Research Topics
Species | Louise KuhnSummaryAffiliation: Columbia University Country: USA Publications
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Publications
Direct visual inspection for cervical cancer screening: an analysis of factors influencing test performanceLynette Denny
Department of Obstetrics and Gynecology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Cancer 94:1699-707. 2002..CONCLUSIONS: This study confirmed the utility of DVI as a primary screening test. Evaluation of the clinical effectiveness of screening with this low-cost and simple test in low-resource settings is necessary...
Does severity of HIV disease in HIV-infected mothers affect mortality and morbidity among their uninfected infants?Louise Kuhn
Gertrude H Sergievsky Center, Mailman School of Public Health, Columbia University, New York, NY, USA
Clin Infect Dis 41:1654-61. 2005..We investigated the hypothesis that the severity of HIV disease and immune dysfunction among mothers is associated with increased morbidity and mortality among their uninfected infants...- Intravaginal practices, bacterial vaginosis, and women's susceptibility to HIV infection: epidemiological evidence and biological mechanismsLandon Myer
Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
Lancet Infect Dis 5:786-94. 2005..Further research into factors that increase women's susceptibility to HIV will help to inform the design of vaginal microbicides and other HIV prevention interventions... - Immune pathogenesis of pediatric HIV-1 infectionCaroline T Tiemessen
AIDS Virus Research Unit, National Institute for Communicable Diseases and University of the Witwatersand, Private Bag X4, Sandringham, 2131, South Africa
Curr HIV/AIDS Rep 3:13-9. 2006..This review focuses on the key host molecules, the CC chemokine CCL3 and HLA, which have taken center stage in these new developments... - CC chemokines and protective immunity: insights gained from mother-to-child transmission of HIVCaroline T Tiemessen
AIDS Virus Research Unit, National Institute for Communicable Diseases and University of the Witwatersand, Sandringham 2131, South Africa
Nat Immunol 8:219-22. 2007 
Switching children previously exposed to nevirapine to nevirapine-based treatment after initial suppression with a protease-inhibitor-based regimen: long-term follow-up of a randomised, open-label trialLouise Kuhn
Gertrude H Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Columbia University, New York, NY 10032, USA
Lancet Infect Dis 12:521-30. 2012..We present the long-term outcomes of switching nevirapine-exposed children to nevirapine-based treatment after effective suppression of virus replication with a protease-inhibitor-based regimen...- Adherence and virologic suppression during the first 24 weeks on antiretroviral therapy among women in Johannesburg, South Africa - a prospective cohort studyZiad El-Khatib
Nordic School of Public Health NHV, Gothenburg, Sweden
BMC Public Health 11:88. 2011..We assessed risk factors for incomplete adherence among a cohort of HIV-infected women initiating ART and examined associations between adherence and virologic response to ART... - Survival and health benefits of breastfeeding versus artificial feeding in infants of HIV-infected women: developing versus developed worldLouise Kuhn
Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Clin Perinatol 37:843-62, x. 2010..For most of the developing world, the health and survival benefits of breastfeeding exceed the risks of HIV transmission, especially when antiretroviral interventions are provided... - Efficacy of human papillomavirus-based screen-and-treat for cervical cancer prevention among HIV-infected womenLouise Kuhn
Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
AIDS 24:2553-61. 2010..Here, we evaluate the efficacy among HIV-infected women of a simpler, screen-and-treat strategy in which all women with a positive screening test are treated with cryotherapy... - Alpha-defensins in the prevention of HIV transmission among breastfed infantsLouise Kuhn
Gertrude H Sergievsky Center and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
J Acquir Immune Defic Syndr 39:138-42. 2005..3, 95% confidence interval: 0.09-0.93). Our data suggest that there may be a role for alpha-defensins in prevention of HIV transmission to breastfed infants... - Prolonged breast-feeding and mortality up to two years post-partum among HIV-positive women in ZambiaLouise Kuhn
Gertrude H Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
AIDS 19:1677-81. 2005..A previously reported association between prolonged lactation and maternal mortality has generated concern that breast-feeding may be detrimental for HIV-positive women... - Elevations in mortality associated with weaning persist into the second year of life among uninfected children born to HIV-infected mothersLouise Kuhn
Gertrude H Sergievsky Center, College of Physicians and Surgeons, and Departments of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
