Research Topics
| HERBERT DAVID KLEBERSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
The best should not be the enemy of the goodHerbert D Kleber
Division on Substance Abuse, Columbia University, 1051 Riverside Drive, Unit 66, New York, NY 10032, USA
Addiction 97:660-1; discussion 664. 2002
Pharmacologic treatments for opioid dependence: detoxification and maintenance optionsHerbert D Kleber
Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Dialogues Clin Neurosci 9:455-70. 2007..Those with strong external motivation may do well on the antagonist naltrexone. Currently, optimum duration of maintenance on either is unclear. Better agents are needed to impact the brain changes related to addiction...- Pharmacologic treatments for heroin and cocaine dependenceHerbert D Kleber
Division on Substance Abuse, Columbia University, New York, NY 10032, USA
Am J Addict 12:S5-S18. 2003..In this paper, we discuss the use of medication in the context of general principles of opioid and cocaine addiction treatment. Both established medications and promising directions in pharmacotherapy will be addressed... - Changing the battle planHerbert D Kleber
Division of Substance Abuse, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
J Trauma 59:S33-6. 2005 - Dopamine D1 receptors in cocaine dependence measured with PET and the choice to self-administer cocaineDiana Martinez
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Neuropsychopharmacology 34:1774-82. 2009.... - Use of dronabinol for cannabis dependence: two case reports and reviewFrances R Levin
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
Am J Addict 17:161-4. 2008..The potential benefit, as well as questions that arise from the use of this medication in cannabis-abusing populations, is presented. Also, future areas of research that might be explored are discussed... 
Dextromethorphan and quinidine combination for heroin detoxificationEvaristo Akerele
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
Am J Addict 17:176-80. 2008..Future studies should examine dextromethorphan as an adjunct to other anti-withdrawal medications and focus more on the relationship between dextrorphan levels and withdrawal suppression...- Depot naltrexone: long-lasting antagonism of the effects of heroin in humansSandra D Comer
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
Psychopharmacology (Berl) 159:351-60. 2002..However, naltrexone is generally not well accepted by patients, and medication non-compliance is a difficult obstacle to treatment. A sustained-release form of naltrexone may improve compliance... - Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletionDiana Martinez
Department of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, USA
Am J Psychiatry 166:1170-7. 2009..The purpose of this study was to measure D(2)/D(3) receptors following acute dopamine depletion in cocaine-dependent volunteers relative to healthy comparison subjects... - Dopamine type 2/3 receptor availability in the striatum and social status in human volunteersDiana Martinez
Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, USA
Biol Psychiatry 67:275-8. 2010..The goal of the present study was to examine this phenomena in human subjects using PET and the radiotracer [(11)C]raclopride... - Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaineDiana Martinez
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Am J Psychiatry 164:622-9. 2007..Furthermore, the relationship between this dopamine response and the choice to self-administer cocaine in a laboratory model of relapse was investigated... - Evaluation of a combined online and in person training in the use of buprenorphineErik W Gunderson
Columbia University College of Physicians and Surgeon and New York State Psychiatric Institute, New York, NY, USA
Subst Abus 27:39-45. 2006..Overall, physicians preferred in person instruction and may benefit from additional experiential training and support after curriculum participation... - Behavioral therapy to augment oral naltrexone for opioid dependence: a ceiling on effectiveness?Edward V Nunes
New York State Psychiatric Institute, Division on Substance Abuse, New York, New York 10032, USA
Am J Drug Alcohol Abuse 32:503-17. 2006..Future research should consider combinations of behavioral methods with new long-acting injectable or implantable naltrexone formulations... - Predictors of retention in naltrexone maintenance for opioid dependence: analysis of a stage I trialMaria A Sullivan
Department of Psychiatry, New York State Psychiatric Institute, New York, NY, USA
Am J Addict 15:150-9. 2006.... - Injectable, sustained-release naltrexone for the treatment of opioid dependence: a randomized, placebo-controlled trialSandra D Comer
Division on Substance Abuse, New York State Psychiatric Institute, and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York 10032, USA
Arch Gen Psychiatry 63:210-8. 2006..Oral naltrexone can completely antagonize the effects produced by opioid agonists. However, poor compliance with naltrexone has been a major obstacle to the effective treatment of opioid dependence... - Response to cocaine, alone and in combination with methylphenidate, in cocaine abusers with ADHDStephanie L Collins
New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 66, New York, NY 10032, USA
Drug Alcohol Depend 82:158-67. 2006..Thus, oral MPH-SR is safe in combination with repeated cocaine doses and decreases some of the positive and reinforcing effects of cocaine in cocaine abusers with ADHD... - Anesthesia-assisted vs buprenorphine- or clonidine-assisted heroin detoxification and naltrexone induction: a randomized trialEric D Collins
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
JAMA 294:903-13. 2005..Rapid opioid detoxification with opioid antagonist induction using general anesthesia has emerged as an expensive, potentially dangerous, unproven approach to treat opioid dependence... - Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behaviorDiana Martinez
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
Neuropsychopharmacology 29:1190-202. 2004..Additional research is warranted to unravel potential neurobiological traits that might confer vulnerability to relapse in detoxified CCD subjects... - Behavioral naltrexone therapy: an integrated treatment for opiate dependenceJami L Rothenberg
The New York State Psychiatric Institute, Division on Substance Abuse, Substance Treatment and Research Service, 1051 Riverside Drive, New York, NY 10032, USA
J Subst Abuse Treat 23:351-60. 2002..Thus, attrition continues to be a serious problem for naltrexone maintenance, although further efforts to develop interventions such as BNT are warranted... - Abuse liability of intravenous buprenorphine/naloxone and buprenorphine alone in buprenorphine-maintained intravenous heroin abusersSandra D Comer
Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
Addiction 105:709-18. 2010..This randomized, double-blind, cross-over study was conducted to assess the intravenous abuse potential of buprenorphine/naloxone compared with buprenorphine in buprenorphine-maintained injection drug users (IDUs)...
Research Grants
- A STUDY OF ANESTHESIA-ASSISTED HEROIN DETOXIFICATIONHerbert Kleber; Fiscal Year: 2001..abstract_text> ..
- Improving Drug Abuse Treatment by Research and TrainingHerbert Kleber; Fiscal Year: 2007..Finally, he will continue active mentoring of young scientists and training at the medical student, resident, fellow, and young faculty levels. ..