JAN K KITAJEWSKISummaryAffiliation: Columbia University Country: USA Publications
Research Grants
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Detail Information
Publications
Studies in mice reveal a role for anthrax toxin receptors in matrix metalloproteinase function and extracellular matrix homeostasisClaire Reeves
Department of Ob Gyn, Columbia University Medical Center, New York, NY 10032, USA
Toxins (Basel) 5:315-26. 2013..Mice mutant in Antxr genes have defects in extracellular matrix homeostasis. We discuss how knowledge of physiological ANTXR function relates to what is already known about anthrax intoxication...
"Large eaters" meet blood vessels: a new thematic series on macrophages and angiogenesisJan Kitajewski
Pathology, Ob Gyn, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St, Nicholas Ave, NY, NY, 10032, USA
Vasc Cell 4:17. 2012..ABSTRACT: Vascular Cell has launched a new series on macrophages and angiogenesis, a quickly evolving field critical to blood and lymphatic vessels during development, inflammation and tumorigenesis...- Expression of HES and HEY genes in infantile hemangiomasOmotinuwe Adepoju
Department of Surgery, College of Physicians and Surgeons, 630 W168th St, New York, 10032, USA
Vasc Cell 3:19. 2011..abstract:.. - Notch regulates the angiogenic response via induction of VEGFR-1Yasuhiro Funahashi
Pathology, Obstetrics and Gynecology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
J Angiogenes Res 2:3. 2010..In summary, we show that Notch1 plays a role in endothelial cells by regulating VEGFR-1, a function that may be important for physiological and pathological angiogenesis... - Chloride intracellular channel 1 functions in endothelial cell growth and migrationJennifer J Tung
Department of Obstetrics Gynecology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St, Nicholas Ave, 926, New York, NY 10032, USA
J Angiogenes Res 2:23. 2010..Little is known about the role of CLIC1 in endothelium. These studies investigate CLIC1 as a regulator of angiogenesis by in vitro techniques that mimic individual steps in the angiogenic process... - Notch modulates VEGF action in endothelial cells by inducing Matrix Metalloprotease activityYasuhiro Funahashi
Pathology and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, NY, NY 10032, USA
Vasc Cell 3:2. 2011..abstract:.. 
Fine-tuning endothelial Notch: SIRT-ainly an unexpected mechanismJan Kitajewski
Department of Ob Gyn, Pathology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
Dev Cell 20:577-8. 2011..This regulation is critical for vascular sprouting and raises intriguing questions about therapeutic targeting of SIRT1 in angiogenesis and the potential mechanisms that link vascular growth and energy homeostasis...- A potential role for notch signaling in the pathogenesis and regulation of hemangiomasJune K Wu
Departments of Surgery, Columbia University College of Physicians and Surgeons, New York, New York, USA
J Craniofac Surg 20:698-702. 2009..These findings support a role for Notch in hemangiomas, meriting further analysis of the functional relevance of Notch signaling in hemangiomas...
Research Grants
- NOTCH FUNCTION IN VASCULAR BIOLOGY AND ANGIOGENESISJan Kitajewski; Fiscal Year: 2009..In Aim II, we utilize mice to explore genetic interaction between Notch and integrins, using mice deficient in a2 integrin or defective in b4 signaling, crossed to mice defective for Notch. ..
- Role of Anthrax Toxin Receptors in Angiogenesis and EndotheliumJAN K KITAJEWSKI; Fiscal Year: 2010..This study will define the potential adverse effects after use of new agents designed to block anthrax and thus help assure that such strategies are safe. ..
- NOTCH FUNCTION IN VASCULAR BIOLOGY AND ANGIOGENESISJAN K KITAJEWSKI; Fiscal Year: 2010..In Aim II, we utilize mice to explore genetic interaction between Notch and integrins, using mice deficient in a2 integrin or defective in b4 signaling, crossed to mice defective for Notch. ..
- NOTCH FUNCTION IN VASCULAR BIOLOGY AND ANGIOGENESISJan Kitajewski; Fiscal Year: 2007..Our long-term objective is to understand Notch function in human vascular disorders and during pathological angiogenesis. ..
- Wnt Function in Angiogenesis and Vascular DevelopmentJan Kitajewski; Fiscal Year: 2009..These studies will define how aberrant Wnt/Frizzled signaling might contribute to vascular pathologies and diseases, such as familial exuditive vitreoretinopathy. ..
- CHARACTERIZATION AND PURIFICATION OF A POLYCYSTIN LIGANDJan Kitajewski; Fiscal Year: 2002..These polypeptides are candidate polycystin ligands. The goals of this proposal are to identify and characterize these proteins and to test whether they are indeed polycystin ligands. ..
- WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESISJan Kitajewski; Fiscal Year: 2003..Thus, the Wnt signaling pathway is linked to the pathology of human cancers. It clearly represents an important problem in cancer biology with increasing relevance to human disease. ..
- Role of Anthrax Toxin Receptors in Angiogenesis and EndotheliumJAN K KITAJEWSKI; Fiscal Year: 2011..This study will define the potential adverse effects after use of new agents designed to block anthrax and thus help assure that such strategies are safe. ..