Research Topics
Genomes and Genes
| E R KandelSummaryAffiliation: Columbia University Country: USA Publications
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Publications
Activity-dependent presynaptic facilitation and hebbian LTP are both required and interact during classical conditioning in AplysiaIgor Antonov
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
Neuron 37:135-47. 2003..In addition, our results suggest that the two mechanisms are not independent but rather interact through retrograde signaling...
The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEBEric R Kandel
Department of Neuroscience, Columbia University, New York, NY 10032, USA
Mol Brain 5:14. 2012....- Transcriptional regulation of long-term memory in the marine snail AplysiaYong Seok Lee
National Creative Research Initiative Center for Memory, Department of Biological Sciences, Seoul National University, Korea
Mol Brain 1:3. 2008..In this review, we examine the roles of these transcription factors during consolidation of LTF induced by different stimulation paradigms... - Strain-dependent differences in LTP and hippocampus-dependent memory in inbred miceP V Nguyen
Department of Physiology and Division of Neuroscience, University of Alberta School of Medicine, Edmonton, Canada, T6G 2H7
Learn Mem 7:170-9. 2000.... - The past, the future and the biology of memory storageE R Kandel
Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Philos Trans R Soc Lond B Biol Sci 354:2027-52. 1999.... - The molecular biology of memory storage: a dialogue between genes and synapsesE R Kandel
Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
Science 294:1030-8. 2001.... 
The biology of memory: a forty-year perspectiveEric R Kandel
Department of Neuroscience, Columbia University, New York, New York 10032, USA
J Neurosci 29:12748-56. 2009..Here I use that chronology to chart a personalized and selective course through forty years of extraordinary advances in our understanding of the biology of memory storage...- The molecular biology of memory storage: a dialog between genes and synapsesE R Kandel
Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Biosci Rep 21:565-611. 2001..The biology of learning, and short-term and long-term memory, as revealed by Aplysia and other organisms, is reviewed... - The molecular biology of memory storage: a dialog between genes and synapsesEric R Kandel
College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Biosci Rep 24:475-522. 2004..The biology of learning, and short-term and long-term memory, as revealed by Aplysia and other organisms, is reviewed... - A parallel between radical reductionism in science and in artEric R Kandel
Howard Hughes Medical Institute, Center for Neurobiology and Behavior, Columbia University College of Physicians Surgeons, New York, New York 10032, USA
Ann N Y Acad Sci 1001:272-94. 2003..Second, in certain instances the humanities and neural sciences use common methodologies to achieve their respective goals... - Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brainB Santoro
Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
Cell 93:717-29. 1998.... - Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memoryI M Mansuy
Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York 10032, USA
Cell 92:39-49. 1998..Our behavioral results suggest that calcineurin has a role in the transition from short- to long-term memory, which correlates with a novel intermediate phase of LTP... - Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinaseS L Patterson
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Neuron 32:123-40. 2001.... - Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurinD G Winder
Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York 10032, USA
Cell 92:25-37. 1998..These data suggest that calcineurin acts as an inhibitory constraint on I-LTP that is relieved by PKA. This inhibitory constraint acts as a gate to regulate the synaptic induction of L-LTP... - Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurinG Malleret
Howard Hughes Medical Institute, Center for Neurobiology and Behavior, Columbia University, 722 West 168th Street, New York, NY 10032, USA
Cell 104:675-86. 2001..The LTP and memory improvements are reversed fully by suppression of transgene expression. These results demonstrate that endogenous calcineurin constrains LTP and memory... - Evidence for synaptotagmin as an inhibitory clamp on synaptic vesicle release in Aplysia neuronsK C Martin
Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 92:11307-11. 1995..In contrast, treatment of cultured presynaptic neurons with synaptotagmin antisense oligonucleotides increased the amplitude of the EPSP by 50-75%. These results are consistent with a role of synaptotagmin as an inhibitor of release... - Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural changeD Bartsch
Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Cell 83:979-92. 1995..This facilitation has the properties of long-term facilitation: it requires transcription and translation, induces the growth of new synaptic connections, and occludes further facilitation by five pulses of 5-HT... - CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitationD Bartsch
Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University and New York State Psychiatric Institute, New York 10032, USA
Cell 95:211-23. 1998..Cytoplasmic CREB1c modulates both the short- and long-term facilitation. Thus, in the sensory neurons, CREB1 encodes a critical regulatory unit converting short- to long-term synaptic changes... - Control of memory formation through regulated expression of a CaMKII transgeneM Mayford
Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, and Howard Hughes Medical Institute, 722 West 168 Street, New York, NY 10032, USA
Science 274:1678-83. 1996..Thus, the CaMKII signaling pathway is critical for both explicit and implicit memory storage, in a manner that is independent of its potential role in development... - A selective role of calcineurin aalpha in synaptic depotentiation in hippocampusM Zhuo
Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 96:4650-5. 1999..These studies provide genetic evidence that the Aalpha isoform of calcineurin is important for the reversal of LTP in the hippocampus and indicate that depotentiation and LTD operate through somewhat different molecular mechanisms... - Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthaseH Son
Howard Hughes Medical Institute and Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Cell 87:1015-23. 1996..They further suggest that there is also a NOS-independent component of LTP in stratum radiatum and that LTP in stratum oriens is largely NOS independent... - The contribution of activity-dependent synaptic plasticity to classical conditioning in AplysiaI Antonov
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, New York, New York 10032, USA
J Neurosci 21:6413-22. 2001.... - Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiationI Antonova
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, Howard Hughes Medical Institute, New York State Psychiatric Institute, New York, NY 10032, USA
Science 294:1547-50. 2001..These results suggest that potentiation involves rapid coordinate changes in the distribution of proteins in the presynaptic neuron as well as the postsynaptic neuron... - Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathwaysY Y Huang
Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York, USA
Proc Natl Acad Sci U S A 93:8699-704. 1996..These results provide genetic evidence that t-PA is a downstream effector gene important for L-LTP and show that modest impairment of L-LTP in CA1 and CA3 does not result in hippocampus-dependent behavioral phenotypes... - Consolidation of learning strategies during spatial working memory task requires protein synthesis in the prefrontal cortexK Touzani
Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 104:5632-7. 2007..We suggest that in addition to storing memory briefly the mPFC is also involved in the consolidation and storage of the long-term learning strategies used in working memory... - Relationships between dishabituation, sensitization, and inhibition of the gill- and siphon-withdrawal reflex in Aplysia californica: effects of response measure, test time, and training stimulusR D Hawkins
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Behav Neurosci 112:24-38. 1998.... - Long-term sensitization training in Aplysia leads to an increase in calreticulin, a major presynaptic calcium-binding proteinT E Kennedy
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York
Neuron 9:1013-24. 1992.... - Classical conditioning, differential conditioning, and second-order conditioning of the Aplysia gill-withdrawal reflex in a simplified mantle organ preparationR D Hawkins
Center for Neurobiology and Behavior, Columbia University, and New York State Psychiatric Institute, New York 10032, USA
Behav Neurosci 112:636-45. 1998..In each of these paradigms, learning in the Aplysia mantle organ preparation resembled learning in vertebrates... - Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in AplysiaA N Hegde
Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Cell 89:115-26. 1997..Thus, through induction of the hydrolase and the resulting up-regulation of the ubiquitin pathway, learning recruits a regulated form of proteolysis that removes inhibitory constraints on long-term memory storage... - C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in AplysiaC M Alberini
Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032
Cell 76:1099-114. 1994..These data indicate that cAMP-inducible immediate-early genes have an essential role in the consolidation of stable long-term synaptic plasticity in Aplysia... - Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout miceS L Patterson
Howard Hughes Medical Institute and Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York 10032, USA
Neuron 16:1137-45. 1996..Thus, BDNF has an acute role in hippocampal synaptic function... - Long-term sensitization training in Aplysia leads to an increase in the expression of BiP, the major protein chaperon of the ERD Kuhl
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032
