Arnold R Kriegstein

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint GABA may act as a self-limiting trophic factor at developing synapses
    A R Kriegstein
    Department of Neurology and Department of Pathology and at the Center for Neurobiology and Behavior, Columbia College of Physicians and Surgeons, New York, NY, USA
    Sci STKE 2001:pe1. 2001
  2. ncbi request reprint Patterns of neuronal migration in the embryonic cortex
    Arnold R Kriegstein
    Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Trends Neurosci 27:392-9. 2004
  3. ncbi request reprint Radial glia diversity: a matter of cell fate
    Arnold R Kriegstein
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Glia 43:37-43. 2003
  4. pmc Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis
    Stephen C Noctor
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA
    J Comp Neurol 508:28-44. 2008
  5. ncbi request reprint Neurogenic radial glial cells in reptile, rodent and human: from mitosis to migration
    Tamily Weissman
    Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, 630 W 168th Street, New York, NY 10032, USA
    Cereb Cortex 13:550-9. 2003
  6. pmc Regulation of microtubule stability and organization by mammalian Par3 in specifying neuronal polarity
    She Chen
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Dev Cell 24:26-40. 2013
  7. pmc Progenitors from the postnatal forebrain subventricular zone differentiate into cerebellar-like interneurons and cerebellar-specific astrocytes upon transplantation
    Ana Milosevic
    GENSAT Project, The Rockefeller University, New York, NY 10065, USA
    Mol Cell Neurosci 39:324-34. 2008
  8. ncbi request reprint Constructing circuits: neurogenesis and migration in the developing neocortex
    Arnold R Kriegstein
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA
    Epilepsia 46:15-21. 2005
  9. ncbi request reprint Neural stem and progenitor cells in cortical development
    Stephen C Noctor
    Department of Neurology, UCSF School of Medicine, 513 Parnassus Avenue, San Francisco, CA 94143 0525, USA
    Novartis Found Symp 288:59-73; discussion 73-8, 96-8. 2007
  10. pmc Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex
    Ronald S Bultje
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Neuron 63:189-202. 2009

