncbi request reprint Glutamate, dopamine, and schizophrenia: from pathophysiology to treatment
    Marc Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Ann N Y Acad Sci 1003:138-58. 2003
  6. ncbi request reprint Mechanism of action of antipsychotic drugs: from dopamine D(2) receptor antagonism to glutamate NMDA facilitation
    Marc Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Clin Ther 27:S16-24. 2005

Research Grants

Detail Information

Publications6

  1. ncbi request reprint Vulnerability of positron emission tomography radiotracers to endogenous competition. New insights
    M Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, NY 10032, USA
    Q J Nucl Med 45:124-38. 2001
    ..A better understanding of the mechanisms underlying these interactions should facilitate the development of PET and SPECT radiotracers suitable for the reporting of synaptic transmitter levels...
  2. ncbi request reprint Positron emission tomography: imaging and quantification of neurotransporter availability
    Marc Laruelle
    Department of Psychiatry and Department of Radiology, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Unit 31, New York, New York 10032, USA
    Methods 27:287-99. 2002
    ..In conclusion, no universally "best" method is applicable to all neurotransporter imaging studies, and careful evaluation of model-based methods is required for each radiotracer...
  3. doi request reprint Schizophrenia: from dopaminergic to glutamatergic interventions
    Marc Laruelle
    New Medicines Neurosciences Therapeutic Area Head, UCB Pharma, S A, Belgium Electronic address
    Curr Opin Pharmacol 14:97-102. 2014
    ..Thus, it is proposed that schizophrenia has a complex aetiology associated with strongly interconnected aberrations of dopamine and glutamate transmission. ..
  4. ncbi request reprint Relationships between radiotracer properties and image quality in molecular imaging of the brain with positron emission tomography
    Marc Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Mol Imaging Biol 5:363-75. 2003
    ..It is shown that, within a given structural family, affinity and lipophilicity are associated with scan outcome in a relatively predictable manner...
  5. ncbi request reprint Glutamate, dopamine, and schizophrenia: from pathophysiology to treatment
    Marc Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Ann N Y Acad Sci 1003:138-58. 2003
    ....
  6. ncbi request reprint Mechanism of action of antipsychotic drugs: from dopamine D(2) receptor antagonism to glutamate NMDA facilitation
    Marc Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Clin Ther 27:S16-24. 2005
    ..The fundamental pathologic processes associated with schizophrenia remain uncertain...

Research Grants19

  1. PET Imaging of Serotonin Transmission in MDMA Users
    Marc Laruelle; Fiscal Year: 2004
    ..abstract_text> ..
  2. FUNCTIONAL MAPPING OF DOPAMINE SYSTEMS IN SCHIZOPHRENIA
    Marc Laruelle; Fiscal Year: 2005
    ..Ultimately, better understanding of these dysregulations and their origin will lead to improved treatment strategies. ..
  3. Imaging of dopamine function in schizophrenia
    Marc Laruelle; Fiscal Year: 2005
    ..This finding, if confirmed, might contribute to a better understanding of the pathophysiology of this illness. ..
  4. NEUROBIOLOGY OF COCAINE INDUCED SENSITIZATION
    Marc Laruelle; Fiscal Year: 1999
    ....
  5. Imaging Ventrostriatal Dopamine System in Cocaine Abuse
    Marc Laruelle; Fiscal Year: 2004
    ..Understanding the neurochemical abnormalities associated with the development and maintenance of cocaine addiction is critical to guide future treatment interventions. ..
  6. SPECT IMAGING OF DOPAMINE FUNCTION IN SCHIZOPHRENIA
    Marc Laruelle; Fiscal Year: 2001
    ..These studies should provide important information regarding the pathophysiology of DA transmission schizophrenia. ..