J Cell Biol 119:1069-76. 1992..These findings suggest that the chaperon function of BiP might serve to fold proteins and assemble protein complexes necessary for the structural changes characteristic of long-term memory... - A VAMP-binding protein from Aplysia required for neurotransmitter releaseP A Skehel
Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Science 269:1580-3. 1995..Presynaptic injection of antibodies specific for VAP-33 inhibited synaptic transmission, which suggests that VAP-33 is required for the exocytosis of neurotransmitter... - A new class of noninactivating K+ channels from aplysia capable of contributing to the resting potential and firing patterns of neuronsB Zhao
Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University
Neuron 13:1205-13. 1994..Thus, by expressing different classes of K+ channels, it is possible to redesign, in specific ways, the signaling capabilities of specific, identified neurons... - Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant miceS G Grant
Center for Neurobiology and Behavior, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032
Science 258:1903-10. 1992..Thus, a common tyrosine kinase pathway may regulate the growth of neurons in the developing hippocampus and the strength of synaptic plasticity in the mature hippocampus... - Subregion- and cell type-restricted gene knockout in mouse brainJ Z Tsien
Howard Hughes Medical Institute, Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
Cell 87:1317-26. 1996..The brain subregional restricted gene knockout should allow a more precise analysis of the impact of a gene mutation on animal behaviors... - Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channelsB Santoro
Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, and Howard Hughes Medical Institute, 722 West 168th Street, New York, NY 10032, USA
Proc Natl Acad Sci U S A 94:14815-20. 1997..These findings suggest the existence of a new type of ion channel, which is potentially able to modulate membrane excitability in the brain and could respond to regulation by cyclic nucleotides... - Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOST J O'Dell
Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032
Science 265:542-6. 1994..These findings suggest that eNOS, rather than nNOS, generates NO within the postsynaptic cell during LTP... - A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learningY Y Huang
Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
Cell 83:1211-22. 1995..In the absence of mossy fiber LTP, adequate spatial and contextual information might reach the CA1 region via other pathways from the entorhinal cortex... - Cloning and characterization of two related serotonergic receptors from the brain and the reproductive system of Aplysia that activate phospholipase CX C Li
Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
J Neurosci 15:7585-91. 1995..The nucleotide sequences of Ap5-HTB1 and Ap5-HTB2 were submitted to GenBank; the accession numbers are L43557 and L43558, respectively... - Modulation of an NCAM-related adhesion molecule with long-term synaptic plasticity in AplysiaM Mayford
Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032
Science 256:638-44. 1992..This rapid, transmitter-mediated down-regulation of a cell adhesion molecule in the sensory neurons may be one of the early molecular changes in long-term synaptic facilitation... - Temporal and spatial regulation of the expression of BAD2, a MAP kinase phosphatase, during seizure, kindling, and long-term potentiationZ Qian
Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Learn Mem 1:180-8. 1994..In these regions, the induction of a MAP kinase-specific phosphatase may provide a negative feedback control associated with long-term synaptic changes... - Identification of a peptide specific for Aplysia sensory neurons by PCR-based differential screeningJ F Brunet
Howard Hughes Medical Institute, New York, NY
Science 252:856-9. 1991..The peptide selectively inhibits certain postsynaptic cells but not others and thereby allows the sensory neurons to achieve target-specific synaptic actions... - A quantitative study of the Ca2+/calmodulin sensitivity of adenylyl cyclase in Aplysia, Drosophila, and ratY Yovell
Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York
J Neurochem 59:1736-44. 1992..Ca2+ sensitivity was dependent on both calmodulin concentration and Mg2+ concentration. Mg2+ raised the threshold for adenylyl cyclase activation by Ca2+ but also acted synergistically with Ca2+ to activate maximally adenylyl cyclase... - Cloning and expression of an Aplysia K+ channel and comparison with native Aplysia K+ currentsP J Pfaffinger
Howard Hughes Medical Institute, Department of Physiology and Biophysics, Columbia University, College of Physicians and Surgeons, New York, New York 10032
J Neurosci 11:918-27. 1991.... - Prospects for neurology and psychiatryW M Cowan
Columbia University of Physicians and Surgeons, Center for Neurobiology and Behavior, 1051 Riverside Dr, New York, NY 10032, USA
JAMA 285:594-600. 2001.... - Sustained CPEB-dependent local protein synthesis is required to stabilize synaptic growth for persistence of long-term facilitation in AplysiaMaria Concetta Miniaci
Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive New York, NY 10032, USA
