JAN K KITAJEWSKI

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Anthrax toxin receptor 2 is expressed in murine and tumor vasculature and functions in endothelial proliferation and morphogenesis
    C V Reeves
    Columbia University Medical Center, New York, NY 10035, USA
    Oncogene 29:789-801. 2010
  2. pmc Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity
    Claire V Reeves
    Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 7:e34862. 2012
  3. pmc Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4)
    Vuk P Jovanovic
    Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W 168th Street, New York, NY 10032, USA
    Reprod Biol Endocrinol 11:43. 2013
  4. pmc Studies in mice reveal a role for anthrax toxin receptors in matrix metalloproteinase function and extracellular matrix homeostasis
    Claire Reeves
    Department of Ob Gyn, Columbia University Medical Center, New York, NY 10032, USA
    Toxins (Basel) 5:315-26. 2013
  5. pmc "Large eaters" meet blood vessels: a new thematic series on macrophages and angiogenesis
    Jan Kitajewski
    Pathology, Ob Gyn, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St, Nicholas Ave, NY, NY, 10032, USA
    Vasc Cell 4:17. 2012
  6. pmc Expression of HES and HEY genes in infantile hemangiomas
    Omotinuwe Adepoju
    Department of Surgery, College of Physicians and Surgeons, 630 W168th St, New York, 10032, USA
    Vasc Cell 3:19. 2011
  7. pmc Notch modulates VEGF action in endothelial cells by inducing Matrix Metalloprotease activity
    Yasuhiro Funahashi
    Pathology and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, NY, NY 10032, USA
    Vasc Cell 3:2. 2011
  8. pmc Chloride intracellular channel 1 functions in endothelial cell growth and migration
    Jennifer J Tung
    Department of Obstetrics Gynecology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St, Nicholas Ave, 926, New York, NY 10032, USA
    J Angiogenes Res 2:23. 2010
  9. pmc Notch regulates the angiogenic response via induction of VEGFR-1
    Yasuhiro Funahashi
    Pathology, Obstetrics and Gynecology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
    J Angiogenes Res 2:3. 2010
  10. pmc Fine-tuning endothelial Notch: SIRT-ainly an unexpected mechanism
    Jan Kitajewski
    Department of Ob Gyn, Pathology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
    Dev Cell 20:577-8. 2011

Collaborators

  • Joy Y Vink
  • June K Wu
  • Dimitris Anastassiou
  • Carrie J Shawber
  • Yasuhiro Funahashi
  • Alvin Wong
  • Vuk P Jovanovic
  • Sonia L Hernandez
  • Claire Reeves
  • Xing Wang
  • Claire V Reeves
  • Omotinuwe Adepoju
  • Anshula Sharma
  • Jennifer J Tung
  • C V Reeves
  • Angela Kadenhe-Chiweshe
  • Wei yi Cheng
  • Christopher M Sauer
  • Pelisa Charles-Horvath
  • Mark V Sauer
  • Thaned Kangsamaksin
  • Raul Gomez
  • Alejandro Garcia
  • Debarshi Banerjee
  • Ralf C Zimmermann
  • Darrell J Yamashiro
  • Jessica J Kandel
  • Alex M Kitajewski
  • Valeriya Y Borisenko
  • Pelisa C Charles-Horvath
  • Krista L Hardy
  • John A T Young
  • Alex Kitajewski
  • Emi Kanamaru
  • Yun K Choi
  • Karen Tong
  • Elisa Boscolo
  • Joyce Bischoff
  • J Dufraine
  • J A T Young
  • Hasina H Outtz
  • Marina Vorontchikhina