Clin Infect Dis 50:437-44. 2010..Early weaning has been recommended to reduce postnatal human immunodeficiency virus (HIV) transmission. We evaluated the safety of stopping breast-feeding at different ages for mortality of uninfected children born to HIV-infected mothers... - HIV prevention is not enough: child survival in the context of prevention of mother to child HIV transmissionLouise Kuhn
Gertrude H, Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
J Int AIDS Soc 12:36. 2009..This will lead to reduced HIV transmission and will protect the health of women without compromising the health and well-being of infants and young children... - Differential effects of early weaning for HIV-free survival of children born to HIV-infected mothers by severity of maternal diseaseLouise Kuhn
Gertrude H Sergievsky Center, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
PLoS ONE 4:e6059. 2009..Since early weaning was poorly accepted, we conducted a secondary analysis to investigate whether beneficial effects may have been hidden... - High uptake of exclusive breastfeeding and reduced early post-natal HIV transmissionLouise Kuhn
Gertrude H Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America
PLoS ONE 2:e1363. 2007..We conducted a prospective, observational study in Lusaka, Zambia, to test the hypothesis that EBF is associated with a lower risk of postnatal HIV transmission than non-EBF... - Mortality and virologic outcomes after access to antiretroviral therapy among a cohort of HIV-infected women who received single-dose nevirapine in Lusaka, ZambiaLouise Kuhn
Gertrude H Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032 3702, USA
J Acquir Immune Defic Syndr 52:132-6. 2009..We investigated mortality and virologic and clinical outcomes after introduction of antiretroviral treatment (ART) among a cohort of women given SDNVP... - Effects of early, abrupt weaning on HIV-free survival of children in ZambiaLouise Kuhn
Gertrude H Sergievsky Center and the Department of Epidemiology, Mailman School of Public Health, Columbia University, New York 10032, USA
N Engl J Med 359:130-41. 2008..We conducted a randomized trial to evaluate whether abrupt weaning at 4 months as compared with the standard practice has a net benefit for HIV-free survival of children... - Synergy between mannose-binding lectin gene polymorphisms and supplementation with vitamin A influences susceptibility to HIV infection in infants born to HIV-positive mothersLouise Kuhn
Gertrude H Sergievsky Center, College of Physicians and Surgeons, and the Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
Am J Clin Nutr 84:610-5. 2006..Mannose-binding lectin (MBL-2) allele variants are associated with deficiencies in innate immunity and have been found to be correlated with HIV infection in adults and children... - Bystander effects: children who escape infection but not harmLouise Kuhn
Gertrude H. Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
J Acquir Immune Defic Syndr 46:517-8. 2007 - Hiv-specific secretory IgA in breast milk of HIV-positive mothers is not associated with protection against HIV transmission among breast-fed infantsLouise Kuhn
Gertrude H Sergievsky Center and the Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
J Pediatr 149:611-6. 2006..To test whether secretory immunoglobulin A (sIgA) to human immunodeficiency virus (HIV) antigens in breast milk of HIV-positive women is associated with protection against HIV transmission among breast-fed infants... - Preventing mother-to-child HIV transmission in the new millennium: the challenge of breast feedingLouise Kuhn
Gertrude H Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
Paediatr Perinat Epidemiol 18:10-6. 2004..Innovative approaches are needed to mobilise and train effective counsellors among health care workers and, as appropriate, community members... - Interferon-gamma and interleukin-10 production among HIV-1-infected and uninfected infants of HIV-1-infected mothersL Kuhn
Gertrude H Sergievsky Center, College of Physicians and Surgeons, and Division of Epidemiology, Joseph L Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Pediatr Res 50:412-6. 2001..Stronger relative production of IFN-gamma to IL-10 in cord blood cells from infants of HIV-1-infected mothers may be associated with protection against perinatal HIV infection... - Human immunodeficiency virus (HIV)-specific cellular immune responses in newborns exposed to HIV in uteroLouise Kuhn
Gertrude H Sergievsky Center, College of Physicians and Surgeons, and Division of Epidemiology, Joseph L Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Clin Infect Dis 34:267-76. 2002..Many questions remain, but much can be learned from this special population that may be informative for development of effective immunity in response to HIV vaccines... - Influence of breastfeeding on cognitive outcomes at age 6-8 years: follow-up of very low birth weight infantsMelanie M Smith
Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
Am J Epidemiol 158:1075-82. 2003..0, 7.6) for verbal ability. Indicators of social advantage confound the association between breastfeeding and cognitive function, but careful measurement can reduce residual confounding and may clarify causal relations... - Prevalence of visible disruption of cervical epithelium and cervical ectopy in African women using Depo-ProveraL Kuhn
Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Contraception 59:363-7. 1999.... - Options for prevention of HIV transmission from mother to child, with a focus on developing countriesLouise Kuhn
Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, and Department of Epidemiology, Joseph L Mailman School of Public Health, New York 10032, USA
Paediatr Drugs 4:191-203. 2002..A promising new line of research has recently been broached with the findings from a study in South Africa, which demonstrated that exclusive breast feeding is associated with a significant reduction in postnatal transmission of HIV... - Human immunodeficiency virus type 1 envelope-stimulated interleukin-2 production and survival of infected children with severe and mild clinical diseaseL Kuhn
Gertrude H Sergievsky Center, College of Physicians and Surgeons, and Division of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
J Infect Dis 184:691-8. 2001..HIV-specific cellular immune responses may play a role in containing progression of HIV-1 infection in children, despite early deficits in cell-mediated immunity... - Disease progression and early viral dynamics in human immunodeficiency virus-infected children exposed to zidovudine during prenatal and perinatal periodsL Kuhn
Columbia University, Sergievsky Center, New York, NY 10032, USA
J Infect Dis 182:104-11. 2000..More rapid disease progression was observed among infected children exposed during pregnancy or birth to Zdv if effective multidrug therapy was not initiated... - Reduced HIV-stimulated T-helper cell reactivity in cord blood with short-course antiretroviral treatment for prevention of maternal-infant transmissionL Kuhn
Gertrude H Sergievsky Center, College of Physicians and Surgeons, Division of Epidemiology, Joseph L Mailman School of Public Health, Columbia University, New York, USA
Clin Exp Immunol 123:443-50. 2001..Our results suggest that short-course antiretroviral treatment given to prevent maternal-infant HIV transmission may attenuate HIV-stimulated T-cell memory responses in the neonate... - Predictors of nonadherence to single-dose nevirapine therapy for the prevention of mother-to-child HIV transmissionSandra Albrecht
Gertrude H. Sergievsky Center, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
J Acquir Immune Defic Syndr 41:114-8. 2006..Nonadherence seems to be affected by place of birth and by poor health status of the newborn. Procedures to ensure that viable yet ill neonates receive nevirapine should be part of clinical protocols and training within pMTCT programs... - Initial response to protease-inhibitor-based antiretroviral therapy among children less than 2 years of age in South Africa: effect of cotreatment for tuberculosisCordula Reitz
Gertrude H Sergievsky Center and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City, New York 10032, USA
J Infect Dis 201:1121-31. 2010..We investigated factors associated with viral suppression and mortality among young children initiating ART... - Reduction in preterm delivery and neonatal mortality after the introduction of antenatal cotrimoxazole prophylaxis among HIV-infected women with low CD4 cell countsJan Walter
Gertrude H. Sergievsky Center and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
J Infect Dis 194:1510-8. 2006..Conclusion. Antenatal provision of cotrimoxazole for HIV-infected pregnant women with low CD4 cell counts may have indirect benefits for neonatal health... - Growth faltering due to breastfeeding cessation in uninfected children born to HIV-infected mothers in ZambiaStephen Arpadi
Columbia University Gertrude H Sergievsky Center, College of Physicians and Surgeons and Mailman School of Public Health, New York, NY 10030, USA
Am J Clin Nutr 90:344-53. 2009..The effect of breastfeeding on growth in HIV-exposed infants is not well described... - Low and undetectable breast milk interleukin-7 concentrations are associated with reduced risk of postnatal HIV transmissionJan Walter
Gertrude H Sergievsky Center and Department of Epidemiology, Mailman School of Public Health, Columbia University New York, NY, USA
J Acquir Immune Defic Syndr 46:200-7. 2007..To investigate if breast milk interleukin [IL]-7 concentrations are associated with postnatal HIV transmission... - Immune reconstitution inflammatory syndrome among HIV-infected South African infants initiating antiretroviral therapyKelly Smith
Columbia University College of Physicians and Surgeons, New York, New York, USA
