Research Topics
Genomes and Genes
| Arianna L KimSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Reduced cyclin D1 ubiquitination in UVB-induced murine squamous cell carcinomasArianna L Kim
Department of Dermatology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Biochem Biophys Res Commun 298:377-82. 2002....- Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless miceArianna L Kim
Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Invest Dermatol 124:1318-25. 2005..Blockade of the p38 MAPK pathway may offer an effective approach to reducing or preventing skin damage resulting from acute solar radiation... - Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathwaysArianna L Kim
Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Exp Dermatol 15:538-46. 2006..Our results demonstrate that resveratrol affects multiple cellular targets in A431 cells, and that the downregulation of both AP-1 and pRb contributes to its antiproliferative activity in these cells... 
CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in miceXiuwei Tang
Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York, USA
J Clin Invest 117:3753-64. 2007..Blocking MPT diminished p53 translocation and apoptosis. These studies indicate that reconstituting p53 tumor suppressor functions in vivo by small molecular weight compounds may block the pathogenesis and progression of skin cancer...- Resveratrol targets transforming growth factor-β2 signaling to block UV-induced tumor progressionKwang Ho Kim
Department of Dermatology, Columbia University Medical Center, Irving Cancer Research Center, New York, New York, USA
J Invest Dermatol 131:195-202. 2011.... - Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosisMohammad Athar
Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Cancer Res 64:7545-52. 2004.... - XPC silencing in normal human keratinocytes triggers metabolic alterations through NOX-1 activation-mediated reactive oxygen speciesHamid Reza Rezvani
Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Biochim Biophys Acta 1807:609-19. 2011..As NOX-1 activation is observed in human squamous cell carcinomas (SCCs), the blockade of NOX-1 could be a target for the prevention and the treatment of skin cancers... - Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1Jung Ho Back
Department of Dermatology, Columbia University Medical Center, New York, New York 10032, USA
J Biol Chem 286:19100-8. 2011..These results demonstrate that the inhibition of SIRT1 by mTOR fosters survival of DNA damage-induced prematurely senescent SCC cells via Bfl-1/A1 in the absence of functional p53... - Ultraviolet-B-induced G1 arrest is mediated by downregulation of cyclin-dependent kinase 4 in transformed keratinocytes lacking functional p53Arianna L Kim
Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Invest Dermatol 118:818-24. 2002..This identifies a novel pathway for G1 cell cycle arrest in transformed keratinocytes following ultraviolet-B irradiation... - Photoprotective effects of sulindac against ultraviolet B-induced phototoxicity in the skin of SKH-1 hairless miceMohammad Athar
Department of Dermatology and Skin Disease Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Toxicol Appl Pharmacol 195:370-8. 2004.... - Multiple molecular targets of resveratrol: Anti-carcinogenic mechanismsMohammad Athar
Departments of Dermatology, Columbia University Medical Center, Irving Cancer Research Center, New York, NY 10032, USA
Arch Biochem Biophys 486:95-102. 2009..This review summarizes in vitro mechanistic data available for resveratrol and discusses new potential anti-cancer targets and the antiproliferative mechanisms of resveratrol... 
Cyclooxygenase-2 inhibitor nimesulide blocks ultraviolet B-induced photocarcinogenesis in SKH-1 hairless miceXiuwei Tang
Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Photochem Photobiol 84:522-7. 2008..These results show that alternative classes of COX-2 inhibitors may likely be efficacious as cancer chemopreventive agents and may have an improved therapeutic index...- Resveratrol-mediated downregulation of Rictor attenuates autophagic process and suppresses UV-induced skin carcinogenesisJung H Back
Department of Dermatology, Columbia University Medical Center, Russ Berrie Medical Science Pavilion, New York, NY, USA
Photochem Photobiol 88:1165-72. 2012..These data indicate that resveratrol attenuates autophagic process via Rictor, and suggest that downregulation of Rictor may be a mechanism of tumor suppression associated with premature senescence... - DDB1 is essential for genomic stability in developing epidermisYong Cang
Howard Hughes Medical Institute and Departments of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 104:2733-7. 2007..Our results suggest that DDB1 plays an important role in development by controlling levels of cell cycle regulators and thereby maintaining genomic stability... - Hedgehog signalling in skin development and cancerMohammad Athar
Department of Dermatology, Columbia University, New York, NY 10032, USA
Exp Dermatol 15:667-77. 2006..This review therefore provides a current understanding of the role of the Shh pathway in skin development and neoplasia. It also provides a basis for the molecular target-based chemoprevention and therapeutic management of skin cancer... - Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- miceXiuwei Tang
Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Clin Invest 113:867-75. 2004..These results demonstrate the crucial importance of ODC for the induction of BCCs and indicate that chemopreventive strategies directed at inhibiting this enzyme may be useful in reducing BCCs in human populations... - Loss of hairless confers susceptibility to UVB-induced tumorigenesis via disruption of NF-kappaB signalingHyunmi Kim
Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, New York, United States of America
PLoS ONE 7:e39691. 2012..Instead, Hr is a crucial UVB response gene and its loss creates a permissive environment that potentiates increased tumorigenesis... - XPC silencing in normal human keratinocytes triggers metabolic alterations that drive the formation of squamous cell carcinomasHamid Reza Rezvani
Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Clin Invest 121:195-211. 2011..Our results demonstrate that genomic instability resulting from XPC silencing results in activation of AKT1 and subsequently NOX1 to induce ROS generation, mtDNA deletions, and neoplastic transformation in human keratinocytes... - Resveratrol: a review of preclinical studies for human cancer preventionMohammad Athar
Department of Dermatology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street VC15 204, New York, NY 10032, USA
Toxicol Appl Pharmacol 224:274-83. 2007..This review discusses the current preclinical and mechanistic data available and assesses resveratrol's anticancer effects to support its potential as an anticancer agent in human populations... - Stage-specific alterations of cyclin expression during UVB-induced murine skin tumor developmentArianna L Kim
Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Photochem Photobiol 75:58-67. 2002..Cyclin D1 and p53 overexpression were coupled with the development of tumors, and these changes are likely to be relevant to the pathogenesis of these lesions...
Research Grants
- Cell cycle regulatory proteins in UVB-skin carcinogenesArianna Kim; Fiscal Year: 2007..In addition, our studies could provide a rationale to develop new therapeutic tools targeted towards the protein degradation machinery. ..
- Chk2 as a target for regulating senescence in skin neoplasiaArianna Kim; Fiscal Year: 2007....