Judith Korner

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Randomized double-blind placebo-controlled study of leptin administration after gastric bypass
    Judith Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Obesity (Silver Spring) 21:951-6. 2013
  2. ncbi request reprint Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY, and insulin
    Judith Korner
    Department of Medicine, Columbia University, College of Physicians and Surgeons, 650 West 168th Street, Black Building, Room 905, New York, New York 10032, USA
    J Clin Endocrinol Metab 90:359-65. 2005
  3. doi request reprint Implantable gastric stimulator does not prevent the increase in plasma ghrelin levels that occurs with weight loss
    Judith Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Obesity (Silver Spring) 19:1935-9. 2011
  4. pmc Exaggerated glucagon-like peptide-1 and blunted glucose-dependent insulinotropic peptide secretion are associated with Roux-en-Y gastric bypass but not adjustable gastric banding
    Judith Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Surg Obes Relat Dis 3:597-601. 2007
  5. ncbi request reprint Differential effects of gastric bypass and banding on circulating gut hormone and leptin levels
    Judith Korner
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Obesity (Silver Spring) 14:1553-61. 2006
  6. pmc Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass
    J Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Obes (Lond) 33:786-95. 2009
  7. ncbi request reprint Pharmacological approaches to weight reduction: therapeutic targets
    Judith Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Endocrinol Metab 89:2616-21. 2004
  8. ncbi request reprint Effects of agouti-related protein on metabolism and hypothalamic neuropeptide gene expression
    J Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Neuroendocrinol 15:1116-21. 2003
  9. pmc The emerging science of body weight regulation and its impact on obesity treatment
    Judith Korner
    Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 111:565-70. 2003
  10. ncbi request reprint Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus
    J Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Neuroendocrinol 13:959-66. 2001