Collaborators

Detail Information

Publications34

  1. ncbi request reprint GABA may act as a self-limiting trophic factor at developing synapses
    A R Kriegstein
    Department of Neurology and Department of Pathology and at the Center for Neurobiology and Behavior, Columbia College of Physicians and Surgeons, New York, NY, USA
    Sci STKE 2001:pe1. 2001
    ..Kriegstein and Owens discuss how GABA-stimulated up-regulation of the expression of the potassium chloride cotransporter KCC2 may be the mechanism underlying this synaptic switch...
  2. ncbi request reprint Patterns of neuronal migration in the embryonic cortex
    Arnold R Kriegstein
    Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Trends Neurosci 27:392-9. 2004
    ..Integrating these findings with the molecular machinery underlying migration will provide a more complete picture of how the cerebral cortex is assembled...
  3. ncbi request reprint Radial glia diversity: a matter of cell fate
    Arnold R Kriegstein
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Glia 43:37-43. 2003
    ..These findings highlight the important but complex role of radial glia as participants in key steps of brain development...
  4. pmc Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis
    Stephen C Noctor
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA
    J Comp Neurol 508:28-44. 2008
    ..We propose a model for predicting daughter cell fate that considers precursor cell type, stage of development, and the planar segregation of fate determinants...
  5. ncbi request reprint Neurogenic radial glial cells in reptile, rodent and human: from mitosis to migration
    Tamily Weissman
    Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, 630 W 168th Street, New York, NY 10032, USA
    Cereb Cortex 13:550-9. 2003
    ..Although radial glial cells have traditionally been characterized by their role in guiding migration, their role as neuronal progenitors may represent their defining characteristic throughout the vertebrate CNS...
  6. pmc Regulation of microtubule stability and organization by mammalian Par3 in specifying neuronal polarity
    She Chen
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Dev Cell 24:26-40. 2013
    ..Together, these results demonstrate a role for mPar3 in directly regulating microtubule organization that is crucial for neuronal polarization...
  7. pmc Progenitors from the postnatal forebrain subventricular zone differentiate into cerebellar-like interneurons and cerebellar-specific astrocytes upon transplantation
    Ana Milosevic
    GENSAT Project, The Rockefeller University, New York, NY 10065, USA
    Mol Cell Neurosci 39:324-34. 2008
    ..Forebrain SVZ progenitors thus have the potential to adapt to a new environment and integrate into diverse regions, and may be a useful tool in transplantation strategies...
  8. ncbi request reprint Constructing circuits: neurogenesis and migration in the developing neocortex
    Arnold R Kriegstein
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA
    Epilepsia 46:15-21. 2005
    ..These new findings have increased our understanding of the mechanisms underlying certain developmental disorders and, in doing so, reveal potentially useful modes of therapeutic intervention...
  9. ncbi request reprint Neural stem and progenitor cells in cortical development
    Stephen C Noctor
    Department of Neurology, UCSF School of Medicine, 513 Parnassus Avenue, San Francisco, CA 94143 0525, USA
    Novartis Found Symp 288:59-73; discussion 73-8, 96-8. 2007
    ..In this model, a temporal sequence of gene expression changes in asymmetrically dividing self-renewed RG cells could lead to the differential inheritance of cell identity genes in cortical cells generated at different cell cycles...
  10. pmc Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex
    Ronald S Bultje
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Neuron 63:189-202. 2009
    ..These results reveal a critical molecular pathway underlying asymmetric cell division of radial glial progenitors in the mammalian neocortex...
  11. ncbi request reprint Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
    Stephen C Noctor
    Department of Neurology, Columbia University College of Physicians and Surgeons, 630 W 168th Street, New York, New York 10032, USA
    Nat Neurosci 7:136-44. 2004
    ..These findings provide a comprehensive and new view of the dynamics of cortical neurogenesis and migration...
  12. ncbi request reprint Calcium waves propagate through radial glial cells and modulate proliferation in the developing neocortex
    Tamily A Weissman
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuron 43:647-61. 2004
    ..Furthermore, we show that wave disruption decreases VZ proliferation during the peak of embryonic neurogenesis. Taken together, these results demonstrate a radial glial signaling mechanism that may regulate cortical neuronal production...
  13. pmc Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development
    Cory R Nicholas
    The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell Stem Cell 12:573-86. 2013
    ..MGE-derived cortical interneuron deficiencies are implicated in a broad range of neurodevelopmental and degenerative disorders, highlighting the importance of these results for modeling human neural development and disease...
  14. ncbi request reprint Contribution of intermediate progenitor cells to cortical histogenesis
    Stephen C Noctor
    Department of Neurology, Institute for Regeneration Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Arch Neurol 64:639-42. 2007
    ..These findings have refined our understanding of cortical neurogenesis, with implications for understanding the causes of neurodevelopmental disorders and for their potential treatment...
  15. pmc LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages
    Jin Wu Tsai
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Cell Biol 170:935-45. 2005
    ..Finally, axonal growth also ceased. These results identify multiple distinct and novel roles for LIS1 in nucleokinesis and process dynamics and suggest that nuclear position controls neural progenitor cell division...
  16. ncbi request reprint Neurons from radial glia: the consequences of asymmetric inheritance
    Gord Fishell
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 550 1st Avenue, New York, NY 10016, USA
    Curr Opin Neurobiol 13:34-41. 2003
