E R Kandel

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Activity-dependent presynaptic facilitation and hebbian LTP are both required and interact during classical conditioning in Aplysia
    Igor Antonov
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 37:135-47. 2003
  2. pmc Ancient origin of somatic and visceral neurons
    Marc Nomaksteinsky
    Institut de Biologie de l Ecole Normale Supérieure IBENS, CNRS UMR8197, Inserm U1024, Paris, France
    BMC Biol 11:53. 2013
  3. pmc The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB
    Eric R Kandel
    Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Mol Brain 5:14. 2012
  4. pmc Transcriptional regulation of long-term memory in the marine snail Aplysia
    Yong Seok Lee
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, Seoul National University, Korea
    Mol Brain 1:3. 2008
  5. pmc Strain-dependent differences in LTP and hippocampus-dependent memory in inbred mice
    P V Nguyen
    Department of Physiology and Division of Neuroscience, University of Alberta School of Medicine, Edmonton, Canada, T6G 2H7
    Learn Mem 7:170-9. 2000
  6. ncbi request reprint The molecular biology of memory storage: a dialogue between genes and synapses
    E R Kandel
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Science 294:1030-8. 2001
  7. ncbi request reprint The molecular biology of memory storage: a dialog between genes and synapses
    E R Kandel
    Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Biosci Rep 21:565-611. 2001
  8. pmc The past, the future and the biology of memory storage
    E R Kandel
    Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Philos Trans R Soc Lond B Biol Sci 354:2027-52. 1999
  9. ncbi request reprint A parallel between radical reductionism in science and in art
    Eric R Kandel
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, Columbia University College of Physicians Surgeons, New York, New York 10032, USA
    Ann N Y Acad Sci 1001:272-94. 2003
  10. ncbi request reprint The molecular biology of memory storage: a dialog between genes and synapses
    Eric R Kandel
    College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Biosci Rep 24:475-522. 2004

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint Activity-dependent presynaptic facilitation and hebbian LTP are both required and interact during classical conditioning in Aplysia
    Igor Antonov
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 37:135-47. 2003
    ..In addition, our results suggest that the two mechanisms are not independent but rather interact through retrograde signaling...
  2. pmc Ancient origin of somatic and visceral neurons
    Marc Nomaksteinsky
    Institut de Biologie de l Ecole Normale Supérieure IBENS, CNRS UMR8197, Inserm U1024, Paris, France
    BMC Biol 11:53. 2013
    ....
  3. pmc The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB
    Eric R Kandel
    Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Mol Brain 5:14. 2012
    ....
  4. pmc Transcriptional regulation of long-term memory in the marine snail Aplysia
    Yong Seok Lee
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, Seoul National University, Korea
    Mol Brain 1:3. 2008
    ..In this review, we examine the roles of these transcription factors during consolidation of LTF induced by different stimulation paradigms...
  5. pmc Strain-dependent differences in LTP and hippocampus-dependent memory in inbred mice
    P V Nguyen
    Department of Physiology and Division of Neuroscience, University of Alberta School of Medicine, Edmonton, Canada, T6G 2H7
    Learn Mem 7:170-9. 2000
    ....
  6. ncbi request reprint The molecular biology of memory storage: a dialogue between genes and synapses
    E R Kandel
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Science 294:1030-8. 2001
    ....
  7. ncbi request reprint The molecular biology of memory storage: a dialog between genes and synapses
    E R Kandel
    Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Biosci Rep 21:565-611. 2001
    ..The biology of learning, and short-term and long-term memory, as revealed by Aplysia and other organisms, is reviewed...
  8. pmc The past, the future and the biology of memory storage
    E R Kandel
    Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Philos Trans R Soc Lond B Biol Sci 354:2027-52. 1999
    ....
  9. ncbi request reprint A parallel between radical reductionism in science and in art
    Eric R Kandel
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, Columbia University College of Physicians Surgeons, New York, New York 10032, USA
    Ann N Y Acad Sci 1001:272-94. 2003
    ..Second, in certain instances the humanities and neural sciences use common methodologies to achieve their respective goals...
  10. ncbi request reprint The molecular biology of memory storage: a dialog between genes and synapses
    Eric R Kandel
    College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Biosci Rep 24:475-522. 2004
    ..The biology of learning, and short-term and long-term memory, as revealed by Aplysia and other organisms, is reviewed...
