Research Topics
Genomes and Genes | Arnold R KriegsteinSummaryAffiliation: Columbia University Country: USA Publications
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Publications
GABA may act as a self-limiting trophic factor at developing synapsesA R Kriegstein
Department of Neurology and Department of Pathology and at the Center for Neurobiology and Behavior, Columbia College of Physicians and Surgeons, New York, NY, USA
Sci STKE 2001:pe1. 2001..Kriegstein and Owens discuss how GABA-stimulated up-regulation of the expression of the potassium chloride cotransporter KCC2 may be the mechanism underlying this synaptic switch...- Patterns of neuronal migration in the embryonic cortexArnold R Kriegstein
Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
Trends Neurosci 27:392-9. 2004..Integrating these findings with the molecular machinery underlying migration will provide a more complete picture of how the cerebral cortex is assembled... - Radial glia diversity: a matter of cell fateArnold R Kriegstein
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Glia 43:37-43. 2003..These findings highlight the important but complex role of radial glia as participants in key steps of brain development... 
Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesisStephen C Noctor
Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA
J Comp Neurol 508:28-44. 2008..We propose a model for predicting daughter cell fate that considers precursor cell type, stage of development, and the planar segregation of fate determinants...- Neurogenic radial glial cells in reptile, rodent and human: from mitosis to migrationTamily Weissman
Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, 630 W. 168th Street, New York, NY 10032, USA
Cereb Cortex 13:550-9. 2003..Although radial glial cells have traditionally been characterized by their role in guiding migration, their role as neuronal progenitors may represent their defining characteristic throughout the vertebrate CNS... - Regulation of microtubule stability and organization by Mammalian par3 in specifying neuronal polarityShe Chen
Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA Electronic address
Dev Cell 24:26-40. 2013..Together, these results demonstrate a role for mPar3 in directly regulating microtubule organization that is crucial for neuronal polarization... - Progenitors from the postnatal forebrain subventricular zone differentiate into cerebellar-like interneurons and cerebellar-specific astrocytes upon transplantationAna Milosevic
GENSAT Project, The Rockefeller University, New York, NY 10065, USA
Mol Cell Neurosci 39:324-34. 2008..Forebrain SVZ progenitors thus have the potential to adapt to a new environment and integrate into diverse regions, and may be a useful tool in transplantation strategies... - Constructing circuits: neurogenesis and migration in the developing neocortexArnold R Kriegstein
Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA
Epilepsia 46:15-21. 2005..These new findings have increased our understanding of the mechanisms underlying certain developmental disorders and, in doing so, reveal potentially useful modes of therapeutic intervention... - Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortexRonald S Bultje
Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Neuron 63:189-202. 2009..These results reveal a critical molecular pathway underlying asymmetric cell division of radial glial progenitors in the mammalian neocortex... - Contribution of intermediate progenitor cells to cortical histogenesisStephen C Noctor
Department of Neurology, Institute for Regeneration Medicine, University of California San Francisco, San Francisco, California 94143, USA
Arch Neurol 64:639-42. 2007..These findings have refined our understanding of cortical neurogenesis, with implications for understanding the causes of neurodevelopmental disorders and for their potential treatment... - Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phasesStephen C Noctor
Department of Neurology, Columbia University College of Physicians and Surgeons, 630 W 168th Street, New York, New York 10032, USA
Nat Neurosci 7:136-44. 2004..These findings provide a comprehensive and new view of the dynamics of cortical neurogenesis and migration... - Calcium waves propagate through radial glial cells and modulate proliferation in the developing neocortexTamily A Weissman
Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
Neuron 43:647-61. 2004..Furthermore, we show that wave disruption decreases VZ proliferation during the peak of embryonic neurogenesis. Taken together, these results demonstrate a radial glial signaling mechanism that may regulate cortical neuronal production... - Neural stem and progenitor cells in cortical developmentStephen C Noctor
Department of Neurology, UCSF School of Medicine, 513 Parnassus Avenue, San Francisco, CA 94143 0525, USA
Novartis Found Symp 288:59-73; discussion 73-8, 96-8. 2007..In this model, a temporal sequence of gene expression changes in asymmetrically dividing self-renewed RG cells could lead to the differential inheritance of cell identity genes in cortical cells generated at different cell cycles... - Neurons from radial glia: the consequences of asymmetric inheritanceGord Fishell
Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 550 1st Avenue, New York, NY 10016, USA
Curr Opin Neurobiol 13:34-41. 2003..We suggest two models that make opposite predictions as to whether the radial glia or nascent neuron inherit the radial glial fiber or the majority of the Numb protein... - LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stagesJin Wu Tsai
Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Cell Biol 170:935-45. 2005..Finally, axonal growth also ceased. These results identify multiple distinct and novel roles for LIS1 in nucleokinesis and process dynamics and suggest that nuclear position controls neural progenitor cell division... - Blind patch clamp recordings in embryonic and adult mammalian brain slicesDavid R Castaneda-Castellanos
Department of Physiology and Cellular Biophysics, Columbia University, 630 West 168th Street, New York, New York 10032, USA
Nat Protoc 1:532-42. 2006..Overall, it takes approximately 3-4 h to set up this procedure... - Increased excitability and decreased sensitivity to GABA in an animal model of dysplastic cortexEthan A Benardete
Department of Neurology and Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons; and Department of Neurosurgery, NYU Medical Center, New York, New York 10032, USA
Epilepsia 43:970-82. 2002..Dysplastic cortex from this model demonstrates features of hyperexcitability and decreased neuronal sensitivity to GABA. Such physiologic alterations may underlie the increased epileptogenicity of dysplastic cortex... - Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial gliaStephen C Noctor
Department of Neurology, Columbia College of Physicians and Surgeons, New York, New York 10032, USA
J Neurosci 22:3161-73. 2002.... - Deriving excitatory neurons of the neocortex from pluripotent stem cellsDavid V Hansen
Department of Neurology, University of California, San Francisco, CA 94143, USA
Neuron 70:645-60. 2011..Finally, we discuss distinguishing features of human cortical development and their translational ramifications for cortical stem cell technologies... - Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cellsJin Wu Tsai
Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York, USA
Nat Neurosci 13:1463-71. 2010..These observations provide direct evidence that kinesins are involved in nuclear migration and neurogenesis and suggest that a cell cycle-dependent switch between distinct microtubule motors drives interkinetic nuclear migration... - Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptorsLidija Ivic
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Biol Chem 278:49279-85. 2003.... 
Commentary: the prospect of cell-based therapy for epilepsyArnold R Kriegstein
Department of Neurology, University of California, San Francisco, California 94143 0525, USA
Neurotherapeutics 6:295-9. 2009..Herein we summarize the current status and future perspectives of cell-based therapies in the treatment of epilepsy...- Gap junctions: multifaceted regulators of embryonic cortical developmentLaura A B Elias
Neuroscience Graduate Program, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Trends Neurosci 31:243-50. 2008..Gap junctions are thus emerging as multifaceted regulators of cortical development playing diverse roles in intercellular communication... - The role of intermediate progenitor cells in the evolutionary expansion of the cerebral cortexVeronica Martinez-Cerdeno
Department of Neurology and the Institute for Stem Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA
Cereb Cortex 16:i152-61. 2006..We propose that the evolution of this two-step pattern of neurogenesis played an important role in the amplification of cell numbers underlying the radial and tangential expansion of the cerebral cortex... - A time and a place for nkx2-1 in interneuron specification and migrationLaura A B Elias
Institute for Regeneration Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Neuron 59:679-82. 2008..demonstrate that postmitotic Nkx2-1 regulates migration and sorting of interneurons to the striatum or cortex by controlling the expression of the guidance receptor, Neuropilin-2... - Developmental neurotransmitters?David F Owens
Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
Neuron 36:989-91. 2002..Demarque et al. (in this issue of Neuron) now report that early release of transmitter is unconventional in not requiring action potentials, Ca(2+) entry, or vesicle fusion, thus potentially reconciling the discrepancy... - GABA regulates excitatory synapse formation in the neocortex via NMDA receptor activationDoris D Wang
Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, California 94143, USA
J Neurosci 28:5547-58. 2008..Our study identifies an essential role for GABA in the synaptic integration of newborn cortical neurons and suggests an activity-dependent mechanism for achieving the balance between excitation and inhibition in the developing cortex... - Is there more to GABA than synaptic inhibition?David F Owens
Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, Building 36, Room 3C09, 36 Convent Drive, Bethesda, Maryland 20892 4092, USA
Nat Rev Neurosci 3:715-27. 2002..The unique features of the early-appearing GABA signalling systems might help to explain how GABA acts as a developmental signal... - Gap junction adhesion is necessary for radial migration in the neocortexLaura A B Elias
Neuroscience Graduate Program, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA
Nature 448:901-7. 2007.... - Controlling neuron number: does Numb do the math?David R Castaneda-Castellanos
Nat Neurosci 7:793-4. 2004 - Estradiol stimulates progenitor cell division in the ventricular and subventricular zones of the embryonic neocortexVeronica Martinez-Cerdeno
Department of Neurology and Program in Developmental and Stem Cell Biology, 513 Parnassus Avenue, HSW 1201, Box 0525, University of California San Francisco, San Francisco, California 94143, USA
Eur J Neurosci 24:3475-88. 2006..These findings demonstrate a new functional role for E2 as a proliferative agent during critical stages of cerebral cortex development... - GABA puts the brake on stem cellsArnold R Kriegstein
Nat Neurosci 8:1132-3. 2005