Collaborators

Detail Information

Publications28

  1. pmc Randomized double-blind placebo-controlled study of leptin administration after gastric bypass
    Judith Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Obesity (Silver Spring) 21:951-6. 2013
    ..The main objective of this study was to determine whether leptin administration to post-RYGB patients would promote further weight reduction...
  2. ncbi request reprint Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY, and insulin
    Judith Korner
    Department of Medicine, Columbia University, College of Physicians and Surgeons, 650 West 168th Street, Black Building, Room 905, New York, New York 10032, USA
    J Clin Endocrinol Metab 90:359-65. 2005
    ....
  3. doi request reprint Implantable gastric stimulator does not prevent the increase in plasma ghrelin levels that occurs with weight loss
    Judith Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Obesity (Silver Spring) 19:1935-9. 2011
    ..Further studies are needed to determine whether changes in technology can improve weight loss and maintenance, perhaps using gut hormones as biomarkers of possible efficacy...
  4. pmc Exaggerated glucagon-like peptide-1 and blunted glucose-dependent insulinotropic peptide secretion are associated with Roux-en-Y gastric bypass but not adjustable gastric banding
    Judith Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Surg Obes Relat Dis 3:597-601. 2007
    ....
  5. ncbi request reprint Differential effects of gastric bypass and banding on circulating gut hormone and leptin levels
    Judith Korner
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Obesity (Silver Spring) 14:1553-61. 2006
    ..To quantify plasma concentrations of hormones that regulate energy homeostasis in order to establish possible mechanisms for greater weight loss after Roux-en-Y gastric bypass (RYGBP) compared with gastric banding (BND)...
  6. pmc Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass
    J Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Obes (Lond) 33:786-95. 2009
    ....
  7. ncbi request reprint Pharmacological approaches to weight reduction: therapeutic targets
    Judith Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Endocrinol Metab 89:2616-21. 2004
  8. ncbi request reprint Effects of agouti-related protein on metabolism and hypothalamic neuropeptide gene expression
    J Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Neuroendocrinol 15:1116-21. 2003
    ..Thus, central administration of AGRP exerts changes in hypothalamic neuropeptide gene expression and metabolic effects that are independent of the effects on food intake and body weight...
  9. pmc The emerging science of body weight regulation and its impact on obesity treatment
    Judith Korner
    Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 111:565-70. 2003
  10. ncbi request reprint Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus
    J Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Neuroendocrinol 13:959-66. 2001
    ..By contrast, the absence of a functional leptin receptor results in the upregulation of Npy but not Agrp mRNA...
  11. ncbi request reprint An update on the science and therapy of obesity and its relationship to osteoarthritis
    J Korner
    Columbia University, Division of Endocrinology, 630 West 168th Street, Black Building Room 905, New York, NY 10032, USA
    Curr Rheumatol Rep 3:101-6. 2001
    ..Improved understanding of obesity will hopefully lead to improved treatment and subsequent amelioration of this important risk factor for osteoarthritis...
  12. ncbi request reprint Effects of leptin receptor mutation on Agrp gene expression in fed and fasted lean and obese (LA/N-faf) rats
    J Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Endocrinology 141:2465-71. 2000
    ..These results suggest that, in the rat, the Agrp response to fasting may involve leptin-mediated phenomena, but factors in addition to leptin must also be involved in the regulation of Agrp gene expression...
  13. doi request reprint Regulation of energy homeostasis and health consequences in obesity
    Judith Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, and Weight Control Center, Columbia University Medical Center, New York, New York 10032, USA
    Am J Med 122:S12-8. 2009
    ....
  14. pmc Comparison of glucostatic parameters after hypocaloric diet or bariatric surgery and equivalent weight loss
    Leona Plum
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Obesity (Silver Spring) 19:2149-57. 2011
    ..In conclusion, RYGB produced greater improvement in Si and DI compared with diet at equivalent weight loss in T2DM subjects. Such a beneficial effect was not observed in nondiabetic subjects at this early time-point...
  15. pmc The utility of [(11)C] dihydrotetrabenazine positron emission tomography scanning in assessing beta-cell performance after sleeve gastrectomy and duodenal-jejunal bypass
    William B Inabnet
    Division of Metabolic, Endocrine and Minimally Invasive Surgery, Department of Surgery, Mount Sinai Medical Center, New York, NY 10029, USA
    Surgery 147:303-9. 2010
    ..The aim of this study was to evaluate the effect of sleeve gastrectomy (SG) and duodenal-jejunal bypass (DJB) on glucose homeostasis and to evaluate the utility of positron emission tomography (PET) scanning for assessing beta-cell mass...
  16. doi request reprint Partial small bowel resection with sleeve gastrectomy increases adiponectin levels and improves glucose homeostasis in obese rodents with type 2 diabetes
    Gift Kopsombut
    College of Physicians and Surgeons, Columbia University, New York, New York, USA
    World J Surg 36:1432-8. 2012
    ..The aim of this study was to examine the effect of small bowel resection with and without sleeve gastrectomy on glucose homeostasis in an obese rodent model of type 2 diabetes...
  17. pmc Very low-calorie diet mimics the early beneficial effect of Roux-en-Y gastric bypass on insulin sensitivity and β-cell Function in type 2 diabetic patients