AIDS 23:1097-107. 2009..To determine the incidence, clinical manifestations and risk factors for immune reconstitution inflammatory syndrome (IRIS) in young children initiating highly active antiretroviral therapy (HAART)... - Maternal versus paternal inheritance of HLA class I alleles among HIV-infected children: consequences for clinical disease progressionLouise Kuhn
Gertrude H Sergievsky Center, College of Physicians and Surgeons, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
AIDS 18:1281-9. 2004..We investigated whether maternal HLA selection pressures on the virus would adversely influence clinical outcomes of HIV-infected children... - Maternal health factors and early pediatric antiretroviral therapy influence the rate of perinatal HIV-1 disease progression in childrenElaine J Abrams
Harlem Hospital Center and Columbia University, College of Physicians and Surgeons, New York, New York 10037, USA
AIDS 17:867-77. 2003..More recent birth year and early treatment with potent antiretroviral therapy significantly diminished the likelihood of developing AIDS or dying during early childhood... - A comparison of human papillomavirus testing of clinician-collected and self-collected samples during follow-up after screen-and-treatSylvia Taylor
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Int J Cancer 129:879-86. 2011..78%, p=0.01). HPV testing using self-collected vaginal specimens may be useful in primary screening but performs poorly for detecting post-treatment failures... - Potential impact of new WHO criteria for antiretroviral treatment for prevention of mother-to- child HIV transmissionLouise Kuhn
Gertrude H Sergievsky Center, Department of Epidemiology, Columbia University, New York, New York, USA
AIDS 24:1374-7. 2010..Using CD4 cell count below 350 cells/microl, irrespective of clinical stage, is more efficient and stricter CD4 cutoffs would be counter productive... - Genital herpes simplex virus infection and perinatal transmission of human immunodeficiency virusKatherine T Chen
Department of Obstetrics and Gynecology, Columbia University, Sergievsky Center and Harlem Hospital Center, New York, New York 10032, USA
Obstet Gynecol 106:1341-8. 2005..To assess the risk of perinatal human immunodeficiency virus (HIV) transmission in HIV-infected women clinically diagnosed with genital herpes simplex virus (HSV) infection during pregnancy... - Initiation of breastfeeding among mothers of very low birth weight infantsMelanie M Smith
Gertrude H. Sergievsky Center, New York, New York, USA
Pediatrics 111:1337-42. 2003..Intervention programs need to consider the sociodemographic factors that influence infant feeding decisions as well as specific challenges encountered by mothers of VLBW infants... - Early weaning increases diarrhea morbidity and mortality among uninfected children born to HIV-infected mothers in ZambiaAshraf Fawzy
Columbia University, Gertrude H Sergievsky Center, College of Physicians and Surgeons and Mailman School of Public Health, New York, New York, USA
J Infect Dis 203:1222-30. 2011..Here we evaluate effects of early weaning on diarrhea morbidity and mortality of uninfected children born to HIV-infected mothers... - African infants' CCL3 gene copies influence perinatal HIV transmission in the absence of maternal nevirapineLouise Kuhn
Gertrude H Sergievsky Centre, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
AIDS 21:1753-61. 2007..We investigated whether maternal or infant CCL3L1 gene copy numbers are associated with perinatal HIV transmission when single-dose nevirapine is given for prevention... - Metabolic abnormalities and body composition of HIV-infected children on Lopinavir or Nevirapine-based antiretroviral therapyStephen Arpadi
Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University Medical Center, 630 W 168th Street, New York, NY 10032, USA
Arch Dis Child 98:258-64. 2013..We compared metabolic profiles and regional fat of children on ritonavir-boosted lopinavir (lopinavir/ritonavir), lamivudine and stavudine to those switched to nevirapine, lamivudine and stavudine... - Prenatal cocaine exposure and prolonged focus attention. Poor infant information processing ability or precocious maturation of attentional systems?Claudia A Chiriboga
Division of Pediatric Neurology, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Dev Neurosci 31:149-58. 2009..Whether focused attention findings impact long term development awaits further study... - Breastfeeding and AIDS in the developing worldLouise Kuhn
Gertrude H Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Curr Opin Pediatr 21:83-93. 2009..Data from recently completed studies provide insight into the safety and hazards of different feeding approaches as well as the use of antiretroviral therapy to prevent postnatal transmission... - Distribution of high-risk human papillomavirus genotypes among HIV-negative women with and without cervical intraepithelial neoplasia in South AfricaAlicia C McDonald
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America
