JAN K KITAJEWSKI
Affiliation: Columbia University
- Notch and VEGF pathways play distinct but complementary roles in tumor angiogenesisSonia L Hernandez
Department of Pediatrics, Columbia University Medical Center, New York, NY, USA
Vasc Cell 5:17. 2013....
- Anthrax toxin receptor 2 is expressed in murine and tumor vasculature and functions in endothelial proliferation and morphogenesisC V Reeves
Columbia University Medical Center, New York, NY 10035, USA
Oncogene 29:789-801. 2010..We conclude that ANTXR2/CMG2 functions to promote endothelial proliferation and morphogenesis during sprouting angiogenesis, consistent with the endothelial expression of ANTXR2/CMG2 in several vascular beds...
- Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activityClaire V Reeves
Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York, United States of America
PLoS ONE 7:e34862. 2012..We identified an ANTXR2/MT1-MMP complex and demonstrated that MT1-MMP activity is dependent on ANTXR2 expression levels in cells. Thus, we have discovered that ANTXR1 and ANTXR2 function as positive regulators of MT1-MMP activity...
- Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4)Vuk P Jovanovic
Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W 168th Street, New York, NY 10032, USA
Reprod Biol Endocrinol 11:43. 2013..We hypothesized that blocking Notch pathways would disrupt follicular maturation in the mouse ovary...
- Studies in mice reveal a role for anthrax toxin receptors in matrix metalloproteinase function and extracellular matrix homeostasisClaire Reeves
Department of Ob Gyn, Columbia University Medical Center, New York, NY 10032, USA
Toxins (Basel) 5:315-26. 2013..Mice mutant in Antxr genes have defects in extracellular matrix homeostasis. We discuss how knowledge of physiological ANTXR function relates to what is already known about anthrax intoxication...
- "Large eaters" meet blood vessels: a new thematic series on macrophages and angiogenesisJan Kitajewski
Pathology, Ob Gyn, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St, Nicholas Ave, NY, NY, 10032, USA
Vasc Cell 4:17. 2012..ABSTRACT: Vascular Cell has launched a new series on macrophages and angiogenesis, a quickly evolving field critical to blood and lymphatic vessels during development, inflammation and tumorigenesis...
- Expression of HES and HEY genes in infantile hemangiomasOmotinuwe Adepoju
Department of Surgery, College of Physicians and Surgeons, 630 W168th St, New York, 10032, USA
Vasc Cell 3:19. 2011..abstract:..
- Fine-tuning endothelial Notch: SIRT-ainly an unexpected mechanismJan Kitajewski
Department of Ob Gyn, Pathology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
Dev Cell 20:577-8. 2011..This regulation is critical for vascular sprouting and raises intriguing questions about therapeutic targeting of SIRT1 in angiogenesis and the potential mechanisms that link vascular growth and energy homeostasis...
- Notch modulates VEGF action in endothelial cells by inducing Matrix Metalloprotease activityYasuhiro Funahashi
Pathology and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, NY, NY 10032, USA
Vasc Cell 3:2. 2011..abstract:..
- Chloride intracellular channel 1 functions in endothelial cell growth and migrationJennifer J Tung
Department of Obstetrics Gynecology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St, Nicholas Ave, 926, New York, NY 10032, USA
J Angiogenes Res 2:23. 2010..Little is known about the role of CLIC1 in endothelium. These studies investigate CLIC1 as a regulator of angiogenesis by in vitro techniques that mimic individual steps in the angiogenic process...
- Notch regulates the angiogenic response via induction of VEGFR-1Yasuhiro Funahashi
Pathology, Obstetrics and Gynecology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
J Angiogenes Res 2:3. 2010..In summary, we show that Notch1 plays a role in endothelial cells by regulating VEGFR-1, a function that may be important for physiological and pathological angiogenesis...
- A potential role for notch signaling in the pathogenesis and regulation of hemangiomasJune K Wu
Departments of Surgery, Columbia University College of Physicians and Surgeons, New York, New York, USA
J Craniofac Surg 20:698-702. 2009..These findings support a role for Notch in hemangiomas, meriting further analysis of the functional relevance of Notch signaling in hemangiomas...
- Propranolol accelerates adipogenesis in hemangioma stem cells and causes apoptosis of hemangioma endothelial cellsAlvin Wong
Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Plast Reconstr Surg 130:1012-21. 2012..The authors hypothesize that propranolol facilitates their involution by altering cellular behavior in both hemangioma endothelial and stem cells...