Neuron 59:1024-36. 2008.... - PKA-activated ApAF-ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitationJin-A Lee
Institute of Molecular Biology and Genetics, Rio, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea
J Cell Biol 174:827-38. 2006..Collectively, these results suggest that PKA-activated ApAF-ApC/EBP heterodimer is a core downstream effector of ApCREB in the consolidation of LTF... - Common molecular mechanisms in explicit and implicit memoryAngel Barco
Instituto de Neurociencias de Alicante (UMH-CSIC, Campus de Sant Joan, Spain
J Neurochem 97:1520-33. 2006..These two processes share common molecular mechanisms that have been highly conserved through evolution... - Molecular mechanisms of memory storage in AplysiaRobert D Hawkins
Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
Biol Bull 210:174-91. 2006.... - Age-related enhancement of a protein synthesis-dependent late phase of LTP induced by low frequency paired-pulse stimulation in hippocampusYan-You Huang
Kavli Institute for Brain Science, New York, New York, USA
Learn Mem 13:298-306. 2006..Because memory ability declines with aging, the age-related enhancement of L-LTP induced by PP-1 Hz stimulation indicates that this form of L-LTP appears to be inversely correlated with memory ability... - Dishabituation in Aplysia can involve either reversal of habituation or superimposed sensitizationRobert D Hawkins
Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
Learn Mem 13:397-403. 2006..5 min after the shock, dishabituation is due to superimposed sensitization. These results thus suggest that dishabituation may involve either process in the same preparation, and begin to define the conditions that favor one or the other... - A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel contextAmit Etkin
Center for Neurobiology and Behavior, Columbia University Medical Center, 1051 Riverside Drive, New York, New York 10032, USA
Neuron 50:127-43. 2006.... - Impaired bidirectional synaptic plasticity and procedural memory formation in striatum-specific cAMP response element-binding protein-deficient miceChristopher Pittenger
Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Neurosci 26:2808-13. 2006.... - Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioningChristoph Kellendonk
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, New York 10032, USA
Neuron 49:603-15. 2006..We found that D2R overexpression in the striatum impacts dopamine levels, rates of dopamine turnover, and activation of D1 receptors in the prefrontal cortex, measures that are critical for working memory... - Theta frequency stimulation induces a local form of late phase LTP in the CA1 region of the hippocampusYan-You Huang
Center for Neurobiology and Behavior, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Learn Mem 12:587-93. 2005..These results indicate that different patterns of synaptic stimulation can induce distinct forms of LTP that may have different roles in memory storage... - stathmin, a gene enriched in the amygdala, controls both learned and innate fearGleb P Shumyatsky
Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA
Cell 123:697-709. 2005..We therefore conclude that stathmin is required for the induction of LTP in afferent inputs to the amygdala and is essential in regulating both innate and learned fear... - Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic captureAngel Barco
Center for Neurobiology and Behavior, Columbia University, 1051 Riverside Drive, New York, New York 10032, USA
Neuron 48:123-37. 2005..We found that the overexpression of brain-derived neurotrophic factor accounts for an important component of this phenotype... - Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdalaAmit Etkin
Center for Neurobiology and Behavior, Columbia University Medical Center, Neurological Institute Box 108, 710 West 168th Street, New York, New York 10032, USA
Neuron 51:871-82. 2006..These data suggest that emotional conflict is resolved through top-down inhibition of amygdalar activity by the rostral cingulate cortex... - Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrusMichael D Saxe
Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 103:17501-6. 2006..These data show that new hippocampal neurons can be preferentially recruited over mature granule cells in vitro and may provide a framework for how this small cell population can influence behavior... - Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animalsJuhyun Kim
Department of Life Science, Pohang University of Science and Technology, Pohang, Gyungbuk 790 784, Korea
Proc Natl Acad Sci U S A 105:9087-92. 2008.... - Synaptic remodeling, synaptic growth and the storage of long-term memory in AplysiaCraig H Bailey
Department of Neuroscience, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
Prog Brain Res 169:179-98. 2008.... - cAMP response element-binding protein-mediated gene expression increases the intrinsic excitability of CA1 pyramidal neuronsMikel Lopez de Armentia
Instituto de Neurociencias de Alicante Universidad Miguel Hernández Consejo Superior de Investigaciones CientÃficas, Campus de Sant Joan, Sant Joan d Alacant, 03550 Alicante, Spain