  11. doi request reprint The biology of memory: a forty-year perspective
    Eric R Kandel
    Department of Neuroscience, Columbia University, New York, New York 10032, USA
    J Neurosci 29:12748-56. 2009
    ..Here I use that chronology to chart a personalized and selective course through forty years of extraordinary advances in our understanding of the biology of memory storage...
  12. ncbi request reprint Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain
    B Santoro
    Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Cell 93:717-29. 1998
    ....
  13. ncbi request reprint Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory
    I M Mansuy
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York 10032, USA
    Cell 92:39-49. 1998
    ..Our behavioral results suggest that calcineurin has a role in the transition from short- to long-term memory, which correlates with a novel intermediate phase of LTP...
  14. ncbi request reprint Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase
    S L Patterson
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuron 32:123-40. 2001
    ....
  15. ncbi request reprint Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin
    D G Winder
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York 10032, USA
    Cell 92:25-37. 1998
    ..These data suggest that calcineurin acts as an inhibitory constraint on I-LTP that is relieved by PKA. This inhibitory constraint acts as a gate to regulate the synaptic induction of L-LTP...
  16. ncbi request reprint Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin
    G Malleret
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, Columbia University, 722 West 168th Street, New York, NY 10032, USA
    Cell 104:675-86. 2001
    ..The LTP and memory improvements are reversed fully by suppression of transgene expression. These results demonstrate that endogenous calcineurin constrains LTP and memory...
  17. pmc Evidence for synaptotagmin as an inhibitory clamp on synaptic vesicle release in Aplysia neurons
    K C Martin
    Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 92:11307-11. 1995
    ..In contrast, treatment of cultured presynaptic neurons with synaptotagmin antisense oligonucleotides increased the amplitude of the EPSP by 50-75%. These results are consistent with a role of synaptotagmin as an inhibitor of release...
  18. ncbi request reprint Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change
    D Bartsch
    Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cell 83:979-92. 1995
    ..This facilitation has the properties of long-term facilitation: it requires transcription and translation, induces the growth of new synaptic connections, and occludes further facilitation by five pulses of 5-HT...
  19. ncbi request reprint Control of memory formation through regulated expression of a CaMKII transgene
    M Mayford
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, and Howard Hughes Medical Institute, 722 West 168 Street, New York, NY 10032, USA
    Science 274:1678-83. 1996
    ..Thus, the CaMKII signaling pathway is critical for both explicit and implicit memory storage, in a manner that is independent of its potential role in development...
  20. ncbi request reprint CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation
    D Bartsch
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University and New York State Psychiatric Institute, New York 10032, USA
    Cell 95:211-23. 1998
    ..Cytoplasmic CREB1c modulates both the short- and long-term facilitation. Thus, in the sensory neurons, CREB1 encodes a critical regulatory unit converting short- to long-term synaptic changes...
  21. ncbi request reprint Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase
    H Son
    Howard Hughes Medical Institute and Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Cell 87:1015-23. 1996
    ..They further suggest that there is also a NOS-independent component of LTP in stratum radiatum and that LTP in stratum oriens is largely NOS independent...
  22. ncbi request reprint The contribution of activity-dependent synaptic plasticity to classical conditioning in Aplysia
    I Antonov
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 21:6413-22. 2001
    ....
  23. pmc A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus
    M Zhuo
    Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 96:4650-5. 1999
    ..These studies provide genetic evidence that the Aalpha isoform of calcineurin is important for the reversal of LTP in the hippocampus and indicate that depotentiation and LTD operate through somewhat different molecular mechanisms...
  24. ncbi request reprint Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation
    I Antonova
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, Howard Hughes Medical Institute, New York State Psychiatric Institute, New York, NY 10032, USA
    Science 294:1547-50. 2001
    ..These results suggest that potentiation involves rapid coordinate changes in the distribution of proteins in the presynaptic neuron as well as the postsynaptic neuron...
  25. pmc Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways
    Y Y Huang
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York, USA
    Proc Natl Acad Sci U S A 93:8699-704. 1996
    ..These results provide genetic evidence that t-PA is a downstream effector gene important for L-LTP and show that modest impairment of L-LTP in CA1 and CA3 does not result in hippocampus-dependent behavioral phenotypes...
