Research Topics
Species | BLANDINE LAFERRERESummaryAffiliation: Columbia University Country: USA Publications
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Publications
Gut feelings about diabetesBLANDINE LAFERRERE
Obesity Nutrition Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
Endocrinol Nutr 59:254-60. 2012..While most patients after bariatric surgery experienced sustained weight loss and improved metabolism, small scale studies have shown weight regain and diabetes relapse, the mechanisms of which remain unknown...
Total body calcium in obese women. Validation of dual-energy X-ray absorptiometry against in vivo neutron activation analysisB Laferrere
New York Obesity Research Center, St Luke s Roosevelt Hospital Center, New York 10025, USA
Ann N Y Acad Sci 904:507-13. 2000..The higher the BMI, the bigger the difference between CaIVNA and CaDXA. In our population with a mean BMI of 35.3, CaIVNA = 69% CaDXA...- Diabetes remission after bariatric surgery: is it just the incretins?B Laferrere
New York Obesity Nutrition Research Center, Division of Endocrinology and Diabetes, Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
Int J Obes (Lond) 35:S22-5. 2011..Changes in rate of eating, gastric emptying, intestinal transit time, nutrient absorption and sensing, as well as bile acid metabolism, may all be implicated... - Do we really know why diabetes remits after gastric bypass surgery?BLANDINE LAFERRERE
New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, 1111 Amsterdam Avenue, New York, NY 10025, USA
Endocrine 40:162-7. 2011..Equally important would be to identify biological predictors of success or failure and to understand the mechanisms of weight regain and/or diabetes relapse... - Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight lossBLANDINE LAFERRERE
New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
Sci Transl Med 3:80re2. 2011..These data suggest that the enhanced decrease in circulating AAs after GBP occurs by mechanisms other than weight loss and may contribute to the better improvement in glucose homeostasis observed with the surgical intervention... 
Rise of oxyntomodulin in response to oral glucose after gastric bypass surgery in patients with type 2 diabetesBLANDINE LAFERRERE
Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
J Clin Endocrinol Metab 95:4072-6. 2010..The mechanisms by which Roux-en-Y gastric bypass surgery (GBP) results in sustained weight loss and remission of type 2 diabetes are not fully understood...- Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetesBLANDINE LAFERRERE
St Lukes Roosevelt Hospital, Obesity Research Center, 1111 Amsterdam Avenue, New York, NY 10025, USA
J Clin Endocrinol Metab 93:2479-85. 2008..Gastric bypass surgery (GBP) results in rapid weight loss, improvement of type 2 diabetes (T2DM), and increase in incretins levels. Diet-induced weight loss also improves T2DM and may increase incretin levels... - Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with type 2 diabetesBLANDINE LAFERRERE
Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, 1111 Amsterdam Ave, New York, NY 10025, USA
Diabetes Care 30:1709-16. 2007..We hypothesized that in obese patients with type 2 diabetes the impaired levels and effect of incretins changed as a consequence of RY-GBP... - Obese subjects respond to the stimulatory effect of the ghrelin agonist growth hormone-releasing peptide-2 on food intakeBLANDINE LAFERRERE
Obesity Research Center, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
Obesity (Silver Spring) 14:1056-63. 2006..The aim of this study was to investigate whether this effect occurs in obese subjects and whether it is dose-dependent... - Effect of one morning meal and a bolus of dexamethasone on 24-hour variation of serum leptin levels in humansB Laferrere
Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University, New York, New York 10025, USA
Obes Res 8:481-6. 2000..The present experiment was undertaken to determine the duration of the effect of dexamethasone on 24-hour serum leptin under fasted and fed conditions in humans... - A pulse of insulin and dexamethasone stimulates serum leptin in fasting human subjectsB Laferrere
Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University, 1111 Amsterdam Avenue, New York, New York 10025, USA
