Lawrence S Kegeles

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. doi request reprint Elevated prefrontal cortex γ-aminobutyric acid and glutamate-glutamine levels in schizophrenia measured in vivo with proton magnetic resonance spectroscopy
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Arch Gen Psychiatry 69:449-59. 2012
  2. ncbi request reprint NMDA antagonist effects on striatal dopamine release: positron emission tomography studies in humans
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Synapse 43:19-29. 2002
  3. doi request reprint Dose-occupancy study of striatal and extrastriatal dopamine D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallypride
    Lawrence S Kegeles
    Department of Psychiatry, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 33:3111-25. 2008
  4. doi request reprint Increased synaptic dopamine function in associative regions of the striatum in schizophrenia
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Arch Gen Psychiatry 67:231-9. 2010
  5. pmc Striatal and extrastriatal dopamine D2/D3 receptors in schizophrenia evaluated with [18F]fallypride positron emission tomography
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and New York State Psychiatric Institute, New York 10032, USA
    Biol Psychiatry 68:634-41. 2010
  6. ncbi request reprint Response of cortical metabolic deficits to serotonergic challenge in familial mood disorders
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University, New York, NY, USA
    Am J Psychiatry 160:76-82. 2003
  7. ncbi request reprint In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Synapse 52:188-208. 2004
  8. ncbi request reprint Increased prefrontal cortical D₁ receptors in drug naive patients with schizophrenia: a PET study with [¹¹C]NNC112
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Psychopharmacol 26:794-805. 2012
  9. pmc Striatal and extrastriatal dopamine release measured with PET and [(18)F] fallypride
    Mark Slifstein
    Columbia University, New York, NY, USA
    Synapse 64:350-62. 2010
  10. ncbi request reprint Altered prefrontal dopaminergic function in chronic recreational ketamine users
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Psychiatry 162:2352-9. 2005