J Neurosci 27:13909-18. 2007..As a result, our study has important implications for both the understanding of the cellular bases of learning and memory and the consideration of therapies targeted to the CREB pathway... - An animal model of a behavioral intervention for depressionDaniela D Pollak
Department of Neuroscience, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
Neuron 60:149-61. 2008..These data suggest that learned safety is an animal model of a behavioral antidepressant that shares some neuronal hallmarks of pharmacological antidepressants but is mediated by different molecular pathways... - Low-frequency stimulation induces a pathway-specific late phase of LTP in the amygdala that is mediated by PKA and dependent on protein synthesisYan You Huang
Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, New York 10032, USA
Learn Mem 14:497-503. 2007..These results indicate that the threshold for the induction of LFS L-LTP is different among these pathways and that the maintenance of LFS L-LTP requires a cross-talk among multiple neurotransmitters... - Nuclear translocation of CAM-associated protein activates transcription for long-term facilitation in AplysiaSeung Hee Lee
Department of Biological Sciences, Institute of Molecular Biology and Genetics, Rio, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Gwanak gu, Seoul 151 747, Korea
Cell 129:801-12. 2007..Combined, our data suggest that CAMAP is a retrograde signaling component that translocates from activated synapses to the nucleus during synapse-specific LTF... - 5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdalaYan You Huang
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Neurosci 27:3111-9. 2007..These results show, for the first time, that 5-HT can produce long-lasting facilitation of synaptic transmission in the amygdala and provides evidence for the possible synaptic role of 5-HT in long-term memory for learned fear... - Paradoxical influence of hippocampal neurogenesis on working memoryMichael D Saxe
Center for Neurobiology and Behavior and Howard Hughes Medical Institute, Columbia University, 722 West 168th Street, New York, NY 10032, USA
Proc Natl Acad Sci U S A 104:4642-6. 2007..These findings suggest that adult-born cells in the dentate gyrus have different, and in some cases, opposite roles in distinct types of memory... - Transient overexpression of striatal D2 receptors impairs operant motivation and interval timingMichael R Drew
Division of Integrative Neuroscience, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
J Neurosci 27:7731-9. 2007..Moreover, overexpression of D2 under pathological conditions such as schizophrenia and Parkinson's disease could give rise to motivational and timing deficits... - Operant conditioning of gill withdrawal in AplysiaRobert D Hawkins
Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
J Neurosci 26:2443-8. 2006.... - Transgenic inhibition of neuronal protein kinase A activity facilitates fear extinctionCarolina Isiegas
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 26:12700-7. 2006..Further, these experiments represent the first genetic evidence that protein kinases may be constraints for the extinction of fear... - Chronically increased Gsalpha signaling disrupts associative and spatial learningRusiko Bourtchouladze
Center for Neurobiology and Behavior and Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Learn Mem 13:745-52. 2006..The learning deficits observed in these transgenic mice suggest that associative and spatial learning requires regulated Gsalpha protein signaling, much as does olfactory learning in Drosophila... - Neuronal transcriptome of Aplysia: neuronal compartments and circuitryLeonid L Moroz
The Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Boulevard, St Augustine, FL 32080, USA
Cell 127:1453-67. 2006.... - Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiationYan You Huang
Center for Neurobiology and Behavior, New York State Psychiatric Institute, New York, NY 10032, USA
Proc Natl Acad Sci U S A 102:9365-70. 2005..Thus Rab3A and its effectors are general modules for four distinct types of PKA-dependent LTP in the brain... - Distinct neural signatures for safety and danger in the amygdala and striatum of the mouseMichael T Rogan
Center for Neurobiology and Behavior, Columbia University Medical Center, New York, New York 10032, USA
Neuron 46:309-20. 2005.... - Axonal transport of eukaryotic translation elongation factor 1alpha mRNA couples transcription in the nucleus to long-term facilitation at the synapseMaurizio Giustetto
Center for Neurobiology and Behavior, College of Physicians and Surgeons, New York State Psychiatric Institute, and Howard Hughes Medical Institute, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
Proc Natl Acad Sci U S A 100:13680-5. 2003..The transport of eEF1A protein and its mRNA to nerve terminals suggests that the translation factor plays a role in the local protein synthesis that is essential for maintaining newly formed synapses... - An unbiased cDNA library prepared from isolated Aplysia sensory neuron processes is enriched for cytoskeletal and translational mRNAsRobert Moccia