PLoS ONE 7:e44332. 2012..Here we describe the prevalence and distribution of hrHPV genotypes among HIV-negative women in South Africa, with and without cervical intraepithelial neoplasia (CIN)... - HIV-1 Concentrations in Human Breast Milk Before and After WeaningLouise Kuhn
Gertrude H Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Sci Transl Med 5:181ra51. 2013..Our results support continuation of maternal antiretroviral drug interventions over the full duration of time when any breast milk exposures may occur after planned weaning... - Factors associated with microcephaly at school age in a very-low-birthweight populationClaudia A Chiriboga
Division of Pediatric Neurology, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Dev Med Child Neurol 45:796-801. 2003..In multivariate analyses predicting IQ at age 7 years, microcephaly was found to modify the association between neonatal lung disease and IQ... - Pregnancy loss and role of infant HIV status on perinatal mortality among HIV-infected womenHae Young Kim
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
BMC Pediatr 12:138. 2012..Here we examine risk factors for these adverse pregnancy outcomes in a cohort of HIV-infected women in Zambia considering the impact of infant HIV status... - Alternative approaches to cervical cancer screening for developing countriesThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, Room 16 404, P and S Building, 630 W 168th Street, New York, NY 10032, USA
Best Pract Res Clin Obstet Gynaecol 26:197-208. 2012.... - Reduced acquisition and reactivation of human papillomavirus infections among older women treated with cryotherapy: results from a randomized trial in South AfricaSylvia Taylor
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
BMC Med 8:40. 2010..We investigated whether cervical cryotherapy reduces newly detected hrHPV infections among HIV-positive and HIV-negative women who were hrHPV negative when treated... - Direct comparison of liquid-based and conventional cytology in a South African screening trialSylvia Taylor
Department of Pathology, Columbia University, New York, NY 10032, USA
Int J Cancer 118:957-62. 2006..Because of the higher unit cost of LBC, low resource settings should carefully consider the potential benefits and drawbacks of LBC before adopting this new technology... - Prenatal cocaine exposures and dose-related cocaine effects on infant tone and behaviorClaudia A Chiriboga
Division of Pediatric Neurology, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Neurotoxicol Teratol 29:323-30. 2007..In humans, numerous studies have sought clinical correlates, but few have focused on dose-related effects, especially as regards neurologic function beyond the neonatal period... - Utilisation and outcomes of cervical cancer prevention services among HIV-infected women in Cape TownPriya Batra
College of Physicians and Surgeons, Columbia University, New York, NY, USA
S Afr Med J 100:39-44. 2010..An audit of outcomes of cervical cancer screening and prevention services for HIV-positive women in Cape Town, South Africa... - Use of visual screening methods for cervical cancer screeningThomas C Wright
Department of Pathology, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Obstet Gynecol Clin North Am 29:701-34. 2002..In the near future we should be able to determine whether these approaches should be incorporated into routine clinical care... - Estimating HIV hazard rates from cross-sectional HIV prevalence dataKam Fai Wong
Department of Biostatistics, Columbia University, New York, NY, USA
Stat Med 25:2441-9. 2006..We assume further the mortality rates for HIV-positive and HIV-negative individuals are known. The method is illustrated using HIV-prevalence data collected over four years among women in Cape Town, South Africa... - Impact of utilizing p16INK4A immunohistochemistry on estimated performance of three cervical cancer screening testsQi Zhang
Department of Pathology, Columbia University, New York, NY, USA
Int J Cancer 120:351-6. 2007..In contrast, the sensitivity of other tests, such as VIA, may be overestimated with an imperfect gold standard... - Coverage of primary mother-to-child HIV transmission isolates by second-generation broadly neutralizing antibodiesKyle J Nakamura
Department of Pediatrics, Children s Hospital of Los Angeles, Los Angeles, CA, USA
AIDS 27:337-46. 2013..To assess the neutralization potency and coverage of a panel of second-generation bNAbs, we cloned and phenotypically characterized 227 primary HIV-1 envelopes from 23 mother-to-child transmission (MTCT) pairs... - Long-term cognitive benefits of antenatal corticosteroids for prematurely born children with cranial ultrasound abnormalitiesIlan Arad
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
Am J Obstet Gynecol 186:818-25. 2002..CONCLUSION: Antenatal corticosteroids appear to confer substantial long-term benefits on cognition of very-low-birth-weight infants with cranial ultrasound abnormalities... - Antiretroviral therapy outcomes in HIV-infected children after adjusting protease inhibitor dosing during tuberculosis treatmentCordula Frohoff
