HERBERT DAVID KLEBER

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint The best should not be the enemy of the good
    Herbert D Kleber
    Division on Substance Abuse, Columbia University, 1051 Riverside Drive, Unit 66, New York, NY 10032, USA
    Addiction 97:660-1; discussion 664. 2002
  2. pmc Pharmacologic treatments for opioid dependence: detoxification and maintenance options
    Herbert D Kleber
    Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Dialogues Clin Neurosci 9:455-70. 2007
  3. ncbi request reprint Pharmacologic treatments for heroin and cocaine dependence
    Herbert D Kleber
    Division on Substance Abuse, Columbia University, New York, NY 10032, USA
    Am J Addict 12:S5-S18. 2003
  4. ncbi request reprint Changing the battle plan
    Herbert D Kleber
    Division of Substance Abuse, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Trauma 59:S33-6. 2005
  5. pmc Dopamine D1 receptors in cocaine dependence measured with PET and the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neuropsychopharmacology 34:1774-82. 2009
  6. pmc Use of dronabinol for cannabis dependence: two case reports and review
    Frances R Levin
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Addict 17:161-4. 2008
  7. doi request reprint Dextromethorphan and quinidine combination for heroin detoxification
    Evaristo Akerele
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Addict 17:176-80. 2008
  8. ncbi request reprint Depot naltrexone: long-lasting antagonism of the effects of heroin in humans
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 159:351-60. 2002
  9. pmc Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion
    Diana Martinez
    Department of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 166:1170-7. 2009
  10. pmc Dopamine type 2/3 receptor availability in the striatum and social status in human volunteers
    Diana Martinez
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 67:275-8. 2010