Eur J Endocrinol 146:839-45. 2002..Whether the presence of transient hyperglycemia and the dose of insulin were important was tested as a secondary aim... - Race, menopause, health-related quality of life, and psychological well-being in obese womenBLANDINE LAFERRERE
New York Obesity Research Center, St Luke s Roosevelt Hospital Center, New York 10025, USA
Obes Res 10:1270-5. 2002..To investigate the health-related quality of life (HR-QOL) in African-American (AA) and white (W) obese women... - Weight loss and incretin responsiveness improve glucose control independently after gastric bypass surgeryMousumi Bose
New York Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
J Diabetes 2:47-55. 2010..The aim of the present study was to determine the mechanisms underlying Type 2 diabetes remission after gastric bypass (GBP) surgery by characterizing the short- and long-term changes in hormonal determinants of blood glucose... - Do Incretins play a role in the remission of type 2 diabetes after gastric bypass surgery: What are the evidence?Mousumi Bose
New York Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, 1111 Amsterdam Avenue, New York, NY 10025, USA
Obes Surg 19:217-29. 2009..Our goals are to provide a thorough update on this field of research so that recommendations for future research and criteria for bariatric surgery can be evaluated... - Effect of weight loss by diet or gastric bypass surgery on peptide YY3-36 levelsBlanca Olivan
Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
Ann Surg 249:948-53. 2009..To examine the effect of an equivalent weight loss, by gastric bypass surgery (GBP) or by diet, on peptide YY3-36 (PYY3-36), ghrelin, and leptin levels and to determine the effect of diabetes status on PYY3-36 levels... - Superior appetite hormone profile after equivalent weight loss by gastric bypass compared to gastric bandingMousumi Bose
New York Obesity Research Center, St Luke s Roosevelt Hospital Center, New York, New York, USA
Obesity (Silver Spring) 18:1085-91. 2010..Mechanisms other than weight loss may explain changes of leptin and amylin after GBP... - Does ghrelin really matter after bariatric surgery?Hongchan Lee
Division of Bariatric Surgery, Department of Surgery, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
Surg Obes Relat Dis 2:538-48. 2006 - Neural responsivity to food cues in fasted and fed states pre and post gastric bypass surgeryChristopher N Ochner
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital, NY 10025, USA
Neurosci Res 74:138-43. 2012..Results were opposite to that predicted and appear inconsistent with the initial hypothesis that postoperative increases in postprandial gut peptides are the primary driver of postoperative changes in neural responsivity... - Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy menBLANDINE LAFERRERE
Obesity Research Center, St Luke s Roosevelt Hospital Center, New York, New York 10025, USA
J Clin Endocrinol Metab 90:611-4. 2005..412 +/- 161 microg/L/240 min, p = 0.003). These data are the first to demonstrate that GHRP-2, like ghrelin, increases food intake, suggesting that GHRP-2 is a valuable tool for investigating ghrelin effects on eating behavior in humans... - Comparisons of waist circumferences measured at 4 sitesJack Wang
Body Composition Unit and New York Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York 10025, USA
Am J Clin Nutr 77:379-84. 2003.... - Accelerated gastric emptying but no carbohydrate malabsorption 1 year after gastric bypass surgery (GBP)Gary Wang
New York Obesity Nutrition Research Center, New York, NY, USA
Obes Surg 22:1263-7. 2012..The mechanisms of enhanced incretin release in response to nutrients after GBP is not elucidated and may be in relation to altered nutrient transit time and/or malabsorption... - Regional subcutaneous-fat loss induced by caloric restriction in obese womenJack Wang
Body Composition Unit, Obesity Research Center, Department of Medicine, St Luke s Roosevelt Hospital, Columbia University, 1111 Amsterdam Avenue, New York, NY 10025, USA
Obes Res 10:885-90. 2002.... - Inhibiting endogenous cortisol blunts the meal-entrained rise in serum leptinBLANDINE LAFERRERE
Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, 1111 Amsterdam Avenue, New York, New York 10025, USA