  26. ncbi request reprint Relationships between dishabituation, sensitization, and inhibition of the gill- and siphon-withdrawal reflex in Aplysia californica: effects of response measure, test time, and training stimulus
    R D Hawkins
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Behav Neurosci 112:24-38. 1998
    ....
  27. pmc Consolidation of learning strategies during spatial working memory task requires protein synthesis in the prefrontal cortex
    K Touzani
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:5632-7. 2007
    ..We suggest that in addition to storing memory briefly the mPFC is also involved in the consolidation and storage of the long-term learning strategies used in working memory...
  28. pmc Long-term sensitization training in Aplysia leads to an increase in the expression of BiP, the major protein chaperon of the ER
    D Kuhl
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    J Cell Biol 119:1069-76. 1992
    ..These findings suggest that the chaperon function of BiP might serve to fold proteins and assemble protein complexes necessary for the structural changes characteristic of long-term memory...
  29. ncbi request reprint Classical conditioning, differential conditioning, and second-order conditioning of the Aplysia gill-withdrawal reflex in a simplified mantle organ preparation
    R D Hawkins
    Center for Neurobiology and Behavior, Columbia University, and New York State Psychiatric Institute, New York 10032, USA
    Behav Neurosci 112:636-45. 1998
    ..In each of these paradigms, learning in the Aplysia mantle organ preparation resembled learning in vertebrates...
  30. ncbi request reprint Long-term sensitization training in Aplysia leads to an increase in calreticulin, a major presynaptic calcium-binding protein
    T E Kennedy
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York
    Neuron 9:1013-24. 1992
    ....
  31. ncbi request reprint Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia
    A N Hegde
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Cell 89:115-26. 1997
    ..Thus, through induction of the hydrolase and the resulting up-regulation of the ubiquitin pathway, learning recruits a regulated form of proteolysis that removes inhibitory constraints on long-term memory storage...
  32. ncbi request reprint C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
    C M Alberini
    Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Cell 76:1099-114. 1994
    ..These data indicate that cAMP-inducible immediate-early genes have an essential role in the consolidation of stable long-term synaptic plasticity in Aplysia...
  33. ncbi request reprint Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice
    S L Patterson
    Howard Hughes Medical Institute and Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York 10032, USA
    Neuron 16:1137-45. 1996
    ..Thus, BDNF has an acute role in hippocampal synaptic function...
  34. ncbi request reprint Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice
    S G Grant
    Center for Neurobiology and Behavior, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Science 258:1903-10. 1992
    ..Thus, a common tyrosine kinase pathway may regulate the growth of neurons in the developing hippocampus and the strength of synaptic plasticity in the mature hippocampus...
  35. ncbi request reprint A new class of noninactivating K+ channels from aplysia capable of contributing to the resting potential and firing patterns of neurons
    B Zhao
    Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University
    Neuron 13:1205-13. 1994
    ..Thus, by expressing different classes of K+ channels, it is possible to redesign, in specific ways, the signaling capabilities of specific, identified neurons...
  36. ncbi request reprint A VAMP-binding protein from Aplysia required for neurotransmitter release
    P A Skehel
    Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Science 269:1580-3. 1995
    ..Presynaptic injection of antibodies specific for VAP-33 inhibited synaptic transmission, which suggests that VAP-33 is required for the exocytosis of neurotransmitter...
  37. ncbi request reprint Subregion- and cell type-restricted gene knockout in mouse brain
    J Z Tsien
    Howard Hughes Medical Institute, Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 87:1317-26. 1996
    ..The brain subregional restricted gene knockout should allow a more precise analysis of the impact of a gene mutation on animal behaviors...
  38. pmc Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels
    B Santoro
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, and Howard Hughes Medical Institute, 722 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 94:14815-20. 1997
    ..These findings suggest the existence of a new type of ion channel, which is potentially able to modulate membrane excitability in the brain and could respond to regulation by cyclic nucleotides...
  39. ncbi request reprint Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS
    T J O'Dell
    Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032
    Science 265:542-6. 1994
    ..These findings suggest that eNOS, rather than nNOS, generates NO within the postsynaptic cell during LTP...
  40. ncbi request reprint A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning
    Y Y Huang
    Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
    Cell 83:1211-22. 1995
    ..In the absence of mossy fiber LTP, adequate spatial and contextual information might reach the CA1 region via other pathways from the entorhinal cortex...
