E Konofagou

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Real-time, transcranial monitoring of safe blood-brain barrier opening in non-human primates
    Fabrice Marquet
    Departments of Biomedical Engineering, Columbia University, New York, New York, United States of America
    PLoS ONE 9:e84310. 2014
  2. pmc Noninvasive, transient and selective blood-brain barrier opening in non-human primates in vivo
    Fabrice Marquet
    Department of Biomedical Engineering, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e22598. 2011
  3. pmc Optimization of the ultrasound-induced blood-brain barrier opening
    Elisa E Konofagou
    Department of Biomedical Engineering, Columbia University, New York, NY, USA
    Theranostics 2:1223-37. 2012
  4. pmc Ultrasound-induced blood-brain barrier opening
    Elisa E Konofagou
    Department of Radiology, Columbia University, New York, NY, USA
    Curr Pharm Biotechnol 13:1332-45. 2012
  5. pmc Electromechanical wave imaging for noninvasive mapping of the 3D electrical activation sequence in canines and humans in vivo
    Elisa E Konofagou
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Biomech 45:856-64. 2012
  6. pmc Dynamic morphometric characterization of local connective tissue network structure in humans using ultrasound
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, VT, USA
    BMC Syst Biol 1:25. 2007
  7. pmc Reduced thoracolumbar fascia shear strain in human chronic low back pain
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington VT, USA
    BMC Musculoskelet Disord 12:203. 2011
  8. ncbi request reprint Using ultrasound to understand acupuncture. Acupuncture needle manipulation and its effect on connective tissue
    Elisa E Konofagou
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    IEEE Eng Med Biol Mag 24:41-6. 2005
  9. ncbi request reprint A theoretical performance assessment tool for myocardial elastography
    E Konofagou
    Associate Member, IEEE, Departments of Biomedical Engineering and Radiology of Columbia University, New York, NY 10032, USA 212 342 0863 fax 212 342 5773 e mail
    Conf Proc IEEE Eng Med Biol Soc 1:985-8. 2005
  10. ncbi request reprint Estimating localized oscillatory tissue motion for assessment of the underlying mechanical modulus
    E E Konofagou
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Ultrasonics 42:951-6. 2004

Collaborators

Detail Information

Publications54

  1. pmc Real-time, transcranial monitoring of safe blood-brain barrier opening in non-human primates
    Fabrice Marquet
    Departments of Biomedical Engineering, Columbia University, New York, New York, United States of America
    PLoS ONE 9:e84310. 2014
    ..This establishes the method and the system as a potentially highly useful tool for brain drug delivery...
  2. pmc Noninvasive, transient and selective blood-brain barrier opening in non-human primates in vivo
    Fabrice Marquet
    Department of Biomedical Engineering, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e22598. 2011
    ..Sonications were combined with two different types of microbubbles (customized 4-5 µm and Definity®). 3T MRI was used to confirm the BBB disruption and to assess brain damage...
  3. pmc Optimization of the ultrasound-induced blood-brain barrier opening
    Elisa E Konofagou
    Department of Biomedical Engineering, Columbia University, New York, NY, USA
    Theranostics 2:1223-37. 2012
    ..All these challenges will be discussed, findings in both small (mice) and large (non-human primates) animals are shown and finally the clinical potential for this technique is shown...
  4. pmc Ultrasound-induced blood-brain barrier opening
    Elisa E Konofagou
    Department of Radiology, Columbia University, New York, NY, USA
    Curr Pharm Biotechnol 13:1332-45. 2012
    ..It is hereby shown that the BBB can be disrupted safely and transiently under specific acoustic pressures (under 0.45 MPa) and microbubble (diameter under 8 μm) conditions...
  5. pmc Electromechanical wave imaging for noninvasive mapping of the 3D electrical activation sequence in canines and humans in vivo
    Elisa E Konofagou
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Biomech 45:856-64. 2012
    ....
  6. pmc Dynamic morphometric characterization of local connective tissue network structure in humans using ultrasound
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, VT, USA
    BMC Syst Biol 1:25. 2007
    ..In ten additional non-surgical subjects, we quantified changes in tissue spatial organization over time during needle rotation vs. no rotation using ultrasound and semi-variogram analyses...
  7. pmc Reduced thoracolumbar fascia shear strain in human chronic low back pain
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington VT, USA
    BMC Musculoskelet Disord 12:203. 2011
    ..The goal of this study was to quantify shear plane motion within the thoracolumbar fascia using ultrasound elasticity imaging in human subjects with and without chronic low back pain (LBP)...