Gertrude H Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America
PLoS ONE 6:e17273. 2011..We aimed to determine virologic and toxicity outcomes among TB/HIV co-treated children with the following modifications to their antiretroviral therapy (ART): (1) super-boosted LPV/r, (2) double-dose LPV/r or (3) ritonavir... - Should treatment be started among all HIV-infected children and then stopped?Elaine J Abrams
Columbia University, New York City NY, USA
Lancet 362:1595-6. 2003 - Breast feeding: A time to craft new policiesZena Stein
HIV Center for Clinical and Behavioral Studies, New York Psychiatric Institute, New York, USA
J Public Health Policy 30:300-10. 2009..To be effective, implementation of any recommendations must consider individual, family, and community resources... - Advances in basic science understanding of mother-to-child HIV-1 transmissionJan Walter
aChildren s Hospital Los Angeles, University of Southern California, Los Angeles, California, USA bGertrude H Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
Curr Opin HIV AIDS 3:146-50. 2008..The present review summarizes and discusses studies on the mechanisms underlying mother-to-child HIV transmission published in 2006-2007... - Preventing postnatal transmission of HIV-1 through breast-feeding: modifying infant feeding practicesNigel Rollins
Africa Centre for Health and Population Studies, Mtubatuba, South Africa
J Acquir Immune Defic Syndr 35:188-95. 2004..This may inform policy, programming, and training options and may be especially valuable in the absence of conclusive data on the efficacy of the interventions to be applied during the breast-feeding period... - Screen-and-treat approaches for cervical cancer prevention in low-resource settings: a randomized controlled trialLynette Denny
Department of Obstetrics and Gynaecology, University of Cape Town, Cape Town, South Africa
JAMA 294:2173-81. 2005..Trial Registration http://clinicaltrials.gov Identifier: NCT00233727... - Nevirapine resistance viral mutations after repeat use of nevirapine for prevention of perinatal HIV transmissionLouise Kuhn
J Acquir Immune Defic Syndr 42:260-2. 2006 - Bacterial vaginosis and susceptibility to HIV infection in South African women: a nested case-control studyLandon Myer
Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
J Infect Dis 192:1372-80. 2005..01 [95% CI, 1.12-3.62]). CONCLUSIONS: BV may account for a substantial fraction of new HIV infections in this setting. Treatment of BV and other interventions to promote normal vaginal flora warrant attention for HIV prevention... - Women in couples antenatal HIV counseling and testing are not more likely to report adverse social eventsKatherine Semrau
Center for International Health and Development at the Boston University School of Public Health, Boston, Massachusetts 02118, USA
AIDS 19:603-9. 2005..CONCLUSIONS: Couple counseling did not increase the risk of adverse social events associated with HIV disclosure. Support services and interventions to improve social situations for people living with HIV need to be further evaluated... - Issues in the design of a clinical trial with a behavioral intervention--the Zambia exclusive breast-feeding studyDonald M Thea
Center for International Health and Development, Boston University School of Public Health, 710 Albany Street, 715, Boston, MA 02118, USA
Control Clin Trials 25:353-65. 2004.... - Human immunodeficiency virus-specific CD8(+) T cells in human breast milkSteffanie Sabbaj
Departments of Medicine, University of Alabama at Birmingham, 35294-2170, USA
J Virol 76:7365-73. 2002..Their presence suggests a role in limiting transmission and provides a rationale for vaccine strategies to enhance these responses... - CD38 expression on CD8(+) T cells as a prognostic marker in vertically HIV-infected pediatric patientsGayle G Sherman
Department of Haematology and Molecular Medicine, School of Pathology, South African Institute for Medical Research, Johannesburg, South Africa
Pediatr Res 51:740-5. 2002..043). These findings support the view that increased CD38 expression on CD8(+) T cells has the same prognostic significance in pediatric as in adult HIV disease... - Detection of human immunodeficiency virus type 1 envelope peptide- stimulated T-helper cell responses and variations in the corresponding regions of viral isolates among vertically infected childrenStephen Meddows-Taylor
AIDS Virus Research Unit, National Institute for Communicable Diseases, Private Bag X4, Sandringham, 2131, Johannesburg, South Africa
Virus Genes 28:311-8. 2004..These results suggest that HIV-1 specific CD4 responses may be somewhat tolerant of viral variation, although further studies are required to fully elucidate the effect of antigenic variation on immune recognition... - Exclusive breast-feeding and HIV transmissionAnna Coutsoudis
