Alexander D Klose
Affiliation: Columbia University
- Fluorescence tomography with simulated data based on the equation of radiative transferAlexander D Klose
Department of Biomedical Engineering and Radiology, Columbia University, ET351 Mudd Building, MC 8904, 500 West 120th Street, New York, New York 10027, USA
Opt Lett 28:1019-21. 2003..We obtain images of either the quantum yield or the fluorophore absorption...
- In vivo bioluminescence tomography with a blocking-off finite-difference SP3 method and MRI/CT coregistrationAlexander D Klose
Columbia University, New York, New York 10027, USA
Med Phys 37:329-38. 2010..Therefore, the authors have developed a linear image reconstruction method for bioluminescence tomography (BLT) that recovers the three-dimensional spatial bioluminescent source distribution in small animals...
- Bioluminescence tomography with CT/MRI co-registrationA D Klose
Department of Radiology at Columbia University, New York, NY 10027, USA
Conf Proc IEEE Eng Med Biol Soc 2009:6327-30. 2009..We present in vivo bioluminescence reconstruction results that demonstrate the performance of our co-registration method...
- Hyperspectral excitation-resolved fluorescence tomography of quantum dotsAlexander D Klose
Department of Radiology, Columbia University, ET351 Mudd Building, MC 8904, 500 West 120th Street, New York, New York 10027, USA
Opt Lett 34:2477-9. 2009..Numerical results suggest that current planar surface imaging technology could easily be retrofitted for performing fluorescence tomography without the use of elaborate source-detector multiplexing...
- Excitation-resolved fluorescence tomography with simplified spherical harmonics equationsAlexander D Klose
Department of Radiology, Columbia University Medical Center, New York, NY 10032, USA
Phys Med Biol 56:1443-69. 2011....
- Transport-theory-based stochastic image reconstruction of bioluminescent sourcesAlexander D Klose
Department of Radiology, Columbia University, New York, NY 10027, USA
J Opt Soc Am A Opt Image Sci Vis 24:1601-8. 2007..Numerical experiments demonstrate the feasibility of reconstructing bioluminescent source distributions in tissuelike media...
- Registration of planar bioluminescence to magnetic resonance and x-ray computed tomography images as a platform for the development of bioluminescence tomography reconstruction algorithmsBradley J Beattie
Memorial Sloan Kettering Cancer Center, Department of Neurology, 1275 York Avenue, New York, New York 10065, USA
J Biomed Opt 14:024045. 2009..36+/-0.23 mm. Additional experiments highlight some of the confounds that are often overlooked in the BLT reconstruction process, and for two of these confounds, simple corrections are proposed...
- Multiparameter classifications of optical tomographic imagesChristian D Klose
Columbia University, Department of Biomedical Engineering, New York, New York 10027, USA
J Biomed Opt 13:050503. 2008..54, and an area under the curve (AUC) of 0.72. These values are higher than for previously reported single parameter classifications with a best sensitivity and specificity of 0.71, a Youden index of 0.41, and an AUC of 0.66...
- Computer-aided interpretation approach for optical tomographic imagesChristian D Klose
Columbia University, Department of Biomedical Engineering, New York, NY 10027, USA
J Biomed Opt 15:066020. 2010..9 can be achieved. These values are much higher than values obtained when only single parameter classifications were used, where sensitivities and specificities remained well below 0.8...
- Sagittal laser optical tomography for imaging of rheumatoid finger jointsAndreas H Hielscher
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Phys Med Biol 49:1147-63. 2004..We have used this system to obtain tomographic images of six proximal interphalangeal finger joints from two patients with rheumatoid arthritis. The optical images were compared to clinical symptoms and ultrasound images...
- Comparison of two and three-dimensional optical tomographic image reconstructions of human finger jointsRong Song
Depts of Biomedical Engineering and Radiology at Columbia University, New York, NY 10027 USA
Conf Proc IEEE Eng Med Biol Soc . 2006..In particular we examined how these different approaches affect the discrimination between healthy and RA joints...