  41. ncbi request reprint Cloning and characterization of two related serotonergic receptors from the brain and the reproductive system of Aplysia that activate phospholipase C
    X C Li
    Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Neurosci 15:7585-91. 1995
    ..The nucleotide sequences of Ap5-HTB1 and Ap5-HTB2 were submitted to GenBank; the accession numbers are L43557 and L43558, respectively...
  42. ncbi request reprint Modulation of an NCAM-related adhesion molecule with long-term synaptic plasticity in Aplysia
    M Mayford
    Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032
    Science 256:638-44. 1992
    ..This rapid, transmitter-mediated down-regulation of a cell adhesion molecule in the sensory neurons may be one of the early molecular changes in long-term synaptic facilitation...
  43. ncbi request reprint Temporal and spatial regulation of the expression of BAD2, a MAP kinase phosphatase, during seizure, kindling, and long-term potentiation
    Z Qian
    Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Learn Mem 1:180-8. 1994
    ..In these regions, the induction of a MAP kinase-specific phosphatase may provide a negative feedback control associated with long-term synaptic changes...
  44. ncbi request reprint Identification of a peptide specific for Aplysia sensory neurons by PCR-based differential screening
    J F Brunet
    Howard Hughes Medical Institute, New York, NY
    Science 252:856-9. 1991
    ..The peptide selectively inhibits certain postsynaptic cells but not others and thereby allows the sensory neurons to achieve target-specific synaptic actions...
  45. ncbi request reprint A quantitative study of the Ca2+/calmodulin sensitivity of adenylyl cyclase in Aplysia, Drosophila, and rat
    Y Yovell
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York
    J Neurochem 59:1736-44. 1992
    ..Ca2+ sensitivity was dependent on both calmodulin concentration and Mg2+ concentration. Mg2+ raised the threshold for adenylyl cyclase activation by Ca2+ but also acted synergistically with Ca2+ to activate maximally adenylyl cyclase...
  46. ncbi request reprint Cloning and expression of an Aplysia K+ channel and comparison with native Aplysia K+ currents
    P J Pfaffinger
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, Columbia University, College of Physicians and Surgeons, New York, New York 10032
    J Neurosci 11:918-27. 1991
    ....
  47. ncbi request reprint Prospects for neurology and psychiatry
    W M Cowan
    Columbia University of Physicians and Surgeons, Center for Neurobiology and Behavior, 1051 Riverside Dr, New York, NY 10032, USA
    JAMA 285:594-600. 2001
    ....
  48. ncbi request reprint Common molecular mechanisms in explicit and implicit memory
    Angel Barco
    Instituto de Neurociencias de Alicante UMH CSIC, Campus de Sant Joan, Spain
    J Neurochem 97:1520-33. 2006
    ..These two processes share common molecular mechanisms that have been highly conserved through evolution...
  49. pmc PKA-activated ApAF-ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation
    Jin A Lee
    Institute of Molecular Biology and Genetics, Rio, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    J Cell Biol 174:827-38. 2006
    ..Collectively, these results suggest that PKA-activated ApAF-ApC/EBP heterodimer is a core downstream effector of ApCREB in the consolidation of LTF...
  50. ncbi request reprint Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala
    Amit Etkin
    Center for Neurobiology and Behavior, Columbia University Medical Center, Neurological Institute Box 108, 710 West 168th Street, New York, New York 10032, USA
    Neuron 51:871-82. 2006
    ..These data suggest that emotional conflict is resolved through top-down inhibition of amygdalar activity by the rostral cingulate cortex...
  51. pmc Age-related enhancement of a protein synthesis-dependent late phase of LTP induced by low frequency paired-pulse stimulation in hippocampus
    Yan You Huang
    Kavli Institute for Brain Science, New York, New York, USA
    Learn Mem 13:298-306. 2006
    ..Because memory ability declines with aging, the age-related enhancement of L-LTP induced by PP-1 Hz stimulation indicates that this form of L-LTP appears to be inversely correlated with memory ability...
  52. pmc Dishabituation in Aplysia can involve either reversal of habituation or superimposed sensitization
    Robert D Hawkins
    Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Learn Mem 13:397-403. 2006
    ..5 min after the shock, dishabituation is due to superimposed sensitization. These results thus suggest that dishabituation may involve either process in the same preparation, and begin to define the conditions that favor one or the other...