  8. ncbi request reprint Using ultrasound to understand acupuncture. Acupuncture needle manipulation and its effect on connective tissue
    Elisa E Konofagou
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    IEEE Eng Med Biol Mag 24:41-6. 2005
  9. ncbi request reprint A theoretical performance assessment tool for myocardial elastography
    E Konofagou
    Associate Member, IEEE, Departments of Biomedical Engineering and Radiology of Columbia University, New York, NY 10032, USA 212 342 0863 fax 212 342 5773 e mail
    Conf Proc IEEE Eng Med Biol Soc 1:985-8. 2005
    ..Preliminary in vivo results of a standard short-axis view in a canine myocardium are shown validating the performance assessment using the proposed model...
  10. ncbi request reprint Estimating localized oscillatory tissue motion for assessment of the underlying mechanical modulus
    E E Konofagou
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Ultrasonics 42:951-6. 2004
    ....
  11. ncbi request reprint Quo vadis elasticity imaging?
    E E Konofagou
    Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, 351 Engineering Terrace, Mail Code 8, New York, NY 10027, USA
    Ultrasonics 42:331-6. 2004
    ..As a result, elasticity imaging with its ever increasing number of applications and demonstrated applicability in a typical, clinical ultrasound setting promises to make an important contribution to the ultrasound practice as we know it...
  12. ncbi request reprint Physiologic cardiovascular strain and intrinsic wave imaging
    Elisa Konofagou
    Ultrasound and Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10023, USA
    Annu Rev Biomed Eng 13:477-505. 2011
    ..This would improve care and outcomes as well as detect stiffness changes and overcome the current global measurement limitations in the progression of vascular disease, at little more cost or risk than that of a clinical ultrasound...
  13. pmc Noninvasive electromechanical wave imaging and conduction-relevant velocity estimation in vivo
    Elisa E Konofagou
    Department of Biomedical Engineering, Columbia University, New York, NY, USA
    Ultrasonics 50:208-15. 2010
    ..Such a technology can be extended to 3D mapping and/or used for early detection of dyssynchrony, arrhythmias, left-bundle branch block, or other conduction abnormalities as well as diagnosis and treatment thereof...
  14. ncbi request reprint Imaging the mechanics and electromechanics of the heart
    Elisa E Konofagou
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Conf Proc IEEE Eng Med Biol Soc . 2006
    ..Ongoing investigations entail assessment of myocardial elastography in characterizing and quantifying ischemia and infarction in vivo...
  15. ncbi request reprint Elastographic Imaging of the Strain Distribution at the Anterior Cruciate Ligament and ACL-Bone Insertions
    E Konofagou
    Associate Member, IEEE, Departments of Biomedical Engineering and Radiology of Columbia University, New York, NY 10032, USA 212 342 0863 fax 212 342 5773 e mail
    Conf Proc IEEE Eng Med Biol Soc 1:972-5. 2005
    ..Compressive strains were observed in the ligament proper when the transducer beam was aligned with respect to the insertion during loading...
  16. ncbi request reprint Elastographic imaging of the normal canine prostate in vitro
    F Kallel
    Department of Radiology, University of Texas Medical School, Houston 77030, USA
    Ultrason Imaging 21:201-15. 1999
    ..In the sagittal view, the elastogram suggested a stiff peripheral zone surrounding a softer central zone, which is traversed by the urethra depicted as soft tissue...
  17. ncbi request reprint Tradeoffs in elastographic imaging
    T Varghese
    The University of Texas Medical School, Department of Radiology, Houston 77030, USA
    Ultrason Imaging 23:216-48. 2001
    ..Finite-element simulations are used to generate examples of elastograms that are confirmed by the theoretical prediction tools...
  18. ncbi request reprint Elastography: ultrasonic estimation and imaging of the elastic properties of tissues
    J Ophir
    Department of Radiology, University of Texas Medical School, Houston 77030, USA
    Proc Inst Mech Eng H 213:203-33. 1999
    ..After discussing some main classes of elastographic artefacts, the paper concludes with recent results of tissue elastography in vitro and in vivo...
  19. ncbi request reprint Theoretical quality assessment of myocardial elastography with in vivo validation
    Wei Ning Lee
    Department of Biomedical Engineering, Columbia University, New York, NY, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 54:2233-45. 2007
    ..In a preliminary study, the 2-D myocardial elastography was shown capable of imaging myocardial deformation comparable to equivalent tMRI estimates in a clinical setting...