Detail Information

Publications15

  1. pmc Anthrax toxin receptor 2 is expressed in murine and tumor vasculature and functions in endothelial proliferation and morphogenesis
    C V Reeves
    Columbia University Medical Center, New York, NY 10035, USA
    Oncogene 29:789-801. 2010
    ..We conclude that ANTXR2/CMG2 functions to promote endothelial proliferation and morphogenesis during sprouting angiogenesis, consistent with the endothelial expression of ANTXR2/CMG2 in several vascular beds...
  2. pmc Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity
    Claire V Reeves
    Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 7:e34862. 2012
    ..We identified an ANTXR2/MT1-MMP complex and demonstrated that MT1-MMP activity is dependent on ANTXR2 expression levels in cells. Thus, we have discovered that ANTXR1 and ANTXR2 function as positive regulators of MT1-MMP activity...
  3. pmc Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4)
    Vuk P Jovanovic
    Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W 168th Street, New York, NY 10032, USA
    Reprod Biol Endocrinol 11:43. 2013
    ..We hypothesized that blocking Notch pathways would disrupt follicular maturation in the mouse ovary...
  4. pmc Studies in mice reveal a role for anthrax toxin receptors in matrix metalloproteinase function and extracellular matrix homeostasis
    Claire Reeves
    Department of Ob Gyn, Columbia University Medical Center, New York, NY 10032, USA
    Toxins (Basel) 5:315-26. 2013
    ..Mice mutant in Antxr genes have defects in extracellular matrix homeostasis. We discuss how knowledge of physiological ANTXR function relates to what is already known about anthrax intoxication...
  5. pmc "Large eaters" meet blood vessels: a new thematic series on macrophages and angiogenesis
    Jan Kitajewski
    Pathology, Ob Gyn, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St, Nicholas Ave, NY, NY, 10032, USA
    Vasc Cell 4:17. 2012
    ..ABSTRACT: Vascular Cell has launched a new series on macrophages and angiogenesis, a quickly evolving field critical to blood and lymphatic vessels during development, inflammation and tumorigenesis...
  6. pmc Expression of HES and HEY genes in infantile hemangiomas
    Omotinuwe Adepoju
    Department of Surgery, College of Physicians and Surgeons, 630 W168th St, New York, 10032, USA
    Vasc Cell 3:19. 2011
    ..abstract:..
  7. pmc Notch modulates VEGF action in endothelial cells by inducing Matrix Metalloprotease activity
    Yasuhiro Funahashi
    Pathology and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, NY, NY 10032, USA
    Vasc Cell 3:2. 2011
    ..abstract:..
  8. pmc Chloride intracellular channel 1 functions in endothelial cell growth and migration
    Jennifer J Tung
    Department of Obstetrics Gynecology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St, Nicholas Ave, 926, New York, NY 10032, USA
    J Angiogenes Res 2:23. 2010
    ..Little is known about the role of CLIC1 in endothelium. These studies investigate CLIC1 as a regulator of angiogenesis by in vitro techniques that mimic individual steps in the angiogenic process...
  9. pmc Notch regulates the angiogenic response via induction of VEGFR-1
    Yasuhiro Funahashi
    Pathology, Obstetrics and Gynecology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
    J Angiogenes Res 2:3. 2010
    ..In summary, we show that Notch1 plays a role in endothelial cells by regulating VEGFR-1, a function that may be important for physiological and pathological angiogenesis...
  10. pmc Fine-tuning endothelial Notch: SIRT-ainly an unexpected mechanism
    Jan Kitajewski
    Department of Ob Gyn, Pathology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
    Dev Cell 20:577-8. 2011
    ..This regulation is critical for vascular sprouting and raises intriguing questions about therapeutic targeting of SIRT1 in angiogenesis and the potential mechanisms that link vascular growth and energy homeostasis...
  11. pmc A potential role for notch signaling in the pathogenesis and regulation of hemangiomas
    June K Wu
    Departments of Surgery, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Craniofac Surg 20:698-702. 2009
    ..These findings support a role for Notch in hemangiomas, meriting further analysis of the functional relevance of Notch signaling in hemangiomas...
  12. pmc Propranolol accelerates adipogenesis in hemangioma stem cells and causes apoptosis of hemangioma endothelial cells
    Alvin Wong
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Plast Reconstr Surg 130:1012-21. 2012
    ..The authors hypothesize that propranolol facilitates their involution by altering cellular behavior in both hemangioma endothelial and stem cells...
  13. pmc Notch and VEGF pathways play distinct but complementary roles in tumor angiogenesis
    Sonia L Hernandez
    Department of Pediatrics, Columbia University Medical Center, New York, NY, USA
    Vasc Cell 5:17. 2013
    ....

