LANCE C KAM

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. doi request reprint Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells
    Erdem Tabdanov
    Department of Biomedical Engineering, Columbia University, New York, NY, USA
    Integr Biol (Camb) 7:1272-84. 2015
  2. pmc Micro- and nanoscale engineering of cell signaling
    L C Kam
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Annu Rev Biomed Eng 15:305-26. 2013
  3. pmc Capturing the nanoscale complexity of cellular membranes in supported lipid bilayers
    LANCE C KAM
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Struct Biol 168:3-10. 2009
  4. pmc Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobility
    Keenan T Bashour
    Department of Biomedical Engineering, Columbia University, New York, New York, USA
    Mol Cell Biol 34:955-64. 2014
  5. pmc Concentration-dependent requirement for local protein synthesis in motor neuron subtype-specific response to axon guidance cues
    Stephane Nedelec
    Department of Pathology and Cell Biology, Center for Motor Neuron Biology and Disease, College of Physicians and Surgeons, PS 14 434, Columbia University, New York, New York 10032, USA
    J Neurosci 32:1496-506. 2012
  6. pmc Mechanosensing in T lymphocyte activation
    Edward Judokusumo
    Department of Biomedical Engineering, Columbia University, New York, New York, USA
    Biophys J 102:L5-7. 2012
  7. pmc Self-aligned supported lipid bilayers for patterning the cell-substrate interface
    Keyue Shen
    Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    J Am Chem Soc 131:13204-5. 2009
  8. doi request reprint A microfluidic platform reveals differential response of regulatory T cells to micropatterned costimulation arrays
    Joung Hyun Lee
    Department of Biomedical Engineering, Columbia University in the City of New York, New York, USA
    Integr Biol (Camb) 7:1442-53. 2015
  9. pmc Micropatterning of costimulatory ligands enhances CD4+ T cell function
    Keyue Shen
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 105:7791-6. 2008
  10. pmc CD28 and CD3 have complementary roles in T-cell traction forces
    Keenan T Bashour
    Departments of Biomedical Engineering and Mechanical Engineering, Columbia University, New York, NY 10027
    Proc Natl Acad Sci U S A 111:2241-6. 2014

Collaborators

  • Xin Liu
  • M L Dustin
  • Michael C Milone
  • Yuan Gao
  • Keyue Shen
  • Keenan T Bashour
  • Peng Shi
  • Jones Tsai
  • Joung Hyun Lee
  • Erdem Tabdanov
  • Stephane Nedelec
  • Sudha Kumari
  • Edward Judokusumo
  • Hynek Wichterle
  • James C Hone
  • Eileen Sun
  • Thomas Iskratsch
  • Michael P Sheetz
  • Sasha Gondarenko
  • Anastasia Liapis
  • Morgan Huse
  • Haoqian Chen
  • Alexander Gondarenko
  • Mirza Peljto
  • Mackenzie W Amoroso
  • V Kaye Thomas

Detail Information

Publications13

  1. doi request reprint Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells
    Erdem Tabdanov
    Department of Biomedical Engineering, Columbia University, New York, NY, USA
    Integr Biol (Camb) 7:1272-84. 2015
    ..LFA-1 adhesion enhances actomyosin forces, which in turn modulate actin assembly downstream of the TCR. Together our data shows a mechanically cooperative system through which ligands presented by an APC modulate T cell activation. ..
  2. pmc Micro- and nanoscale engineering of cell signaling
    L C Kam
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Annu Rev Biomed Eng 15:305-26. 2013
    ....
  3. pmc Capturing the nanoscale complexity of cellular membranes in supported lipid bilayers
    LANCE C KAM
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Struct Biol 168:3-10. 2009
    ....
  4. pmc Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobility
    Keenan T Bashour
    Department of Biomedical Engineering, Columbia University, New York, New York, USA
    Mol Cell Biol 34:955-64. 2014
    ..These results demonstrate a subcellular reaction-diffusion system that allows cells to sense the microscale organization of the extracellular environment. ..
  5. pmc Concentration-dependent requirement for local protein synthesis in motor neuron subtype-specific response to axon guidance cues
    Stephane Nedelec
    Department of Pathology and Cell Biology, Center for Motor Neuron Biology and Disease, College of Physicians and Surgeons, PS 14 434, Columbia University, New York, New York 10032, USA
    J Neurosci 32:1496-506. 2012
    ....
  6. pmc Mechanosensing in T lymphocyte activation
    Edward Judokusumo
    Department of Biomedical Engineering, Columbia University, New York, New York, USA
    Biophys J 102:L5-7. 2012
    ..The ability of T cells to quantitatively respond to substrate rigidly provides an intriguing new model for mechanobiology...
  7. pmc Self-aligned supported lipid bilayers for patterning the cell-substrate interface
    Keyue Shen
    Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    J Am Chem Soc 131:13204-5. 2009
    ..Our results present a novel platform for the study of spatial separation of extracellular ligands and its impact on cell signals...
  8. doi request reprint A microfluidic platform reveals differential response of regulatory T cells to micropatterned costimulation arrays
    Joung Hyun Lee
    Department of Biomedical Engineering, Columbia University in the City of New York, New York, USA
    Integr Biol (Camb) 7:1442-53. 2015
    ....
  9. pmc Micropatterning of costimulatory ligands enhances CD4+ T cell function
    Keyue Shen
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 105:7791-6. 2008
    ..With these patterns, we show that the peripheral presentation of CD28 has a larger impact on IL-2 secretion than CD3 colocalization/segregation...
  10. pmc CD28 and CD3 have complementary roles in T-cell traction forces
    Keenan T Bashour
    Departments of Biomedical Engineering and Mechanical Engineering, Columbia University, New York, NY 10027
    Proc Natl Acad Sci U S A 111:2241-6. 2014
    ..Mouse cells expressing the 5C.C7 TCR exerted traction forces on pillars presenting peptide-loaded MHCs that were similar to those with α-CD3, suggesting that forces are applied to antigen-presenting cells during activation. ..
  11. pmc Combined microfluidics/protein patterning platform for pharmacological interrogation of axon pathfinding
    Peng Shi
    Department of Biomedical Engineering, Columbia University, New York, NY, USA
    Lab Chip 10:1005-10. 2010
    ..These results demonstrate that cell signaling must take into account the spatial layout of the cell. This new platform provides a powerful tool for understanding such effects over a wide range of signaling systems...
  12. pmc Non-Brownian diffusion of membrane molecules in nanopatterned supported lipid bilayers
    Jones Tsai
    Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    Nano Lett 8:425-30. 2008
    ....

Research Grants2

  1. Neuronal Biointerface: Micropatterned Lipid Bilayers
    Lance Kam; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  2. Modulation of T Cell Function by Patterning of Costimulatory Ligands
    Lance Kam; Fiscal Year: 2008
    ..Successful completion of these studies will lead to a better understanding of immune system function and can lead to improved devices and methods for tailoring immune responses. [unreadable] [unreadable] [unreadable]..