J Clin Endocrinol Metab 91:2232-8. 2006..Administration of glucocorticoids increases serum leptin levels in lean and obese individuals. A morning meal produces an increase in insulin, a cortisol peak, and an increase in leptin; these changes do not occur during fasting... - Magnitude and variability of the glucagon-like peptide-1 response in patients with type 2 diabetes up to 2 years following gastric bypass surgeryBart J Van der Schueren
New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital Center, New York, NewYork, USA
Diabetes Care 35:42-6. 2012..To characterize the magnitude and variance of the change of glucose and glucagon-like peptide-1 (GLP-1) concentrations, and to identify determinants of glucose control up to 2 years after gastric bypass (GBP)... - The bariatric surgery patient: lost to follow-up; from morbid obesity to severe malnutritionGregory B Dodell
Division of Endocrinology, Diabetes and Nutrition, St Luke s Roosevelt Hospital Center, New York, New York 10025, USA
Endocr Pract 18:e21-5. 2012.... - Prevalence of co-morbidities in obese patients before bariatric surgery: effect of raceLuigi Residori
Obesity Research Center and Department of Medicine, St Luke's Roosevelt Hospital, College of Physicians and Surgeons, Columbia University, New York, NY 10025, USA
Obes Surg 13:333-40. 2003..Age, ethnicity and gender influence the type of co-morbid conditions. More research is needed to understand why diabetes and other metabolic complications remain undiagnosed and untreated in a large number of these high risk patients... - Calorie intake and meal patterns up to 4 years after Roux-en-Y gastric bypass surgeryJoumana Wardé-Kamar
Obesity Research Center, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
Obes Surg 14:1070-9. 2004..This study was undertaken to evaluate the caloric amount, nutrient composition and meal patterns of patients 18 months to 4 years after RYGBP. Ethnic differences in food intake were also investigated... - Stress and obesity: the role of the hypothalamic-pituitary-adrenal axis in metabolic diseaseMousumi Bose
New York Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
Curr Opin Endocrinol Diabetes Obes 16:340-6. 2009..This association may be mediated by alterations in the hypothalamic-pituitary-adrenal (HPA) axis. In this review, we summarize the major research that has been conducted on the role of the HPA axis in obesity and metabolic disease... - Korean and Caucasian overweight premenopausal women have different relationship of body mass index to percent body fat with ageSochung Chung
Department of Medicine, Obesity Research Center, St. Luke's-Roosevelt Hospital and College of Physicians and Surgeons, Columbia University, New York, NY 10025, USA
J Appl Physiol 99:103-7. 2005..Investigators who use BMI as an index of fatness should be aware of the well documented differences in the relationship of BMI and fatness across race/ethnic groups... - Incretins, diabetes, and bariatric surgery: a reviewRachel Fetner
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
Surg Obes Relat Dis 1:589-97; discussion 597-8. 2005 - Depression score predicts weight loss following Roux-en-Y gastric bypassYelena Averbukh
Department of Medicine, St.Luke's-Roosevelt Hospital, New York, USA
Obes Surg 13:833-6. 2003..Future prospective studies should examine possible mechanisms and effects of depression and other psychiatric disturbances on long-term weight loss after RYGBP... - Physical disability and obesityTsan-Hon Liou
New York Obesity Research Center, St. Luke's-Roosevelt Hospital, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, USA
Nutr Rev 63:321-31. 2005..Health professionals should identify disabled patients at risk and provide early prevention guidance. Research is needed to help generate detailed clinical guidelines to promote weight control among people with physical disabilities...
Research Grants
- Mechanisms of Diabetes Control After Weight Loss SurgeryBLANDINE LAFERRERE; Fiscal Year: 2006..As more obese diabetic patients undergo GBP, understanding the mechanisms that produce improvement in their diabetes is increasingly important. ..
- Mechanisms of Diabetes Control After Weight Loss SurgeryBLANDINE B LAFERRERE; Fiscal Year: 2010..We wish to apply our findings to possible medical alternatives for the treatment of obesity and T2DM. ..
- Mechanisms of Diabetes Control After Weight Loss SurgeryBLANDINE B LAFERRERE; Fiscal Year: 2010..We wish to apply our findings to possible medical alternatives for the treatment of obesity and T2DM. ..