    ..We suggest two models that make opposite predictions as to whether the radial glia or nascent neuron inherit the radial glial fiber or the majority of the Numb protein...
  17. ncbi request reprint Blind patch clamp recordings in embryonic and adult mammalian brain slices
    David R Castaneda-Castellanos
    Department of Physiology and Cellular Biophysics, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Nat Protoc 1:532-42. 2006
    ..Overall, it takes approximately 3-4 h to set up this procedure...
  18. ncbi request reprint Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia
    Stephen C Noctor
    Department of Neurology, Columbia College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 22:3161-73. 2002
    ....
  19. ncbi request reprint Increased excitability and decreased sensitivity to GABA in an animal model of dysplastic cortex
    Ethan A Benardete
    Department of Neurology and Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons and Department of Neurosurgery, NYU Medical Center, New York, New York 10032, USA
    Epilepsia 43:970-82. 2002
    ..The mechanism underlying seizures with cortical malformations is still poorly understood. To study the physiology of dysplastic cortex, we developed an experimental model of CD...
  20. pmc Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex
    Bridget E Lamonica
    Department of Neurology, University of California, San Francisco, 35 Medical Center Way, San Francisco, California 94143, USA
    Nat Commun 4:1665. 2013
    ..Our results suggest that altered regulation of mitotic spindle orientation increased outer radial glial cell number, and ultimately neuronal number, during human brain evolution...
  21. pmc Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells
    Jin Wu Tsai
    Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Nat Neurosci 13:1463-71. 2010
    ..These observations provide direct evidence that kinesins are involved in nuclear migration and neurogenesis and suggest that a cell cycle-dependent switch between distinct microtubule motors drives interkinetic nuclear migration...
  22. pmc Deriving excitatory neurons of the neocortex from pluripotent stem cells
    David V Hansen
    Department of Neurology, University of California, San Francisco, CA 94143, USA
    Neuron 70:645-60. 2011
    ..Finally, we discuss distinguishing features of human cortical development and their translational ramifications for cortical stem cell technologies...
  23. doi request reprint Commentary: the prospect of cell-based therapy for epilepsy
    Arnold R Kriegstein
    Department of Neurology, University of California, San Francisco, California 94143 0525, USA
    Neurotherapeutics 6:295-9. 2009
    ..Herein we summarize the current status and future perspectives of cell-based therapies in the treatment of epilepsy...
  24. ncbi request reprint Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors
    Lidija Ivic
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:49279-85. 2003
    ....
  25. pmc Gap junctions: multifaceted regulators of embryonic cortical development
    Laura A B Elias
    Neuroscience Graduate Program, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Trends Neurosci 31:243-50. 2008
    ..Gap junctions are thus emerging as multifaceted regulators of cortical development playing diverse roles in intercellular communication...
  26. ncbi request reprint The role of intermediate progenitor cells in the evolutionary expansion of the cerebral cortex
    Veronica Martinez-Cerdeno
    Department of Neurology and the Institute for Stem Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA
    Cereb Cortex 16:i152-61. 2006
    ..We propose that the evolution of this two-step pattern of neurogenesis played an important role in the amplification of cell numbers underlying the radial and tangential expansion of the cerebral cortex...
  27. ncbi request reprint GABA puts the brake on stem cells
    Arnold R Kriegstein
    Nat Neurosci 8:1132-3. 2005
  28. pmc A time and a place for nkx2-1 in interneuron specification and migration
    Laura A B Elias
    Institute for Regeneration Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuron 59:679-82. 2008
    ..demonstrate that postmitotic Nkx2-1 regulates migration and sorting of interneurons to the striatum or cortex by controlling the expression of the guidance receptor, Neuropilin-2...
  29. ncbi request reprint Is there more to GABA than synaptic inhibition?
    David F Owens
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, Building 36, Room 3C09, 36 Convent Drive, Bethesda, Maryland 20892 4092, USA
    Nat Rev Neurosci 3:715-27. 2002
    ..The unique features of the early-appearing GABA signalling systems might help to explain how GABA acts as a developmental signal...
  30. pmc GABA regulates excitatory synapse formation in the neocortex via NMDA receptor activation
    Doris D Wang
    Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 28:5547-58. 2008
    ..Our study identifies an essential role for GABA in the synaptic integration of newborn cortical neurons and suggests an activity-dependent mechanism for achieving the balance between excitation and inhibition in the developing cortex...
  31. ncbi request reprint Developmental neurotransmitters?
    David F Owens
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    Neuron 36:989-91. 2002
    ..Demarque et al. (in this issue of Neuron) now report that early release of transmitter is unconventional in not requiring action potentials, Ca(2+) entry, or vesicle fusion, thus potentially reconciling the discrepancy...
  32. ncbi request reprint Gap junction adhesion is necessary for radial migration in the neocortex
    Laura A B Elias
    Neuroscience Graduate Program, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Nature 448:901-7. 2007
    ....
  33. ncbi request reprint Controlling neuron number: does Numb do the math?
    David R Castaneda-Castellanos
    Nat Neurosci 7:793-4. 2004
  34. ncbi request reprint Estradiol stimulates progenitor cell division in the ventricular and subventricular zones of the embryonic neocortex
    Veronica Martinez-Cerdeno
    Department of Neurology and Program in Developmental and Stem Cell Biology, 513 Parnassus Avenue, HSW 1201, Box 0525, University of California San Francisco, San Francisco, California 94143, USA
    Eur J Neurosci 24:3475-88. 2006
    ..These findings demonstrate a new functional role for E2 as a proliferative agent during critical stages of cerebral cortex development...