Brain Research Institute Interdepartmental Program in Neuroscience, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
J Neurosci 23:9409-17. 2003..Our finding of mRNAs encoding components of the translational machinery suggests that local protein synthesis serves to increase the translational capacity of synapses... - Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapsesStanislav S Zakharenko
Center for Neurobiology and Behavior, Columbia University, 722 West 168th Street, New York, NY 10032, USA
Neuron 39:975-90. 2003..These results suggest that long-term synaptic plasticity has distinct presynaptic and postsynaptic modules. Release of BDNF from CA3 neurons is required to recruit the presynaptic, but not postsynaptic, module of plasticity... - Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteinsAmy Chen
Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Neuron 39:655-69. 2003..Relief of this inhibition lowers the threshold for hippocampal-dependent long-term synaptic potentiation and memory storage in mice... - p38 MAP kinase mediates both short-term and long-term synaptic depression in aplysiaZhonghui Guan
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Neurosci 23:7317-25. 2003..We conclude that p38 kinase, which itself is bidirectionally regulated by FMRFa and 5-HT, acts as a modulator of synaptic plasticity by positively regulating depression and serving as an inhibitory constraint for facilitation... - Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memoryAlexei Morozov
Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
Neuron 39:309-25. 2003..These results indicate that Rap1 couples cAMP signaling to a selective membrane-associated pool of p42/44MAPK to control excitability of pyramidal cells, the early and late phases of LTP, and the storage of spatial memory... - Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampusMartin Theis
Howard Hughes Medical Institute and Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
Proc Natl Acad Sci U S A 100:9602-7. 2003..Coexpression of mCPEB-1 and the B region-containing splice isoforms suggests that a variety of different signaling pathways can recruit CPEB activity in hippocampal neurons... - In search of general mechanisms for long-lasting plasticity: Aplysia and the hippocampusChristopher Pittenger
Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
Philos Trans R Soc Lond B Biol Sci 358:757-63. 2003.... - CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospectsAngel Barco
Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
Expert Opin Ther Targets 7:101-14. 2003.... - Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fearGleb P Shumyatsky
Howard Hughes Medical Institute, Center for Neurobiology and Behavior, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
Cell 111:905-18. 2002..These experiments provide genetic evidence that GRP and its neural circuitry operate as a negative feedback regulating fear and establish a causal relationship between Grpr gene expression, LTP, and amygdala-dependent memory for fear... - Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structureZhonghui Guan
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
Cell 111:483-93. 2002..When the two transmitters are applied together, facilitation is blocked because CREB2 and HDAC5 displace CREB1-CBP, thereby deacetylating histones... - Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampus-dependent spatial memoryChristopher Pittenger
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
Neuron 34:447-62. 2002..Nevertheless, they suggest that some experimental forms of plasticity bypass the requirement for CREB... - Fear conditioning occludes LTP-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdalaEvgeny Tsvetkov
McLean Hospital, Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Neuron 34:289-300. 2002.... - The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar Purkinje cellsMatthew F Nolan
Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
Cell 115:551-64. 2003..We suggest that this nonsynaptic integrative function of HCN1 is required for accurate decoding of input patterns and thereby enables synaptic plasticity to appropriately influence the performance of motor activity... - A neuronal isoform of the aplysia CPEB has prion-like propertiesKausik Si
Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 722 West 168th Street, New York, NY 10032, USA
Cell 115:879-91. 2003..We hypothesize that conversion of CPEB to a prion-like state in stimulated synapses helps to maintain long-term synaptic changes associated with memory storage... - Serotonin-induced regulation of the actin network for learning-related synaptic growth requires Cdc42, N-WASP, and PAK in Aplysia sensory neuronsHiroshi Udo
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Neuron 45:887-901. 2005.... - Presynaptic and postsynaptic roles of NO, cGK, and RhoA in long-lasting potentiation and aggregation of synaptic proteinsHong-Gang Wang
Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