  53. ncbi request reprint A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context
    Amit Etkin
    Center for Neurobiology and Behavior, Columbia University Medical Center, 1051 Riverside Drive, New York, New York 10032, USA
    Neuron 50:127-43. 2006
    ....
  54. ncbi request reprint Operant conditioning of gill withdrawal in Aplysia
    Robert D Hawkins
    Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    J Neurosci 26:2443-8. 2006
    ....
  55. ncbi request reprint Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning
    Christoph Kellendonk
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, New York 10032, USA
    Neuron 49:603-15. 2006
    ..We found that D2R overexpression in the striatum impacts dopamine levels, rates of dopamine turnover, and activation of D1 receptors in the prefrontal cortex, measures that are critical for working memory...
  56. pmc Theta frequency stimulation induces a local form of late phase LTP in the CA1 region of the hippocampus
    Yan You Huang
    Center for Neurobiology and Behavior, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Learn Mem 12:587-93. 2005
    ..These results indicate that different patterns of synaptic stimulation can induce distinct forms of LTP that may have different roles in memory storage...
  57. ncbi request reprint stathmin, a gene enriched in the amygdala, controls both learned and innate fear
    Gleb P Shumyatsky
    Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA
    Cell 123:697-709. 2005
    ..We therefore conclude that stathmin is required for the induction of LTP in afferent inputs to the amygdala and is essential in regulating both innate and learned fear...
  58. ncbi request reprint Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture
    Angel Barco
    Center for Neurobiology and Behavior, Columbia University, 1051 Riverside Drive, New York, New York 10032, USA
    Neuron 48:123-37. 2005
    ..We found that the overexpression of brain-derived neurotrophic factor accounts for an important component of this phenotype...
  59. ncbi request reprint Molecular mechanisms of memory storage in Aplysia
    Robert D Hawkins
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Bull 210:174-91. 2006
    ....
  60. pmc Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
    Michael D Saxe
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:17501-6. 2006
    ..These data show that new hippocampal neurons can be preferentially recruited over mature granule cells in vitro and may provide a framework for how this small cell population can influence behavior...
  61. pmc Chronically increased Gsalpha signaling disrupts associative and spatial learning
    Rusiko Bourtchouladze
    Center for Neurobiology and Behavior and Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Learn Mem 13:745-52. 2006
    ..The learning deficits observed in these transgenic mice suggest that associative and spatial learning requires regulated Gsalpha protein signaling, much as does olfactory learning in Drosophila...
  62. pmc An animal model of a behavioral intervention for depression
    Daniela D Pollak
    Department of Neuroscience, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 60:149-61. 2008
    ..These data suggest that learned safety is an animal model of a behavioral antidepressant that shares some neuronal hallmarks of pharmacological antidepressants but is mediated by different molecular pathways...
  63. pmc Sustained CPEB-dependent local protein synthesis is required to stabilize synaptic growth for persistence of long-term facilitation in Aplysia
    Maria Concetta Miniaci
    Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive New York, NY 10032, USA
    Neuron 59:1024-36. 2008
    ....
  64. pmc Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals
    Juhyun Kim
    Department of Life Science, Pohang University of Science and Technology, Pohang, Gyungbuk 790 784, Korea
    Proc Natl Acad Sci U S A 105:9087-92. 2008
    ....
  65. doi request reprint Synaptic remodeling, synaptic growth and the storage of long-term memory in Aplysia
    Craig H Bailey
    Department of Neuroscience, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Prog Brain Res 169:179-98. 2008
    ....
  66. ncbi request reprint cAMP response element-binding protein-mediated gene expression increases the intrinsic excitability of CA1 pyramidal neurons
    Mikel Lopez de Armentia
    Instituto de Neurociencias de Alicante Universidad Miguel Hernández Consejo Superior de Investigaciones Científicas, Campus de Sant Joan, Sant Joan d Alacant, 03550 Alicante, Spain
    J Neurosci 27:13909-18. 2007
    ..As a result, our study has important implications for both the understanding of the cellular bases of learning and memory and the consideration of therapies targeted to the CREB pathway...
