Research Topics
| M LaruelleSummaryAffiliation: Columbia University Country: USA Publications
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Publications
Dopamine as the wind of the psychotic fire: new evidence from brain imaging studiesM Laruelle
Department of Psychiatry, Columbia University College of Physicians and Surgeons, and New York State Psychiatric Institute, New York 10032, USA
J Psychopharmacol 13:358-71. 1999..This finding has important consequences for the development of new treatment strategies for the remission phase...- The role of endogenous sensitization in the pathophysiology of schizophrenia: implications from recent brain imaging studiesM Laruelle
Department of Psychiatry, Columbia University, New York State Psychiatric Institute, 1051 Riverside Dr, Unit 42, New York, NY, USA
Brain Res Brain Res Rev 31:371-84. 2000..A better understanding of the neurocircuitry associated with endogenous sensitization and its consequence in schizophrenia might be important for the development of better treatment and relapse prevention strategies... - Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophreniaT Bowen
University of Wales College of Medicine, Division of Psychological Medicine, Heath Park, Cardiff, UK
Mol Psychiatry 3:266-9. 1998..820, P = 0.047, 1-tail). Our data therefore provide modest support for the hypothesis that polymorphism in the hKCa3 gene may contribute to susceptibility to schizophrenia... - PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756A Abi-Dargham
Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York State Psychiatric Institute, New York 10032, USA
Synapse 32:93-109. 1999..These findings may also imply that a simple binding competition model is inadequate to account for the effects of manipulation of endogenous DA levels on the in vivo binding of radiolabeled antagonists... - The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporter phenotype in humansD Martinez
Division of Functional Brain Mapping, New York State Psychiatry Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Neuropsychopharmacology 24:553-60. 2001..Thus, we did not replicate the findings of two previous studies, which had suggested that the 9 repeat allele was associated with either an increased or decreased DAT expression, albeit in different patient populations... - Stability of [123I]IBZM SPECT measurement of amphetamine-induced striatal dopamine release in humansL S Kegeles
Department of Psychiatry, Columbia University College of Physicians and Surgeons, and New York State Psychiatric Institute, New York 10032, USA
Synapse 31:302-8. 1999..In conclusion, this scanning technique provides a reliable measurement of amphetamine-induced reduction of [123I]IBZM BP and enables detection of between-subject differences that appear stable over time... - Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohortA Abi-Dargham
Department of Psychiatry, Yale University, New Haven, Conn, USA
Am J Psychiatry 155:761-7. 1998..The purpose of this study was to replicate this finding in a new cohort of schizophrenic patients and healthy subjects... - Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECTR T Malison
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
Am J Psychiatry 155:832-4. 1998..The authors examined whether striatal dopamine transporters were altered in acutely (96 hours or less) abstinent cocaine-abusing subjects, as suggested by postmortem studies... 
Increased baseline occupancy of D2 receptors by dopamine in schizophreniaA Abi-Dargham
Departments of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Proc Natl Acad Sci U S A 97:8104-9. 2000..This finding provides direct evidence of increased stimulation of D(2) receptors by dopamine in schizophrenia, consistent with increased phasic activity of dopaminergic neurons...- (-)-N-[(11)C]propyl-norapomorphine: a positron-labeled dopamine agonist for PET imaging of D(2) receptorsD R Hwang
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, New York, USA
Nucl Med Biol 27:533-9. 2000..8 in baboon was the highest reported with a radiolabeled D(2) agonist. (-)-[(11)C]NPA is a promising new D(2) agonist PET tracer for probing D(2) receptors in vivo using PET... - Age-related decline in central serotonin transporter availability with [(123)I]beta-CIT SPECTC H van Dyck
Department of Psychiatry, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Neurobiol Aging 21:497-501. 2000..5% over the age range 18 to 88, or approximately 4.2% per decade. These results demonstrate reductions in the availability of central SERT binding sites with age in living human subjects... - Dopamine D(2) receptor availability and amphetamine-induced dopamine release in unipolar depressionR V Parsey
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
Biol Psychiatry 50:313-22. 2001..CONCLUSIONS: This study did not replicate previously reported alterations in striatal D(2) receptor density in depressed patients and suggests that stimulant-induced dopamine release is not altered in major depression... - Low dopamine D(2) receptor binding potential in social phobiaF R Schneier
Anxiety Disorders Clinic and the Brain Imaging Division, New York State Psychiatric Institute, New York 10032, USA
Am J Psychiatry 157:457-9. 2000..This study compared dopamine D(2) receptor binding potential in patients with social phobia and healthy comparison subjects... - D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor geneM Laruelle