Research Grants

Detail Information

Publications20

  1. ncbi request reprint The best should not be the enemy of the good
    Herbert D Kleber
    Division on Substance Abuse, Columbia University, 1051 Riverside Drive, Unit 66, New York, NY 10032, USA
    Addiction 97:660-1; discussion 664. 2002
  2. pmc Pharmacologic treatments for opioid dependence: detoxification and maintenance options
    Herbert D Kleber
    Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Dialogues Clin Neurosci 9:455-70. 2007
    ..Those with strong external motivation may do well on the antagonist naltrexone. Currently, optimum duration of maintenance on either is unclear. Better agents are needed to impact the brain changes related to addiction...
  3. ncbi request reprint Pharmacologic treatments for heroin and cocaine dependence
    Herbert D Kleber
    Division on Substance Abuse, Columbia University, New York, NY 10032, USA
    Am J Addict 12:S5-S18. 2003
    ..In this paper, we discuss the use of medication in the context of general principles of opioid and cocaine addiction treatment. Both established medications and promising directions in pharmacotherapy will be addressed...
  4. ncbi request reprint Changing the battle plan
    Herbert D Kleber
    Division of Substance Abuse, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Trauma 59:S33-6. 2005
  5. pmc Dopamine D1 receptors in cocaine dependence measured with PET and the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neuropsychopharmacology 34:1774-82. 2009
    ....
  6. pmc Use of dronabinol for cannabis dependence: two case reports and review
    Frances R Levin
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Addict 17:161-4. 2008
    ..The potential benefit, as well as questions that arise from the use of this medication in cannabis-abusing populations, is presented. Also, future areas of research that might be explored are discussed...
  7. doi request reprint Dextromethorphan and quinidine combination for heroin detoxification
    Evaristo Akerele
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Addict 17:176-80. 2008
    ..Future studies should examine dextromethorphan as an adjunct to other anti-withdrawal medications and focus more on the relationship between dextrorphan levels and withdrawal suppression...
  8. ncbi request reprint Depot naltrexone: long-lasting antagonism of the effects of heroin in humans
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 159:351-60. 2002
    ..However, naltrexone is generally not well accepted by patients, and medication non-compliance is a difficult obstacle to treatment. A sustained-release form of naltrexone may improve compliance...
  9. pmc Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion
    Diana Martinez
    Department of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 166:1170-7. 2009
    ..The purpose of this study was to measure D(2)/D(3) receptors following acute dopamine depletion in cocaine-dependent volunteers relative to healthy comparison subjects...
  10. pmc Dopamine type 2/3 receptor availability in the striatum and social status in human volunteers
    Diana Martinez
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 67:275-8. 2010
    ..The goal of the present study was to examine this phenomena in human subjects using PET and the radiotracer [(11)C]raclopride...
  11. ncbi request reprint Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Psychiatry 164:622-9. 2007
    ..Furthermore, the relationship between this dopamine response and the choice to self-administer cocaine in a laboratory model of relapse was investigated...
  12. ncbi request reprint Evaluation of a combined online and in person training in the use of buprenorphine
    Erik W Gunderson
    Columbia University College of Physicians and Surgeon and New York State Psychiatric Institute, New York, NY, USA
    Subst Abus 27:39-45. 2006
    ..Overall, physicians preferred in person instruction and may benefit from additional experiential training and support after curriculum participation...
  13. ncbi request reprint Behavioral therapy to augment oral naltrexone for opioid dependence: a ceiling on effectiveness?
    Edward V Nunes
    New York State Psychiatric Institute, Division on Substance Abuse, New York, New York 10032, USA
    Am J Drug Alcohol Abuse 32:503-17. 2006
    ..Future research should consider combinations of behavioral methods with new long-acting injectable or implantable naltrexone formulations...
  14. ncbi request reprint Predictors of retention in naltrexone maintenance for opioid dependence: analysis of a stage I trial
    Maria A Sullivan
    Department of Psychiatry, New York State Psychiatric Institute, New York, NY, USA
    Am J Addict 15:150-9. 2006
    ....
  15. ncbi request reprint Injectable, sustained-release naltrexone for the treatment of opioid dependence: a randomized, placebo-controlled trial
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute, and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Arch Gen Psychiatry 63:210-8. 2006
    ..Oral naltrexone can completely antagonize the effects produced by opioid agonists. However, poor compliance with naltrexone has been a major obstacle to the effective treatment of opioid dependence...
  16. ncbi request reprint Response to cocaine, alone and in combination with methylphenidate, in cocaine abusers with ADHD
    Stephanie L Collins
    New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 66, New York, NY 10032, USA
    Drug Alcohol Depend 82:158-67. 2006
    ..Thus, oral MPH-SR is safe in combination with repeated cocaine doses and decreases some of the positive and reinforcing effects of cocaine in cocaine abusers with ADHD...
  17. ncbi request reprint Anesthesia-assisted vs buprenorphine- or clonidine-assisted heroin detoxification and naltrexone induction: a randomized trial
    Eric D Collins
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    JAMA 294:903-13. 2005
    ..Rapid opioid detoxification with opioid antagonist induction using general anesthesia has emerged as an expensive, potentially dangerous, unproven approach to treat opioid dependence...
  18. ncbi request reprint Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 29:1190-202. 2004
    ..Additional research is warranted to unravel potential neurobiological traits that might confer vulnerability to relapse in detoxified CCD subjects...
  19. ncbi request reprint Behavioral naltrexone therapy: an integrated treatment for opiate dependence
    Jami L Rothenberg
    The New York State Psychiatric Institute, Division on Substance Abuse, Substance Treatment and Research Service, 1051 Riverside Drive, New York, NY 10032, USA
    J Subst Abuse Treat 23:351-60. 2002
    ..Thus, attrition continues to be a serious problem for naltrexone maintenance, although further efforts to develop interventions such as BNT are warranted...
  20. pmc Abuse liability of intravenous buprenorphine/naloxone and buprenorphine alone in buprenorphine-maintained intravenous heroin abusers
    Sandra D Comer
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Addiction 105:709-18. 2010
    ..This randomized, double-blind, cross-over study was conducted to assess the intravenous abuse potential of buprenorphine/naloxone compared with buprenorphine in buprenorphine-maintained injection drug users (IDUs)...

Research Grants7

  1. A STUDY OF ANESTHESIA-ASSISTED HEROIN DETOXIFICATION
    Herbert Kleber; Fiscal Year: 2001
    ..abstract_text> ..
  2. Improving Drug Abuse Treatment by Research and Training
    Herbert Kleber; Fiscal Year: 2007
    ..Finally, he will continue active mentoring of young scientists and training at the medical student, resident, fellow, and young faculty levels. ..