  67. ncbi request reprint Transient overexpression of striatal D2 receptors impairs operant motivation and interval timing
    Michael R Drew
    Division of Integrative Neuroscience, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Neurosci 27:7731-9. 2007
    ..Moreover, overexpression of D2 under pathological conditions such as schizophrenia and Parkinson's disease could give rise to motivational and timing deficits...
  68. pmc Low-frequency stimulation induces a pathway-specific late phase of LTP in the amygdala that is mediated by PKA and dependent on protein synthesis
    Yan You Huang
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, New York 10032, USA
    Learn Mem 14:497-503. 2007
    ..These results indicate that the threshold for the induction of LFS L-LTP is different among these pathways and that the maintenance of LFS L-LTP requires a cross-talk among multiple neurotransmitters...
  69. ncbi request reprint Nuclear translocation of CAM-associated protein activates transcription for long-term facilitation in Aplysia
    Seung Hee Lee
    Department of Biological Sciences, Institute of Molecular Biology and Genetics, Rio, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Gwanak gu, Seoul 151 747, Korea
    Cell 129:801-12. 2007
    ..Combined, our data suggest that CAMAP is a retrograde signaling component that translocates from activated synapses to the nucleus during synapse-specific LTF...
  70. ncbi request reprint 5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala
    Yan You Huang
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 27:3111-9. 2007
    ..These results show, for the first time, that 5-HT can produce long-lasting facilitation of synaptic transmission in the amygdala and provides evidence for the possible synaptic role of 5-HT in long-term memory for learned fear...
  71. pmc Axonal transport of eukaryotic translation elongation factor 1alpha mRNA couples transcription in the nucleus to long-term facilitation at the synapse
    Maurizio Giustetto
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, New York State Psychiatric Institute, and Howard Hughes Medical Institute, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:13680-5. 2003
    ..The transport of eEF1A protein and its mRNA to nerve terminals suggests that the translation factor plays a role in the local protein synthesis that is essential for maintaining newly formed synapses...
  72. pmc Paradoxical influence of hippocampal neurogenesis on working memory
    Michael D Saxe
    Center for Neurobiology and Behavior and Howard Hughes Medical Institute, Columbia University, 722 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:4642-6. 2007
    ..These findings suggest that adult-born cells in the dentate gyrus have different, and in some cases, opposite roles in distinct types of memory...
  73. ncbi request reprint Neuronal transcriptome of Aplysia: neuronal compartments and circuitry
    Leonid L Moroz
    The Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Boulevard, St Augustine, FL 32080, USA
    Cell 127:1453-67. 2006
    ....
  74. pmc Transgenic inhibition of neuronal protein kinase A activity facilitates fear extinction
    Carolina Isiegas
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:12700-7. 2006
    ..Further, these experiments represent the first genetic evidence that protein kinases may be constraints for the extinction of fear...
  75. ncbi request reprint Impaired bidirectional synaptic plasticity and procedural memory formation in striatum-specific cAMP response element-binding protein-deficient mice
    Christopher Pittenger
    Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 26:2808-13. 2006
    ....
  76. pmc Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation
    Yan You Huang
    Center for Neurobiology and Behavior, New York State Psychiatric Institute, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:9365-70. 2005
    ..Thus Rab3A and its effectors are general modules for four distinct types of PKA-dependent LTP in the brain...
  77. ncbi request reprint The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar Purkinje cells
    Matthew F Nolan
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Cell 115:551-64. 2003
    ..We suggest that this nonsynaptic integrative function of HCN1 is required for accurate decoding of input patterns and thereby enables synaptic plasticity to appropriately influence the performance of motor activity...
  78. ncbi request reprint An unbiased cDNA library prepared from isolated Aplysia sensory neuron processes is enriched for cytoskeletal and translational mRNAs
    Robert Moccia
    Brain Research Institute Interdepartmental Program in Neuroscience, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
    J Neurosci 23:9409-17. 2003
    ..Our finding of mRNAs encoding components of the translational machinery suggests that local protein synthesis serves to increase the translational capacity of synapses...
  79. ncbi request reprint Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses
    Stanislav S Zakharenko
    Center for Neurobiology and Behavior, Columbia University, 722 West 168th Street, New York, NY 10032, USA
    Neuron 39:975-90. 2003
    ..These results suggest that long-term synaptic plasticity has distinct presynaptic and postsynaptic modules. Release of BDNF from CA3 neurons is required to recruit the presynaptic, but not postsynaptic, module of plasticity...
