Fay Kastrinos

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. doi request reprint History, Genetics, and Strategies for Cancer Prevention in Lynch Syndrome
    Fay Kastrinos
    Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York Division of Digestive and Liver Diseases, Columbia University Medical Center, New York, New York Electronic address
    Clin Gastroenterol Hepatol 12:715-27. 2014
  2. pmc Comparison of the clinical prediction model PREMM(1,2,6) and molecular testing for the systematic identification of Lynch syndrome in colorectal cancer
    Fay Kastrinos
    Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA
    Gut 62:272-9. 2013
  3. pmc Development and validation of a colon cancer risk assessment tool for patients undergoing colonoscopy
    Fay Kastrinos
    Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Gastroenterol 104:1508-18. 2009
  4. pmc The PREMM(1,2,6) model predicts risk of MLH1, MSH2, and MSH6 germline mutations based on cancer history
    Fay Kastrinos
    Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Columbia University Medical Center, New York, New York 10032, USA
    Gastroenterology 140:73-81. 2011
  5. pmc Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome
    Elena Stoffel
    Brigham and Women s Hospital, Boston, Massachusetts Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Gastroenterology 137:1621-7. 2009
  6. doi request reprint Phenotype comparison of MLH1 and MSH2 mutation carriers in a cohort of 1,914 individuals undergoing clinical genetic testing in the United States
    Fay Kastrinos
    Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:2044-51. 2008
  7. pmc Shortened surveillance intervals following suboptimal bowel preparation for colonoscopy: results of a national survey
    Grace Clarke Hillyer
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th Street, New York, NY 10032, USA
    Int J Colorectal Dis 28:73-81. 2013
  8. doi request reprint Risk of pancreatic cancer in families with Lynch syndrome
    Fay Kastrinos
    Department of Internal Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    JAMA 302:1790-5. 2009
  9. pmc Prevalence and phenotypes of APC and MUTYH mutations in patients with multiple colorectal adenomas
    Shilpa Grover
    Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    JAMA 308:485-92. 2012
  10. pmc Performance of PREMM(1,2,6), MMRpredict, and MMRpro in detecting Lynch syndrome among endometrial cancer cases
    Rowena C Mercado
    Population Sciences Division, Dana Farber Cancer Institute, Boston, MA, USA
    Genet Med 14:670-80. 2012