Research Grants

  1. DOPAMINE AND GABA IMAGING IN SCHIZOPHRENIA
    Lawrence Kegeles; Fiscal Year: 2004

Detail Information

Publications35

  1. doi request reprint Elevated prefrontal cortex γ-aminobutyric acid and glutamate-glutamine levels in schizophrenia measured in vivo with proton magnetic resonance spectroscopy
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Arch Gen Psychiatry 69:449-59. 2012
    ..Abnormalities in these transmitters are thought to play a role in cognitive impairments in the illness...
  2. ncbi request reprint NMDA antagonist effects on striatal dopamine release: positron emission tomography studies in humans
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Synapse 43:19-29. 2002
    ....
  3. doi request reprint Dose-occupancy study of striatal and extrastriatal dopamine D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallypride
    Lawrence S Kegeles
    Department of Psychiatry, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 33:3111-25. 2008
    ....
  4. doi request reprint Increased synaptic dopamine function in associative regions of the striatum in schizophrenia
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Arch Gen Psychiatry 67:231-9. 2010
    ....
  5. pmc Striatal and extrastriatal dopamine D2/D3 receptors in schizophrenia evaluated with [18F]fallypride positron emission tomography
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and New York State Psychiatric Institute, New York 10032, USA
    Biol Psychiatry 68:634-41. 2010
    ..We used positron emission tomography with [(18)F]fallypride to evaluate D(2)/D(3) receptors in both striatal and extrastriatal regions in schizophrenia...
  6. ncbi request reprint Response of cortical metabolic deficits to serotonergic challenge in familial mood disorders
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University, New York, NY, USA
    Am J Psychiatry 160:76-82. 2003
    ..The authors applied a dl-fenfluramine challenge method to study metabolic response in this region to serotonergic challenge in familial major depression...
  7. ncbi request reprint In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Synapse 52:188-208. 2004
    ..In conclusion, [11C]NPA might provide a superior radiotracer to probe presynaptic DA function with PET in health and disease...
  8. ncbi request reprint Increased prefrontal cortical D₁ receptors in drug naive patients with schizophrenia: a PET study with [¹¹C]NNC112
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Psychopharmacol 26:794-805. 2012
    ..We conclude that upregulation of D1 receptors in schizophrenia is related to the illness itself and may be corrected and normalized by chronic antipsychotic treatment...
  9. pmc Striatal and extrastriatal dopamine release measured with PET and [(18)F] fallypride
    Mark Slifstein
    Columbia University, New York, NY, USA
    Synapse 64:350-62. 2010
    ....
  10. ncbi request reprint Altered prefrontal dopaminergic function in chronic recreational ketamine users
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Psychiatry 162:2352-9. 2005
    ..In this study, dopamine D1 receptor availability was assessed by using positron emission tomography and the selective D1 receptor radioligand [11C]NNC 112 in a group of 14 recreational chronic ketamine users and matched healthy subjects...
  11. ncbi request reprint Striatal amphetamine-induced dopamine release in patients with schizotypal personality disorder studied with single photon emission computed tomography and [123I]iodobenzamide
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, 10032, USA
    Biol Psychiatry 55:1001-6. 2004
    ..Schizotypal personality disorder (SPD) is a schizophrenia spectrum disorder, genetically related to schizophrenia. The goal of this study was to investigate striatal DA function in patients with SPD...
  12. ncbi request reprint Modulation of amphetamine-induced dopamine release by group II metabotropic glutamate receptor agonist LY354740 in non-human primates studied with positron emission tomography
    Bart N M van Berckel
    Department of Psychiatry, Columbia University, New York, NY, USA
    Neuropsychopharmacology 31:967-77. 2006
    ....
  13. doi request reprint Baseline and amphetamine-stimulated dopamine activity are related in drug-naïve schizophrenic subjects
    Anissa Abi-Dargham
    Department of Psychiatry, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Biol Psychiatry 65:1091-3. 2009
    ..We report here on the relationship between these two aspects of DA release in drug-naïve patients with schizophrenia (SCZ) and matched healthy control subjects (HC)...
  14. ncbi request reprint Comparative evaluation in nonhuman primates of five PET radiotracers for imaging the serotonin transporters: [11C]McN 5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Cereb Blood Flow Metab 22:1377-98. 2002
    ....
  15. ncbi request reprint Quantitative analysis of (-)-N-(11)C-propyl-norapomorphine in vivo binding in nonhuman primates
    Dah Ren Hwang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Nucl Med 45:338-46. 2004
    ..The goal of this study was to develop and evaluate analytic strategies to derive in vivo (11)C-NPA binding parameters...
  16. doi request reprint Measurement of the serotonin 1A receptor availability in patients with schizophrenia during treatment with the antipsychotic medication ziprasidone
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    J Psychopharmacol 25:734-43. 2011
    ..The finding of a relationship between 5-HT(1A) binding and the degree of improvement in negative symptoms provides further support for the role of the 5-HT(1A) receptor in the pathophysiology and treatment of this symptom domain...
  17. ncbi request reprint Mechanism of action of antipsychotic drugs: from dopamine D(2) receptor antagonism to glutamate NMDA facilitation
    Marc Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Clin Ther 27:S16-24. 2005
    ..The fundamental pathologic processes associated with schizophrenia remain uncertain...
  18. ncbi request reprint Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression
    Maria A Oquendo
    Department of Psychiatry, Columbia University, New York, USA
    Arch Gen Psychiatry 60:14-22. 2003
    ..Postmortem studies of serotonin receptors in suicides localize changes to the ventral prefrontal cortex (PFC). We studied serotonergic response in ventral PFC in depressed patients surviving a high-lethality suicide attempt...
  19. pmc Investigation of cortical glutamate-glutamine and γ-aminobutyric acid in obsessive-compulsive disorder by proton magnetic resonance spectroscopy
    HELEN B SIMPSON
    Department of Psychiatry at Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Neuropsychopharmacology 37:2684-92. 2012
    ..However, they may have decreased MPFC GABA levels. How GABA abnormalities might contribute to corticostriatal dysfunction in OCD deserves further study...