  20. ncbi request reprint ECG-gated, mechanical and electromechanical wave imaging of cardiovascular tissues in vivo
    Mathieu Pernot
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Ultrasound Med Biol 33:1075-85. 2007
    ..This method could potentially be used for mapping the stiffness of the myocardium and the artery walls and may lead to the early diagnosis of cardiovascular diseases...
  21. ncbi request reprint A focused ultrasound method for simultaneous diagnostic and therapeutic applications--a simulation study
    E Konofagou
    Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    Phys Med Biol 46:2967-84. 2001
    ..This study showed that relatively higher frequencies constitute the optimal range in the use of USAE for coagulation monitoring. A preliminary experimental verification in vitro is also provided...
  22. pmc Preliminary validation of angle-independent myocardial elastography using MR tagging in a clinical setting
    Wei Ning Lee
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Ultrasound Med Biol 34:1980-97. 2008
    ..The principal strains were concluded to be a potential diagnostic measure for detection of cardiac disease with reduced centroid dependence...
  23. ncbi request reprint Detection of murine infarcts using myocardial elastography at both high temporal and spatial resolution
    Jianwen Luo
    Department of Biomedical Engineering, Columbia University, New York, NY 10025, USA
    Conf Proc IEEE Eng Med Biol Soc 1:1552-5. 2006
    ....
  24. ncbi request reprint An all-ultrasound-based system for real-time monitoring and sonication of temperature change and ablation
    Caroline Maleke
    Dept of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Conf Proc IEEE Eng Med Biol Soc 1:164-7. 2006
    ....
  25. ncbi request reprint In vivo feasibility of real-time monitoring of focused ultrasound surgery (FUS) using harmonic motion imaging (HMI)
    Caroline Maleke
    Department of Biomedical Engineering, ColumbiaUniversity, New York, NY 10027, USA
    IEEE Trans Biomed Eng 57:7-11. 2010
    ..The HMIFU system may, therefore, constitute a cost-efficient and reliable alternative for real-time monitoring of thermal ablation...
  26. ncbi request reprint Challenges in atherosclerotic plaque characterization with intravascular ultrasound (IVUS): from data collection to classification
    Amin Katouzian
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    IEEE Trans Inf Technol Biomed 12:315-27. 2008
    ....
  27. pmc Angle-independent and multi-dimensional myocardial elastography--from theory to clinical validation
    Wei Ning Lee
    Ultrasound and Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Ultrasonics 48:563-7. 2008
    ....
  28. ncbi request reprint Simulation study of amplitude-modulated (AM) harmonic motion imaging (HMI) for stiffness contrast quantification with experimental validation
    Caroline Maleke
    Departments of Biomedical Engineering, 351 Engineering Terrace, Mail Code 8904, 1210 Amsterdam Avenue, New York, NY 10027, USA
    Ultrason Imaging 32:154-76. 2010
    ..HMI may thus constitute a promising technique in tumor detection (>3 mm in diameter) and mapping based on its distinct stiffness...
  29. ncbi request reprint Myocardial elastography at both high temporal and spatial resolution for the detection of infarcts
    Jianwen Luo
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Ultrasound Med Biol 33:1206-23. 2007
    ..05 microm displacement). This technique was thus capable of accurately characterizing normal myocardial function throughout an entire cardiac cycle, at the same high resolution, and detecting and localizing myocardial infarction in vivo...
  30. doi request reprint A composite high-frame-rate system for clinical cardiovascular imaging
    Shougang Wang
    Department of Biomedical Engineering, Columbia University, NY, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 55:2221-33. 2008
    ....
  31. ncbi request reprint Autocorrelation-based technique for automated segmentation of endocardial border in 3D echocardiograms
    Louis S Morda
    Ultrasound and Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY10032, USA
    Ultrason Imaging 28:159-78. 2006
    ..2%-6%. Thus, the new technique constitutes a robust segmentation method for automated segmentation of endocardial borders and is suitable for wall motion tracking for automated detection of ischemia in vivo...
  32. ncbi request reprint Fundamental performance assessment of 2-D myocardial elastography in a phased-array configuration
    Jianwen Luo
    Dept of Biomed Eng, Columbia Univ, New York, NY, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 56:2320-7. 2009
    ..The proposed framework can further be used to assess the estimation quality, explore the theoretical limitation and investigate the effects of various parameters in 2-D myocardial elastography under more realistic conditions...
  33. pmc Electromechanical wave imaging of normal and ischemic hearts in vivo
    Jean Provost
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    IEEE Trans Med Imaging 29:625-35. 2010
    ..Those results indicate that EWI could be used to assess the conduction properties of the myocardium, and detect its ischemic onset and disease progression entirely noninvasively...