  80. ncbi request reprint Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins
    Amy Chen
    Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Neuron 39:655-69. 2003
    ..Relief of this inhibition lowers the threshold for hippocampal-dependent long-term synaptic potentiation and memory storage in mice...
  81. ncbi request reprint p38 MAP kinase mediates both short-term and long-term synaptic depression in aplysia
    Zhonghui Guan
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 23:7317-25. 2003
    ..We conclude that p38 kinase, which itself is bidirectionally regulated by FMRFa and 5-HT, acts as a modulator of synaptic plasticity by positively regulating depression and serving as an inhibitory constraint for facilitation...
  82. ncbi request reprint Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory
    Alexei Morozov
    Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 39:309-25. 2003
    ..These results indicate that Rap1 couples cAMP signaling to a selective membrane-associated pool of p42/44MAPK to control excitability of pyramidal cells, the early and late phases of LTP, and the storage of spatial memory...
  83. pmc Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus
    Martin Theis
    Howard Hughes Medical Institute and Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:9602-7. 2003
    ..Coexpression of mCPEB-1 and the B region-containing splice isoforms suggests that a variety of different signaling pathways can recruit CPEB activity in hippocampal neurons...
  84. pmc In search of general mechanisms for long-lasting plasticity: Aplysia and the hippocampus
    Christopher Pittenger
    Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    Philos Trans R Soc Lond B Biol Sci 358:757-63. 2003
    ....
  85. ncbi request reprint CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospects
    Angel Barco
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Expert Opin Ther Targets 7:101-14. 2003
    ....
  86. ncbi request reprint Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear
    Gleb P Shumyatsky
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Cell 111:905-18. 2002
    ..These experiments provide genetic evidence that GRP and its neural circuitry operate as a negative feedback regulating fear and establish a causal relationship between Grpr gene expression, LTP, and amygdala-dependent memory for fear...
  87. ncbi request reprint Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure
    Zhonghui Guan
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Cell 111:483-93. 2002
    ..When the two transmitters are applied together, facilitation is blocked because CREB2 and HDAC5 displace CREB1-CBP, thereby deacetylating histones...
  88. ncbi request reprint Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampus-dependent spatial memory
    Christopher Pittenger
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 34:447-62. 2002
    ..Nevertheless, they suggest that some experimental forms of plasticity bypass the requirement for CREB...
  89. ncbi request reprint Fear conditioning occludes LTP-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdala
    Evgeny Tsvetkov
    McLean Hospital, Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neuron 34:289-300. 2002
    ....
  90. ncbi request reprint A neuronal isoform of the aplysia CPEB has prion-like properties
    Kausik Si
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 722 West 168th Street, New York, NY 10032, USA
    Cell 115:879-91. 2003
    ..We hypothesize that conversion of CPEB to a prion-like state in stimulated synapses helps to maintain long-term synaptic changes associated with memory storage...
  91. ncbi request reprint A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia
    Kausik Si
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 722 West 168th Street, New York, NY 10032, USA
    Cell 115:893-904. 2003
    ..We suggest that Aplysia CPEB is one of the stabilizing components of the synaptic mark...
  92. ncbi request reprint Distinct neural signatures for safety and danger in the amygdala and striatum of the mouse
    Michael T Rogan
    Center for Neurobiology and Behavior, Columbia University Medical Center, New York, New York 10032, USA
    Neuron 46:309-20. 2005
    ....
  93. ncbi request reprint Serotonin-induced regulation of the actin network for learning-related synaptic growth requires Cdc42, N-WASP, and PAK in Aplysia sensory neurons
    Hiroshi Udo
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Neuron 45:887-901. 2005
    ....
  94. ncbi request reprint Presynaptic and postsynaptic roles of NO, cGK, and RhoA in long-lasting potentiation and aggregation of synaptic proteins
    Hong Gang Wang
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuron 45:389-403. 2005
    ..cGK phosphorylates synaptic VASP during the potentiation, whereas Rho GTPases act both in parallel and upstream of cGMP, in part by maintaining the synaptic localization of soluble guanylyl cyclase...
