Arianna L Kim

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Reduced cyclin D1 ubiquitination in UVB-induced murine squamous cell carcinomas
    Arianna L Kim
    Department of Dermatology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Biochem Biophys Res Commun 298:377-82. 2002
  2. ncbi request reprint Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice
    Arianna L Kim
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Invest Dermatol 124:1318-25. 2005
  3. ncbi request reprint Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways
    Arianna L Kim
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Exp Dermatol 15:538-46. 2006
  4. pmc CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice
    Xiuwei Tang
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Invest 117:3753-64. 2007
  5. pmc Resveratrol targets transforming growth factor-β2 signaling to block UV-induced tumor progression
    Kwang Ho Kim
    Department of Dermatology, Columbia University Medical Center, Irving Cancer Research Center, New York, New York, USA
    J Invest Dermatol 131:195-202. 2011
  6. ncbi request reprint Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis
    Mohammad Athar
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Cancer Res 64:7545-52. 2004
  7. pmc XPC silencing in normal human keratinocytes triggers metabolic alterations through NOX-1 activation-mediated reactive oxygen species
    Hamid Reza Rezvani
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Biochim Biophys Acta 1807:609-19. 2011
  8. pmc Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1
    Jung Ho Back
    Department of Dermatology, Columbia University Medical Center, New York, New York 10032, USA
    J Biol Chem 286:19100-8. 2011
  9. ncbi request reprint Ultraviolet-B-induced G1 arrest is mediated by downregulation of cyclin-dependent kinase 4 in transformed keratinocytes lacking functional p53
    Arianna L Kim
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Invest Dermatol 118:818-24. 2002
  10. ncbi request reprint Photoprotective effects of sulindac against ultraviolet B-induced phototoxicity in the skin of SKH-1 hairless mice
    Mohammad Athar
    Department of Dermatology and Skin Disease Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Toxicol Appl Pharmacol 195:370-8. 2004