  34. doi request reprint Pulse wave imaging of normal and aneurysmal abdominal aortas in vivo
    Jianwen Luo
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    IEEE Trans Med Imaging 28:477-86. 2009
    ..This novel technique may thus constitute an early detection tool of vascular degeneration as well as serve as a suitable predictor of AAA rupture, complementary to the current clinical screening practice...
  35. ncbi request reprint Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice
    James J Choi
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Ultrasound Med Biol 33:95-104. 2007
    ....
  36. doi request reprint Quantitative viscoelastic parameters measured by harmonic motion imaging
    Jonathan Vappou
    Biomedical Engineering Department, Columbia University, New York, NY, USA
    Phys Med Biol 54:3579-94. 2009
    ....
  37. ncbi request reprint Single-element focused ultrasound transducer method for harmonic motion imaging
    Caroline Maleke
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Ultrason Imaging 28:144-58. 2006
    ..The new HMI method may thus enable a highly-localized force and stiffness-dependent measurements as well as real-time and low-cost HIFU monitoring...
  38. ncbi request reprint A novel noninvasive technique for pulse-wave imaging and characterization of clinically-significant vascular mechanical properties in vivo
    Kana Fujikura
    Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, New York, NY 10027, USA
    Ultrason Imaging 29:137-54. 2007
    ..In future clinical applications, it may contribute to the detection of early stages of cardiovascular disease, which may decrease mortality among high-risk patients...
  39. ncbi request reprint High-resolution ultrasound elastography of articular cartilage in vitro
    Daniel T Ginat
    Department of Biomedical Engineering, Columbia University, New York, NY, USA
    Conf Proc IEEE Eng Med Biol Soc . 2006
    ..Despite the complex boundary conditions, the feasibility of imaging strain within the cartilage during a sustained compression using elastographic techniques was demonstrated...
  40. ncbi request reprint Elastographic imaging of strain distribution in the anterior cruciate ligament and at the ligament-bone insertions
    Jeffrey P Spalazzi
    Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, and St Luke s Roosevelt Hospital Center, Department of Orthopaedic Surgery, New York, New York 10027, USA
    J Orthop Res 24:2001-10. 2006
    ..Our results indicate that elastography is a novel method that can be readily used to characterize the mechanical properties of the ACL and its insertions into bone...
  41. pmc Identifying the inertial cavitation threshold and skull effects in a vessel phantom using focused ultrasound and microbubbles
    Yao Sheng Tung
    Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    Ultrasound Med Biol 36:840-52. 2010
    ..The broadband response could be captured through the murine skull, so the same PCD set-up can be used in future in vivo applications...
  42. pmc Pulse wave imaging for noninvasive and quantitative measurement of arterial stiffness in vivo
    Jonathan Vappou
    Ultrasound and Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USA
    Am J Hypertens 23:393-8. 2010
    ..In this article, the novel ultrasound-based pulse wave imaging (PWI) method is hereby proposed for visualization of the pulse wave during its propagation and for calculation of the PWV...
  43. pmc Molecules of various pharmacologically-relevant sizes can cross the ultrasound-induced blood-brain barrier opening in vivo
    James J Choi
    Department of Biomedical Engineering, Columbia University, New York, NY, USA
    Ultrasound Med Biol 36:58-67. 2010
    ..E-mail: ek2191@columbia.edu)...
  44. pmc Microbubble-size dependence of focused ultrasound-induced blood-brain barrier opening in mice in vivo
    James J Choi
    Department of Biomedical Engineering, Columbia University, NewYork, NY10027, USA
    IEEE Trans Biomed Eng 57:145-54. 2010
    ..In conclusion, it was determined that the FUS-induced BBB opening was dependent on both the size distribution in the injected microbubble volume and the brain region targeted...
  45. pmc Effects of various parameters on lateral displacement estimation in ultrasound elastography
    Jianwen Luo
    Ultrasound and Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Ultrasound Med Biol 35:1352-66. 2009
    ..In conclusion, smaller pitch, wider beamwidth and spline interpolation were shown to be key in reducing the jitter error in the lateral displacement estimation...
  46. pmc Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimer's double transgenic mice using focused ultrasound
    James J Choi
    Department Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Ultrason Imaging 30:189-200. 2008
    ..In conclusion, a BBB-impermeable molecule was noninvasively, transiently and reproducibly delivered to the hippocampus of Alzheimer's APP/PS1 mice...