  95. ncbi request reprint Individual differences in trait anxiety predict the response of the basolateral amygdala to unconsciously processed fearful faces
    Amit Etkin
    Center for Neurobiology and Behavior, Columbia University Medical Center, fMRI Research Center, 170 West 168th Street, Box 108, New York, New York 10032, USA
    Neuron 44:1043-55. 2004
    ..These findings provide a biological basis for the unconscious emotional vigilance characteristic of anxiety and a means for investigating the mechanisms and efficacy of treatments for anxiety...
  96. ncbi request reprint A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons
    Matthew F Nolan
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Cell 119:719-32. 2004
    ..We suggest that HCN1 channels constrain learning and memory by regulating dendritic integration of distal synaptic inputs to pyramidal cells...
  97. pmc Transient expansion of synaptically connected dendritic spines upon induction of hippocampal long-term potentiation
    Cynthia Lang
    Center for Neurobiology and Behavior, Department of Pharmacology, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 101:16665-70. 2004
    ..Thus, transient spine expansion is a characteristic feature of the initial phases of plasticity at mature synapses and so may contribute to synapse remodeling important for LTP...
  98. pmc A semi-persistent adult ocular dominance plasticity in visual cortex is stabilized by activated CREB
    Tony A Pham
    Department of Psychiatry and Behavioral Sciences, University of Washington, School of Medicine, Seattle, Washington 98104, USA
    Learn Mem 11:738-47. 2004
    ..These results suggest that in development and adulthood, the regulation of a trans-synaptic signaling pathway controls the adaptive potential of cortical circuits...
  99. pmc Role of Aplysia cell adhesion molecules during 5-HT-induced long-term functional and structural changes
    Jin Hee Han
    National Research Laboratory of Neurobiology, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 742, Korea
    Learn Mem 11:421-35. 2004
    ..Thus, our data suggest that TM-apCAM may act as a suppressor of both synaptic-strength enhancement in pre-existing synapses and of new synaptic varicosity formation in the nonsynaptic region, via different mechanisms...
  100. ncbi request reprint Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration
    Juan M Alarcon
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 42:947-59. 2004
    ....
  101. pmc Selective modulation of some forms of schaffer collateral-CA1 synaptic plasticity in mice with a disruption of the CPEB-1 gene
    Juan M Alarcon
    College of Physicians and Surgeons of Columbia University, Columbia University, New York, New York 10032, USA
    Learn Mem 11:318-27. 2004
    ..These data suggest that CPEB-1 contributes in the translational control of mRNAs that is critical only for some selected forms of LTP and LTD...

Research Grants13

  1. A Molecular Analysis of the Gateway Hypothesis in Mice
    Eric Kandel; Fiscal Year: 2009
    ..The findings of the research may make it possible to develop new drugs to prevent and treat substance abuse. ..
  2. A Molecular Analysis of the Gateway Hypothesis in Mice
    Amir Levine; Fiscal Year: 2010
    ..The findings of the research may make it possible to develop new drugs to prevent and treat substance abuse. ..
  3. The Role of Neuronal Integration in Working Memory
    Eric Kandel; Fiscal Year: 2009
    ..does HCN1 knockout affect the physiological properties of circuits involved in short-term memory both in the prefrontal cortex? 3) Does HCN1 influence the 'on-line' neural representation of information during working memory? ..
  4. A Molecular Analysis of the Gateway Hypothesis in Mice
    Eric Kandel; Fiscal Year: 2007
    ..The findings of the research may make it possible to develop new drugs to prevent and treat substance abuse. ..
  5. The Role of Neuronal Integration in Working Memory
    Eric Kandel; Fiscal Year: 2007
    ..2) How does HCN1 knockout affect the physiological properties of circuits involved in short-term memory both in the prefrontal cortex? 3) Does HCN1 influence the 'on-line' neural representation of information during working memory? ..
  6. MOLECULAR BIOLOGICAL APPROACHES: LTP IN THE HIPPOCAMPUS
    Eric Kandel; Fiscal Year: 2004
    ..abstract_text> ..
  7. The Role of Neuronal Integration in Working Memory
    Eric R Kandel; Fiscal Year: 2010
    ..does HCN1 knockout affect the physiological properties of circuits involved in short-term memory both in the prefrontal cortex? 3) Does HCN1 influence the 'on-line'neural representation of information during working memory? ..