Neuron 45:389-403. 2005..cGK phosphorylates synaptic VASP during the potentiation, whereas Rho GTPases act both in parallel and upstream of cGMP, in part by maintaining the synaptic localization of soluble guanylyl cyclase... - Individual differences in trait anxiety predict the response of the basolateral amygdala to unconsciously processed fearful facesAmit Etkin
Center for Neurobiology and Behavior, Columbia University Medical Center, fMRI Research Center, 170 West 168th Street, Box 108, New York, New York 10032, USA
Neuron 44:1043-55. 2004..These findings provide a biological basis for the unconscious emotional vigilance characteristic of anxiety and a means for investigating the mechanisms and efficacy of treatments for anxiety... - A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neuronsMatthew F Nolan
Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
Cell 119:719-32. 2004..We suggest that HCN1 channels constrain learning and memory by regulating dendritic integration of distal synaptic inputs to pyramidal cells... - Transient expansion of synaptically connected dendritic spines upon induction of hippocampal long-term potentiationCynthia Lang
Center for Neurobiology and Behavior, Department of Pharmacology, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
Proc Natl Acad Sci U S A 101:16665-70. 2004..Thus, transient spine expansion is a characteristic feature of the initial phases of plasticity at mature synapses and so may contribute to synapse remodeling important for LTP... - A semi-persistent adult ocular dominance plasticity in visual cortex is stabilized by activated CREBTony A Pham
Department of Psychiatry and Behavioral Sciences, University of Washington, School of Medicine, Seattle, Washington 98104, USA
Learn Mem 11:738-47. 2004..These results suggest that in development and adulthood, the regulation of a trans-synaptic signaling pathway controls the adaptive potential of cortical circuits... - Role of Aplysia cell adhesion molecules during 5-HT-induced long-term functional and structural changesJin-Hee Han
National Research Laboratory of Neurobiology, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-742, Korea
Learn Mem 11:421-35. 2004..Thus, our data suggest that TM-apCAM may act as a suppressor of both synaptic-strength enhancement in pre-existing synapses and of new synaptic varicosity formation in the nonsynaptic region, via different mechanisms... - Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its ameliorationJuan M Alarcon
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
Neuron 42:947-59. 2004.... - Selective modulation of some forms of schaffer collateral-CA1 synaptic plasticity in mice with a disruption of the CPEB-1 geneJuan M Alarcon
College of Physicians and Surgeons of Columbia University, Columbia University, New York, New York 10032, USA
Learn Mem 11:318-27. 2004..These data suggest that CPEB-1 contributes in the translational control of mRNAs that is critical only for some selected forms of LTP and LTD... - Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegenerationCarlos A Saura
Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
Neuron 42:23-36. 2004..These results define essential roles and molecular targets of presenilins in synaptic plasticity, learning and memory, and neuronal survival in the adult cerebral cortex... - The long-term stability of new hippocampal place fields requires new protein synthesisNaveen T Agnihotri
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 101:3656-61. 2004..Our results indicate that place fields parallel both behavioral memories and the late phase of long-term potentiation in requiring the synthesis of new proteins for consolidation...
Research Grants
- A Molecular Analysis of the Gateway Hypothesis in MiceEric Kandel; Fiscal Year: 2009..The findings of the research may make it possible to develop new drugs to prevent and treat substance abuse. ..
- A Molecular Analysis of the Gateway Hypothesis in MiceAmir Levine; Fiscal Year: 2010..The findings of the research may make it possible to develop new drugs to prevent and treat substance abuse. ..
- The Role of Neuronal Integration in Working MemoryEric Kandel; Fiscal Year: 2009..does HCN1 knockout affect the physiological properties of circuits involved in short-term memory both in the prefrontal cortex? 3) Does HCN1 influence the 'on-line' neural representation of information during working memory? ..
- A Molecular Analysis of the Gateway Hypothesis in MiceEric Kandel; Fiscal Year: 2007..The findings of the research may make it possible to develop new drugs to prevent and treat substance abuse. ..
- The Role of Neuronal Integration in Working MemoryEric Kandel; Fiscal Year: 2007..2) How does HCN1 knockout affect the physiological properties of circuits involved in short-term memory both in the prefrontal cortex? 3) Does HCN1 influence the 'on-line' neural representation of information during working memory? ..
- MOLECULAR BIOLOGICAL APPROACHES: LTP IN THE HIPPOCAMPUSEric Kandel; Fiscal Year: 2004..abstract_text> ..
- The Role of Neuronal Integration in Working MemoryEric R Kandel; Fiscal Year: 2010..does HCN1 knockout affect the physiological properties of circuits involved in short-term memory both in the prefrontal cortex? 3) Does HCN1 influence the 'on-line'neural representation of information during working memory? ..