AIDS 16:498-9. 2002 - Decay of K103N mutants in cellular DNA and plasma RNA after single-dose nevirapine to reduce mother-to-child HIV transmissionShayne Loubser
AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
AIDS 20:995-1002. 2006..Resistant variants were detected less frequently in cellular DNA with persistence in this compartment by 12 months post-sd-NVP among only a minority... - Re: HIV-1 disease progression in breast-feeding and formula-feeding mothers: a prospective 2-year comparison of T cell subsets, HIV-1 RNA levels, and mortalityLouise Kuhn
J Infect Dis 195:1728-9; author reply 1729-30. 2007 - Reduced mortality associated with breast-feeding-acquired HIV infection and breast-feeding among HIV-infected children in ZambiaMatthew P Fox
Center for International Health and Development, Boston University, Boston, MA 02118, USA
J Acquir Immune Defic Syndr 48:90-6. 2008..This study assessed whether children infected postpartum have longer survival from time of infection versus those infected during gestation or delivery... - Distinguishing the temporal association between women's intravaginal practices and risk of human immunodeficiency virus infection: a prospective study of South African womenLandon Myer
Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
Am J Epidemiol 163:552-60. 2006..Intravaginal practices appear unlikely to be a cofactor in the male-to-female transmission of HIV in this setting... - Post-weaning breast milk HIV-1 viral load, blood prolactin levels and breast milk volumeDonald M Thea
Center for International Health and Development at the Boston University School of Public Health, Boston, Massachusetts, USA
AIDS 20:1539-47. 2006..The effect of abrupt weaning, advocated as a safe transition from exclusive breastfeeding in HIV-exposed children, on the quantity of HIV viral load in breast milk (BMVL) is not known... - Prospective study of hormonal contraception and women's risk of HIV infection in South AfricaLandon Myer
Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
Int J Epidemiol 36:166-74. 2007..We investigated associations between HIV incidence and use of combined oral contraceptives (COC), norethindrone enanthate (NET-EN) or depot medroxyprogesterone acetate (DMPA) in a cohort of South African women... - Host CCL3L1 gene copy number in relation to HIV-1-specific CD4+ and CD8+ T-cell responses and viral load in South African womenSharon Shalekoff
AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
J Acquir Immune Defic Syndr 48:245-54. 2008..017), and women who had CD4 and CD8 Gag-specific responses had significantly lower viral loads (P=0.004) and higher CCL3L1 copy number (P=0.015) than those women with only CD8 Gag-specific responses... - Temporal and lateral dynamics of HIV shedding and elevated sodium in breast milk among HIV-positive mothers during the first 4 months of breast-feedingKatherine Semrau
Center for International Health and Development at the Boston University School of Public Health, Boston, Massachusetts, USA
J Acquir Immune Defic Syndr 47:320-8. 2008..To better understand the dynamics of breast milk HIV shedding and its relation to postnatal HIV transmission, we investigated the temporal and lateral relations of breast milk viral shedding and sodium concentrations in HIV-positive women... - Nested case-control study of cervical mucosal lesions, ectopy, and incident HIV infection among women in Cape Town, South AfricaLandon Myer
Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, South Africa
Sex Transm Dis 33:683-7. 2006..Protection of the mucosa of the cervix may provide an important approach for new HIV prevention technologies... - Reduced ability of newborns to produce CCL3 is associated with increased susceptibility to perinatal human immunodeficiency virus 1 transmissionStephen Meddows-Taylor
AIDS Virus Research Unit, National Institute for Communicable Diseases, Department of Virology, University of the Witwatersrand, Sandringham, Johannesburg 2131, South Africa
J Gen Virol 87:2055-65. 2006..Our findings suggest that infants who display a deficient-production phenotype of CCL3 are at increased risk of acquiring HIV-1, indicating that this chemokine in particular plays an essential role in protective immunity... - Impact of chloroquine on viral load in breast milkKatherine Semrau
Center for International Health and Development, Boston University School of Public Health, Boston, MA 02118, USA
Trop Med Int Health 11:800-3. 2006..Further research is needed to determine the potential role of chloroquine in prevention of HIV transmission through breastfeeding... - In vivo effects of HIV-1 exposure in the presence and absence of single-dose nevirapine on cellular plasma activation markers of infants born to HIV-1-seropositive mothersDiana B Schramm
AIDS Virus Research Unit, National Institute for Communicable Diseases and Department of Virology, University of the Witwatersrand, Gauteng, South Africa