  20. pmc Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with [¹¹C]DASB and [¹¹C]MDL 100907
    Nina Bl Urban
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 37:1465-73. 2012
    ..Alterations in mood, cognition, and impulse control associated with these changes might contribute to sustain MDMA use. The reversibility of these changes upon abstinence remains to be firmly established...
  21. pmc Sex differences in striatal dopamine release in young adults after oral alcohol challenge: a positron emission tomography imaging study with [¹¹C]raclopride
    Nina B L Urban
    Department of Psychiatry at New York State Psychiatric Institute and Columbia University, New York, New York 10032, USA
    Biol Psychiatry 68:689-96. 2010
    ..We used a positron emission tomography paradigm with the D2/3 radiotracer [¹¹C]raclopride and an alcohol challenge to examine the magnitude of alcohol-induced dopamine release and compare it between young men and women...
  22. ncbi request reprint [11C]NNC 112 selectivity for dopamine D1 and serotonin 5-HT(2A) receptors: a PET study in healthy human subjects
    Mark Slifstein
    Department of Psychiatry, Columbia University, New York, New York, USA
    J Cereb Blood Flow Metab 27:1733-41. 2007
    ..These results suggest caution in interpreting data from studies using this tracer to measure cortical D(1) receptors as well as the need for more selective radioligands to assess cortical D(1) receptors...
  23. ncbi request reprint Dopamine mediation of positive reinforcing effects of amphetamine in stimulant naïve healthy volunteers: results from a large cohort
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University, New York, NY, USA
    Eur Neuropsychopharmacol 13:459-68. 2003
    ..This study indicates that both a large dopaminergic response and young age during a first encounter with a drug of abuse potential contribute to higher positive reinforcing effects...
  24. ncbi request reprint A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors
    Sanjay J Mathew
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 54:727-35. 2003
    ..Long-term behavioral, immunologic, and neurochemical alterations have been found in primates exposed to adverse early rearing...
  25. ncbi request reprint Glutamate, dopamine, and schizophrenia: from pathophysiology to treatment
    Marc Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Ann N Y Acad Sci 1003:138-58. 2003
    ....
  26. pmc Effects of davunetide on N-acetylaspartate and choline in dorsolateral prefrontal cortex in patients with schizophrenia
    L Fredrik Jarskog
    Department of Psychiatry, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC, USA
    Neuropsychopharmacology 38:1245-52. 2013
    ..Future clinical and preclinical studies are needed to fully define the mechanism of action and cognitive effects of davunetide in schizophrenia...
  27. ncbi request reprint Synthesis and pharmacological characterization of a new PET ligand for the serotonin transporter: [11C]5-bromo-2-[2-(dimethylaminomethylphenylsulfanyl)]phenylamine ([11C]DAPA)
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nucl Med Biol 29:741-51. 2002
    ..In summary, [11C]DAPA appears to be a promising radioligand suitable for the visualization of SERT in vivo using PET...
  28. ncbi request reprint Synthesis and in vivo evaluation of [11C]zolpidem, an imidazopyridine with agonist properties at central benzodiazepine receptors
    Filip Dumont
    Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, New York 10032, USA
    Nucl Med Biol 30:435-9. 2003
    ..A PET brain imaging study in one baboon confirmed the results obtained in rats. Therefore, it can be concluded that [(11)C]zolpidem is not a suitable tracer for in vivo visualization of central benzodiazepine receptors...
  29. pmc Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: proof-of-concept
    Carolyn I Rodriguez
    1 New York State Psychiatric Institute, New York, NY, USA 2 Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 38:2475-83. 2013
    ..This is the first randomized, controlled trial to demonstrate that a drug affecting glutamate neurotransmission can reduce OCD symptoms without the presence of an SRI and is consistent with a glutamatergic hypothesis of OCD...
  30. pmc Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [(11)C]ABP688 and magnetic resonance spectroscopy
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York Electronic address
    Biol Psychiatry 75:165-71. 2014
    ..The goal of this study was to use imaging of the human brain to investigate alterations in the glutamate signaling in cocaine addiction...
  31. ncbi request reprint Pharmacokinetics and brain distribution in non human primate of R(-)[123I]DOI, A 5HT(2A/2C) serotonin agonist
    Yolanda Zea-Ponce
    Departments of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Nucl Med Biol 29:575-83. 2002
    ....
  32. pmc Glutamatergic abnormalities in schizophrenia: a review of proton MRS findings
    Eline M P Poels
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA New York State Psychiatric Institute, New York, NY, USA
    Schizophr Res 152:325-32. 2014
    ..We will review the contribution of (1)H-MRS studies to our knowledge about glutamatergic abnormalities in the brains of individuals with SCZ and discuss the implications for future research and clinical care. ..
  33. pmc Maternal-fetal blood incompatibility and neuromorphologic anomalies in schizophrenia: Preliminary findings
    David Freedman
    Department of Epidemiology, Mailman School of Public Health of Columbia University, New York, NY, USA
    Prog Neuropsychopharmacol Biol Psychiatry 35:1525-9. 2011
    ..The findings also suggest that the larger hippocampal volume in exposed controls may indicate a mechanism of adaptive resilience which diminishes the risk that controls will develop schizophrenia...
  34. pmc (99m)Tc hexamethyl-propylene-aminoxime single-photon emission computed tomography prediction of conversion from mild cognitive impairment to Alzheimer disease
    D P Devanand
    NYSPI, Columbia University, New York, NY 10032, USA
    Am J Geriatr Psychiatry 18:959-72. 2010
    ..To examine the utility of single-photon emission computed tomography (SPECT) to predict conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD)...
  35. ncbi request reprint Serotonin 1A receptor availability in patients with schizophrenia and schizo-affective disorder: a positron emission tomography imaging study with [11C]WAY 100635
    W Gordon Frankle
    Departments of Psychiatry and Radiology, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 189:155-64. 2006
    ..This study examines 5-HT(1A) availability in vivo in individuals with schizophrenia and schizo-affective disorder...

Research Grants1

  1. DOPAMINE AND GABA IMAGING IN SCHIZOPHRENIA
    Lawrence Kegeles; Fiscal Year: 2004
    ..abstract_text> ..