M Laruelle

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies
    M Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and New York State Psychiatric Institute, New York 10032, USA
    J Psychopharmacol 13:358-71. 1999
  2. ncbi request reprint The role of endogenous sensitization in the pathophysiology of schizophrenia: implications from recent brain imaging studies
    M Laruelle
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, 1051 Riverside Dr, Unit 42, New York, NY, USA
    Brain Res Brain Res Rev 31:371-84. 2000
  3. ncbi request reprint Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia
    T Bowen
    University of Wales College of Medicine, Division of Psychological Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 3:266-9. 1998
  4. ncbi request reprint PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756
    A Abi-Dargham
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York State Psychiatric Institute, New York 10032, USA
    Synapse 32:93-109. 1999
  5. ncbi request reprint The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporter phenotype in humans
    D Martinez
    Division of Functional Brain Mapping, New York State Psychiatry Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neuropsychopharmacology 24:553-60. 2001
  6. ncbi request reprint Stability of [123I]IBZM SPECT measurement of amphetamine-induced striatal dopamine release in humans
    L S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and New York State Psychiatric Institute, New York 10032, USA
    Synapse 31:302-8. 1999
  7. ncbi request reprint Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort
    A Abi-Dargham
    Department of Psychiatry, Yale University, New Haven, Conn, USA
    Am J Psychiatry 155:761-7. 1998
  8. ncbi request reprint Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT
    R T Malison
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Am J Psychiatry 155:832-4. 1998
  9. pmc Increased baseline occupancy of D2 receptors by dopamine in schizophrenia
    A Abi-Dargham
    Departments of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 97:8104-9. 2000
  10. ncbi request reprint (-)-N-[(11)C]propyl-norapomorphine: a positron-labeled dopamine agonist for PET imaging of D(2) receptors
    D R Hwang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, New York, USA
    Nucl Med Biol 27:533-9. 2000

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies
    M Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and New York State Psychiatric Institute, New York 10032, USA
    J Psychopharmacol 13:358-71. 1999
    ..This finding has important consequences for the development of new treatment strategies for the remission phase...
  2. ncbi request reprint The role of endogenous sensitization in the pathophysiology of schizophrenia: implications from recent brain imaging studies
    M Laruelle
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, 1051 Riverside Dr, Unit 42, New York, NY, USA
    Brain Res Brain Res Rev 31:371-84. 2000
    ..A better understanding of the neurocircuitry associated with endogenous sensitization and its consequence in schizophrenia might be important for the development of better treatment and relapse prevention strategies...
  3. ncbi request reprint Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia
    T Bowen
    University of Wales College of Medicine, Division of Psychological Medicine, Heath Park, Cardiff, UK
    Mol Psychiatry 3:266-9. 1998
    ..820, P = 0.047, 1-tail). Our data therefore provide modest support for the hypothesis that polymorphism in the hKCa3 gene may contribute to susceptibility to schizophrenia...
  4. ncbi request reprint PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756
    A Abi-Dargham
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York State Psychiatric Institute, New York 10032, USA
    Synapse 32:93-109. 1999
    ..These findings may also imply that a simple binding competition model is inadequate to account for the effects of manipulation of endogenous DA levels on the in vivo binding of radiolabeled antagonists...
  5. ncbi request reprint The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporter phenotype in humans
    D Martinez
    Division of Functional Brain Mapping, New York State Psychiatry Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neuropsychopharmacology 24:553-60. 2001
    ..Thus, we did not replicate the findings of two previous studies, which had suggested that the 9 repeat allele was associated with either an increased or decreased DAT expression, albeit in different patient populations...
  6. ncbi request reprint Stability of [123I]IBZM SPECT measurement of amphetamine-induced striatal dopamine release in humans
    L S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and New York State Psychiatric Institute, New York 10032, USA
    Synapse 31:302-8. 1999
    ..In conclusion, this scanning technique provides a reliable measurement of amphetamine-induced reduction of [123I]IBZM BP and enables detection of between-subject differences that appear stable over time...
  7. ncbi request reprint Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort
    A Abi-Dargham
    Department of Psychiatry, Yale University, New Haven, Conn, USA
    Am J Psychiatry 155:761-7. 1998
    ..The purpose of this study was to replicate this finding in a new cohort of schizophrenic patients and healthy subjects...
  8. ncbi request reprint Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT
    R T Malison
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Am J Psychiatry 155:832-4. 1998
    ..The authors examined whether striatal dopamine transporters were altered in acutely (96 hours or less) abstinent cocaine-abusing subjects, as suggested by postmortem studies...
  9. pmc Increased baseline occupancy of D2 receptors by dopamine in schizophrenia
    A Abi-Dargham
    Departments of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 97:8104-9. 2000
    ..This finding provides direct evidence of increased stimulation of D(2) receptors by dopamine in schizophrenia, consistent with increased phasic activity of dopaminergic neurons...
  10. ncbi request reprint (-)-N-[(11)C]propyl-norapomorphine: a positron-labeled dopamine agonist for PET imaging of D(2) receptors
    D R Hwang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, New York, USA
    Nucl Med Biol 27:533-9. 2000
    ..8 in baboon was the highest reported with a radiolabeled D(2) agonist. (-)-[(11)C]NPA is a promising new D(2) agonist PET tracer for probing D(2) receptors in vivo using PET...
  11. ncbi request reprint Age-related decline in central serotonin transporter availability with [(123)I]beta-CIT SPECT
    C H van Dyck
    Department of Psychiatry, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Neurobiol Aging 21:497-501. 2000
    ..5% over the age range 18 to 88, or approximately 4.2% per decade. These results demonstrate reductions in the availability of central SERT binding sites with age in living human subjects...