J Acquir Immune Defic Syndr 42:545-53. 2006.... - The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infectionEleonora Castelletti
Department of Preclinical Sciences, Laboratorio Interdisciplinare Technologie Avanzate Vialba, University of Milano, Milano, Italy
PLoS ONE 2:e969. 2007..The CCL28 circuit was analyzed in HIV-infected and-exposed individuals and in HIV-unexposed controls; the effect of CCL28 administration on gastrointestinal MLP IgA-ASC was verified in a mouse model... - Recurrence of symptomatic bacterial vaginosis 12 months after oral metronidazole therapy in HIV-positive and -negative womenLandon Myer
J Infect Dis 194:1797-9. 2006 - Development of a whole blood intracellular cytokine staining assay for mapping CD4(+) and CD8(+) T-cell responses across the HIV-1 genomeStephen Meddows-Taylor
AIDS Virus Research Unit, National Institute for Communicable Diseases, and Department of Virology, University of the Witwatersrand, Johannesburg, South Africa
J Virol Methods 144:115-21. 2007.... - Cervical cancer prevention - a paradigm shift?Lynnette Denny
University of Cape Town, Groote Schuur Hospital, H 45, Old Main Building, Observatory 7925, South Africa
Gynecol Oncol 99:S12. 2005 - Low maternal viral loads and reduced granulocyte-macrophage colony-stimulating factor levels characterize exposed, uninfected infants who develop protective human immunodeficiency virus type 1-specific responsesDiana B Schramm
AIDS Virus Research Unit, National Institute for Communicable Diseases, Department of Virology, University of the Witwatersrand, Gauteng, South Africa
Clin Vaccine Immunol 14:348-54. 2007.... - Intravaginal practices, HIV and other sexually transmitted diseases among South African womenLandon Myer
School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
Sex Transm Dis 31:174-9. 2004....
Research Grants
- Pathogenesis Of Essential Tremor: Cerebellar MetabolismElan Louis; Fiscal Year: 2007..Knowledge of the pathological changes and neurochemical abnormality in ET is critical for the design of new therapies for ET. ..
- Safer Weaning Practices for HIV-infected womenLouise Kuhn; Fiscal Year: 2007..Our goal is to develop evidence-based nutrition counseling messages about safer practices for HIV-infected women and their infants around the time of weaning. ..
- Safer Weaning Practices for HIV-infected womenLouise Kuhn; Fiscal Year: 2009..Our goal is to develop evidence-based nutrition counseling messages about safer practices for HIV-infected women and their infants around the time of weaning. ..
- ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMORElan Louis; Fiscal Year: 2009..This is a five-year competitive renewal in which we propose to firmly establish the links between this neurotoxin and ET. ..
- Pathogenesis Of Essential Tremor: Cerebellar MetabolismElan Louis; Fiscal Year: 2009..Our tissue-based research will place us in unique a position to begin to address basic mechanistic questions about ET and may allow treating physicians to predict during life which subtype of ET a patient is likely to have. ..
- ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMORElan D Louis; Fiscal Year: 2010..This is a five-year competitive renewal in which we propose to firmly establish the links between this neurotoxin and ET. ..
- Safer Weaning Practices for HIV-infected womenLouise Kuhn; Fiscal Year: 2010..Our goal is to develop evidence-based nutrition counseling messages about safer practices for HIV-infected women and their infants around the time of weaning. ..
- Treatment Options for Protease Inhibitor Exposed ChildrenLouise Kuhn; Fiscal Year: 2010....
- Pathogenesis Of Essential Tremor: Cerebellar MetabolismElan D Louis; Fiscal Year: 2010..Our tissue-based research will place us in unique a position to begin to address basic mechanistic questions about ET and may allow treating physicians to predict during life which subtype of ET a patient is likely to have. ..
- Oral Transmission of HIV through BreastfeedingLOUISE contact KUHN; Fiscal Year: 2010..We will evaluate the role of these factors in reducing oral transmission via breastfeeding, preventing mucosal viral shedding and delaying disease progression in infected breast-fed infants. ..
- Clinical Relevance of Transient Nevirapine ResistanceLouise Kuhn; Fiscal Year: 2007....
- ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMORElan Louis; Fiscal Year: 2007..Identification and understanding these toxicants is the first step in preventing a disease with only limited treatment options. ..
- ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMORElan Louis; Fiscal Year: 2003..In addition, we will evaluate the associations between manganese, organic solvents and ET using a lifetime Occupational History. ..
- HIV Protective Immunity and Perinatal ExposureLouise Kuhn; Fiscal Year: 2006..abstract_text> ..
- Treatment Options for Protease Inhibitor Exposed ChildrenLouise Kuhn; Fiscal Year: 2010....