    Clifton Jackness
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Diabetes 62:3027-32. 2013
    ..Likewise, changes in fasting glucose and fructosamine levels were similar. Based on these data, VLCD improves insulin sensitivity and β-cell function just as well as RYGB in the short term. ..
  18. pmc Hormonal responses and test meal intake among obese teenagers before and after laparoscopic adjustable gastric banding
    Robyn Sysko
    Columbia Center for Eating Disorders, Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY RS, MJD, JS, EZ, BTW the Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY RS, MJD, JS, EZ, BTW the Department of Medical and Clinical Psychology, Uniformed Services University of Health Sciences, Bethesda, MD MT K the Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD MT K and JAY the Department of Medicine, Columbia University, New York, NY JK and the Center for Adolescent Bariatric Surgery, Department of Surgery, Division of Pediatric Surgery, Columbia University Medical Center, New York, NY JLZ
    Am J Clin Nutr 98:1151-61. 2013
    ..Relatively little is known about changes in eating behavior or hormonal responses to food after bariatric surgery in adolescents...
  19. ncbi request reprint To eat or not to eat - how the gut talks to the brain
    Judith Korner
    College of Physicians and Surgeons, Columbia University, New York, USA
    N Engl J Med 349:926-8. 2003
  20. pmc Leptin administration does not prevent the bone mineral metabolism changes induced by weight loss
    Rushika Conroy
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Metabolism 60:1222-6. 2011
    ..These results suggest that both decreased bone formation and increased bone resorption underlie bone loss associated with weight loss. Leptin administration did not prevent the uncoupling of bone remodeling that accompanies weight loss...
  21. doi request reprint Hormone changes affecting energy homeostasis after metabolic surgery
    E John Harvey
    Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 77:446-65. 2010
    ..In the future, individualized metabolic surgery alone or modulated by targeted pharmacological therapy may achieve the most reliable and effective results with the highest safety and lowest side effect profile...
  22. doi request reprint Review of physiology, clinical manifestations, and management of hypothalamic obesity in humans
    Michelle Lee
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY, 10032, USA
    Pituitary 12:87-95. 2009
    ..Hypothalamic obesity confers significant morbidity and mortality, and there is a need for greater elucidation of its risk factors and pathogenesis so that more effective interventions can be developed...
  23. pmc Hypothalamic obesity in patients with craniopharyngioma: treatment approaches and the emerging role of gastric bypass surgery
    Gabrielle Page-Wilson
    Department of Medicine, Columbia University College of Physicians and Surgeons, William Black Medical Research Building, 650 West 168th Street, Room 905, New York, NY 10032, USA
    Pituitary 15:84-92. 2012
    ....
  24. pmc A rodent model of metabolic surgery for study of type 2 diabetes and positron emission tomography scanning of beta cell mass
    William B Inabnet
    Division of Gastrointestinal and Endocrine Surgery, Department of Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Surg Obes Relat Dis 5:212-7. 2009
    ..The aim of this study was to describe the operative technique, improvements in perioperative management, and the technique of micro-positron emission tomography (PET) scanning of the beta-cell mass in GK rodents...
  25. pmc Isolation and functional expression of a mammalian prohormone processing enzyme, murine prohormone convertase 1
    J Korner
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032
    Proc Natl Acad Sci U S A 88:6834-8. 1991
    ....
  26. pmc Prohormone processing in Xenopus oocytes: characterization of cleavage signals and cleavage enzymes
    J Korner
    Department of Biochemistry and Biophysics, Columbia University, New York, NY 10032
    Proc Natl Acad Sci U S A 88:11393-7. 1991
    ..Mutations that generate this sequence in the alpha-factor prohormone also result in efficient processing within oocytes. Cleavage at this consensus sequence may be due to the action of the Xenopus homologues of mammalian furin...
  27. ncbi request reprint Gastric distention activates satiety circuitry in the human brain
    Gene Jack Wang
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 39:1824-31. 2008
    ..These findings provide evidence that the left amygdala and insula process interoceptive signals of fullness produced by gastric distention involved in the controls of food intake...
  28. ncbi request reprint Treatment with cabergoline is associated with weight loss in patients with hyperprolactinemia
    Judith Korner
    Obes Res 11:311-2. 2003

Research Grants9

  1. Leptin and Neuroendocrine Gene Regulation in Obesity
    Judith Korner; Fiscal Year: 2005
    ..Leibel and Dr. Wardlaw, are experienced in basic and clinical research. They are easily accessible, enthusiastic about my projects, and will facilitate my transition to status as an independent investigator. ..
  2. Leptin and Neuroendocrine Gene Regulation in Obesity
    Judith Korner; Fiscal Year: 2005
    ..abstract_text> ..
  3. Bariatric Surgery, Gastric Stimulation: Metabolic Effects
    Judith Korner; Fiscal Year: 2009
    ..The ultimate goal is to use information from these studies for the development of obesity treatments that are less invasive than bariatric surgery and more effective than current pharmacotherapy. ..
  4. Bariatric Surgery, Gastric Stimulation: Metabolic Effects
    Judith Korner; Fiscal Year: 2010
    ..The ultimate goal is to use information from these studies for the development of obesity treatments that are less invasive than bariatric surgery and more effective than current pharmacotherapy. ..