  12. ncbi request reprint Dopamine D(2) receptor availability and amphetamine-induced dopamine release in unipolar depression
    R V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Biol Psychiatry 50:313-22. 2001
    ..CONCLUSIONS: This study did not replicate previously reported alterations in striatal D(2) receptor density in depressed patients and suggests that stimulant-induced dopamine release is not altered in major depression...
  13. ncbi request reprint Low dopamine D(2) receptor binding potential in social phobia
    F R Schneier
    Anxiety Disorders Clinic and the Brain Imaging Division, New York State Psychiatric Institute, New York 10032, USA
    Am J Psychiatry 157:457-9. 2000
    ..This study compared dopamine D(2) receptor binding potential in patients with social phobia and healthy comparison subjects...
  14. ncbi request reprint D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene
    M Laruelle
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Mol Psychiatry 3:261-5. 1998
    ..Similarly, we found no effect of the B1 allele on [123I]IBZM-binding potential. In conclusion, the results of this study failed to replicate the previously reported association between A1 allele and lower D2 receptor expression...
  15. ncbi request reprint Vulnerability of positron emission tomography radiotracers to endogenous competition. New insights
    M Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, NY 10032, USA
    Q J Nucl Med 45:124-38. 2001
    ..A better understanding of the mechanisms underlying these interactions should facilitate the development of PET and SPECT radiotracers suitable for the reporting of synaptic transmitter levels...
  16. ncbi request reprint Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123I]iomazenil
    A Abi-Dargham
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Am J Psychiatry 155:1550-5. 1998
    ..The authors attempted to replicate these findings using single photon emission computed tomography and the benzodiazepine receptor radiotracer [123I]iomazenil...
  17. ncbi request reprint An improved one-pot procedure for the preparation of [11C-carbonyl]-WAY100635
    D R Hwang
    Department of Medicine and Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nucl Med Biol 26:815-9. 1999
    ..The radiochemical purity was >99%, and the specific activity was 3.6 +/- 1.9 Ci/micromol (EOS, n = 40), or 21.3 +/- 9.8 Ci/micromol at EOB. This method is reliable and flexible for routine clinical studies...
  18. ncbi request reprint Derivation of [(11)C]WAY-100635 binding parameters with reference tissue models: effect of violations of model assumptions
    M Slifstein
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Nucl Med Biol 27:487-92. 2000
    ..In conclusion, the SRTM is associated with a bias in the derivation of k(3)/k(4) that is not a simple scaling factor. This magnitude of these errors should be carefully evaluated for each new radioligand...
  19. ncbi request reprint Protein precipitation: an expedient procedure for the routine analysis of the plasma metabolites of [123I]IBZM
    Y Zea-Ponce
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and New York State Psychiatric Institute, New York 10032, USA
    Nucl Med Biol 26:811-4. 1999
    ..8% (n = 22). Free fraction of parent was 15% +/- 8% (n = 85). The results indicate that acetonitrile protein precipitation is an adequate method for the analysis of the [123I]IBZM plasma metabolites...
  20. ncbi request reprint Imaging neurochemical endophenotypes: promises and pitfalls
    D Martinez
    New York State Psychiatric Institute, 1051 Riverside Drive, Box 31, New York, NY 10032, USA
    Pharmacogenomics 2:223-37. 2001
    ..These studies illustrate the unique opportunities, as well as the pitfalls, generated by combining genetic analysis with brain imaging studies...
  21. ncbi request reprint Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands
    Y Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Bioorg Med Chem Lett 11:1375-7. 2001
    ..All new compounds display high affinity and selectivity for the D(4) receptors and compounds 5b, 5d, and 5e were identified as candidates for radioligand development...
  22. ncbi request reprint Hippocampal pathology in schizophrenia: magnetic resonance imaging and spectroscopy studies
    L S Kegeles
    Department of Psychiatry, Columbia University, New York, NY, USA
    Psychiatry Res 98:163-75. 2000
    ..The preliminary finding of a lateralized abnormality in Glx is consistent with postmortem findings of asymmetric neurochemical temporal lobe abnormalities in schizophrenia...
  23. ncbi request reprint Synthesis of [123I]IBZM: a reliable procedure for routine clinical studies
    Y Zea-Ponce
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and New York State Psychiatric Institute, New York, USA
    Nucl Med Biol 26:661-5. 1999
    ..For example, for volumes between 417 and 523 microL the labeling yield was 61 +/- 5% (n = 21), radiochemical yield was 56 +/- 5% and radiochemical purity was 98 +/- 1%...
  24. ncbi request reprint Models and methods for derivation of in vivo neuroreceptor parameters with PET and SPECT reversible radiotracers
    M Slifstein
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nucl Med Biol 28:595-608. 2001
    ..In conclusion, there is no universally "best" method that is applicable to all neuroreceptor imaging studies, and carefully evaluation of model-based methods is required for each radiotracer...
  25. ncbi request reprint Imaging human mesolimbic dopamine transmission with positron emission tomography: I. Accuracy and precision of D(2) receptor parameter measurements in ventral striatum
    O Mawlawi
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Cereb Blood Flow Metab 21:1034-57. 2001
    ....
  26. ncbi request reprint Occupancy of dopamine D2 receptors by the atypical antipsychotic drugs risperidone and olanzapine: theoretical implications
    W G Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA
    Psychopharmacology (Berl) 175:473-80. 2004
    ..To examine the D2 occupancy of two commonly used antipsychotic medications and relate this to the D2 occupancy by endogenous dopamine in schizophrenia...
  27. doi request reprint COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET
    M Slifstein
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Psychiatry 13:821-7. 2008
    ..These results confirm the prominent role of COMT in regulating DA transmission in cortex but not striatum, and the reliability of [11C]NNC 112 as a marker for low DA tone as previously suggested by studies in patients with schizophrenia...