Research Grants27

  1. NOTCH FUNCTION IN VASCULAR BIOLOGY AND ANGIOGENESIS
    Jan Kitajewski; Fiscal Year: 2009
    ..In Aim II, we utilize mice to explore genetic interaction between Notch and integrins, using mice deficient in a2 integrin or defective in b4 signaling, crossed to mice defective for Notch. ..
  2. Role of Anthrax Toxin Receptors in Angiogenesis and Endothelium
    JAN K KITAJEWSKI; Fiscal Year: 2010
    ..This study will define the potential adverse effects after use of new agents designed to block anthrax and thus help assure that such strategies are safe. ..
  3. NOTCH FUNCTION IN VASCULAR BIOLOGY AND ANGIOGENESIS
    JAN K KITAJEWSKI; Fiscal Year: 2010
    ..In Aim II, we utilize mice to explore genetic interaction between Notch and integrins, using mice deficient in a2 integrin or defective in b4 signaling, crossed to mice defective for Notch. ..
  4. Role of Anthrax Toxin Receptors in Angiogenesis and Endothelium
    JAN K KITAJEWSKI; Fiscal Year: 2011
    ..This study will define the potential adverse effects after use of new agents designed to block anthrax and thus help assure that such strategies are safe. ..
  5. Wnt Function in Angiogenesis and Vascular Development
    Jan Kitajewski; Fiscal Year: 2009
    ..These studies will define how aberrant Wnt/Frizzled signaling might contribute to vascular pathologies and diseases, such as familial exuditive vitreoretinopathy. ..
  6. Wnt Function in Angiogenesis and Vascular Development
    Jan Kitajewski; Fiscal Year: 2006
    ..These studies will define how aberrant Wnt/Frizzled signaling might contribute to vascular pathologies and diseases, such as familial exuditive vitreoretinopathy. ..
  7. NOTCH FUNCTION IN VASCULAR BIOLOGY AND ANGIOGENESIS
    Jan Kitajewski; Fiscal Year: 2006
    ..Our long-term objective is to understand Notch function in human vascular disorders and during pathological angiogenesis. ..
  8. NOTCH FUNCTION IN VASCULAR BIOLOGY AND ANGIOGENESIS
    Jan Kitajewski; Fiscal Year: 2005
    ..Our long-term objective is to understand Notch function in human vascular disorders and during pathological angiogenesis. ..
  9. WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESIS
    Jan Kitajewski; Fiscal Year: 2003
    ..Thus, the Wnt signaling pathway is linked to the pathology of human cancers. It clearly represents an important problem in cancer biology with increasing relevance to human disease. ..
  10. WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESIS
    Jan Kitajewski; Fiscal Year: 2002
    ..Thus, the Wnt signaling pathway is linked to the pathology of human cancers. It clearly represents an important problem in cancer biology with increasing relevance to human disease. ..
  11. WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESIS
    Jan Kitajewski; Fiscal Year: 2001
    ..Thus, the Wnt signaling pathway is linked to the pathology of human cancers. It clearly represents an important problem in cancer biology with increasing relevance to human disease. ..
  12. CHARACTERIZATION AND PURIFICATION OF A POLYCYSTIN LIGAND
    Jan Kitajewski; Fiscal Year: 2001
    ..These polypeptides are candidate polycystin ligands. The goals of this proposal are to identify and characterize these proteins and to test whether they are indeed polycystin ligands. ..
  13. WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESIS
    Jan Kitajewski; Fiscal Year: 1999
    ..Thus, the Wnt signaling pathway is linked to the pathology of human cancers. It clearly represents an important problem in cancer biology with increasing relevance to human disease. ..
  14. Role of Anthrax Toxin Receptors in Angiogenesis and Endothelium
    Jan Kitajewski; Fiscal Year: 2009
    ..This study will define the potential adverse effects after use of new agents designed to block anthrax and thus help assure that such strategies are safe. ..
  15. NOTCH FUNCTION IN VASCULAR BIOLOGY AND ANGIOGENESIS
    Jan Kitajewski; Fiscal Year: 2007
    ..Our long-term objective is to understand Notch function in human vascular disorders and during pathological angiogenesis. ..
  16. Wnt Function in Angiogenesis and Vascular Development
    Jan Kitajewski; Fiscal Year: 2007
    ..These studies will define how aberrant Wnt/Frizzled signaling might contribute to vascular pathologies and diseases, such as familial exuditive vitreoretinopathy. ..
  17. WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESIS
    Jan Kitajewski; Fiscal Year: 2003
    ..Thus, the Wnt signaling pathway is linked to the pathology of human cancers. It clearly represents an important problem in cancer biology with increasing relevance to human disease. ..
  18. CHARACTERIZATION AND PURIFICATION OF A POLYCYSTIN LIGAND
    Jan Kitajewski; Fiscal Year: 2002
    ..These polypeptides are candidate polycystin ligands. The goals of this proposal are to identify and characterize these proteins and to test whether they are indeed polycystin ligands. ..
  19. WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESIS
    Jan Kitajewski; Fiscal Year: 2002
    ..Thus, the Wnt signaling pathway is linked to the pathology of human cancers. It clearly represents an important problem in cancer biology with increasing relevance to human disease. ..
  20. NOTCH FUNCTION IN VASCULAR BIOLOGY AND ANGIOGENESIS
    Jan Kitajewski; Fiscal Year: 2004
    ..Our long-term objective is to understand Notch function in human vascular disorders and during pathological angiogenesis. ..
  21. WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESIS
    Jan Kitajewski; Fiscal Year: 2000
    ..Thus, the Wnt signaling pathway is linked to the pathology of human cancers. It clearly represents an important problem in cancer biology with increasing relevance to human disease. ..