  47. ncbi request reprint Tissue displacements during acupuncture using ultrasound elastography techniques
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, VT, USA
    Ultrasound Med Biol 30:1173-83. 2004
    ..In addition to being a valuable tool for studies of acupuncture's mechanism of action, this technique may have applications to other types of needling including biopsies...
  48. ncbi request reprint Localized harmonic motion imaging: theory, simulations and experiments
    Elisa E Konofagou
    Department of Radiology MRI research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ultrasound Med Biol 29:1405-13. 2003
    ..Due to the highly localized and harmonic nature of the estimated response, this technique may be proven to be highly suitable for simple and accurate estimation of the elastic modulus variation in tissues due to disease...
  49. ncbi request reprint Estimation of material elastic moduli in elastography: a local method, and an investigation of Poisson's ratio sensitivity
    Timothy P Harrigan
    Exponent Failure Analysis Associates, 21 Strathmore Road, Natick, MA 10760, USA
    J Biomech 37:1215-21. 2004
    ....
  50. doi request reprint High-frame rate, full-view myocardial elastography with automated contour tracking in murine left ventricles in vivo
    Jianwen Luo
    IEEE Trans Ultrason Ferroelectr Freq Control 55:240-8. 2008
    ....
  51. ncbi request reprint Ultrasound myocardial elastography and registered 3D tagged MRI: quantitative strain comparison
    Zhen Qian
    Center for Computational Biomedicine Imaging and Modeling CBIM, Rutgers University, New Brunswick, NJ, USA
    Med Image Comput Comput Assist Interv 10:800-8. 2007
    ..From the experimental results, we conclude that qualitatively the two modalities share similar overall trends. But error and variations in UME accumulate over time. Quantitatively tMRI is more robust and accurate than UME...
  52. doi request reprint A mechanical model to compute elastic modulus of tissues for harmonic motion imaging
    Baoxiang Shan
    Mechanical and Aerospace Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, USA
    J Biomech 41:2150-8. 2008
    ..The computational scheme is also implemented to estimate 3D elastic modulus of bovine liver in vitro...
  53. ncbi request reprint Myocardial elastography--a feasibility study in vivo
    Elisa E Konofagou
    Focused Ultrasound Laboratory, Department of Radiology MRI research, Brigham and Women s Hospital, Harvard Medical School, LMRC 013, 221 Longwood Avenue, Boston, MA 02115, USA
    Ultrasound Med Biol 28:475-82. 2002
    ..Future prospects include assessment of the role of elastography in detection of ischemia and infarction...
  54. ncbi request reprint The temperature dependence of ultrasound-stimulated acoustic emission
    Elisa E Konofagou
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ultrasound Med Biol 28:331-8. 2002
    ..These results indicate that USAE may have important promise as a potential method for localizing temperature elevation and, thus, thermal surgery monitoring, as well as detection of irreversible changes in tissues...

Research Grants11

  1. EARLY DETECTION AND MAPPING OF ISCHEMIA USING MYOCARDIAL ELASTOGRAPHY
    Elisa Konofagou; Fiscal Year: 2006
    ....
  2. EARLY DETECTION AND MAPPING OF ISCHEMIA USING MYOCARDIAL ELASTOGRAPHY
    Elisa E Konofagou; Fiscal Year: 2010
    ..4 million Americans who die each year. Myocardial elastography is a unique technique that may be capable of mapping both the mechanical and electrical properties of the myocardium for early detection of disease. ..
  3. Noninvasive qualitative and quantitative assessment of vascular disease in vivo
    Elisa E Konofagou; Fiscal Year: 2010
    ..We propose a novel technique Pulse Wave Imaging (PWI) for direct estimation of vascular stiffness to follow disease progression and predict propensity for rupture. ..
  4. Optimization of ultrasound-facilitated blood-brain barrier opening
    Elisa Konofagou; Fiscal Year: 2009
    ..The objective of this study is to elucidate the interactions between ultrasound, microbubbles and the local microenvironment during BBB opening with FUS. ..
  5. ULTRASOUND-INDUCED DRUG DELIVERY THROUGH THE BLOOD-BRAIN BARRIER
    Elisa Konofagou; Fiscal Year: 2007
    ....
  6. EARLY DETECTION AND MAPPING OF ISCHEMIA USING MYOCARDIAL ELASTOGRAPHY
    Elisa Konofagou; Fiscal Year: 2007
    ....
  7. Optimization of ultrasound-facilitated blood-brain barrier opening
    Elisa E Konofagou; Fiscal Year: 2010
    ..The objective of this study is to elucidate the interactions between ultrasound, microbubbles and the local microenvironment during BBB opening with FUS. ..