LANCE C KAM

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Micro- and nanoscale engineering of cell signaling
    L C Kam
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Annu Rev Biomed Eng 15:305-26. 2013
  2. pmc Capturing the nanoscale complexity of cellular membranes in supported lipid bilayers
    LANCE C KAM
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Struct Biol 168:3-10. 2009
  3. pmc Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobility
    Keenan T Bashour
    Department of Biomedical Engineering, Columbia University, New York, New York, USA
    Mol Cell Biol 34:955-64. 2014
  4. pmc Concentration-dependent requirement for local protein synthesis in motor neuron subtype-specific response to axon guidance cues
    Stephane Nedelec
    Department of Pathology and Cell Biology, Center for Motor Neuron Biology and Disease, College of Physicians and Surgeons, PS 14 434, Columbia University, New York, New York 10032, USA
    J Neurosci 32:1496-506. 2012
  5. pmc Self-aligned supported lipid bilayers for patterning the cell-substrate interface
    Keyue Shen
    Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    J Am Chem Soc 131:13204-5. 2009
  6. pmc CD28 and CD3 have complementary roles in T-cell traction forces
    Keenan T Bashour
    Departments of Biomedical Engineering and Mechanical Engineering, Columbia University, New York, NY 10027
    Proc Natl Acad Sci U S A 111:2241-6. 2014
  7. pmc Mechanosensing in T lymphocyte activation
    Edward Judokusumo
    Department of Biomedical Engineering, Columbia University, New York, New York, USA
    Biophys J 102:L5-7. 2012
  8. pmc Micropatterning of costimulatory ligands enhances CD4+ T cell function
    Keyue Shen
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 105:7791-6. 2008
  9. pmc Combined microfluidics/protein patterning platform for pharmacological interrogation of axon pathfinding
    Peng Shi
    Department of Biomedical Engineering, Columbia University, New York, NY, USA
    Lab Chip 10:1005-10. 2010
  10. pmc Non-Brownian diffusion of membrane molecules in nanopatterned supported lipid bilayers
    Jones Tsai
    Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    Nano Lett 8:425-30. 2008

Collaborators

  • Xin Liu
  • M L Dustin
  • Michael C Milone
  • Yuan Gao
  • Keyue Shen
  • Keenan T Bashour
  • Peng Shi
  • Jones Tsai
  • Stephane Nedelec
  • Edward Judokusumo
  • Eileen Sun
  • James C Hone
  • Hynek Wichterle
  • Morgan Huse
  • Joung Hyun Lee
  • Haoqian Chen
  • Alexander Gondarenko
  • Erdem Tabdanov
  • Sudha Kumari
  • Mackenzie W Amoroso
  • Mirza Peljto
  • V Kaye Thomas

Detail Information

Publications11

  1. pmc Micro- and nanoscale engineering of cell signaling
    L C Kam
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Annu Rev Biomed Eng 15:305-26. 2013
    ....
  2. pmc Capturing the nanoscale complexity of cellular membranes in supported lipid bilayers
    LANCE C KAM
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Struct Biol 168:3-10. 2009
    ....
  3. pmc Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobility
    Keenan T Bashour
    Department of Biomedical Engineering, Columbia University, New York, New York, USA
    Mol Cell Biol 34:955-64. 2014
    ..These results demonstrate a subcellular reaction-diffusion system that allows cells to sense the microscale organization of the extracellular environment. ..
  4. pmc Concentration-dependent requirement for local protein synthesis in motor neuron subtype-specific response to axon guidance cues
    Stephane Nedelec
    Department of Pathology and Cell Biology, Center for Motor Neuron Biology and Disease, College of Physicians and Surgeons, PS 14 434, Columbia University, New York, New York 10032, USA
    J Neurosci 32:1496-506. 2012
    ....
  5. pmc Self-aligned supported lipid bilayers for patterning the cell-substrate interface
    Keyue Shen
    Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    J Am Chem Soc 131:13204-5. 2009
    ..Our results present a novel platform for the study of spatial separation of extracellular ligands and its impact on cell signals...
  6. pmc CD28 and CD3 have complementary roles in T-cell traction forces
    Keenan T Bashour
    Departments of Biomedical Engineering and Mechanical Engineering, Columbia University, New York, NY 10027
    Proc Natl Acad Sci U S A 111:2241-6. 2014
    ..Mouse cells expressing the 5C.C7 TCR exerted traction forces on pillars presenting peptide-loaded MHCs that were similar to those with α-CD3, suggesting that forces are applied to antigen-presenting cells during activation. ..
  7. pmc Mechanosensing in T lymphocyte activation
    Edward Judokusumo
    Department of Biomedical Engineering, Columbia University, New York, New York, USA
    Biophys J 102:L5-7. 2012
    ..The ability of T cells to quantitatively respond to substrate rigidly provides an intriguing new model for mechanobiology...
  8. pmc Micropatterning of costimulatory ligands enhances CD4+ T cell function
    Keyue Shen
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 105:7791-6. 2008
    ..With these patterns, we show that the peripheral presentation of CD28 has a larger impact on IL-2 secretion than CD3 colocalization/segregation...
  9. pmc Combined microfluidics/protein patterning platform for pharmacological interrogation of axon pathfinding
    Peng Shi
    Department of Biomedical Engineering, Columbia University, New York, NY, USA
    Lab Chip 10:1005-10. 2010
    ..These results demonstrate that cell signaling must take into account the spatial layout of the cell. This new platform provides a powerful tool for understanding such effects over a wide range of signaling systems...
  10. pmc Non-Brownian diffusion of membrane molecules in nanopatterned supported lipid bilayers
    Jones Tsai
    Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    Nano Lett 8:425-30. 2008
    ....

Research Grants4

  1. Neuronal Biointerface: Micropatterned Lipid Bilayers
    Lance Kam; Fiscal Year: 2006
    ....
  2. Modulation of T Cell Function by Patterning of Costimulatory Ligands
    Lance Kam; Fiscal Year: 2007
    ..Successful completion of these studies will lead to a better understanding of immune system function and can lead to improved devices and methods for tailoring immune responses. ..
  3. Spatial coordination of CD28 and TCR signaling
    LANCE C KAM; Fiscal Year: 2010
    ..These studies provide new tools dissecting such pathways, and may lead to improved system for directing the activation of T cells for therapeutic applications. ..