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Reduced cyclin D1 ubiquitination in UVB-induced murine squamous cell carcinomas
    Arianna L Kim
    Department of Dermatology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Biochem Biophys Res Commun 298:377-82. 2002
    ....
  2. ncbi request reprint Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice
    Arianna L Kim
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Invest Dermatol 124:1318-25. 2005
    ..Blockade of the p38 MAPK pathway may offer an effective approach to reducing or preventing skin damage resulting from acute solar radiation...
  3. ncbi request reprint Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways
    Arianna L Kim
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Exp Dermatol 15:538-46. 2006
    ..Our results demonstrate that resveratrol affects multiple cellular targets in A431 cells, and that the downregulation of both AP-1 and pRb contributes to its antiproliferative activity in these cells...
  4. pmc CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice
    Xiuwei Tang
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Invest 117:3753-64. 2007
    ..Blocking MPT diminished p53 translocation and apoptosis. These studies indicate that reconstituting p53 tumor suppressor functions in vivo by small molecular weight compounds may block the pathogenesis and progression of skin cancer...
  5. pmc Resveratrol targets transforming growth factor-β2 signaling to block UV-induced tumor progression
    Kwang Ho Kim
    Department of Dermatology, Columbia University Medical Center, Irving Cancer Research Center, New York, New York, USA
    J Invest Dermatol 131:195-202. 2011
    ....
  6. ncbi request reprint Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis
    Mohammad Athar
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Cancer Res 64:7545-52. 2004
    ....
  7. pmc XPC silencing in normal human keratinocytes triggers metabolic alterations through NOX-1 activation-mediated reactive oxygen species
    Hamid Reza Rezvani
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Biochim Biophys Acta 1807:609-19. 2011
    ..As NOX-1 activation is observed in human squamous cell carcinomas (SCCs), the blockade of NOX-1 could be a target for the prevention and the treatment of skin cancers...
  8. pmc Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1
    Jung Ho Back
    Department of Dermatology, Columbia University Medical Center, New York, New York 10032, USA
    J Biol Chem 286:19100-8. 2011
    ..These results demonstrate that the inhibition of SIRT1 by mTOR fosters survival of DNA damage-induced prematurely senescent SCC cells via Bfl-1/A1 in the absence of functional p53...
  9. ncbi request reprint Ultraviolet-B-induced G1 arrest is mediated by downregulation of cyclin-dependent kinase 4 in transformed keratinocytes lacking functional p53
    Arianna L Kim
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Invest Dermatol 118:818-24. 2002
    ..This identifies a novel pathway for G1 cell cycle arrest in transformed keratinocytes following ultraviolet-B irradiation...
  10. ncbi request reprint Photoprotective effects of sulindac against ultraviolet B-induced phototoxicity in the skin of SKH-1 hairless mice
    Mohammad Athar
    Department of Dermatology and Skin Disease Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Toxicol Appl Pharmacol 195:370-8. 2004
    ....
  11. pmc Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms
    Mohammad Athar
    Departments of Dermatology, Columbia University Medical Center, Irving Cancer Research Center, New York, NY 10032, USA
    Arch Biochem Biophys 486:95-102. 2009
    ..This review summarizes in vitro mechanistic data available for resveratrol and discusses new potential anti-cancer targets and the antiproliferative mechanisms of resveratrol...
  12. doi request reprint Cyclooxygenase-2 inhibitor nimesulide blocks ultraviolet B-induced photocarcinogenesis in SKH-1 hairless mice
    Xiuwei Tang
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Photochem Photobiol 84:522-7. 2008
    ..These results show that alternative classes of COX-2 inhibitors may likely be efficacious as cancer chemopreventive agents and may have an improved therapeutic index...
  13. doi request reprint Resveratrol-mediated downregulation of Rictor attenuates autophagic process and suppresses UV-induced skin carcinogenesis
    Jung H Back
    Department of Dermatology, Columbia University Medical Center, Russ Berrie Medical Science Pavilion, New York, NY, USA
    Photochem Photobiol 88:1165-72. 2012
    ..These data indicate that resveratrol attenuates autophagic process via Rictor, and suggest that downregulation of Rictor may be a mechanism of tumor suppression associated with premature senescence...
  14. pmc DDB1 is essential for genomic stability in developing epidermis
    Yong Cang
    Howard Hughes Medical Institute and Departments of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:2733-7. 2007
    ..Our results suggest that DDB1 plays an important role in development by controlling levels of cell cycle regulators and thereby maintaining genomic stability...
  15. ncbi request reprint Hedgehog signalling in skin development and cancer
    Mohammad Athar
    Department of Dermatology, Columbia University, New York, NY 10032, USA
    Exp Dermatol 15:667-77. 2006
    ..This review therefore provides a current understanding of the role of the Shh pathway in skin development and neoplasia. It also provides a basis for the molecular target-based chemoprevention and therapeutic management of skin cancer...
  16. pmc Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice
    Xiuwei Tang
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 113:867-75. 2004
    ..These results demonstrate the crucial importance of ODC for the induction of BCCs and indicate that chemopreventive strategies directed at inhibiting this enzyme may be useful in reducing BCCs in human populations...
  17. pmc Loss of hairless confers susceptibility to UVB-induced tumorigenesis via disruption of NF-kappaB signaling
    Hyunmi Kim
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, New York, United States of America
    PLoS ONE 7:e39691. 2012
    ..Instead, Hr is a crucial UVB response gene and its loss creates a permissive environment that potentiates increased tumorigenesis...
  18. pmc XPC silencing in normal human keratinocytes triggers metabolic alterations that drive the formation of squamous cell carcinomas
    Hamid Reza Rezvani
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 121:195-211. 2011
    ..Our results demonstrate that genomic instability resulting from XPC silencing results in activation of AKT1 and subsequently NOX1 to induce ROS generation, mtDNA deletions, and neoplastic transformation in human keratinocytes...
  19. pmc Resveratrol: a review of preclinical studies for human cancer prevention
    Mohammad Athar
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street VC15 204, New York, NY 10032, USA
    Toxicol Appl Pharmacol 224:274-83. 2007
    ..This review discusses the current preclinical and mechanistic data available and assesses resveratrol's anticancer effects to support its potential as an anticancer agent in human populations...
  20. ncbi request reprint Stage-specific alterations of cyclin expression during UVB-induced murine skin tumor development
    Arianna L Kim
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Photochem Photobiol 75:58-67. 2002
    ..Cyclin D1 and p53 overexpression were coupled with the development of tumors, and these changes are likely to be relevant to the pathogenesis of these lesions...

Research Grants3

  1. Cell cycle regulatory proteins in UVB-skin carcinogenes
    Arianna Kim; Fiscal Year: 2007
    ..In addition, our studies could provide a rationale to develop new therapeutic tools targeted towards the protein degradation machinery. ..
  2. Chk2 as a target for regulating senescence in skin neoplasia
    Arianna Kim; Fiscal Year: 2007
    ....