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Mol Psychiatry 3:261-5. 1998..Similarly, we found no effect of the B1 allele on [123I]IBZM-binding potential. In conclusion, the results of this study failed to replicate the previously reported association between A1 allele and lower D2 receptor expression... - Vulnerability of positron emission tomography radiotracers to endogenous competition. New insightsM Laruelle
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, NY 10032, USA
Q J Nucl Med 45:124-38. 2001..A better understanding of the mechanisms underlying these interactions should facilitate the development of PET and SPECT radiotracers suitable for the reporting of synaptic transmitter levels... - Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123I]iomazenilA Abi-Dargham
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
Am J Psychiatry 155:1550-5. 1998..The authors attempted to replicate these findings using single photon emission computed tomography and the benzodiazepine receptor radiotracer [123I]iomazenil... - An improved one-pot procedure for the preparation of [11C-carbonyl]-WAY100635D R Hwang
Department of Medicine and Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Nucl Med Biol 26:815-9. 1999..The radiochemical purity was >99%, and the specific activity was 3.6 +/- 1.9 Ci/micromol (EOS, n = 40), or 21.3 +/- 9.8 Ci/micromol at EOB. This method is reliable and flexible for routine clinical studies... - Derivation of [(11)C]WAY-100635 binding parameters with reference tissue models: effect of violations of model assumptionsM Slifstein
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
Nucl Med Biol 27:487-92. 2000..In conclusion, the SRTM is associated with a bias in the derivation of k(3)/k(4) that is not a simple scaling factor. This magnitude of these errors should be carefully evaluated for each new radioligand... - Protein precipitation: an expedient procedure for the routine analysis of the plasma metabolites of [123I]IBZMY Zea-Ponce
Department of Psychiatry, Columbia University College of Physicians and Surgeons, and New York State Psychiatric Institute, New York 10032, USA
Nucl Med Biol 26:811-4. 1999..8% (n = 22). Free fraction of parent was 15% +/- 8% (n = 85). The results indicate that acetonitrile protein precipitation is an adequate method for the analysis of the [123I]IBZM plasma metabolites... - Imaging neurochemical endophenotypes: promises and pitfallsD Martinez
New York State Psychiatric Institute, 1051 Riverside Drive, Box 31, New York, NY 10032, USA
Pharmacogenomics 2:223-37. 2001..These studies illustrate the unique opportunities, as well as the pitfalls, generated by combining genetic analysis with brain imaging studies... - Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligandsY Huang
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Bioorg Med Chem Lett 11:1375-7. 2001..All new compounds display high affinity and selectivity for the D(4) receptors and compounds 5b, 5d, and 5e were identified as candidates for radioligand development... - Hippocampal pathology in schizophrenia: magnetic resonance imaging and spectroscopy studiesL S Kegeles
Department of Psychiatry, Columbia University, New York, NY, USA
Psychiatry Res 98:163-75. 2000..The preliminary finding of a lateralized abnormality in Glx is consistent with postmortem findings of asymmetric neurochemical temporal lobe abnormalities in schizophrenia... - Synthesis of [123I]IBZM: a reliable procedure for routine clinical studiesY Zea-Ponce
Department of Psychiatry, Columbia University College of Physicians and Surgeons, and New York State Psychiatric Institute, New York, USA
Nucl Med Biol 26:661-5. 1999..For example, for volumes between 417 and 523 microL the labeling yield was 61 +/- 5% (n = 21), radiochemical yield was 56 +/- 5% and radiochemical purity was 98 +/- 1%... - Models and methods for derivation of in vivo neuroreceptor parameters with PET and SPECT reversible radiotracersM Slifstein
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Nucl Med Biol 28:595-608. 2001..In conclusion, there is no universally "best" method that is applicable to all neuroreceptor imaging studies, and carefully evaluation of model-based methods is required for each radiotracer... - Imaging human mesolimbic dopamine transmission with positron emission tomography: I. Accuracy and precision of D(2) receptor parameter measurements in ventral striatumO Mawlawi
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
J Cereb Blood Flow Metab 21:1034-57. 2001.... - Occupancy of dopamine D2 receptors by the atypical antipsychotic drugs risperidone and olanzapine: theoretical implicationsW G Frankle
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA
Psychopharmacology (Berl) 175:473-80. 2004..To examine the D2 occupancy of two commonly used antipsychotic medications and relate this to the D2 occupancy by endogenous dopamine in schizophrenia... 
COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PETM Slifstein
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Mol Psychiatry 13:821-7. 2008..These results confirm the prominent role of COMT in regulating DA transmission in cortex but not striatum, and the reliability of [11C]NNC 112 as a marker for low DA tone as previously suggested by studies in patients with schizophrenia...