Collaborators

Detail Information

Publications18

  1. doi request reprint History, Genetics, and Strategies for Cancer Prevention in Lynch Syndrome
    Fay Kastrinos
    Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York Division of Digestive and Liver Diseases, Columbia University Medical Center, New York, New York Electronic address
    Clin Gastroenterol Hepatol 12:715-27. 2014
    ..This article will provide a review of the major advances in risk assessment, molecular genetics, DNA mutational analyses, and cancer prevention and management made since Lynch syndrome was first described 100 years ago. ..
  2. pmc Comparison of the clinical prediction model PREMM(1,2,6) and molecular testing for the systematic identification of Lynch syndrome in colorectal cancer
    Fay Kastrinos
    Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA
    Gut 62:272-9. 2013
    ..Lynch syndrome is caused by germline mismatch repair (MMR) gene mutations. The PREMM(1,2,6) model predicts the likelihood of a MMR gene mutation based on personal and family cancer history...
  3. pmc Development and validation of a colon cancer risk assessment tool for patients undergoing colonoscopy
    Fay Kastrinos
    Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Gastroenterol 104:1508-18. 2009
    ..Our aim was to develop a simple, preprocedural risk assessment tool to identify who may be at highest risk for CRC...
  4. pmc The PREMM(1,2,6) model predicts risk of MLH1, MSH2, and MSH6 germline mutations based on cancer history
    Fay Kastrinos
    Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Columbia University Medical Center, New York, New York 10032, USA
    Gastroenterology 140:73-81. 2011
    ..We developed and validated a model to estimate the risks of mutations in the mismatch repair (MMR) genes MLH1, MSH2, and MSH6 based on personal and family history of cancer...
  5. pmc Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome
    Elena Stoffel
    Brigham and Women s Hospital, Boston, Massachusetts Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Gastroenterology 137:1621-7. 2009
    ..Some previous estimates of lifetime risk for CRC and endometrial cancer (EC) did not control for ascertainment and were susceptible to bias toward overestimated risk...
  6. doi request reprint Phenotype comparison of MLH1 and MSH2 mutation carriers in a cohort of 1,914 individuals undergoing clinical genetic testing in the United States
    Fay Kastrinos
    Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:2044-51. 2008
    ..We examined the phenotypic differences between MLH1 and MSH2 gene mutation carriers and whether mutation type (point versus large rearrangement) affected phenotypic expression...
  7. pmc Shortened surveillance intervals following suboptimal bowel preparation for colonoscopy: results of a national survey
    Grace Clarke Hillyer
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th Street, New York, NY 10032, USA
    Int J Colorectal Dis 28:73-81. 2013
    ..A random sample of a national organization of gastroenterologists in the U.S. was surveyed...
  8. doi request reprint Risk of pancreatic cancer in families with Lynch syndrome
    Fay Kastrinos
    Department of Internal Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    JAMA 302:1790-5. 2009
    ..A number of extracolonic tumors have been associated with the disorder, including pancreatic cancer; however, the risk of pancreatic cancer in Lynch syndrome is uncertain and not quantified...
  9. pmc Prevalence and phenotypes of APC and MUTYH mutations in patients with multiple colorectal adenomas
    Shilpa Grover
    Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    JAMA 308:485-92. 2012
    ..Patients with multiple colorectal adenomas may carry germline mutations in the APC or MUTYH genes...
  10. pmc Performance of PREMM(1,2,6), MMRpredict, and MMRpro in detecting Lynch syndrome among endometrial cancer cases
    Rowena C Mercado
    Population Sciences Division, Dana Farber Cancer Institute, Boston, MA, USA
    Genet Med 14:670-80. 2012
    ..Lynch syndrome accounts for 2-5% of endometrial cancer cases. Lynch syndrome prediction models have not been evaluated among endometrial cancer cases...
  11. pmc Split dose and MiraLAX-based purgatives to enhance bowel preparation quality becoming common recommendations in the US
    Grace Clarke Hillyer
    Associate Research Scientist, Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY 10032, USA
    Therap Adv Gastroenterol 6:5-14. 2013
    ..We examined the patterns of utilization of these newer approaches to improve precolonoscopy bowel preparation quality among American gastroenterologists...
  12. pmc Gastroenterologists' perceived barriers to optimal pre-colonoscopy bowel preparation: results of a national survey
    Grace Clarke Hillyer
    Department of Epidemiology, Mailman School of Public Health of Columbia University, 722 W 168th Street, Room 704, New York, NY, 10032, USA
    J Cancer Educ 27:526-32. 2012
    ..Bowel preparation instruction communication and unmet patient educational needs contribute to suboptimal bowel preparation. Educational interventions should address both practice and patient-related factors...
  13. pmc Knowledge of quality performance measures associated with endoscopy among gastroenterology trainees and the impact of a web-based intervention
    Jennifer S Thompson
    Division of Liver and Digestive Diseases at Columbia University Medical Center, New York, New York 10032, USA
    Gastrointest Endosc 76:100-6.e1-4. 2012
    ..Knowledge of quality measures in endoscopy among trainees is unknown...
  14. pmc Prediction models in Lynch syndrome
    Fay Kastrinos
    Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA
    Fam Cancer 12:217-28. 2013
    ....
  15. pmc Inherited colorectal cancer syndromes
    Fay Kastrinos
    Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA
    Cancer J 17:405-15. 2011
    ..Through personalized strategies for diagnosis and management, a substantial reduction in morbidity and mortality has been appreciated among patients at highest risk for the development of colorectal cancer...
  16. pmc Recently identified colon cancer predispositions: MYH and MSH6 mutations
    Fay Kastrinos
    Division of Gastroenterology, Brigham and Women s Hospital, Boston, MA, USA
    Semin Oncol 34:418-24. 2007
    ..Recognizing these heritable syndromes is essential and predictive genetic testing will continue to transform the field of cancer risk assessment by offering the opportunity to focus on more precise risk management and cancer prevention...
  17. ncbi request reprint Attitudes toward prenatal genetic testing in patients with familial adenomatous polyposis
    Fay Kastrinos
    Division of Gastroenterology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Am J Gastroenterol 102:1284-90. 2007
    ..If a mutation is identified, prenatal testing can reveal whether an embryo or fetus is affected. We conducted a pilot study to assess FAP patients' attitudes toward prenatal testing...
  18. pmc The impact of suboptimal bowel preparation on adenoma miss rates and the factors associated with early repeat colonoscopy
    Benjamin Lebwohl
    Department of Medicine, Division of Digestive and Liver Diseases, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Gastrointest Endosc 73:1207-14. 2011
    ..There are no guidelines for the recommended interval to the next examination after colonoscopy with suboptimal bowel preparation...